CN115178315A

CN115178315A - Full-automatic high-flux workstation integration device

Info

Publication number: CN115178315A
Application number: CN202210609827.7A
Authority: CN
Inventors: 朱勇; 陈永坤; 满正厚
Original assignee: Suzhou Aikeshi Zhizao Technology Co ltd
Current assignee: Suzhou Aikeshi Zhizao Technology Co ltd
Priority date: 2022-05-31
Filing date: 2022-05-31
Publication date: 2022-10-14

Abstract

The invention discloses a full-automatic high-throughput workstation integration device, which comprises a rack, wherein a machine shell is arranged on the rack, supporting legs are arranged at the bottom of the machine shell, two high-efficiency filters are arranged at the top of the machine shell, an observation window is arranged at the upper part of the front end of the machine shell, an operation door is hinged to the lower part of the front end of the machine shell, a displacement assembly is arranged in the machine shell, a liquid-transfering single-channel assembly and an eight-channel liquid-transfering assembly are arranged on the displacement assembly, a feeding assembly is further arranged on the displacement assembly, a code scanning assembly, a disposable tip head placing assembly, a sample microporous plate placing assembly, a uniform-mixing microporous plate placing assembly and a standing microporous plate placing assembly are sequentially arranged below the displacement assembly from left to right, and a recovery box and a constant-temperature oscillation assembly are further arranged at the bottom of the machine shell; the invention realizes the simple, intelligent and efficient biological medicine and in-vitro diagnosis experiments, and the high-flux experiments are executed through the simple experiment design of the high-flux workstation.

Description

Full-automatic high-flux workstation integration device

Technical Field

The invention relates to the technical field of pipetting equipment, in particular to a full-automatic high-throughput workstation integration device.

Background

In vitro diagnosis of medical examination is mostly operated based on liquid phase, for example, based on applications such as serological luminescence immunoassay, and development of products can be rapidly completed by using a high-throughput platform according to the requirements of examination items of an in vitro diagnostic instrument. The high-throughput intelligent automatic workstation is an automatic liquid treatment system, can replace a traditional liquid pretreatment tool, automatically complete high-precision liquid treatment tasks such as gradient dilution, liquid transfer and liquid combination, and can integrate a detection module and a detection instrument to realize efficient and accurate full-automatic detection of a target object. The automatic operation process of the high-throughput intelligent automatic workstation not only can enable experimenters to get rid of complex experimental operation, effectively reduce human errors, improve the reproducibility of experiments and reduce the cost, but also can carry out process control and tracing, and is widely applied to bioengineering, DNA plasmid purification, drug screening, ELISA reaction, PCR pretreatment, DNA sequencing treatment, clinical test sample treatment, high-throughput sample analysis of a blood station system and the like. The high-throughput intelligent automatic workstation is a core unit of a high-throughput intelligent automatic integrated system, executes a complex pretreatment process, and specifically comprises high-throughput software and a high-throughput modularized manipulator platform, wherein the software platform has the functions of process design, formula design, data management and analysis and the like, and develops the high-throughput intelligent automatic workstation by aiming at the high-throughput precise liquid distribution requirements of biological medicines and medical instruments, overcoming the key core technologies such as high-precision high-throughput liquid distribution technology, high-throughput oscillation technology, micropore plate rotation and transfer and the like, developing a high-throughput liquid distribution module, a high-throughput oscillation module and a micropore plate transfer module, and combining the high-precision multifunctional manipulator platform and a high-throughput software control technology. In view of the above disadvantages, it is desirable to design a fully automatic high throughput workstation integration apparatus.

Disclosure of Invention

The present invention is directed to a fully automatic high throughput workstation integration apparatus to solve the above problems.

In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a full-automatic high flux workstation integration device, includes the frame, install the casing in the frame, the supporting legs is installed to the bottom of casing, two high efficiency filter are installed at the top of casing, the observation window is installed on the upper portion of casing front end, the lower part of casing front end articulates there is the operation door, the internally mounted of casing has the displacement subassembly, install the single channel on the displacement subassembly and move liquid subassembly and eight move liquid passageway subassemblies, still install the material loading subassembly on the displacement subassembly, the below of displacement subassembly has set gradually from a left side to the right side and has swept a yard subassembly, disposable tip head and place subassembly, sample micropore board and place subassembly, the micropore board is placed the subassembly and the micropore board that stews and is placed the subassembly, the chassis bottom still installs collection box and constant temperature and vibrates the subassembly.

