CN109030151A - Liquid-based flaking method - Google Patents
Liquid-based flaking method Download PDFInfo
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- CN109030151A CN109030151A CN201810911550.7A CN201810911550A CN109030151A CN 109030151 A CN109030151 A CN 109030151A CN 201810911550 A CN201810911550 A CN 201810911550A CN 109030151 A CN109030151 A CN 109030151A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
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Abstract
The present invention provides a kind of liquid-based flaking methods comprising the steps of: Sputum cup processing step: handling Sputum cup internal specimen liquid, obtains pretreating liquid；Filter cup action step: pretreating liquid is obtained by filtration to film-making liquid in filter cup；Glass slide action step: the filter cup that glass slide contact fills film-making liquid carries out bat printing, obtains Thinprep.The entire film-making process of the present invention can be realized automatically, be not necessarily to human intervention；Realize really liquefaction film-making: all samples add digestive juice and buffer automatically, realize sample liquefaction.
Description
Technical field
The present invention relates to medical instruments fields, and in particular, to a kind of liquid-based flaking method.
Background technique
Liquid-based pelleter is used for the film-making before pathological analysis to human body cell sample, is turned by stirring, cell absorption, cell
Move, cell filtering device composition, be aim at clinic, disease control, quality inspection, quality department all kinds of specialized laboratories automatic sheet
And the product manufactured and designed.Liquid-based pelleter be according to liquid based cytology principle, using low adsorption micro porous filtration membrane filtration technique,
By film bat printing mode, cooperates dedicated Sample dilution and the high absorption glass slide of cation, one is made on glass slide
Uniform cell thin, convenient for further examining and diagnosing.
Existing liquid-based flaking method usually requires human assistance operation, and there are the possibility of operator and sample contact
Property, the convenience used and safety all existing defects.
Summary of the invention
For the defects in the prior art, the object of the present invention is to provide a kind of liquid-based flaking methods.
The liquid-based flaking method provided according to the present invention comprising the steps of:
Sputum cup processing step: handling Sputum cup internal specimen liquid, obtains pretreating liquid；
Filter cup action step: pretreating liquid is obtained by filtration to film-making liquid in filter cup；
Glass slide action step: the filter cup that glass slide contact fills film-making liquid carries out bat printing, obtains Thinprep.
Preferably, the Sputum cup processing step includes to puncture concussion step and stirring imbibing step；
The concussion step that punctures comprises the steps of:
Step S1.1.1: the Sputum cup equipped with sample liquid on Sputum cup apparatus for placing is punctured, and digestion is injected in Sputum cup
Liquid；
Step S1.1.2: by Sputum cup clamping to concussion instrument, setting time is shaken；
The stirring imbibing step comprises the steps of:
Step S1.2.1: by Sputum cup clamping to cap rotating device, Sputum cup lid is unscrewed；
Step S1.2.2: buffer is added into Sputum cup；
Step S1.2.3: liquid absorption device drives TIP to be inserted into Sputum cup and is stirred the pre- place of acquisition to Sputum cup internal liquid
Liquid is managed, enables and draws TIP absorption pretreating liquid；
Step S1.2.4: after cap rotating device screws Sputum cup lid, Sputum cup clamping is put back on Sputum cup apparatus for placing.
Preferably, the concussion step that punctures also includes step S1.1.3: the Sputum cup clamping after concussion is put back into Sputum cup
On apparatus for placing, S1.1.1 is returned to step, until Sputum cup completion all on Sputum cup apparatus for placing is punctured and operated with concussion；
In the step S1.1.2, the setting time of concussion is 5~10s；
In the step S1.2.2, buffer is added into Sputum cup using diaphragm pump；
In the step S1.2.3, TIP bias is inserted into Sputum cup.
Preferably, the filter cup action step comprises the steps of:
Step S2.1: filter cup is taken out from filter cup apparatus for placing, and is loaded into filter module group；
Step S2.2: making vacuum slot withstand filter cup, takes out negative pressure to filter cup inside；
Step S2.3: after the pretreating liquid in TIP is injected into filter cup, TIP is pulled out from liquid absorption device；
Step S2.4: the filtering upper cover of filter cup is chosen.
