CN206799622U - A kind of fermentation tank sterile sampling and sample reception system - Google Patents
A kind of fermentation tank sterile sampling and sample reception system Download PDFInfo
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- CN206799622U CN206799622U CN201720559592.XU CN201720559592U CN206799622U CN 206799622 U CN206799622 U CN 206799622U CN 201720559592 U CN201720559592 U CN 201720559592U CN 206799622 U CN206799622 U CN 206799622U
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Abstract
A kind of fermentation tank sterile sampling and sample reception system, including fermentation tank are the utility model is related to, described fermentation tank is provided with sample tap, and described sample tap is connected with sample cock, steam valve；Described sample tap is connected with sampling line, and sampling line is provided with bypass decontamination duct network, and sampling line end is connected with sample reception bottle；The first valve is connected with described bypass decontamination duct network, the second valve is connected with described sampling line, the second described valve is arranged on the bypass decontamination duct network rear end on sampling line；Described sample reception bottle is connected with air cleaner.The utility model may be implemented in the sterile sampling in any region, not influenceed by clean environment；Use cost is low, and fermented sample precision of analysis is high, contributes to the judgement of fermented and cultured state.
Description
Technical field
A kind of fermentation tank sterile sampling and sample reception system are the utility model is related to, belongs to biopharmaceutical technology.
Background technology
During the vital movement of microorganism, caused low molecule amount metabolin can be suppressed with extremely low concentration or influence it
Allogene function.Microbiological pharmacy utilizes microbial technique, by highly engineered novel integrated technology, to utilize microorganism
Based on course of reaction, certain product is synthesized dependent on growth and breeding of the microflora organisms in reactor and metabolic process,
Hydrolysis kinetics are carried out by separating and purifying technology, and final preparation is molded to realize the production of drug products.Fermentation is microorganism
The important process step of pharmacy, the right hydrolysis and fermentation sterilizing of sterile sampling in fermentation process, fermentation process cultivation conditions are very heavy
Will.Current fermentation majority is in D level clean areas, even in general area, how to be accomplished in the progress of the region of these low levels
Sterile sampling seems extremely important, and fermentation tank can not carry out sterile sampling, influence the judgement of fermented and cultured state.
Utility model content
The utility model is in view of the deficienciess of the prior art, provide a kind of fermentation tank sterile sampling and sample reception system
System, the utility model can be incorporated into existing ferment tank control system, realized in the progress of the clean area of low level
Sterile sampling, fermented sample precision of analysis is high, contributes to the judgement of fermented and cultured state.
The technical scheme that the utility model solves above-mentioned technical problem is as follows：A kind of fermentation tank sterile sampling and sample reception
System, including fermentation tank, described fermentation tank are provided with sample tap, and described sample tap is connected with sample cock, steam valve；Institute
The sample tap stated is connected with sampling line, and sampling line is provided with bypass decontamination duct network, and sampling line end is connected with sample reception
Bottle；The first valve is connected with described bypass decontamination duct network, is connected with the second valve on described sampling line, described
Two valves are arranged on the bypass decontamination duct network rear end on sampling line；Described sample reception bottle is connected with air cleaner.
A kind of fermentation tank sterile sampling as described above and sample reception system, described sample tap and sampling line interface
Place is provided with sealing shroud.Sealing shroud is able to ensure that sample tap and sampling line interface airtight connection, it is ensured that sampling line it is complete
It is closed, ensure the accuracy of sampling.
A kind of fermentation tank sterile sampling as described above and sample reception system, described bypass decontamination duct network are connected with cold
Condensed water collection container.Condensate water collection reservoir is used in collecting disinfecting process the condensed water discharged, convenient processing.
A kind of fermentation tank sterile sampling and sample reception system, described valve as described above use ball valve, and valve is
Stainless steel.Valve is used to control sampling line or bypass decontamination duct network to connect and close, using stainless steel ball valve, wear-resisting,
Good seal performance, sealed reliable.
A kind of fermentation tank sterile sampling and sample reception system, described sample reception bottle as described above are connected with air pressure
Pipeline is balanced, air pressure double-beat drop valve is connected with air pressure balance pipeline.Air pressure double-beat drop valve is identical with air filter function, samples
The pressure differential of bottle cap both sides, convenient sampling are balanced in journey.