Preferably, the displacement subassembly includes X axis nature module, first Y axis nature module, second Y axis nature module, first Z axis nature module and second Z axis nature module, first Z axis nature module is installed on first Z axis nature module mounting panel, first Z axis nature module mounting panel is installed on the slip table of first Y axis nature module, first Y axis nature module is installed on first Y axis nature module mounting panel, the one end of first Y axis nature module mounting panel is passed through the support frame and is installed in the one end of left side movable plate, and the left side movable plate is installed on the slip table of X axis nature module.

Preferably, X axis nature module is installed on X axis nature module mounting panel, and X axis nature module mounting panel is installed on the left socle, the support frame is installed to the other end of left side movable plate, the one end fixed connection of support frame and second Y axis nature module mounting panel, the one end of second Y axis nature module mounting panel is passed through the support frame and is installed in the one end of right movable plate, installs second Y axis nature module on the second Y axis nature module mounting panel, install second Z axis nature module mounting panel on the slip table of second Y axis nature module, install second Z axis nature module on the second Z axis nature module mounting panel.

Preferably, the single channel moves the liquid subassembly including moving the liquid suction head and moving the liquid mounting bracket, move the liquid mounting bracket and install in one side of fixed plate, the fixed plate is installed on the slip table of first Z axis nature module, move the liquid suction head connector to install in the upper end of liquid suction head, the top centre gripping that moves the liquid suction head connector has the grip block, it has the pipe to move the last cover of liquid suction head, the pipe is installed in moving liquid mounting bracket bottom, moves liquid mounting bracket internally mounted and has the slide rail, and slidable mounting has the slider on the slide rail, installs the grip block on the slider, the piston rod fixed connection of grip block and cylinder.

Preferably, eight passageway move liquid subassembly including move liquid suction head and move liquid suction head mount, be equipped with the multiunit fixed orifices on moving liquid suction head mount along length direction, all be provided with in every group fixed orifices and move liquid suction head connector, move liquid suction head mount under parallel arrangement have move liquid suction head push pedal, just move liquid suction head push pedal and be equipped with a plurality of needle holes of moving back side by side, every needle hole of moving back corresponds a set of liquid suction head connector respectively, and every group moves liquid suction head connector and runs through the needle hole of moving back that corresponds respectively, move liquid suction head connector lower extreme and be connected with and move liquid suction head.

Preferably, the needle withdrawing motor is installed to the top of liquid-transfering tip mount, and the needle withdrawing motor is installed on the motor mounting panel, the opposite side at the fixed plate is installed to the motor installation, the position that corresponds vertical needle withdrawing motor in the liquid-transfering tip mount is equipped with needle withdrawing guide hole, be equipped with the needle withdrawing lead screw in the vertical needle withdrawing motor, the lower extreme that the needle withdrawing lead screw is connected with the needle withdrawing guiding axle, the lower extreme that the needle withdrawing guiding axle runs through and is connected to in the liquid-transfering tip push pedal behind the needle withdrawing guide hole.

Preferably, the material loading subassembly includes rotatory jack catch, and rotatory jack catch is installed in the bottom of rotatory jack catch mounting panel, and rotatory jack catch mounting panel is installed on the slip table of the linear module of second Z axis.

Preferably, the disposable tip head placing assembly comprises a plurality of disposable tip head placing frames, the disposable tip head placing frames are installed on a drawing plate at even intervals, a drawing handle is installed at one end of the drawing plate, sliding strips are installed at two ends of the bottom of the drawing plate and are L-shaped structures, the sliding strips are arranged on a rail in a sliding mode, the rail is of a T-shaped structure, a bearing plate is installed on the disposable tip placing frames, a hollow groove is formed in the middle of the bearing plate, disposable tip head supporting plates are placed on the bearing plate, grooves are formed in two ends of the disposable tip head supporting plates, baffle plates are installed on two sides of the top of the disposable tip head supporting plates, and limiting plates are installed on two sides of the bottom of the disposable tip head supporting plates.