Preferably, in the step S2.2, vacuum slot, which moves upwards, withstands filter cup, by vacuum generator to filtering
Cup is internal to take out negative pressure；
In the step S2.3, after TIP is moved to above filter cup, the pretreating liquid in TIP is injected into filtering
In cup；TIP is pulled out after TIP is moved to abandoned stope.
Preferably, glass slide action step comprises the steps of:
Step S3.1: glass slide is taken out from glass slide apparatus for placing；
Step S3.2: glass slide is placed in filter module group and carries out 90 degree of overturnings；
Step S3.3: glass slide contact filtration cup carries out bat printing；
Step S3.4: the glass slide for completing bat printing is taken out, and is returned the slide into glass slide apparatus for placing.
Preferably, in the step S3.3, glass slide is pressed on filter cup using compression socket cap and carries out bat printing；It moves
Vacuum generator bleeds off vacuum when print, under the action of negative pressure kickback pressure, increases bat printing effect.
Preferably, liquid-based flaking method also comprises the steps of:
Step S4.1: filtering upper cover is pushed back on filter cup；
Step S4.2: filter plate is put back on filter cup apparatus for placing.
Preferably, the first clamping jaw that the Sputum cup passes through setting with filter plate is clamped, and glass slide passes through setting
Second clamping jaw is clamped.
Preferably, the filter cup includes low adsorption micropore filtering film；The glass slide includes that the high absorption of cation carries glass
Piece.
Compared with prior art, the present invention have it is following the utility model has the advantages that
1, the entire film-making process of the present invention can be realized automatically, be not necessarily to human intervention；
2, realize really liquefaction film-making: all samples add digestive juice and buffer automatically, realize sample liquefaction；
3, the present invention is filtered using film: film bat printing rate is high, and enrichment is efficient；
4, it is equipped with display screen, it is easily operated, it is easily understood；
5, bio-safety: covered, liquefaction sterilization processing is realized；
6, the present invention enables vacuum generator bleed off vacuum suddenly in pad-printing process, effectively increases bat printing effect；
7, realize that the liquid-based pelleter of liquid-based flaking method provided by the invention can pass through all parts of reasonably arranging
Position reduce size so that compact overall structure is reasonable, save manufacturing cost；Transport structure is reduced in entire film-making simultaneously
Moving displacement in the process reduces energy consumption.
Detailed description of the invention
Upon reading the detailed description of non-limiting embodiments with reference to the following drawings, other feature of the invention,
Objects and advantages will become more apparent upon:
Fig. 1 is the schematic perspective view after liquid-based pelleter hidden parts shield；
Fig. 2 is liquid-based pelleter protective zone schematic diagram of internal structure；
Fig. 3 is liquid-based pelleter front view；
Fig. 4 is liquid absorption device and filter module group structural schematic diagram；
Fig. 5 is liquid-based flaking method flow chart.
It is shown in figure:
Specific embodiment
The present invention is described in detail combined with specific embodiments below.Following embodiment will be helpful to the technology of this field
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill of this field
For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention
Protection scope.
In the description of the present invention, it is to be understood that, term " on ", "lower", "front", "rear", "left", "right", " perpendicular
Directly ", the orientation or positional relationship of the instructions such as "horizontal", "top", "bottom", "inner", "outside" is orientation based on the figure or position
Relationship is set, is merely for convenience of description of the present invention and simplification of the description, rather than the device or element of indication or suggestion meaning are necessary
It with specific orientation, is constructed and operated in a specific orientation, therefore is not considered as limiting the invention.
As shown in figure 5, liquid-based flaking method provided by the invention comprises the steps of: Sputum cup processing step: in Sputum cup
Portion's sample liquid is handled, and pretreating liquid is obtained；Filter cup action step: pretreating liquid is filtered in filter cup
To film-making liquid；Glass slide action step: the filter cup that glass slide contact fills film-making liquid carries out bat printing, and it is thin to obtain liquid-based
Piece.
