CN204439552U - A kind of immunofluorescence quantitative analysis instrument - Google Patents
A kind of immunofluorescence quantitative analysis instrument Download PDFInfo
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- CN204439552U CN204439552U CN201520125661.7U CN201520125661U CN204439552U CN 204439552 U CN204439552 U CN 204439552U CN 201520125661 U CN201520125661 U CN 201520125661U CN 204439552 U CN204439552 U CN 204439552U
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Abstract
A kind of immunofluorescence quantitative analysis instrument, it comprises: temperature control module, light source module, photoelectric conversion module, control analysis module, network connecting module, sample introduction module, and data memory module; Wherein, first by described sample introduction module, reagent card to be detected is sent into detection zone, described light source module exciting light irradiates the signaling zone of reagent card, then obtain fluorescence signal by described photoelectric conversion module and be converted into electric signal, flow to described control analysis module, finally undertaken processing by control analysis module and carry out data storage and result display.A kind of immunofluorescence quantitative analysis instrument of the present utility model, excitation source is optional, can change for the product that sensitivity requirement is different; Utilizing emitted light wide ranges can be accepted; Use SD Quality Control chip or one dimension/Quick Response Code recognizer, make instrument Quality Control more flexible; Add temperature control module, improve the preci-sion and accuracy of instrument.
Description
Technical field
The utility model relates to medical detection technology, particularly relates to a kind of immunofluorescence quantitative analysis instrument.
Background technology
Immunofluorescence test technology is Fast Detection Technique conventional in biomedical inspection at present, and the major advantage of this technology is high specificity, highly sensitive, speed is fast.It equals by Coons a kind of immunolabelling technique that phase early 1940s sets up the earliest.Its ultimate principle is using fluorescent material as label, the responsive measurability of fluorescence is combined with the specific reaction of antigen-antibody height.Fluorescent material, under the exciting light effect of specific wavelength, can absorb luminous energy and enter excited state, with the luminous energy absorbed before the release of electromagnetic radiation form, produces fluorescence.Specificity fluorescent directly can use fluorescence microscope; also process further again after can being converted into electric signal with photoelectric commutator reception; can accurate, sensitive, rapidly detection and localization go out some trace or ultramicron material, be widely used in multiple fields such as medical science, biology, environmental protection.
Several special fluorescence immunoassay of development in recent years, the same with enzyme immunoassay (EIA) and radiommunoassay, be applied in clinical examination.
The development of Quantum Dot Labeling technology is advanced by leaps and bounds, and makes quantum dot become a kind of novel fluorescence label.Alivisalos and Nie in 1998 simultaneously on science reported first quantum dot be applied to the achievement in research of the initiative in biomarker and cell imaging field, tentatively solve quantum dot as the targeting of bioprobe and biocompatibility issues, impel quantum dot really to enter biological fluorescent labelling field.Quantum dot is compared with the organic conventional fluorescent agent of tradition, has special optical characteristics: 1. quantum dot has the advantages that its fluorescence emission wavelengths is undertaken by the size and composition changing itself regulating.Its exciting light spectrum width and continuously, absorptivity is large, fluorescence intensity is high, and fluorescence emission peak is narrow and symmetrical, trails without long wave.2. quantum dot has larger Stokes shift.Between the wavelength of exciting light and the peak value of wavelength of transmitted light, difference is large, therefore can avoid the overlapping of emission spectrum and excitation spectrum.3. quantum dot has good light stability, resistance to photobleaching.It can stand repeated multiple times exciting, and unlike organic fluorescent dye easy generation photobleaching, this in research cell between biomolecule long-time interaction provide powerful.4. the quantum dot fluorescence life-span is longer, sustainablely reaches several 10ns.After optical excitation number nanosecond, most autofluorescence background decays, and quantum dot fluorescence still exists, and now can obtain the fluorescence signal without background interference.The unique optical properties of this novel nano-material of quantum dot, for immunofluorescence quantitative test provide sensitiveer, judge more accurately.