A kind of fermentation tank sterile sampling and sample reception system, the bottleneck of described sample reception bottle as described above are provided with
Bottle cap, bottle cap use quality of rubber materials, and bottle cap is provided with pipeline port.Sample reception bottle can achieve a butt joint with steriling test, side
Just examine, bottle cap uses quality of rubber materials, good airproof performance.
The beneficial effects of the utility model are：Sample tap is connected with sampling line, and sampling line is provided with bypass decontamination duct network,
Sampling line end is connected with sample reception bottle；The first valve is connected with bypass decontamination duct network, the is connected with sampling line
Two valves, the second valve are arranged on the bypass decontamination duct network rear end on sampling line；Sample reception bottle is connected with air cleaner.
The utility model may be implemented in the sterile sampling in any region, not influenceed by clean environment；Use cost is low, fermented sample point
It is high to analyse accuracy, contributes to the judgement of fermented and cultured state.
Brief description of the drawings
Fig. 1 is fermentation tank sterile sampling and sample reception system schematic.
Fig. 2 is fermentation tank sterile sampling and sample reception system schematic provided with air pressure balance pipeline.
Embodiment
Principle of the present utility model and feature are described below in conjunction with accompanying drawing, example is served only for explaining this practicality
It is new, it is not intended to limit the scope of the utility model.
As shown in figure 1, a kind of sterile sampling of fermentation tank 1 and sample reception system, including fermentation tank 1, described fermentation tank 1
Provided with sample tap 2, described sample tap 2 is connected with sample cock, steam valve；Described sample tap 2 is connected with sampling line
3, sampling line 3 is provided with bypass decontamination duct network 4, and the end of sampling line 3 is connected with sample reception bottle 5；Described bypass sterilization pipe
The first valve 6 is connected with road 4, the second valve 7 is connected with described sampling line 3, the second described valve 7 is arranged on
The rear end of bypass decontamination duct network 4 on sampling line 3；Described sample reception bottle 5 is connected with air cleaner 8.
In one embodiment of the sterile sampling of fermentation tank 1 and sample reception system, described sample tap 2 and sampling line 3
Interface is provided with sealing shroud.Sealing shroud is able to ensure that sample tap 2 and the interface airtight connection of sampling line 3, it is ensured that sampling line 3
It is complete closed, ensure sampling accuracy.
In one embodiment of the sterile sampling of fermentation tank 1 and sample reception system, described bypass decontamination duct network 4 is connected with
Condensate water collection reservoir 9.Condensate water collection reservoir 9 is used in collecting disinfecting process the condensed water discharged, convenient processing.
In one embodiment of the sterile sampling of fermentation tank 1 and sample reception system, described valve uses ball valve, and valve is
Stainless steel.Valve is used to control sampling line 3 or bypass decontamination duct network 4 to connect and close, resistance to using stainless steel ball valve
Mill, good seal performance, sealed reliable.
As shown in Fig. 2 in one embodiment of the sterile sampling of fermentation tank 1 and sample reception system, described sample reception
Bottle 5 is connected with air pressure balance pipeline 10, and air pressure double-beat drop valve 11 is connected with air pressure balance pipeline 10.Air pressure double-beat drop valve 11 and air
The function phase of filter 8 is same, and the pressure differential of bottle cap both sides, convenient sampling are balanced in sampling process.
In one embodiment of the sterile sampling of fermentation tank 1 and sample reception system, the bottleneck of described sample reception bottle 5
Provided with bottle cap, bottle cap uses quality of rubber materials, and bottle cap is provided with pipeline port.Bottle cap uses quality of rubber materials, good airproof performance.