The Sputum cup processing step includes to puncture concussion step and stirring imbibing step；
The concussion step that punctures comprises the steps of:
Step S1.1.1: the Sputum cup equipped with sample liquid on Sputum cup apparatus for placing 14 is punctured, injects and disappears in Sputum cup
Change liquid；
Step S1.1.2: by Sputum cup clamping to concussion instrument 18, setting time is shaken；
The stirring imbibing step comprises the steps of:
Step S1.2.1: by Sputum cup clamping to cap rotating device 19, Sputum cup lid is unscrewed；
Step S1.2.2: buffer is added into Sputum cup；
Step S1.2.3: liquid absorption device 11 drives TIP to be inserted into Sputum cup and is stirred acquisition in advance to Sputum cup internal liquid
Treatment liquid enables and draws TIP absorption pretreating liquid；
Step S1.2.4: after cap rotating device 19 screws Sputum cup lid, Sputum cup clamping is put back into Sputum cup apparatus for placing 14
On.
The concussion step that punctures also includes step S1.1.3: the Sputum cup clamping after concussion is put back into Sputum cup apparatus for placing
On 14, S1.1.1 is returned to step, until Sputum cup completion all on Sputum cup apparatus for placing 14 is punctured and operated with concussion；
In the step S1.1.2, the setting time of concussion is 5~10s；
In the step S1.2.2, buffer is added into Sputum cup using diaphragm pump；
In the step S1.2.3, TIP bias is inserted into Sputum cup.
The filter cup action step comprises the steps of:
Step S2.1: filter cup is taken out from filter cup apparatus for placing 15, and is loaded into filter module group 20；
Step S2.2: making vacuum slot withstand filter cup, takes out negative pressure to filter cup inside；
Step S2.3: after the pretreating liquid in TIP is injected into filter cup, TIP is pulled out from liquid absorption device 11；
Step S2.4: the filtering upper cover of filter cup is chosen.
In the step S2.2, vacuum slot, which moves upwards, withstands filter cup, by vacuum generator to filter cup inside
Take out negative pressure；
In the step S2.3, after TIP is moved to above filter cup, the pretreating liquid in TIP is injected into filtering
In cup；TIP is pulled out after TIP is moved to abandoned stope.
Glass slide action step comprises the steps of:
Step S3.1: glass slide is taken out from glass slide apparatus for placing 16；
Step S3.2: glass slide is placed in filter module group 20 and carries out 90 degree of overturnings；
Step S3.3: glass slide contact filtration cup carries out bat printing；
Step S3.4: the glass slide for completing bat printing is taken out, and is returned the slide into glass slide apparatus for placing 16.
In the step S3.3, glass slide is pressed on filter cup using compression socket cap and carries out bat printing；It is true when bat printing
Empty generator bleeds off vacuum, under the action of negative pressure kickback pressure, increases bat printing effect.
Liquid-based flaking method also comprises the steps of:
Step S4.1: filtering upper cover is pushed back on filter cup；
Step S4.2: filter plate is put back on filter cup apparatus for placing 15.
Preferably, the first clamping jaw 9 that the Sputum cup passes through setting with filter plate is clamped, and glass slide passes through setting
Second clamping jaw 10 is clamped.The filter cup includes low adsorption micropore filtering film；The glass slide includes the high absorption of cation
Glass slide.
As shown in Figure 1 to Figure 3, can be realized the present invention and provide the liquid-based pelleter of liquid-based flaking method includes frame knot
Structure, displacement drive and film-making functional unit；The displacement drive and film-making functional unit are installed in frame knot
On structure, the displacement drive includes transport structure and picks and places structure, picks and places structure and is mounted on transport structure.
The frame structure includes pedestal 1, shield 2 and support frame 3, and pedestal 1 connect with shield 2 and in internal shape
At protective zone, the film-making functional unit is mounted in protective zone, and support frame 3 is mounted on protective zone in whole or in part
In.In embodiment, the shield 2 includes side panel and main panel, and side panel is directly installed on pedestal 1 and support frame 3, and
Main panel is then hingedly mounted on support frame 3, that is to say, that main panel is indirectly attached on pedestal 1 by support frame 3, convenient
It opens or closes so that protective zone internal structure is operated or be protected.