Preferably, the sample micropore plate placing component comprises a plurality of micropore plate placing frames, and is a plurality of even interval of micropore plate placing frames is installed on the pull board, and the pull handle is installed to the one end of pull board, the draw runner is installed at the both ends of pull board bottom, two the draw runner is L shape structure, two the draw runner slides and sets up on the track, the track is T shape structure, install on the micropore plate placing frame and place the board, place all install the stopper around the board, the inclined plane has been seted up to one side of stopper.

Compared with the prior art, the full-automatic high-flux workstation integration device has the advantages that each sample component in the target microporous plate is set through the system of the upper computer, each component is controlled to work through the controller, a formula is added to a sample, the microporous plate transfer and processing operation is realized through the rotary mechanical gripper, the simple, intelligent and efficient biological medicine and in-vitro diagnosis experiment is realized, and the high-flux experiment is executed through the simple experiment design of the high-flux workstation; the invention is provided with the single-channel pipetting assembly and the eight-channel pipetting assembly, can sample different reagents by replacing the TIP head, and effectively avoids cross contamination.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention without limiting the invention in which:

FIG. 1 is a schematic structural diagram of an integrated device of a fully automatic high-throughput workstation according to the present invention;

FIG. 2 is a side view of a fully automated high throughput workstation integration apparatus of the present invention;

FIG. 3 is a schematic diagram of the internal structure of an integrated device of a fully automatic high throughput workstation according to the present invention;

FIG. 4 is a perspective view of a displacement assembly in a fully automated high throughput workstation integration apparatus of the present invention;

FIG. 5 is a schematic structural diagram of a disposable tip head placement assembly in a fully automatic high throughput workstation alignment apparatus of the present invention;

FIG. 6 is a schematic view of the structure at A in FIG. 4;

FIG. 7 is a schematic structural view of a single-channel pipetting assembly in the fully automatic high-throughput workstation integrating device of the present invention.

In the drawings:

1. a frame; 2. a housing; 3. supporting legs; 4. a high efficiency filter; 5. an observation window; 6. an operating door; 7. a displacement assembly; 8. a single channel pipetting assembly; 9. an eight channel pipetting assembly; 10. a feeding assembly; 11. a code scanning component; 12. a disposable tip head placement assembly; 13. a sample microplate placement assembly; 14. a mixing micropore plate placing component; 15. standing the micropore plate placing component; 16. a recycling bin; 17. a constant temperature oscillation component; 18. (ii) a 19. (ii) a 20. An X-axis linear module; 21. a first Y-axis linear module; 22. a second Y-axis linear module; 23. a first Z-axis linear module; 24. a second Z-axis linear module; 25. a first Z-axis linear module mounting plate; 26. a first Y-axis linear module mounting plate; 27. a support frame; 28. a left moving plate; 29. an X-axis linear module mounting plate; 30. a left bracket; 31. a support frame; 32. a second Y-axis linear module mounting plate; 33. a support frame; 34. a right moving plate; 35. a second Z-axis linear module mounting plate; 36. a support frame; 37. a slider; 38. a slide rail; 39. a right bracket; 40. pipetting a pipette tip; 41. a circular tube; 42. a clamping block; 43. a liquid transfer mounting rack; 44. a slide rail; 45. a slider; 46. a cylinder; 47. a liquid transfer pipette tip connector; 48. pipetting a pipette tip; 49. a pipetting tip fixing frame; 50. a liquid transfer pipette tip connector; 51. a liquid transfer sucker push plate; 52. a needle withdrawing motor; 53. withdrawing the needle screw; 54. a motor mounting plate; 55. a fixing plate; 56. rotating the clamping jaw; 57. rotating the jaw mounting plate; 58. a code scanner; 59. a code scanner bracket; 60. a lighting lamp; 61. an ultraviolet germicidal lamp; 62. placing a disposable tip head rack; 63. a drawing plate; 64. a pull handle; 65. a slide bar; 66. carrying a plate; 67. a disposable tip head rest; 68. a baffle plate; 69. a limiting plate; 70. a microplate placing rack; 71. a drawing plate; 72. a pull handle; 73. a slide bar; 74. placing the plate; 75. a limiting block; 76. a drawing plate; 77. a pull handle; 78. and (4) a slide bar.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-7, the present invention provides a technical solution: the utility model provides a full-automatic high flux workstation integration device, includes frame 1, install casing 2 in the frame 1, supporting legs 3 are installed to the bottom of casing 2, two high efficiency filter 4 are installed at the top of casing 2, observation window 5 is installed on the upper portion of 2 front ends of casing, the lower part of 2 front ends of casing articulates there is operation door 6, the internally mounted of casing 2 has displacement subassembly 7, install single channel on the displacement subassembly 7 and move liquid subassembly 8 and eight passageway and move liquid subassembly 9, still install material loading subassembly 10 on the displacement subassembly 7, the below of displacement subassembly 7 has set gradually from a left side to the right side and has swept a yard subassembly 11, disposable tip head and place subassembly 12, sample micropore board and place subassembly 13, mixing micropore board and place subassembly 14 and the micropore board and place subassembly 15, collection box 16 and constant temperature shock subassembly 17 are still installed to casing 2 bottom, high efficiency filter 4, displacement subassembly 7, single channel move liquid subassembly 8, eight passageway and shake subassembly 9, material loading subassembly 10, sweep yard subassembly 11 and move liquid subassembly 17 respectively with controller electric connection, controller and host computer-electronics nature connection.

