CN202429568U - Fully enclosed liquid storage tank capable of online cleaning and online sterilizing - Google Patents
Fully enclosed liquid storage tank capable of online cleaning and online sterilizing Download PDFInfo
- Publication number
- CN202429568U CN202429568U CN2011205671841U CN201120567184U CN202429568U CN 202429568 U CN202429568 U CN 202429568U CN 2011205671841 U CN2011205671841 U CN 2011205671841U CN 201120567184 U CN201120567184 U CN 201120567184U CN 202429568 U CN202429568 U CN 202429568U
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- tank body
- pipeline
- tank
- cooling water
- pipe
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Abstract
The utility model discloses a fully enclosed liquid storage tank capable of online cleaning and online sterilizing. The fully enclosed liquid storage tank comprises a tank body, a tank jacket and pipelines, wherein the tank jacket is disposed outside the tank body and the pipelines are connected with the tank body and the tank jacket. The tank body is a cylinder with a round top and a round bottom. A discharge hole is reserved in the center of the tank bottom. A spray hole, a hand hole, a feed hole, a steam inlet, a steam outlet, a pressure gage and an ultrasonic liquid level gauge are disposed on the tank top. An observation window is disposed on the tank body. A sample opening, a thermal resistor and a thermometer are disposed on the lower portion of the tank body. The tank body and the tank bottom are wrapped by the tank jacket. A cooling water inlet is reserved on the bottom of the tank jacket and a cooling water outlet is reserved on the top of the tank jacket. The pipelines include a feed pipeline, a discharge pipeline, a steam inlet pipeline, a steam outlet pipeline, a sampling pipeline, a cooling water inlet pipeline and a cooling water outlet pipeline. A pipeline valve is disposed on each pipeline. A steam pipeline and a sewage pipeline are connected to the pipelines. By the fully enclosed liquid storage tank, pure steam is used for sterilizing, no dead angle exists, and accordingly, asepsis is guaranteed and production requirement is met.
Description
Technical field
The utility model relates to a kind of totally-enclosed receiver, particularly, relates to a kind of totally-enclosed on-line cleaning, online sterilization receiver.
Background technology
In the biological medicine industry, sterile working is particularly crucial.Because cell growth rate is slower, average about 24 ~ 30 hours breeding amplification generation, and general germ just multiplied a generation in about 20 minutes, when cell when an amplification is two, germ has reached more than trillion, usually said microbiological contamination that Here it is.So sterile working is the most key in cell is cultivated.At present, in the Quantity production, also have the dead angle in culture receiver and the design of nutrient solution holding tank, thoroughly CIP and SIP are easy to pollute.
The utility model content
The purpose of the utility model provides a kind of nutrient solution fluid reservoir that mass cell is cultivated that is used for; Can satisfy suspension cell controlled requirement of operation such as nutrient media storage, cell liquid collection in Quantity production; Can accomplish on-line cleaning, online sterilization, guarantee asepticly, reduce contamination hazard.
In order to achieve the above object, the utility model provides a kind of totally-enclosed on-line cleaning, online sterilization receiver, and this receiver comprises tank body, is arranged on outer tank body chuck of tank body and the pipeline that is connected with tank body, tank body chuck; Described tank body is the cylinder of dome round bottom, and the central authorities of tank deck are provided with mouth spray, and the central authorities at jar end are provided with discharging opening; Described tank deck also is respectively equipped with hand hole, inlet point, admission port, air extractor duct, compression indicator and ultrasonic level gage; Described tank body, its can body is provided with observation window, and this can body bottom also is provided with sample tap and an end inserts a jar interior PT100 resistance to heat and a heat indicator; The can body and a jar end of described tank body chuck parcel tank body, described tank body chuck bottom is provided with cooling water intake, and top is provided with cooling water outlet.Described pipeline comprises feed pipe, discharge pipe, induction tract, vent pipe, sampling line, cooling water inlet pipe road and cooling water outlet pipe road, is respectively equipped with pipeline valve on each pipeline; Be connected with steam pipe on described feed pipe, discharge pipe, induction tract and the sampling line respectively, be respectively equipped with pipeline valve on each steam pipe; Also be connected with blow-off line on described feed pipe, induction tract, vent pipe, the sampling line respectively, be respectively equipped with pipeline valve (row's of being used for steam condensate (SC)) on each blow-off line, be respectively equipped with drain valve on the blow-off line behind each pipeline valve.