Be provided with X-axis guide rail 4 on support frame as described above 3, transport structure includes crossbeam 5, crossbeam 5 along length extending direction two
End is slidably connected at respectively in two X-axis guide rails 4；X-axis driving device 6, the X-axis are provided on support frame 3 and/or crossbeam 5
Driving device 6 can drive crossbeam 5 to slide along X-axis guide rail 4.
Transport structure also includes Y-axis driving device 7 and Y-axis connector 8, and the Y-axis connector 8 is slidably mounted on crossbeam 5
On, Y-axis driving device 7 drives Y-axis connector 8 to move along 5 length extending direction of crossbeam；The pick-and-place fastening structure is mounted on Y
On shaft coupling piece 8.
X-axis driving device 6 and/or Y-axis driving device 7 include following any or various structures: screw structure, gear
Rack structure, roller structure, air pressure rod structure, hydraulic cylinder structure.For screw structure, gear & rack structure, electricity can be passed through
Machine driving is simultaneously completed self-locking after crossbeam 5 reaches target position；For roller structure, friction pair can be configured, when crossbeam 5 reaches
Behind target position, by being frictionally held on support frame 3；By taking X-axis driving device 6 as an example, for air pressure rod structure or hydraulic
Rod structure, both ends are connected with crossbeam 5, support frame 3 respectively, are moved in the X-axis direction by flexible driving crossbeam 5.Certainly, the X
Axial brake device 6 and/or Y-axis driving device 7 can also be that other can generate the structure of straight-line displacement, such as linear motor
Deng.
It include the first clamping jaw 9, the second clamping jaw 10 and liquid absorption device 11 in multiple pick-and-place structures；Pick and place structure and Y-axis
Connector 8 quantitatively corresponds or exists different；Z axis displacement knot is provided on one or more of Y-axis connectors 8
Structure.In practical application, the first clamping jaw 9 is inhaled for clamping Sputum cup and filter plate, second clamping jaw 10 for clamping glass slide
Liquid device 11 is for installing TIP (i.e. pipetting head or fluid suction head).The Z axis displacement structure picks and places structure in upper and lower for adjusting
Upward position, specifically can be pneumatic structure, hydraulic structure, screw structure or linear motor etc. can generate straight-line displacement
Structure.
Preferably, liquid absorption device 11 includes the main part 12 and TIP mounting portion 13 for being integrally formed or being fastenedly connected, main part
12 central axes and the central axes of TIP mounting portion 13 are not arranged on the same straight line.
Film-making functional unit includes Sputum cup apparatus for placing 14, the filter cup apparatus for placing 15, glass slide being mounted on pedestal 1
Apparatus for placing 16, TIP apparatus for placing 17, concussion instrument 18, cap rotating device 19, filter module group 20.In embodiment, Sputum cup apparatus for placing
14, filter cup apparatus for placing 15, glass slide apparatus for placing 16 are sequentially arranged along base length extending direction；In addition concussion instrument
18 are mounted on 14 place side of Sputum cup apparatus for placing with cap rotating device 19, and filter module group 20 is mounted on where filter cup apparatus for placing 15
Side, TIP apparatus for placing 17 are mounted on 16 place side of glass slide apparatus for placing.It, on the one hand being capable of root by the arrangement of above-mentioned position
Space distribution is rationally carried out according to the size of each film-making functional unit, reduces the size of protective zone；On the other hand, in conjunction with
Liquid-based pelleter carries out the operating process of film-making, reduces the move distance of displacement drive, reduces power consumption.
Preferably, the cap rotating device 19 is equipped with diaphragm pump, for buffering to be added in the Sputum cup on cap rotating device 19
Liquid.
Preferably, the glass slide apparatus for placing 16 includes glass frame, and glass slide apparatus for placing 16 is for placing glass slide.
Preferably, glass frame is equipped with heating device.