Displacement subassembly 7 includes X axis nature module 20, first Y axis nature module 21, second Y axis nature module 22, first Z axis nature module 23 and second Z axis nature module 24, first Z axis nature module 23 is installed on first Z axis nature module mounting panel 25, first Z axis nature module mounting panel 25 is installed on the slip table of first Y axis nature module 21, first Y axis nature module 21 is installed on first Y axis nature module mounting panel 26, the one end at left movable plate 28 is passed through support frame 27 to the one end of first Y axis nature module mounting panel 26, and left movable plate 28 is installed on the slip table of X axis nature module 20, and X axis nature module 20 is installed on X axis nature module mounting panel 29, and X axis nature module mounting panel 29 is installed on left support 30, support frame 31 is installed to the other end of left side movable plate 28, and support frame 31 and the one end fixed connection of second Y axis nature module mounting panel 32, the one end of second Y axis nature module 32 is passed through support frame 33 and is installed in the one end at right 34, installs second Y axis nature module 32 on the second Y axis nature module mounting panel 32, and installs second Z axis nature module 22 on the second Z axis nature module mounting panel 35.

One end of the first Y-axis linear module mounting plate 26 is mounted at the other end of the right moving plate 34 through a support frame 36, a slider 37 is mounted at the bottom of the right moving plate 34, the slider 37 is slidably disposed on a slide rail 38, and the slide rail 38 is mounted on a right bracket 39.

The single channel is moved liquid subassembly 8 and is included pipetting tip 40 and move liquid mounting bracket 43, move liquid mounting bracket 43 and install in one side of fixed plate 55, fixed plate 55 is installed on the slip table of first Z axis nature module 23, move liquid tip connector 47 is installed to the upper end of pipetting tip 40, and the upper end of moving liquid tip connector 47 communicates to the liquid pump through coupling hose to realize inhaling liquid operation, the top centre gripping of moving liquid tip connector 47 has grip block 42, the cover has pipe 41 on the pipetting tip 40, pipe 41 is installed in pipetting mounting bracket 43 bottom, moves liquid mounting bracket 43 internally mounted have slide rail 44, and slidable mounting has slider 45 on slide rail 44, installs grip block 42 on the slider 45, grip block 42 and cylinder 46's piston rod fixed connection, and cylinder 46 installs the top at the liquid mounting bracket 43 that moves liquid. 42 and 47 are driven by the air cylinder 46 to move, and 40 drives the tip head to move upwards along with the movement, so that the liquid transfer suction head 40 is separated from the tip head, and finally, the needle withdrawing operation is realized.