Workflow of the present utility model is as follows：
The first step：First by sampling line 3, bypass decontamination duct network 4, sample reception bottle 5, condensate water collection reservoir 9 before sampling
Connecting, the interface of sample tap 2 is sealed with the bypass side of decontamination duct network 4 with eight layers of gauze, and the first valve 6 and the second valve 7 are opened,
Moist heat sterilization in moist heat sterilization cabinet is then placed in, sterilising conditions are 121 degree, more than 15 minutes, are sterilized after terminating respectively by first
The valve 7 of valve 6 and second is shut；
Second step：The sample tap 2 of fermentation tank 1 is connected with the interface of sampling line 3 to (bore can be according to fermentation after the completion of sterilizing
The bore of tank 1 is supporting), while junction is sealed using sealing shroud or fluid sealant, it is ensured that sampling line 3 it is complete close
Close；
3rd step：Carry out bypassing decontamination duct network 4, manually open the controlling switch of the first valve 6, by the sample tap 2 of fermentation tank 1
On steam valve open, steam carries out disinfection along the first route S1 to sampling line 3, disinfecting time at least 5 minutes, this mistake
The first valve of journey 6 remains on, and sterilization distinguishes steam off valve and the first valve 6 after terminating, and treats that line temperature drops to
Less than 30 degree can carry out next step operation；
4th step：Sample cock and the second valve 7 are opened, sampling line 3 is unobstructed, and the sample in fermentation tank 1 is along sampling
The route S2 of pipeline 3 second is flowed into sample reception bottle 5, completes sampling.
Preferred embodiment of the present utility model is the foregoing is only, it is all in this practicality not to limit the utility model
Within new spirit and principle, any modification, equivalent substitution and improvements made etc., guarantor of the present utility model should be included in
Within the scope of shield.
Claims (6)
1. a kind of fermentation tank sterile sampling and sample reception system, including fermentation tank, described fermentation tank is provided with sample tap, described
Sample tap be connected with sample cock, steam valve；It is characterized in that：Described sample tap is connected with sampling line, probe tube
Road is provided with bypass decontamination duct network, and sampling line end is connected with sample reception bottle；Is connected with described bypass decontamination duct network
One valve, the second valve is connected with described sampling line, the bypass that the second described valve is arranged on sampling line disappears
Malicious pipeline rear end；Described sample reception bottle is connected with air cleaner.
2. a kind of fermentation tank sterile sampling according to claim 1 and sample reception system, it is characterised in that：Described takes
Sample mouth is provided with sealing shroud with sampling line interface.
3. a kind of fermentation tank sterile sampling according to claim 1 and sample reception system, it is characterised in that：Described side
Logical decontamination duct network is connected with condensate water collection reservoir.
4. a kind of fermentation tank sterile sampling according to claim 1 and sample reception system, it is characterised in that：Described valve
Door uses ball valve, and valve is stainless steel.
5. a kind of fermentation tank sterile sampling according to claim 1 and sample reception system, it is characterised in that：Described sample
Product receiving bottle is connected with air pressure balance pipeline, and air pressure double-beat drop valve is connected with air pressure balance pipeline.
6. a kind of fermentation tank sterile sampling according to claim 1 and sample reception system, it is characterised in that：Described sample
The bottleneck of product receiving bottle is provided with bottle cap, and bottle cap uses quality of rubber materials, and bottle cap is provided with pipeline port.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720559592.XU CN206799622U (en) | 2017-05-18 | 2017-05-18 | A kind of fermentation tank sterile sampling and sample reception system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720559592.XU CN206799622U (en) | 2017-05-18 | 2017-05-18 | A kind of fermentation tank sterile sampling and sample reception system |
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| Publication Number | Publication Date |
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| CN206799622U true CN206799622U (en) | 2017-12-26 |
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| CN201720559592.XU Active CN206799622U (en) | 2017-05-18 | 2017-05-18 | A kind of fermentation tank sterile sampling and sample reception system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109007019A (en) * | 2018-08-31 | 2018-12-18 | 许国武 | A kind of circulation stirring fermentor based on sampling valve fluid pressure balance |
-
2017
- 2017-05-18 CN CN201720559592.XU patent/CN206799622U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109007019A (en) * | 2018-08-31 | 2018-12-18 | 许国武 | A kind of circulation stirring fermentor based on sampling valve fluid pressure balance |
| CN109007019B (en) * | 2018-08-31 | 2021-10-26 | 江苏岭南发酵设备有限公司 | Circulation stirring fermentation cylinder based on sample valve fluid pressure is balanced |
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