Preferably, as shown in figure 4, the filter module group 20 include filter cup clamping device, it is glass slide overturning structure 22, true
Suction mouth and vacuum tracheae 25；The clamping of filter cup is respectively arranged on filter cup clamping device, glass slide overturning structure 22
Space, glass slide clamping space；Filter cup clamping device is mounted on the side of glass slide overturning structure 22；Filter cup clamps dress
It sets, glass slide overturning structure 22 has been separately equipped with filter cup clamping cylinder 21, glass slide tumble cylinder 23；Glass slide overturns structure
22 are flipped under the driving of glass slide tumble cylinder 23, and glass slide is made to be attached to the filter cup in filter cup clamping device
Rim of a cup on.The vacuum slot is connected with vacuum tracheae 25, and wherein vacuum slot is equipped with suction nozzle driving cylinder 24, for driving
The filter cup that dynamic vacuum slot moves up and down to be inserted into or leave on filter cup clamping device；Vacuum tracheae 25 is along length extension side
To both ends in respect to the other end with vacuum slot connecting pin be connected with vacuum generator.
Preferably, the pick-and-place structure also includes compression socket cap, and the compression socket cap is for glass slide to be pressed on
Bat printing operation is carried out on filter cup.The process of the bat printing are as follows: glass slide is overturn by glass slide overturning structure 22, is pressed in
On filter cup, at this moment glass slide and filter cup compress can bat printing, while in order to increase bat printing effect, vacuum generator can pressed
It is next, vacuum is bled off suddenly, due to the pressure of negative pressure recoil, can also increase bat printing effect.
Preferably, liquid-based pelleter also includes display screen 26, and the installation of display screen 26 on the frame structure, and is located at anti-
It protects except space.Display screen 26 is connected with film-making functional unit, in conjunction with the application of sensor, is displayed for the state of instrument
Number of samples is selected with for user, can also realize the functions such as prompt alarm.
Preferred embodiment:
1.1 sample disc capacity: 1-36；It can be determined according to sample size difference.
1.2 automatic sheet processes are full-automatic, and overall flow is divided into: concussion, digestion, liquid feeding, dilution, filtering, film-making
Etc. processes.
When 1.3 film-makings are completed, smear has been dried, and can be directly used for dyeing microscopic examination.
1.4 film-making digestion process samples are not necessarily to manual operation intervention, ensure that the safety of reviewer.
1.5 use advanced membrane filtration technique and film transfer technique, so that smear is uniformly distributed, transfer efficiency is high.
1.6 automation ultraviolet disinfections, automatically turn on ultraviolet sterilization after operation.
1.7 capacity: 1-36 slides can be once dyed, per hour film-making >=50 slide.
1.8 clients, which only need to add Sputum cup and filter cup, can start film-making.
1.9 entire digestion process are carried out in Sputum cup, and reviewer does not have the risk of biohazard.
1.10 totally-enclosed systems do not need not pollute laboratory environment close to sink.
1.11 touch screen operations, can customize number of samples.
1.12 complete Chinese operation interfaces, 10 cun of Flat panel touch display screen visualized operations, operation is very easy.
Full sensing module built in 1.13, can detecte whether each consumptive material is ready to.
1.14 can be configured for different samples, sputum specimen, Pleural effusions, cerebrospinal fluid, irrigating solution, urine, human body
Cast-off cells sample.
Specific embodiments of the present invention are described above.It is to be appreciated that the invention is not limited to above-mentioned
Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow
Ring substantive content of the invention.In the absence of conflict, the feature in embodiments herein and embodiment can any phase
Mutually combination.
Claims (10)
1. a kind of liquid-based flaking method, which is characterized in that comprise the steps of:
Sputum cup processing step: handling Sputum cup internal specimen liquid, obtains pretreating liquid；
Filter cup action step: pretreating liquid is obtained by filtration to film-making liquid in filter cup；
Glass slide action step: the filter cup that glass slide contact fills film-making liquid carries out bat printing, obtains Thinprep.