Immunofluorescence quantitative analysis instrument hardware components is generally made up of computer, IO interface, analog to digital converter, scan control circuit, photoelectric switching circuit, background compensation circuit, display etc.But the usual volume of immunofluorescence quantitative analysis instrument general in prior art is comparatively large, is not easy to real-time test, limits it and having inconvenient traffic, the development of under-developed area.And due to the combination of antigen-antibody and marker material expensive, operation is accurate, can not resemble chemical reagent and can make large area colour developing, test in sample has the impurity such as water, blood, marker material simultaneously, and the reason such as uneven adds difficulty and the precision of detection in process of osmosis.Therefore, keeping, the volume of POCT product is small, and while easy to carry, improving the scope of application of instrument, stability, sensitivity and accuracy is problem to be solved in the utility model.
Utility model content
The purpose of this utility model is to provide a kind of immunofluorescence quantitative analysis instrument, and which solve current fluorescence analyser volume comparatively large, carry inconvenience, usable range is little, the technical matters of stability and poor sensitivity.
For achieving the above object, the technical scheme that the utility model proposes is:
A kind of immunofluorescence quantitative analysis instrument of the present utility model, it comprises: temperature control module, light source module, photoelectric conversion module, control analysis module, network connecting module, sample introduction module, and data memory module; Wherein, first by described sample introduction module, reagent card to be detected is sent into detection zone, described light source module exciting light irradiates the signaling zone of reagent card, then obtain fluorescence signal by described photoelectric conversion module and be converted into electric signal, flow to described control analysis module, finally undertaken processing by control analysis module and carry out data storage and result display.
Wherein, also comprise one dimension and/or Quick Response Code recognizer and Quality Control SD chip-stored interface, wherein, described one dimension and/or Quick Response Code recognizer recognition detection project name, batch number, mark curve, clinical reference value information.
Wherein, described light source module comprises LASER Light Source and LED light source.
Wherein, the number of described photoelectric conversion module is two, and one of them photoelectric conversion module is used for visible ray conversion, and another is changed for infrared light.
Wherein, the sensor front end portion of described photoelectric conversion module is provided with transparent temperature control quartz.
Wherein, described photoelectric conversion module also comprises a signal compensation circuit.
Wherein, described sample introduction module is semi-automatic, and described sample introduction module also comprises time reminding module.
Wherein, the temperature controlling range of described temperature control module is 15-30 degree Celsius.
Wherein, described control analysis module comprises main circuit, motor, display screen and printer.
Compared with prior art, a kind of immunofluorescence quantitative analysis instrument of the present utility model, adopts semi-automatic sampling device, decreases proving time; Excitation source is optional, can change for the product that sensitivity requirement is different; Utilizing emitted light wide ranges can be accepted; Use SD Quality Control chip or one dimension/Quick Response Code recognizer, make instrument Quality Control more flexible; Add temperature control module and transparent temperature control quartz, ensure that the instrument impact normally using and decrease receiving optical signals reading at low temperatures, improve the preci-sion and accuracy of instrument.
Accompanying drawing explanation
Fig. 1 is a kind of immunofluorescence quantitative analysis instrument of the utility model Facad structure schematic diagram;
Fig. 2 is a kind of immunofluorescence quantitative analysis instrument of the utility model side structure schematic diagram.
Embodiment
Below with reference to accompanying drawing, elaboration is further given to the utility model.
Refer to Fig. 1 and accompanying drawing 2, in the present embodiment, a kind of immunofluorescence quantitative analysis instrument of the present utility model, comprises temperature control module 1, light source module 2, photoelectric conversion module 3, control analysis module 4, network connecting module 5, sample introduction module 8.Sample Room temperature when wherein temperature control module 1 is for regulating temperature too low; Light source module 2 is for launching excitation beam to the signaling zone on reagent card, and LASER Light Source 21 and LED light source 22 can use simultaneously can also switch use; Photoelectric conversion module 3 is for receiving fluorescence signal and carrying out photoelectric signal transformation; Control analysis module 4 comprises main circuit, motor, display screen, printer, and described control analysis module 4 outputs to display screen for the treatment of receiving the electric signal row relax of going forward side by side that photoelectric conversion module exports, and can touch input instruction or printing; Network connecting module 5 is connected with computer for remote transmission WiFi; Sample introduction module 8 has detected rear automatic push to test card for a upper test card and has entered sample introduction tank and complete test.Software systems comprise start calibration module, initialization module, signal acquisition module, test sample analysis module and system parameter setting module.This quantitative fluorescence analysis instrument is provided with the slot for placing reagent card and places the slot of Quality Control SD chip, and Quality Control SD chip or one-dimension code/Quick Response Code are for obtaining the Quality Control information of respective item reagent card.