Above-mentioned totally-enclosed on-line cleaning, online sterilization receiver; Wherein, Described feed pipe, discharge pipe, induction tract, vent pipe, sampling line, cooling water inlet pipe road and cooling water outlet pipe road are connected with inlet point, discharging opening, admission port, air extractor duct, sample tap, cooling water intake and cooling water outlet respectively.
Above-mentioned totally-enclosed on-line cleaning, online sterilization receiver wherein, are respectively equipped with filter on described induction tract and the vent pipe.
Above-mentioned totally-enclosed on-line cleaning, online sterilization receiver wherein, are provided with sample valve between described sample tap and the sampling line.
Above-mentioned totally-enclosed on-line cleaning, online sterilization receiver wherein, are provided with bottom valve between described discharging opening and the discharge pipe.
Above-mentioned totally-enclosed on-line cleaning, online sterilization receiver; Wherein, The position of described tank body chuck observation window, heat indicator, sample tap and discharging opening on said tank body forms depression respectively, and observation window, heat indicator, sample tap and discharging opening are exposed.
Above-mentioned totally-enclosed on-line cleaning, online sterilization receiver, wherein, described tank body chuck inner hollow.
The advantage that the totally-enclosed on-line cleaning that the utility model provides, online sterilization receiver have is; Whole tank body, pipeline can be implemented line and clean (CIP), online sterilization (SIP); Reduce the human operational error; And pipeline is easy and simple to handle, can guarantee sterile working, thereby guarantees that the culture or the cell liquid that store in the jar are pollution-free.
Description of drawings
Fig. 1 is the totally-enclosed on-line cleaning of the utility model, online sterilization receiver scheme drawing.
The specific embodiment
Below in conjunction with accompanying drawing the specific embodiment of the utility model is done explanation further.
As shown in Figure 1, the totally-enclosed on-line cleaning that the utility model provides, online sterilization receiver comprise tank body 9, are arranged on tank body chuck 8 outside the tank body 9 and the pipeline 5 that is connected with tank body 9, tank body chuck 8; Tank body 9 is the cylinder of dome round bottom, and the central authorities of tank deck are provided with mouth spray 91, and the central authorities at jar end are provided with discharging opening; Tank deck also is respectively equipped with hand hole 92, inlet point, admission port, air extractor duct, compression indicator 93 and ultrasonic level gage 94; Tank body 9, its can body is provided with observation window, and this can body bottom also is provided with sample tap and an end inserts PT100 resistance to heat 952 and heat indicator 951 in the tank body 9; The can body and a jar end of tank body chuck 8 parcel tank bodies 9, tank body chuck 8 bottoms are provided with cooling water intake, and top is provided with cooling water outlet; Pipeline 5 comprises feed pipe 51, discharge pipe 52, induction tract 53, vent pipe 54, sampling line 55, cooling water inlet pipe road 56 and cooling water outlet pipe road 57, is respectively equipped with pipeline valve 1 on each pipeline; Be connected with steam pipe 6 respectively on feed pipe 51, discharge pipe 52, induction tract 53 and the sampling line 55, be respectively equipped with pipeline valve 1 on each steam pipe 6; Also be connected with blow-off line 7 on feed pipe 51, induction tract 53, vent pipe 54, the sampling line 55 respectively; Be respectively equipped with pipeline valve 1 on each blow-off line, also be respectively equipped with first drain valve 21, second drain valve 22, the 3rd drain valve 23 on the blow-off line 7 behind each pipeline valve 1.
Feed pipe 51, discharge pipe 52, induction tract 53, vent pipe 54, sampling line 55, cooling water inlet pipe road 56 and cooling water outlet pipe road 57 are connected with inlet point, discharging opening, admission port, air extractor duct, sample tap, cooling water intake and cooling water outlet respectively.Be respectively equipped with filter 10 on induction tract 53 and the vent pipe 54.Be provided with sample valve 3 between sample tap and the sampling line 55.Be provided with bottom valve 4 between discharging opening and the discharge pipe 52.
The position of tank body chuck 8 observation window, heat indicator 951, sample tap and discharging opening on tank body 9 forms depression respectively, and observation window, heat indicator 951, sample tap and discharging opening are exposed.Tank body chuck 8 inner hollow.
The CIP totally-enclosed on the throne that the utility model provides, SIP receiver can guarantee not have the dead angle in CIP, the whole process of SIP.When using at the scene, operation according to the following steps:
With flexible pipe with jar at the bottom of discharging opening connect second drain valve 22 on the blow-off line 7.
The cooling circulation water valve is set.
Close tank body chuck 8 cooling circulating water flood valves 151, cooling circulating water backwater valve 152.