2. liquid-based flaking method according to claim 1, which is characterized in that the Sputum cup processing step includes to puncture concussion
Step and stirring imbibing step；
The concussion step that punctures comprises the steps of:
Step S1.1.1: the Sputum cup equipped with sample liquid on Sputum cup apparatus for placing (14) is punctured, and digestion is injected in Sputum cup
Liquid；
Step S1.1.2: by Sputum cup clamping to concussion instrument (18), setting time is shaken；
The stirring imbibing step comprises the steps of:
Step S1.2.1: by Sputum cup clamping to cap rotating device (19), Sputum cup lid is unscrewed；
Step S1.2.2: buffer is added into Sputum cup；
Step S1.2.3: liquid absorption device (11) drives TIP to be inserted into Sputum cup and is stirred the pre- place of acquisition to Sputum cup internal liquid
Liquid is managed, enables and draws TIP absorption pretreating liquid；
Step S1.2.4: after cap rotating device (19) screws Sputum cup lid, Sputum cup clamping is put back into Sputum cup apparatus for placing (14)
On.
3. liquid-based flaking method according to claim 2, which is characterized in that the concussion step that punctures also includes step
S1.1.3: the Sputum cup clamping after concussion is put back on Sputum cup apparatus for placing (14), S1.1.1 is returned to step, until Sputum cup
The completion of all Sputum cups is punctured on apparatus for placing (14) operates with concussion；
In the step S1.1.2, the setting time of concussion is 5~10s；
In the step S1.2.2, buffer is added into Sputum cup using diaphragm pump；
In the step S1.2.3, TIP bias is inserted into Sputum cup.
4. liquid-based flaking method according to claim 2, which is characterized in that the filter cup action step includes following step
It is rapid:
Step S2.1: filter cup is taken out from filter cup apparatus for placing (15), and is loaded on filter module group (20)；
Step S2.2: making vacuum slot withstand filter cup, takes out negative pressure to filter cup inside；
Step S2.3: after the pretreating liquid in TIP is injected into filter cup, TIP is pulled out from liquid absorption device (11)；
Step S2.4: the filtering upper cover of filter cup is chosen.
5. liquid-based flaking method according to claim 4, which is characterized in that in the step S2.2, vacuum slot is upward
Filter cup is withstood in movement, takes out negative pressure to filter cup inside by vacuum generator；
In the step S2.3, after TIP is moved to above filter cup, the pretreating liquid in TIP is injected into filter cup；
TIP is pulled out after TIP is moved to abandoned stope.
6. liquid-based flaking method according to claim 4, which is characterized in that glass slide action step comprises the steps of:
Step S3.1: glass slide is taken out from glass slide apparatus for placing (16)；
Step S3.2: glass slide is placed in filter module group (20) and carries out 90 degree of overturnings；
Step S3.3: glass slide contact filtration cup carries out bat printing；
Step S3.4: the glass slide for completing bat printing is taken out, and is returned the slide on glass slide apparatus for placing (16).
7. liquid-based flaking method according to claim 6, which is characterized in that in the step S3.3, use compression cylinder
Glass slide is pressed on filter cup by head carries out bat printing；Vacuum generator bleeds off vacuum when bat printing, in the work of negative pressure kickback pressure
Under, increase bat printing effect.
8. liquid-based flaking method according to claim 7, which is characterized in that liquid-based flaking method also comprises the steps of:
Step S4.1: filtering upper cover is pushed back on filter cup；
Step S4.2: filter plate is put back on filter cup apparatus for placing (15).
9. liquid-based flaking method according to claim 8, which is characterized in that the Sputum cup and filter plate pass through setting
First clamping jaw (9) is clamped, and glass slide is clamped by the second clamping jaw (10) of setting.
10. liquid-based flaking method according to claim 1, which is characterized in that the filter cup includes low adsorption micropore mistake
Filter membrane；The glass slide, which includes that cation is high, adsorbs glass slide.
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| CN201810848339 | 2018-07-27 | ||
| CN2018108483395 | 2018-07-27 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110186737A (en) * | 2019-06-27 | 2019-08-30 | 宁波舜宇仪器有限公司 | A kind of liquid-based specimens film-making dyeing all-in-one machine |
| CN110631878A (en) * | 2019-10-28 | 2019-12-31 | 宁波美生医疗器材有限公司 | Sample transfer mechanism of liquid-based cell automatic sheet-making medical equipment |
| CN113640502A (en) * | 2021-06-18 | 2021-11-12 | 浙江理工大学 | Experimental method for improving dyeing fastness of grass and wood |
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