Described LASER Light Source 21 comprises generating laser, spectroscope 23, excitation beam is transmitted in the signaling zone of reagent strip through lens, through reflecting fluorescence signal, the first photoelectric conversion module 32 (namely for the photoelectric commutator of visible ray conversion) is shone through optical filter 25, light transmission piece 26, grating 27, then input main circuit, be presented at display screen.
Described LED light source 22 comprises LED illuminator, spectroscope 23 and light transmission piece 24, main circuit controls LED transmitted beam, the signaling zone on reagent strip is transmitted into through spectroscope 23 and light transmission piece 24, through reflecting fluorescence signal, again through the second photoelectric conversion module 33, then input main circuit, be presented at display screen.
The excitation source that this excitation source module sends is radiated at the signaling zone of test agent card, and the fluorescence signal that signaling zone the sends module that is photoelectrically converted is caught and is converted to electric signal, exports electric signal to control analysis module, output display screen display.Described photoelectric conversion module comprises the first photosignal converter 32 and the second photoelectric commutator 33 (namely for the photoelectric commutator of infrared light conversion).
Described first photoelectric conversion module 32 is for receiving the signal of reflects laser, and signaling zone information on reading reagent bar, inputs main circuit by signal and be converted to the output of detection product concentration on a display screen.
Described second photoelectric conversion module 33, for receiving the signal of reflected fluorescent light, is amplified by opto-electronic conversion, signal, and the photon intensity obtained also is converted to the output of detection product concentration on a display screen.
Wherein, excitation source module is for launching excitation beam to the signaling zone on reagent card, and LASER Light Source and LED light source can use simultaneously can also switch use, increases the sensitivity of instrument, makes the scope of application of the present utility model wider.
Because laser has the advantage of good directivity, unicity, coherence, and LED light source have stability higher, excite scope advantage more widely, use laser and LED as excitation source in the utility model immunofluorescence quantitative analysis instrument, signaling zone in reagent card is mapped to by exciting incident illumination, quantum dot on C, T line is inspired the stronger photon of energy, there is electronic transition thus produce a kind of new wavelength, being generally greater than the wavelength of exciting light.The utilizing emitted light produced is received by photodiode and is converted into electric signal, and the power of electric signal is strictly relevant to detection material molecular amounts, after the electric signal that receiver converts is amplified by amplifying circuit, is translated into accessible numeral with A/D converter.
Described control analysis module 4 comprises main circuit 41, motor 44, printer 43 and display screen 42, and main circuit controls the motion of detecting sensor.
The software systems of a kind of immunofluorescence quantitative analysis instrument of the utility model are made up of the detection control algorithm routine of machine intimate and the analysis of Based PC platform and database software.(this instrument can be connected with PC, preserves management by detection statistical conversion to PC, also can not be connected with PC, directly be kept in storage card, or prints preservation, and whether connect, pattern can be selected)
Wherein, described software systems comprise start calibration module: self-verifying instrument duty and static parameter whether normal;
Initialization module: each cell operation state initialization of the system that arranges;
Signal processing and analysis module: gather reagent card signaling zone information, analyzes input reagent card corrected parameter, test sample book parameter;
Test sample analysis module: collecting test signaling zone information, according to the parameter of signal processing and analysis, utilizes the algorithm of pre-programmed to calculate the concentration of detected material;
System parameter setting module: arrange and change Instrument working state and parameter, detecting pattern etc.;
Preferably, the network connecting module of this immunofluorescence quantitative analysis instrument can be used for remote transmission WiFi and is connected with computer.