The eight-channel pipetting assembly 9 comprises a pipetting tip 48 and a pipetting tip fixing frame 49, a plurality of groups of fixing holes are formed in the pipetting tip fixing frame 49 along the length direction, a pipetting tip connector 50 is arranged in each group of fixing holes, and the upper end of the pipetting tip connector 50 is communicated to a pipetting pump through a connecting hose, so that the pipetting and injecting operations are realized; move liquid suction head mount 49 under parallel arrangement have move liquid suction head push pedal 51, just move liquid suction head push pedal 51 is last to be equipped with a plurality of needle holes of moving back side by side, and every moves back the needle hole and corresponds a set of liquid suction head connector 50 respectively, and every group moves liquid suction head connector 50 and runs through the needle hole that moves back that corresponds respectively, move liquid suction head connector 50 lower extreme and be connected with liquid suction head 48.

Move liquid suction head mount 49's top and install needle withdrawing motor 52, needle withdrawing motor 52 is double-end lead screw motor, and needle withdrawing motor 52 installs on motor mounting panel 54, the opposite side at fixed plate 55 is installed to the motor installation 54, the position that corresponds vertical needle withdrawing motor 52 in the liquid suction head mount 49 is equipped with needle withdrawing guide hole, be equipped with needle withdrawing lead screw 53 in the vertical needle withdrawing motor 52, needle withdrawing lead screw 53's lower extreme is connected with the needle withdrawing guiding axle, the lower extreme of needle withdrawing guiding axle runs through and moves back needle guide hole and be connected to on the liquid suction head push pedal 51. Rotate through moving back needle motor 52 synchronous for move back needle lead screw 53 drive and move back needle guiding axle along vertical linear displacement, and then drive pipetting tip push pedal 51 vertical motion, promote pipetting tip 48 through moving back the needle hole on pipetting tip push pedal 51 and move down, make pipetting tip 48 and tip break away from, finally realize moving back the needle operation.

The feeding assembly 10 comprises a rotary clamping jaw 56, the rotary clamping jaw 56 is mounted at the bottom of a rotary clamping jaw mounting plate 57, and the rotary clamping jaw mounting plate 57 is mounted on a sliding table of the second Z-axis linear module 24.

The code scanning assembly 11 comprises a code scanner 58, the code scanner 58 is mounted on a code scanner bracket 59, and an illuminating lamp 60 and an ultraviolet germicidal lamp 61 are mounted on two sides of the rack 1.

The disposable tip head placing component 12 comprises a plurality of disposable tip head placing frames 62, the disposable tip head placing frames 62 are arranged in sequence, the disposable tip head placing frames 62 are installed on a drawing plate 63 at even intervals, a drawing handle 64 is installed at one end of the drawing plate 63, sliding strips 65 and two sliding strips 65 are installed at two ends of the bottom of the drawing plate 63, the sliding strips 65 are L-shaped structures and two sliding strips 6 are arranged on a rail in a sliding mode, the rail is a T-shaped structure, a bearing plate 66 is installed on the disposable tip head placing frames 62, a hollowed-out groove is formed in the middle of the bearing plate 66, a disposable tip head supporting plate 67 is placed on the bearing plate 66, disposable tip heads are placed on the disposable tip head supporting plate 67, baffle plates 68 are arranged at two ends of the disposable tip head supporting plate 67, and limiting plates 69 are installed on two sides of the top of the disposable tip head supporting plate 67.

Sample micropore board placing component 13 includes a plurality of micropore board rack 70, and is a plurality of micropore board rack 70 arranges the setting in proper order, and is a plurality of even interval of micropore board rack 70 is installed on pull board 71, and pull handle 72 is installed to the one end of pull board 71, draw bar 73 is installed at the both ends of pull board 71 bottom, two draw bar 73 is L shape structure, two draw bar 73 slides and sets up on the track, the track is T shape structure, install on the micropore board rack 70 and place board 74, place the sample micropore board on the rack 74, place all install stopper 75 around board 74, the inclined plane has been seted up to one side of stopper 75.