Open cooling circulating water foul valve 141.
Advance steam discharging gas.
Open air inlet filter valve 113, exhaust filter valve 121, steam inlet main valve 111, bottom valve 4 and bleeder valve 101.
Open steam bottom admission valve 114, steam is fed in the tank body 9.Check a jar last temperature gage 951, can most of air in the jar be drained when temperature rises to 98 ℃.
Close blow off valve 122 after having arranged air, close pure steam bottom admission valve 114.
Open pure steam top admission valve 112, inlet valve 102, row's condensation water valve 103 immediately with in the pure steam feeding jar, check tank deck compression indicator 93, treat that pressure rises to 1.2 * 10
5Pa, temperature are regarded as tank body 9 sterilization beginnings, timing 30 minutes when rising to 121 ℃.Answer the pure steam of manual regulation top air inlet valve 112 to come control system pressure in the sterilization process 1.2～1.5 * 10
5In the scope of Pa.
After tank body 9 sterilizations finish, the water valve of the row's of closing condensation immediately 103, air inlet filter valve 113, exhaust filter valve 121, bottom valve 4 and bleeder valve 101.
Close pure steam top air inlet valve 112, steam inlet main valve 111.
The slight blow off valve 122 of opening is opened compressed air inlet valve 161 then, control its opening degree sound that pressurized air flows can be heard and jar in press and be no more than 0.5 * 10
5Pa.
Treat a jar interior temperature natural be cooled to 80 ℃ after closes compression air inlet valve 161, open blow off valve 122, system is remained under the normal pressure.
Prove that through multiple batches of cell liquid novel totally-enclosed CIP on the throne, SIP receiver thoroughly do not produce pollution because of the tank body sterilization.
Although the content of the utility model has been done detailed introduction through above-mentioned preferred embodiment, will be appreciated that above-mentioned description should not be considered to the restriction to the utility model.After those skilled in the art have read foregoing, for the multiple modification of the utility model with to substitute all will be conspicuous.Therefore, the protection domain of the utility model should be limited appended claim.
Claims (7)
1. a totally-enclosed on-line cleaning, online sterilization receiver is characterized in that, this receiver comprises tank body (9), is arranged on outer tank body chuck (8) of tank body (9) and the pipeline (5) that is connected with tank body (9), tank body chuck (8);
Described tank body (9) is the cylinder of dome round bottom, and the central authorities of tank deck are provided with mouth spray (91), and the central authorities at jar end are provided with discharging opening;
Described tank deck also is respectively equipped with hand hole (92), inlet point, admission port, air extractor duct, compression indicator (93) and ultrasonic level gage (94);
Described tank body (9), its can body is provided with observation window, and this can body bottom also is provided with sample tap and an end inserts PT100 resistance to heat (952) and heat indicator (951) in the tank body (9);
The can body of described tank body chuck (8) parcel tank body (9) and a jar end, described tank body chuck (8) bottom is provided with cooling water intake, and top is provided with cooling water outlet;
Described pipeline (5) comprises feed pipe (51), discharge pipe (52), induction tract (53), vent pipe (54), sampling line (55), cooling water inlet pipe road (56) and cooling water outlet pipe road (57), is respectively equipped with pipeline valve (1) on each pipeline;
Be connected with steam pipe (6) respectively on described feed pipe (51), discharge pipe (52), induction tract (53) and the sampling line (55), be respectively equipped with pipeline valve (1) on each steam pipe (6);
Also be connected with blow-off line (7) respectively on described feed pipe (51), induction tract (53), vent pipe (54), the sampling line (55); Be respectively equipped with pipeline valve (1) on each blow-off line, also be respectively equipped with drain valve (2) on the blow-off line (7) behind each pipeline valve (1).
2. totally-enclosed on-line cleaning as claimed in claim 1, online sterilization receiver; It is characterized in that; Described feed pipe (51), discharge pipe (52), induction tract (53), vent pipe (54), sampling line (55), cooling water inlet pipe road (56) and cooling water outlet pipe road (57) are connected with inlet point, discharging opening, admission port, air extractor duct, sample tap, cooling water intake and cooling water outlet respectively.
3. totally-enclosed on-line cleaning as claimed in claim 1, online sterilization receiver is characterized in that, are respectively equipped with filter (10) on described induction tract (53) and the vent pipe (54).
4. totally-enclosed on-line cleaning as claimed in claim 1, online sterilization receiver is characterized in that, are provided with sample valve (3) between described sample tap and the sampling line (55).