Preferably, described sample introduction module comprises a semi-automatic sample introduction time reminding device, can setup times length voluntarily, and after a upper detection terminates, automatically remind next detection, before next pattern detection, 15s sounds a buzzer.The feature of semi-automatic sampling device be can on platform the multiple test card of parallel placement, one of them is placed in sample introduction tank, other are parallel to sample introduction tank, after the test card in sample introduction tank has been tested and has been extracted, the spring clamp plate of semi-automatic sampling device can enter sample introduction tank and completes test by push to test card, until all test cards have all been tested, this semi-automatic sampling device can disposable sample introduction 1-20 sample.
Preferably, a kind of immunofluorescence quantitative analysis instrument of the present utility model there is also mounted a miniature printer, can be used for printing testing result, checks to retain.
Wherein, a signal compensation circuit is also added, for reducing undesired signal in described first photoelectric conversion module 32.
During detection, test item by the automatic recognition detection project of Operation system setting, and is presented in LCDs by instrument, confirms that whether test item is correct when starting to detect for operator further.
Preferably, display screen 42 adopts touch-screen to show.
Quantum Dot Labeling antibody/antigen is through surface chemical modification by this for quantum dot novel nano-material, directed connection nucleic acid, albumen and the Small molecular etc. with particular organisms function, to realize the specific recognition of antigen-antibody, the immunofluorescence quantitative analysis instrument that the reagent card reacted in advance utilizes the utility model to provide, the quantum dot built up by signaling zone on light source activation nitrocellulose filter, light signal is changed into electric signal through photoelectric conversion process by the fluorescence that quantum dot reflects, and by the automatic Control system arranged in instrument, signal is exported, final detectable concentration is demonstrated at display screen.
Wherein, what system of fluorescence analysis adopted is the laser of 365nm wavelength, and when irradiating reagent card, its fluorescent material quantum dot can send the light wave of 610nm.
Immunofluorescence test technology to be marked thing with fluorescence quantum, and chromatography strip is made by multiple material compound.Detecting instrument hardware components is generally made up of computer, IO interface, photoelectric switching circuit, scan control circuit, background compensation circuit, analog to digital converter, display etc.For the ease of preserving test result, mini-printer is installed.
The relation of optical density value and concentration represents with typical curve, and when measuring, control analysis module and software systems can convert optical density value to concentration value automatically, and then analyze in unknown sample the concentration analyzing thing at every turn.
In the utility model, Quality Control 6 comprises SD chip 61 and and one dimension and/or Quick Response Code recognizer 62.Use SD chip 61 and one dimension and/or Quick Response Code recognizer 62 to carry out quality control, SD chip 61 and one dimension and/or Quick Response Code recognizer 62 comprise the information such as test item title, batch number, typical curve, clinical reference value.
Quality Control SD card before use, is inserted the slot of the Quality Control SD card of machine by reagent card 7, reads chip and obtains Quality Control information, or obtains the Quality Control information of this test item by one dimension/Quick Response Code scanning.Described reagent card 7 comprises signaling zone 71 and well 72.The housing of a kind of immunofluorescence quantitative analysis instrument of the present utility model is also provided with supply hub 9 and instrument switch 10.
The operational mode of this fluorescent quantitative detector is used to comprise the following steps:
The first step, first selects the detecting pattern needed for test item after start;
Second step, the reagent card reacted in advance injects reagent card slot;
3rd step, be radiated at the signaling zone of test agent card from the excitation source of excitation source module transmitting, the fluorescence quantum on signaling zone, under the effect of exciting light, launches fluorescence signal.
4th step, the fluorescence signal that signaling zone is launched is caught by the photoelectric conversion module arranged in immunofluorescence quantitative analysis instrument, is completed the conversion of photosignal by photoelectric conversion module.The light that test agent card signal district launches by photoelectric conversion module by being converted to electric signal, and is amplified by amplifying circuit, shows result by analysis after system process.
Double antibody sandwich method is used as detected PCT.With two plant height specificitys, hypersensitivity PCT monoclonal antibody, wherein PCT monoclonal antibody I is fixed on pad, is quantum dot-labeled antibody, for detectable antigens; PCT monoclonal antibody II is coated in chromatographic film and forms detection line (T line), for capture antibody.For whether monitoring test paper is effective, control line (C line) is set.Application antigen-antibody reaction and fluorescence quantum immunochromatography technique, detect the content of PCT in human blood.During test, if the PCT monoclonal antibody I being first marked with quantum dot containing PCT, PCT in pad in sample is combined, is then combined with the PCT monoclonal antibody II of nitrocellulose filter T line place bag quilt and forms " sandwich " structure.T line place fluorescence developing intensity and PCT content proportional, according to the quantitative PCT concentration of fluorescence intensity.
Using fluorescence quantum as label, be applied to antigen-antibody reaction, the detection of PCT etc. is used for by immunofluorescence quantitative analysis instrument, fluorescent quantitation testing result is of great significance judging the infective power of the state of an illness and instructing anti-inflammatory medicaments to treat, state of an illness information more accurately can be provided, and testing result can preserve with data mode, set up patient's state of an illness database, conveniently inquire about in the future.The principal feature of the utility model immunofluorescence quantitative analysis instrument facilitates small and exquisite portable, fast simple to operate, do not need professional, highly sensitive, accurately reliable.Be specially adapted to vast grass-roots unit, hospital, field work personnel and large batch of pattern detection and large immunity generaI investigation and without professional's environment on the scene, can test item many, applied widely.
The immunofluorescence quantitative analysis instrument deft design that the utility model provides, easy to use, be easy to carry, friendly interface, can the concentration of Procalcitonin in external Quantitative detection human serum/blood plasma, be adapted to the auxiliary diagnosis to pyemia, bacteriological infection and systemic fungal infection, parasitic infection, meningitis.The quantitative Fast Detection Technique of the immunofluorescence adopted, detection sensitivity can reach fg/ml.Test item can be made all to complete in 3-15 minute, detection speed <10 in instrument second/test, the requirement of mass detection can be met.
The repeated coefficient of variation of the present utility model: fluorescent value coefficient of variation CV≤2.0% of the fluoroscopic examination card 20 times of instrument duplicate measurements varying strength
The stability coefficient of variation: the fluoroscopic examination card of the same concentration of instrument duplicate measurements in 30min, fluorescent value reading fluctuate be no more than ± 3%.
Immunofluorescence quantitative analysis instrument in the utility model is preferably applicable to the concentration of Procalcitonin in external Quantitative detection human serum/blood plasma, is adapted to the auxiliary diagnosis to pyemia, bacteriological infection and systemic fungal infection, parasitic infection, meningitis.The utility model is applicable to vitro detection, can be used for the quick and quantitative determination system of the central laboratory of medical institutions, outpatient service or Laboratory, clinical department and other medical services point, MEC.
Foregoing; be only preferred embodiment of the present utility model; not for limiting embodiment of the present utility model; those of ordinary skill in the art are according to central scope of the present utility model and spirit; can carry out corresponding flexible or amendment very easily, therefore protection domain of the present utility model should be as the criterion with the protection domain required by claims.
Claims (9)
1. an immunofluorescence quantitative analysis instrument, is characterized in that, comprising: temperature control module, light source module, photoelectric conversion module, control analysis module, network connecting module, sample introduction module, and data memory module; Wherein, first by described sample introduction module, reagent card to be detected is sent into detection zone, described light source module exciting light irradiates the signaling zone of reagent card, then obtain fluorescence signal by described photoelectric conversion module and be converted into electric signal, flow to described control analysis module, finally undertaken processing by control analysis module and carry out data storage and result display.
2. immunofluorescence quantitative analysis instrument as claimed in claim 1, it is characterized in that, also comprise one dimension and/or Quick Response Code recognizer and Quality Control SD chip-stored interface, wherein, described one dimension and/or Quick Response Code recognizer recognition detection project name, batch number, mark curve, clinical reference value information.
3. immunofluorescence quantitative analysis instrument as claimed in claim 1, it is characterized in that, described light source module comprises LASER Light Source and LED light source.
4. immunofluorescence quantitative analysis instrument as claimed in claim 1, it is characterized in that, the number of described photoelectric conversion module is two, and one of them photoelectric conversion module is used for visible ray conversion, and another is changed for infrared light.
5. immunofluorescence quantitative analysis instrument as claimed in claim 4, is characterized in that, the sensor front end portion of described photoelectric conversion module is provided with transparent temperature control quartz.
6. immunofluorescence quantitative analysis instrument as claimed in claim 4, it is characterized in that, described photoelectric conversion module also comprises a signal compensation circuit.
7. immunofluorescence quantitative analysis instrument as claimed in claim 1, it is characterized in that, described sample introduction module is semi-automatic sample introduction module, and described sample introduction module also comprises time reminding module.
8. immunofluorescence quantitative analysis instrument as claimed in claim 1, it is characterized in that, the temperature controlling range of described temperature control module is 15-30 degree Celsius.
9. immunofluorescence quantitative analysis instrument as claimed in claim 1, it is characterized in that, described control analysis module comprises main circuit, motor, display screen and printer.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107884571A (en) * | 2016-09-30 | 2018-04-06 | 张磊 | Portable fluorescence immunity analysis instrument and Portable fluorescence analysis method |
| CN108828206A (en) * | 2018-05-24 | 2018-11-16 | 广州天宝颂原生物科技开发有限公司 | A kind of dry type fluorescence immunity analyzer and its test method |
| CN109270264A (en) * | 2018-11-29 | 2019-01-25 | 福州大学 | A kind of immune and bio-chemical detector control system and its method |
| CN109557300A (en) * | 2019-01-17 | 2019-04-02 | 湖北中医药高等专科学校 | A kind of full-automatic fluoroimmunoassay system and method |
| CN109655628A (en) * | 2019-02-01 | 2019-04-19 | 深圳市金准生物医学工程有限公司 | Have both the optical sampling module and fluorescence immunity analyzer of sampling width and precision |
| CN111426666A (en) * | 2020-02-27 | 2020-07-17 | 中国科学院上海技术物理研究所 | High-throughput automatic detector for simultaneously detecting multiple kinds of viruses |
| CN112180076A (en) * | 2019-07-02 | 2021-01-05 | 康泰医学系统（秦皇岛）股份有限公司 | POCT analysis device |
| CN118518644A (en) * | 2024-05-15 | 2024-08-20 | 苏州康医诺生物科技有限公司 | Fluorescence analyzer and analysis method thereof |
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2015
- 2015-03-04 CN CN201520125661.7U patent/CN204439552U/en active Active
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107884571A (en) * | 2016-09-30 | 2018-04-06 | 张磊 | Portable fluorescence immunity analysis instrument and Portable fluorescence analysis method |
| CN108828206A (en) * | 2018-05-24 | 2018-11-16 | 广州天宝颂原生物科技开发有限公司 | A kind of dry type fluorescence immunity analyzer and its test method |
| CN109270264A (en) * | 2018-11-29 | 2019-01-25 | 福州大学 | A kind of immune and bio-chemical detector control system and its method |
| CN109557300A (en) * | 2019-01-17 | 2019-04-02 | 湖北中医药高等专科学校 | A kind of full-automatic fluoroimmunoassay system and method |
| CN109655628A (en) * | 2019-02-01 | 2019-04-19 | 深圳市金准生物医学工程有限公司 | Have both the optical sampling module and fluorescence immunity analyzer of sampling width and precision |
| WO2020155314A1 (en) * | 2019-02-01 | 2020-08-06 | 深圳市金准生物医学工程有限公司 | Optical sampling module having balanced sampling width and precision, and immunofluorescence assay equipment |
| CN112180076A (en) * | 2019-07-02 | 2021-01-05 | 康泰医学系统（秦皇岛）股份有限公司 | POCT analysis device |
| CN111426666A (en) * | 2020-02-27 | 2020-07-17 | 中国科学院上海技术物理研究所 | High-throughput automatic detector for simultaneously detecting multiple kinds of viruses |
| CN118518644A (en) * | 2024-05-15 | 2024-08-20 | 苏州康医诺生物科技有限公司 | Fluorescence analyzer and analysis method thereof |
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