The mixing micropore plate placing component 14 and the standing micropore plate placing component 15 have the same structure as the sample micropore plate placing component 13.

Constant temperature vibrates subassembly 17 including vibrating module and constant temperature module, constant temperature module and vibration module, collection box 16 is provided with two, collection box 16 and constant temperature vibrate subassembly 17 and are located the both sides that the micropore board placed subassembly 15 of stewing, collection box 16, the micropore board of stewing place subassembly 15 and constant temperature vibrate subassembly 17 and install in proper order on pull board 76, and pull handle 77 is installed to the one end of pull board 76, draw 78, two are installed at the both ends of pull board 76 the draw 78 is L shape structure, two the draw 78 slides and sets up on the track, the track is T shape structure.

The working principle of the invention is as follows: opening the operation door 6, drawing out the pull plate 71 and the pull plate 76 by a drawing mode, respectively adding a disposable Tip head, a sample microplate and a target microplate on the disposable Tip head placing assembly 12, the sample microplate placing assembly 13 and the mixing microplate placing assembly 14, respectively, placing a sample on the sample microplate, after the addition is completed, pushing the pull plate 71 and the pull plate 76 into the housing 2, driving the left moving plate 28 to move by the operation of the X axis linear module 20, driving the left moving plate by the first Y axis linear module 21, driving the first Z axis linear module 23, moving the eight-channel pipetting assembly 9 to the upper side of the disposable Tip head placing assembly 12, scanning the Tip head by the code scanner 58, recording the Tip head code by the code scanner 58, driving the eight-channel pipetting assembly 9 to move downwards by the operation of the first Z axis linear module 23, inserting the pipetting head 48 into the first row of the disposable Tip head placing assembly 12 under the drive of the first Z axis linear module 23, then driving the eight-channel pipetting assembly 9 to move, driving the first Z axis pipetting assembly 23 to drive the eight-channel pipetting assembly 23, and driving the eight-channel pipetting assembly to move the sample pipetting assembly 14, driving the eight-channel pipetting assembly to the sample pipetting assembly 23, and driving the eight-channel pipetting assembly to move the sample pipetting assembly 14, driving the eight-channel pipetting assembly to move the upper row pipetting assembly 23, and driving the eight-pipetting assembly 14, the pump works to make the eight-channel pipetting assembly 9 and the TIP head drain the sample liquid on the mixing micro-pore plate placing assembly 14, after the drainage is completed, the needle withdrawing motor 52 synchronously rotates to make the needle withdrawing screw 53 drive the needle withdrawing guide shaft to linearly displace along the vertical direction, and further drive the pipetting TIP push plate 51 to vertically move, the pipetting TIP 48 is pushed downwards through the needle withdrawing hole on the pipetting TIP push plate 51, so that the pipetting TIP 48 is separated from the TIP head, finally the needle withdrawing operation is realized, the TIP heads are all unloaded into the recycling box, after the completion, the X-axis linear module 20 works to drive the first Z-axis linear module 23 and the eight-channel pipetting assembly 9 to move to the disposable TIP head placing assembly 12, the first Z-axis linear module 23 works to drive the eight-channel pipetting assembly 9 to move downwards, so that the pipetting TIP head 48 is inserted into the TIP head in the disposable TIP head placing assembly 12 under the driving of the first Z-axis linear module 23, then the first Z-axis linear module 23 works to drive the eight-channel pipetting assembly 9 to reset, the X-axis linear module 20 works to drive the first Z-axis linear module 23 and the eight-channel pipetting assembly 9 to move to the sample microplate placing assembly 13, the first Z-axis linear module 23 works to drive the eight-channel pipetting assembly 9 to move downwards to drive the eight-channel pipetting assembly 9 to move to a sample microplate on the sample microplate placing assembly 13, the pump works to enable the eight-channel pipetting assembly 9 and the second row of TIP heads to suck a second row of sample liquid on the sample microplate, after the suction is completed, the first Z-axis linear module 23 works to drive the eight-channel pipetting assembly 9 to reset, the X-axis linear module 20 works to drive the first Z-axis linear module 23 and the eight-channel pipetting assembly 9 to move to the mixing microplate placing assembly 14 to drive the eight-channel pipetting assembly 9 to move to a sample on the microplate placing assembly 14, move the TIP head to the mixing micropore plate and place in the first row of micropore plate of subassembly 14, pump work, make eight passageway move liquid subassembly 9 and TIP head to the mixing micropore plate place on the subassembly 14 sample liquid carry out the flowing back, after the flowing back is accomplished, X axle linear module 20 work drives 23 and eight passageway move liquid subassembly 9 and move to the collection box on, eight passageway move liquid subassembly 9 move back needle motor 52 work and drive 53 and rotate, X axle linear module 20 work drives second Z axle linear module 24 and rotatory jack catch 56 moves to the micropore plate and places on the subassembly 14, rotatory jack catch 56 work is placed the mixing micropore plate and is got on the subassembly 14 and put last in proper order to press from both sides, make the sample, dilute and dissolve and vibrate, after the completion, X axle linear module 20 and second Z axle linear module 24 drive rotatory jack catch 56 and reset.

According to the invention, each sample component in the target microporous plate is set through the system of the upper computer, each component is controlled to work through the controller, a formula is added to a sample, the microporous plate transfer and processing operation is realized through the rotary mechanical gripper, the simple, intelligent and efficient biological medicine and in-vitro diagnosis experiment is realized, the simple experiment design and the high-throughput experiment execution are realized through the high-throughput workstation; the invention is provided with the single-channel pipetting assembly and the eight-channel pipetting assembly, can sample different reagents by replacing the TIP head, and effectively avoids cross contamination.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a full-automatic high flux workstation integration device which characterized in that: including frame (1), install casing (2) in frame (1), supporting legs (3) are installed to the bottom of casing (2), two high efficiency filter (4) are installed at the top of casing (2), observation window (5) are installed on the upper portion of casing (2) front end, the lower part of casing (2) front end articulates there is operation door (6), the internally mounted of casing (2) has displacement subassembly (7), install on displacement subassembly (7) and move liquid single channel subassembly (8) and eight passageway subassemblies (9), still install on displacement subassembly (7) and move liquid feeding subassembly (10), the below of displacement subassembly (7) has set gradually from a left side to the right side and has swept yard subassembly (11), disposable tip head and place subassembly (12), sample micropore board place subassembly (13), the micropore board place subassembly (14) and the micropore board of stewing and place subassembly (15), casing (2) bottom still installs constant temperature collection box (16) and vibrates subassembly (17).

2. The fully automatic high throughput workstation integration apparatus of claim 1, wherein: displacement subassembly (7) include X axis nature module (20), first Y axis nature module (21), second Y axis nature module (22), first Z axis nature module 23 and second Z axis nature module (24), first Z axis nature module (23) is installed on first Z axis nature module mounting panel (25), install on the slip table of first Y axis nature module (21) first Z axis nature module mounting panel (25), install on first Y axis nature module mounting panel (26) first Y axis nature module (21), the one end of first Y axis nature module mounting panel (26) is passed through support frame (27) and is installed the one end at left side movable plate (28), and left side movable plate (28) are installed on the slip table of X axis nature module (20).

3. The fully automated high throughput workstation integration apparatus of claim 2, wherein: install on X axis nature module mounting panel (29) X axis nature module (20), install on left socle (30) X axis nature module mounting panel (29), support frame (31) are installed to the other end of left side movable plate (28), the one end fixed connection of support frame (31) and second Y axis nature module mounting panel (32), the one end of second Y axis nature module mounting panel (32) is installed in the one end of right movable plate (34) through support frame (33), installs second Y axis nature module (22) on second Y axis nature module mounting panel (32), install second Z axis nature module mounting panel (35) on the slip table of second Y axis nature module (22), install second Z axis nature module (24) on second Z axis nature module mounting panel (35).

4. The fully automated high throughput workstation integration apparatus of claim 1, wherein: the single channel is moved liquid subassembly (8) and is included liquid-transfering suction head (40) and move liquid mounting bracket (43), move liquid mounting bracket (43) and install the one side at fixed plate (55), install on the slip table of first Z axis nature module (23) fixed plate (55), move liquid suction head connector (47) is installed to the upper end of liquid suction head (40), and the top clamp of liquid suction head connector (47) has grip block (42), it has pipe (41) to move liquid suction head (40) to go up the cover, pipe (41) are installed and are being moved liquid mounting bracket (43) bottom, move liquid mounting bracket (43) internally mounted have slide rail (44), and slidable mounting has slider (45) on slide rail (44), installs grip block (42) on slider (45), and the piston rod fixed connection of grip block (42) and cylinder (46).

5. The fully automated high throughput workstation integration apparatus of claim 1, wherein: eight passageways move liquid subassembly (9) including moving liquid suction head (48) and moving liquid suction head mount (49), be equipped with the multiunit fixed orifices on moving liquid suction head mount (49) along length direction, all be provided with in every group fixed orifices and move liquid suction head connector (50), move liquid suction head mount (49) under parallel arrangement have move liquid suction head push pedal (51), just move liquid suction head push pedal (51) and go up to be equipped with a plurality of needle holes that move back side by side, every needle hole that moves back corresponds a set of liquid suction head connector (50) respectively, every group moves liquid suction head connector (50) and runs through the needle hole that moves back that corresponds respectively, it is connected with and moves liquid suction head (48) to move liquid suction head connector (50) lower extreme.

6. The fully automated high throughput workstation integration apparatus of claim 5, wherein: move back needle motor (52) is installed to the top of liquid-transfering tip mount (49), moves back needle motor (52) and installs on motor mounting panel (54), the motor installation is installed (54) the opposite side at fixed plate (55), the position that corresponds vertical back needle motor (52) in liquid-transfering tip mount (49) is equipped with moves back the needle guide hole, be equipped with in vertical back needle motor (52) and move back needle lead screw (53), the lower extreme that moves back needle lead screw (53) is connected with the guide shaft that moves back the needle, the lower extreme that moves back the needle guide shaft runs through and moves back needle guide hole after-connected to on the liquid-transfering tip push pedal (51).

7. The fully automated high throughput workstation integration apparatus of claim 1, wherein: the feeding assembly 10 comprises a rotary clamping jaw 56, the rotary clamping jaw 56 is mounted at the bottom of a rotary clamping jaw mounting plate 57, and the rotary clamping jaw mounting plate 57 is mounted on a sliding table of the second Z-axis linear module 24.

8. The fully automated high throughput workstation integration apparatus of claim 1, wherein: subassembly (12) is placed to disposable tip head includes a plurality of disposable tip head rack (62), and is a plurality of the even interval of disposable tip head rack (62) is installed on pull board (63), and pull handle (64) are installed to the one end of pull board (63), draw runner (65) are installed at the both ends of pull board (63) bottom, two draw runner (6) slide and set up on the track, install loading board (66) on disposable tip rack (62), the fretwork groove has been seted up at the middle part of loading board (66), disposable tip head layer board (67) have been placed on loading board (66), the both ends of disposable tip head layer board (67) are seted up slottedly, baffle (68) are all installed to the both sides at disposable tip head layer board (67) top, limiting plate (69) are all installed to the both sides of disposable tip head layer board (67) bottom.

9. The fully automated high throughput workstation integration apparatus of claim 1, wherein: the sample micropore plate placing component (13) comprises a plurality of micropore plate placing frames (70) and is multiple, wherein the micropore plate placing frames (70) are uniformly installed on a drawing plate (71) at intervals, a drawing handle (72) is installed at one end of the drawing plate (71), a slide bar (73) is installed at two ends of the bottom of the drawing plate (71), two slide bars (73) are arranged on a track in a sliding mode, a placing plate (74) is installed on the micropore plate placing frames (70), a limiting block (75) is installed around the placing plate (74), and an inclined plane is formed in one side of the limiting block (75).