5. totally-enclosed on-line cleaning as claimed in claim 1, online sterilization receiver is characterized in that, are provided with bottom valve (4) between described discharging opening and the discharge pipe (52).
6. totally-enclosed on-line cleaning as claimed in claim 1, online sterilization receiver; It is characterized in that; The position that described tank body chuck (8) is gone up observation window, heat indicator (951), sample tap and discharging opening at said tank body (9) forms depression respectively, and observation window, heat indicator (951), sample tap and discharging opening are exposed.
7. totally-enclosed on-line cleaning as claimed in claim 1, online sterilization receiver is characterized in that, described tank body chuck (8) inner hollow.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011205671841U CN202429568U (en) | 2011-12-30 | 2011-12-30 | Fully enclosed liquid storage tank capable of online cleaning and online sterilizing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011205671841U CN202429568U (en) | 2011-12-30 | 2011-12-30 | Fully enclosed liquid storage tank capable of online cleaning and online sterilizing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202429568U true CN202429568U (en) | 2012-09-12 |
Family
ID=46779034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011205671841U Expired - Fee Related CN202429568U (en) | 2011-12-30 | 2011-12-30 | Fully enclosed liquid storage tank capable of online cleaning and online sterilizing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202429568U (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212558A (en) * | 2013-04-28 | 2013-07-24 | 广州丽盈塑料有限公司 | Automatic cleaning and disinfecting system of canning device |
| CN103420054A (en) * | 2013-09-02 | 2013-12-04 | 四川郎酒集团有限责任公司 | Wine tank and cleaning method of wine tank |
| CN105414130A (en) * | 2016-01-06 | 2016-03-23 | 广州达意隆包装机械股份有限公司 | Automatic cleaning device |
| CN105800193A (en) * | 2016-06-03 | 2016-07-27 | 谈磊 | Intelligent sterile transportation tank |
| CN106081381A (en) * | 2016-06-29 | 2016-11-09 | 芜湖杨燕制药有限公司 | A kind of percolate receiver |
| CN107487560A (en) * | 2017-09-30 | 2017-12-19 | 江阴市南丰科技有限公司 | A kind of pharmaceutical purpose decoction storage tank |
| CN108728331A (en) * | 2018-06-29 | 2018-11-02 | 江苏丰泽生物工程设备制造有限公司 | A kind of fermentation tank automatic flushing device |
-
2011
- 2011-12-30 CN CN2011205671841U patent/CN202429568U/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103212558A (en) * | 2013-04-28 | 2013-07-24 | 广州丽盈塑料有限公司 | Automatic cleaning and disinfecting system of canning device |
| CN103420054A (en) * | 2013-09-02 | 2013-12-04 | 四川郎酒集团有限责任公司 | Wine tank and cleaning method of wine tank |
| CN103420054B (en) * | 2013-09-02 | 2015-05-13 | 四川郎酒集团有限责任公司 | Wine tank and cleaning method of wine tank |
| CN105414130A (en) * | 2016-01-06 | 2016-03-23 | 广州达意隆包装机械股份有限公司 | Automatic cleaning device |
| CN105800193A (en) * | 2016-06-03 | 2016-07-27 | 谈磊 | Intelligent sterile transportation tank |
| CN106081381A (en) * | 2016-06-29 | 2016-11-09 | 芜湖杨燕制药有限公司 | A kind of percolate receiver |
| CN107487560A (en) * | 2017-09-30 | 2017-12-19 | 江阴市南丰科技有限公司 | A kind of pharmaceutical purpose decoction storage tank |
| CN108728331A (en) * | 2018-06-29 | 2018-11-02 | 江苏丰泽生物工程设备制造有限公司 | A kind of fermentation tank automatic flushing device |
| CN108728331B (en) * | 2018-06-29 | 2020-03-27 | 江苏丰泽生物工程设备制造有限公司 | Fermentation cylinder with self-cleaning device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI SAIJIN BIOMEDICAL CO., LTD. Free format text: FORMER OWNER: SHANGHAI KANDA BIOLOGICAL MEDICINE TECHNOLOGY CO., LTD. Effective date: 20130722 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20130722 Address after: 201203 Shanghai Zhangjiang hi tech Park Chunxiao Road No. 300 room 306 Patentee after: Shanghai Saijin Biomedical Co., Ltd. Address before: 201203 Shanghai Zhangjiang High Tech Park of Pudong New Area Chunxiao Road No. 300 Patentee before: Shanghai Kanda Biotechnology Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120912 Termination date: 20201230 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |