WO2020155314A1

WO2020155314A1 - Optical sampling module having balanced sampling width and precision, and immunofluorescence assay equipment

Info

Publication number: WO2020155314A1
Application number: PCT/CN2019/077734
Authority: WO
Inventors: 招睿雄; 蒋庭彦; 杜沛深; 肖林; 卢鹏; 冯娅雯; 聂浩英; 李浩勃; 张二盈; 章国建
Original assignee: 深圳市金准生物医学工程有限公司
Priority date: 2019-02-01
Filing date: 2019-03-12
Publication date: 2020-08-06
Also published as: CN109655628A

Abstract

An optical sampling module (2) having a balanced sampling width and precision, and immunofluorescence assay equipment. The optical sampling module (2) comprises a photocell (201), a signal acquisition device (202) connected to the photocell (201), a processor (203), and a sampling resistor (204). One end of the sampling resistor (204) is connected between the signal acquisition device (202) and the photocell (201), and the other end is connected to N compensation resistors (205) arranged in series. Each of the compensation resistors (205) is connected to a switch in parallel, and a control end of the switch is connected to the processor (203); the switch is turned off when the processor (203) outputs a low voltage, such that the compensation resistor (205) is connected to the sampling resistor (204) to increase resistance when the signal acquisition device (202) is performing a sampling operation, and the switch is turned on when the processor (203) outputs a high voltage, such that the compensation resistor (205) is short circuited to reduce the resistance when the signal acquisition device (202) is performing a sampling operation. The immunofluorescence assay equipment comprises the optical sampling module (2). The invention realizes dynamic sampling, achieves a balance between sensitivity and signal detection range, and automates information detection and ejection of a test card.

Description

Manual Title of the invention: Optical sample module and fluorescence immunoassay analyzer with sample width and precision

[0001] This application is based on a Chinese patent application with an application number of 201910104165.6 and a filing date of February 1, 2019, and claims its priority. The entire content of the application is hereby incorporated into this application as a whole.

[0002] Technical Field

[0003] The present application relates to the field of detection technology, in particular to an optical sampling module and a photoimmunoanalyzer with both sampling width and accuracy.

[0004] Background Technology

[0005] At present, it is impossible to balance the measurement sensitivity and the detection signal range at the same time. Generally speaking, if the sensitivity of the device is higher, special processing is required for the weak light signal, for example, by amplifying the signal of the photocell. It will cause high-value signals to overflow, and if you want to take high-value signals into consideration and choose a lower signal gain, the ability to recognize weak signals will be insufficient, and it is often impossible to take care of the two at the same time. At the same time, the optical sampling system in the prior art uses a fixed-value sampling resistor for sampling, and cannot be dynamically adjusted, so it can only sample an optical signal within a fixed small range.

[0006] There are two ways to withdraw the card from the fluorescence immunoassay analyzer. One is that after the test card enters the fluorescence immunoassay analyzer to complete the measurement, the operator needs to manually remove the card from the card slot. Inconvenience; Another way to withdraw the card is that the test card is automatically slid out from the slope through the gravity action of the test card itself after it exits from the card slot through the card ejection structure inside the machine. The card accumulates at the exit of the card ejection, eventually causing the card ejection port to be blocked, and the test card can no longer be ejected from the device normally, causing malfunction or even damage to the device.

[0007] At the same time, existing fluorescence immunoassay analyzers still have the problem of low modularity. When designing hardware boards for general equipment, all or most of the functions are often integrated on the main control board, and when it is necessary to add or change The function is very inconvenient. In addition, many fluorescence immunoassay analyzers integrate the optical module and the code scanning module. The equipment loses the scalability and is difficult to upgrade. At the same time, the maintenance of the equipment is also very limited. It can be returned to the factory for processing, and the maintenance cost is very high.

[0008] Application content

[0009] The purpose of this application is to solve the shortcomings of the prior art and provide an optical sampling device with both sampling width and accuracy. Sample module and light immunoassay analyzer.

[0010] A technical solution of the present application:

[0011] An optical sampling module with both sampling width and accuracy, including a photocell, a signal collector connected to the photocell, a processor, and a sampling resistor; one end of the sampling resistor is connected between the signal collector and the photocell, and the other N compensation resistors are connected in series at one end, and a switch is connected in parallel at both ends of each compensation resistor. The control end of the switch is connected to the processor; when the processor outputs a low level, the switch is turned off, and the compensation resistor is connected to the sampling resistor to Increase the resistance value of the resistor when the signal collector is sampling; when the processor outputs a high level, the switch is turned on to compensate for the short circuit of the resistance to reduce the resistance of the resistor when the signal collector is sampling.

[0012] A preferred solution is that the switch is a triode, the input and output ends of the triode are connected to both ends of the compensation resistor, and the control end of the triode is connected to the processor.

[0013] Another technical solution of this application:

[0014] A fluorescence immunoassay analyzer for measuring various blood indicators on the surface of a test card and printing the indicators, including an optical sampling module, a housing, a printer, a display screen, an automatic card ejection mechanism and a main control board; the housing It is provided with a card inlet and a card outlet. The optical sampling module, the automatic card ejection mechanism, the main control board and the printer are respectively arranged in the housing, and the optical sampling module, the display screen, the automatic card ejection mechanism and the printer are respectively connected with the main The control board is electrically connected; the automatic card ejection mechanism includes a bottom plate, a sliding rail, a sliding mechanism, a gear mechanism, and a card pushing mechanism; the bottom plate is provided with a long hollow part, and the card ejection mechanism is fixed under the bottom plate The top of the card ejecting slide is open and corresponding to the hollow part, the card ejecting slide has a first end and a second end opposite to the first end, and the first end is provided with a test card The slideway opening for entry and exit, the slideway opening is butted with the bayonet entrance, and the slideway opening is butted with the bayonet exit; the slide rail is installed on the bottom plate and is arranged close to the hollow part; the sliding mechanism is movably mounted on the slide rail and The optical sampling module can be moved in the direction of the sliding rail, and the test card can be placed on the sliding mechanism; the optical sampling module is set directly above the sliding rail through a bracket provided, and the optical sampling module is used to measure various indicators and parameters of blood on the surface of the test card. The index parameter is transferred to the main control board, and after receiving the index parameter, the main control board controls the printer to print the index parameter; the gear mechanism is fixed on the bottom plate and is close to the second end of the card ejecting slide, in the sliding mechanism When moving to a position close to the second end of the card ejecting slide, the test card is blocked from continuing to move, so that the test card falls into the card ejecting slide; the card pushing mechanism is installed on the sliding mechanism and partially extends into the card ejecting slide to When the sliding mechanism moves along the second end of the card ejecting chute to the first end, the test card is pushed out of the chute of the card ejecting chute to realize automatic card ejection [0015] A preferred solution is that the housing is further provided with a code scanning module for scanning code test card information, the code scanning module is electrically connected to the main control board, and the code scanning module scans information of the test card information, And transfer the information to the main control board, the main control board hole printer prints the test card information.

[0016] A preferred solution is that the main control board is provided with a number of slots, and a WIFI module and 4 are inserted in the slots.

G module.

[0017] A preferred solution is that the sliding mechanism is a card tray slider, the card tray slider is formed with a storage slot that can accommodate the test card along the sliding rail direction, and the storage slot is located above the card ejecting slide , And one end of the receiving groove is formed with a discharge opening set at the same end as the chute opening of the card ejecting chute.

[0018] A preferred solution is that the stop mechanism is a baffle, a retreat is formed in the middle of the baffle, and a stop block that can abut the test card is provided on the side of the baffle close to the slide rail.

[0019] A preferred solution is that the card pushing mechanism is a pushing plate, and a gap is reserved between the pushing plate and the bottom of the card ejecting slide

, The gap is less than or equal to the thickness of the test card.

[0020] A preferred solution is that one side of the push plate for pushing the test card is provided with a curved pushing portion.

[0021] A preferred solution is that the automatic card ejection mechanism further includes a drive mechanism installed on the bottom plate, and the drive mechanism drives the card holder slider to reciprocate in the direction of the slide rail.

[0022] A preferred solution is that the drive mechanism includes a motor, a belt, and a positioning wheel, and the card holder slider is also provided with a connecting piece and is fixedly connected to the belt through the connecting piece, so as to drive the belt and the card when the motor is working. The sliding block moves.

[0023] Combining the above technical solutions, the beneficial effects of this application are: to realize dynamic sampling, an optical sampling module with sampling width and accuracy, sampling resistors and _N compensation resistors are used for sampling, and the compensation resistors are switched to connect to the sampling In the resistance, the resistance value of the resistance when the signal collector is sampled is increased to ensure that the high signal will not overflow, and at the same time, the application scenario of the low signal can be recognized normally; specifically, when the signal collected by the signal collector is strong , The signal collector is closed by the processor control switch, and the resistance short circuit is compensated to reduce the resistance value of the resistance when the signal collector is sampling to ensure that the signal will not overflow; when the signal collected by the signal collector is very weak, the signal collector is controlled by the processor The switch is turned on, and the compensation resistor is connected to the sampling resistor to increase the resistance value of the resistor when the signal collector is sampling to ensure that weak signals can also be identified and sampled normally. This application can expand the measurement range of the optical sampling module, that is, increase the range of signal measurement. Therefore, the optical sampling module can identify weaker signals, that is, improve the signal-to-noise ratio of the system, and large resistance sampling for weak signals can improve the stability of the measurement results. The automatic card ejecting mechanism includes a bottom plate, a sliding rail, a sliding mechanism, a gear mechanism, and a card pushing mechanism. The bottom plate is provided with a card ejecting slide, the slide rail is fixedly installed on the bottom plate, and the slide mechanism is slidably connected to the slide rail, and A test card can be placed on the sliding mechanism, and when the sliding mechanism moves close to the other end of the sliding rail, the shift mechanism can avoid the sliding mechanism and block the test card from continuing to move. In this way, the test card falls into the card ejecting chute, and when the sliding mechanism moves in the reverse direction, the card pushing mechanism provided on the sliding mechanism can abut the test card and push the test card out of the card ejecting chute with the movement of the sliding mechanism , Realize automatic card withdrawal. This solution can proactively launch the test card without adding additional power. This active card ejection method will ensure that the test card is smoothly sent out of the card ejection chute, ensure smooth card ejection, reduce failure rates, and improve the stability of equipment testing.

[0024] The above description is only an overview of the technical solutions of this application. In order to understand the technical means of this application more clearly, it can be implemented in accordance with the content of the specification, and to make the above and other purposes, features, and advantages of this application better. Obviously and easily understandable, the following is a detailed description of the preferred embodiments with accompanying drawings.

[0025] Description of the drawings

[0026] FIG. 1 is a schematic diagram of the first embodiment of the present application;

[0027] FIG. 2 is a flowchart of the first embodiment of the present application;

[0028] FIG. 3 is a perspective view of a second embodiment of the present application;

[0029] FIG. 4 is an exploded view of a second embodiment of the present application;

[0030] FIG. 5 is a perspective view of the sampling module, the automatic card ejection mechanism and the code scanning module of the middle school of this application when connected;

[0031] FIG. 6 is a perspective view 1 of the automatic card ejection mechanism in this application;

[0032] FIG. 7 is a second perspective view of the automatic card ejection mechanism in this application.

[0033] Specific embodiments

[0034] The following will clearly and completely describe the technical solutions in the embodiments of the present application in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all of them. Examples. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of this application.

[0035] It should be noted that the descriptions related to "first", "second", etc. in this application are only used for descriptive purposes and cannot be justified. The solution is to indicate or imply its relative importance or implicitly indicate the number of technical features indicated. Therefore, the features defined with “first” and “second” may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but it must be based on what can be achieved by a person of ordinary skill in the art. When the combination of technical solutions is contradictory or cannot be achieved, it should be considered that such a combination of technical solutions does not exist. , Is not within the scope of protection required by this application.

[0036] The first embodiment, as shown in FIG. 1, an optical sampling module 2 with both sampling width and accuracy, including a photocell 201, a signal collector 202 connected to the photocell 201, a processor 203, and a sampling resistor 204; The sampling resistor 204 is a resistor R1. One end of the sampling resistor 204 is connected between the signal collector 202 and the photocell 201, and the other end is connected in series with N compensation resistors 205. Each compensation resistor 205 is connected in parallel with a switch. The processor 203 is connected; the compensation resistor 205 can be set according to needs, and can be set to one, two or more. In this application, two compensation resistors 205 are used for illustration, which are resistor R2 and resistor R3, and resistor R2. A switch 1 is connected in parallel with the resistor R3, and a switch 2 is connected in parallel at both ends of the resistor R3. The control terminals of the switch 1 and switch 2 are respectively electrically connected to the processor 203. The processor 203 individually controls the on and off of the switch 1 and switch 2, when the processor When 203 outputs a low level, the switch is off, that is, switch one or/and switch two are off. The compensation resistor 205 is connected to the sampling resistor 204 to increase the resistance of the signal collector 202 during sampling, that is, the resistor R2 or/and The resistor R3 is connected to the sampling resistor 204; when the processor 203 outputs a high level, the switch is turned on, that is, the switch one or/and the switch two are turned on, and the compensation resistor 205 is short-circuited to reduce the resistance value of the resistor when the signal collector 202 is sampling. That is, the resistance R2 or/and the resistance R3 are bypassed, and the resistance R2 or/and the resistance R3 does not participate in the resistance when the signal collector 202 is sampling.

[0037] As shown in FIG. 1 and FIG. 2, the resistance value of the sampling resistor 204 is greater than the resistance value of the compensation resistor 205, and two different resistors, one large and one small, are used for sampling, and the processor 203 controls the closing of the switch. When the compensation resistor 205 is connected or not connected together, it can ensure that the high signal will not overflow, and at the same time, the low signal can be recognized normally. The specific principle is that when the signal collector 202 detects that the signal is strong, the processor 203 switches to make the sampled resistance of the signal collector 202 small to ensure that the signal does not overflow; when the signal collected by the signal collector 202 is very weak, the processor The 203 switching makes the resistance value of the sampling resistance of the signal collector 202 large, ensuring that weak signals can also be identified and sampled normally. The sampling system sets an initial sampling resistance value according to the actual application scenario, and then performs the first sampling. The processor 203 analyzes the data of this sampling. If the data overflows, it represents the resistance of the front end of the signal collector 202 during sampling. Too big, so Reduce the resistance of the signal collector 202 during sampling, and then perform another sampling and output appropriate data; if the first sampled signal is found to be weak, it means that the sampling resistance at the front end of the signal collector 202 is too small, so increase the sampling time The resistance value and output the appropriate data. Through the optimization of the processor 203, the resistance value of the resistor during sampling can be adjusted in real time to obtain the best sampling data.

[0038] As shown in FIG. 1 and FIG. 2, the sampling steps of the optical sampling module 2 are: S1, the optical sampling module 2 sets an initialized sampling resistance value according to the actual application scenario; S2, and then performs the first sampling; S3 , The signal collector 202 transmits the collected signal to the processor 203, and the processor 203 analyzes and judges the strength of the signal according to the data sampled this time; S4, if the data signal is weak, that is, the signal sampled for the first time is weak, It means that the resistance during sampling at the front end of the signal collector 202 is too small, and the processor 203 controls the switch to turn off to increase the resistance of the resistance during sampling, and then performs sampling until appropriate data is output; S5, if the data signal is strong, that is Data overflow means that the resistance of the front end of the signal collector 202 during sampling is too large. At this time, the processor 203 controls the switch to close to reduce the resistance of the resistance during sampling, and then performs sampling; S6, until appropriate sampling data is output; Therefore, dynamic data sampling can be achieved.

[0039] Preferably, as shown in FIG. 1, the switch is a triode, the input end and output end of the triode are connected to both ends of the compensation resistor 205, and the control end of the triode is connected to the processor 203. In this application, two compensation resistors 205 are used for illustration, which are resistor R2 and resistor R3. The resistor R2 is connected in parallel with switch one, switch one is transistor Q1, and resistor R3 is connected in parallel with switch two, and switch two is transistor Q2. , The control ends of the transistor Q1 and the transistor Q2 are electrically connected to the processor 203, and the processor 203 separately controls the on and off of the transistor Q1 and the transistor Q2. A resistor R7 is connected between the transistor Q1 and the processor 203, and the transistor Q1 and The resistor R7 is grounded through a resistor R6; a resistor R5 is connected between the transistor Q2 and the processor 203, and a resistor R4 is connected between the transistor Q2 and the resistor R5. Among them, the negative electrode of the photo cell 201 is connected to the signal collector 202, and the positive electrode of the photo cell 201 is connected to the power source.

[0040] As shown in FIGS. 1 and 2, the optical sampling module 2 has a unique design, and has higher sensitivity and a wider signal measurement range than existing products. The optical sampling module 2 adopts a confocal optical structure. The confocal optical structure has a strong optical path focusing ability. After the excitation light source is focused, the energy is concentrated, so it can excite a larger signal, and the confocal optical structure can Collect more light signals, after focusing, the light transmitted to the photoelectric sensor is more concentrated, the signal strength is greater, the stability is better, and the anti-interference ability is stronger. The optical components of the optical sampling module 2 include: ultraviolet LED lamp, plano-convex lens, Narrowband filters, collimating lenses and dichroic mirrors. The processor 203 in the optical sampling module 2 adopts a dynamic gain control scheme. For weak signals, the optical sampling module 2 adopts a high multiple of gain, which can increase the amplitude of weak optical signals and reduce the influence of interference signals. For the signal, the processor 203 uses a low multiple of gain to prevent the signal from overflowing and resulting in distortion. By adopting a solution with excellent focusing performance in the optical structure, combined with a dynamic gain control solution, the optical sampling module 2 can not only have extremely high detection sensitivity but also have an extremely wide detection range, which is superior to current existing products. Performance.

[0041] The second embodiment, as shown in FIGS. 3 to 7, a fluorescence immunoassay analyzer for measuring various blood indicators on the surface of the test card 70 and printing the indicators, including an optical sampling module 2, a housing 3, Printer 4, display screen 5, automatic card ejection mechanism 1 and main control board 6; shell 3 is provided with bayonet inlet 301 and bayonet outlet 302, optical sampling module 2, automatic card ejection mechanism 1, main control board 6 and printer 4 The optical sampling module 2, the display screen 5, the automatic card ejection mechanism 1 and the printer 4 are respectively arranged in the housing 3 and are electrically connected to the main control board 6. The automatic card ejection mechanism 1 includes a bottom plate 10, a sliding rail 20, and a sliding mechanism 30, The gear mechanism 40 and the card pushing mechanism 50; the bottom plate 10 is provided with a long hollow part 11, the card ejecting slide 12 is fixed under the bottom plate 10, and the top of the card ejecting slide 12 is open and corresponds to the hollow part 11 The card ejecting slide 12 has a first end and a second end opposite to the first end. The first end is provided with a slideway opening for the test card 70 to enter and exit. The slideway openings are respectively connected to the bayonet inlet 301 and the bayonet outlet 30 2 docking; the sliding rail 20 is installed on the bottom plate 10 and located close to the hollow part 11; the sliding mechanism 30 is movably installed on the sliding rail 20 and can move along the sliding rail 20, and the test card 70 can be placed on the sliding mechanism 30; optical sampling module 2 The optical sampling module 2 is used to measure various index parameters of the blood on the surface of the test card 70 and transmit the index parameters to the main control board 6, and the main control board 6 receives After the index parameter, the printer 4 is controlled to print the index parameter. The bottom of the bracket 201 is fixedly connected to the bottom plate 10, and the optical sampling module 2 is fixed on the top; the shift mechanism 40 is fixed on the bottom plate 10 and is close to the second end of the card ejecting slide 12 Position, when the sliding mechanism 30 moves to a position close to the second end of the card ejecting slide 12, the test card 70 is blocked from continuing to move, so that the test card 70 falls into the card ejecting slide 12; the card pushing mechanism 50 is installed on the sliding mechanism 30 and partially extend into the card ejecting slide 12 to push the test card 70 out of the slideway opening of the card ejecting slide 12 when the sliding mechanism 30 moves along the second end of the card ejecting slide 12 to the first end. Realize automatic card refund.

[0042] As shown in FIGS. 3 to 7, during specific work, the sliding mechanism 30 can reciprocate along the direction of the sliding rail 20 under the driving force, and the sliding mechanism 30 drives the test card 70 into the instrument for testing. Sampling mode Block 2 tests the blood on the surface of the test card 70 and sends the test results to the main control board 6. At this time, the main control board 6 controls the printer 4 to print the test results. After the test card 70 passes the test, the sliding mechanism 30 drives The test card 70 continues to move in the direction of the slide rail 20 to other inspection stations. When the test card 70 fails the test, the test card 70 can be automatically withdrawn from the card eject chute 12. Specifically, after the test card 70 continues to move with the sliding mechanism 30 for a certain distance, the test card 70 is separated from the sliding mechanism 30 under the action of the shift mechanism 40 and falls into the card ejecting slide 12; the sliding mechanism 30 moves in the reverse direction At this time, the card pushing mechanism 50 fixedly connected to the sliding mechanism 30 can abut the test card 70, and with the sliding mechanism 30 that continues to move, push the test card 70 out of the card eject chute 12 to realize automatic card ejection. The card pushing mechanism 50 can provide thrust, and even if the test card 70 accumulates in the card ejecting chute 12, it will not cause the instrument to jam.

[0043] As shown in FIGS. 3 to 7, the automatic card ejecting mechanism 1 in the technical solution of the present application mainly includes a bottom plate 10, a sliding rail 20, a sliding mechanism 30, a gear mechanism 40, and a card pushing mechanism 50, wherein the bottom plate 10 is provided with a card ejecting slide 12, the slide rail 20 is fixedly installed on the bottom plate 10, the slide mechanism 30 is slidably connected to the slide rail 20, and a test card 70 can be placed on the slide mechanism 30, and the slide mechanism 30 moves close to At the other end of the sliding rail 20, the gear mechanism 40 can avoid the sliding mechanism 30 and block the test card 70 from continuing to move. In this way, the test card 70 falls into the card eject chute 12, and when the sliding mechanism 30 moves in the reverse direction, the card pushing mechanism 50 provided on the sliding mechanism 30 can abut the test card 70, and follow the movement of the sliding mechanism 30. The test card 70 is pushed out from the card ejecting chute 12 to realize automatic card ejection. In this solution, the test card 70 can be actively launched without adding additional power. This active card ejection method will ensure that the test card 70 is smoothly sent out of the card ejection chute 12, ensuring smooth card ejection, reducing the failure rate, and improving the stability of equipment testing.

[0044] As shown in FIGS. 3 to 7, the sliding mechanism 30 is a card tray slider 31, and the card tray slider 31 is formed with a storage slot that can accommodate the test card 70 along the direction of the slide rail 20, and the storage slot is located in the card ejecting slide. Above the channel 12, and at one end of the receiving groove, a discharge opening is formed at the same end as the chute opening of the card ejecting chute ₁₂ . In order to simplify the equipment mechanism, a relatively simple card tray slider 31 is used in this solution. The storage slot of the card tray slider 31 can conveniently limit the position of the test card 70, and the discharge port of the storage slot can facilitate the insertion of the test card 70. . In addition, the outlet of the receiving slot can be set at a wide angle, so that the test card 70 can slide in smoothly from the discharge port.

[0045] As shown in FIGS. 3 to 7, the gear mechanism 40 is a baffle 41. The baffle 41 forms an escape position in the middle, and the side of the baffle 41 close to the slide rail 20 is provided with a gear that can abut the test card 70. Block 42. In order to simplify the equipment mechanism, the baffle 41 is used as the gear mechanism 40. The baffle 41 straddles the card ejecting slide 12, and the baffle 41 is fixed on the side away from the slide rail 20 On the bottom plate 10, the middle is an avoidance position, and the other side is provided with a stop block 42 as large as the gear test card 70.

[0046] As shown in FIGS. 3 to 7, further, the baffle 41 is arranged in a reverse "r" shape. The shorter side of the "r" type is the hook, which is the position of the gear block. Actually, the length of the hook can be designed according to actual requirements.

[0047] Specifically, as shown in FIGS. 3 to 7, the card pushing mechanism 50 is a pushing plate, and a gap is reserved between the pushing plate and the bottom of the card ejecting slide 12, and the gap is less than or equal to the thickness of the test card 70. In order to simplify the equipment mechanism, a push plate is used as the card pushing mechanism 50. There are gaps between the two sides of the push plate and the inner walls of both sides of the card ejecting slide 12 to prevent the push plate from obstructing the movement of the card tray slider 31, and the pushing plate and ejecting card A gap less than or equal to the thickness of the test card 70 is left at the bottom of the slideway 12, so as to facilitate the end of the push plate to push the test card 70. Using the same set of driving mechanism, it can provide the driving force for active card withdrawal.

[0048] Further, as shown in FIG. 3 to FIG. 7, a side of the push plate for pushing the test card 70 is provided with a push portion in a bent shape. In order to facilitate the ejection of the card, a pushing part is provided on one side of the push plate pushing the test card 70, and the pushing part is arranged in a bent shape, so that the test card 70 can be pushed out better.

6 and 7, specifically, the automatic card ejecting mechanism further includes a driving mechanism 60 installed on the bottom plate 10, and the driving mechanism 60 drives the card holder slider 31 to reciprocate along the direction of the slide rail 20. Through the driving mechanism 60, the reciprocating movement of the card holder slider 31 can be realized,

[0050] Further, as shown in FIGS. 3 to 7, the driving mechanism 60 includes a motor 61, a belt 62, and a positioning wheel 63 (or a synchronous wheel). The card holder slider 31 is also provided with a connecting member 32 and connected by The member 32 is fixedly connected with the belt 62 to drive the belt 62 and the carriage slider 31 to move when the motor 61 is working. The belt 62 is sleeved on the synchronization wheel and the positioning wheel 63 of the motor 61. The motor 61 drives the belt 62 to move when the motor 61 works. Since the belt 62 is fixedly connected to the card holder slider 31, it can drive the card holder slider when the belt 62 moves. 31-Exercise.

[0051] Specifically, as shown in FIGS. 3 to 7, the slide rail 20 is a single rail, and two sides of the single rail are provided with a card slot, and the card tray slider 31 is clamped in the card slot. The card holder slider 31 is engaged with the monorail, so that the card holder slider 31 reciprocates stably along the monorail direction.

[0052] As shown in FIG. 3 to FIG. 7, the housing 3 is also provided with a code scanning module 7 for scanning code information of the test card 70, the code scanning module 7 is electrically connected to the main control board 6, and the code scanning module 7 scans the test card 70 information information, and transfer the information to the main control board 6, and the main control board 6-hole printer 4 prints the test card 70 information. The code scanning module 7 is fixed on the top of the bracket 201 and is located in the optical sampling module 2. [0053] As shown in FIGS. 3 to 7, a number of slots are provided on the main control board 6, and a WIFI module, a Bluetooth module or a 4G module is inserted in the slots.

[0054] As shown in FIGS. 3 to 7, the card pushing mechanism 50 is a pushing plate, and a gap is reserved between the pushing plate and the bottom of the card ejecting slide 12, and the gap is less than or equal to the thickness of the test card 70.

[0055] In summary, this application has at least the following advantages:

[0056] 1. The test card 70 adopts the front-to-front out method, and the test card 70 collection frame is placed under the instrument before the test. When the test is completed, the test card 70 is pushed out from the front of the instrument and drops directly into the test card 70 collection frame , Save the manpower of the operator;

[0057] 2. The test card 70 after the test is allowed to accumulate outside the instrument does not affect the normal card ejection, and the operator does not need to complete a test to collect the test card 70 once, so as to avoid the waste of manpower caused by the frequent operation of the operator;

[0058] 3. The card returning (test card 70) shares the same set of drivers with the card entering, which simplifies the structure, improves the stability, and reduces the cost of the whole machine;

[0059] 4. Active card ejection ensures that the test card 70 slides out of the instrument smoothly.

[0060] 5. In the design, a functional interface is reserved on the bottom plate, so that new functions can be added to the device conveniently and quickly. Therefore, the fluorescence immunoassay analyzer of this design has complete functions. Compared with existing brand products, it not only has WIFI function It can also have 4G and Bluetooth wireless functions in multiple ways;

[0061] 6. Since the functions of the modules are independent, only a fixed control interface and protocol are required. Therefore, the modules can be upgraded independently according to market demand, and then the original modules can be quickly replaced to achieve secondary design.

[0062] 7. The fluorescence immunoassay analyzer has a variety of wireless function modules, including WIFI, 4G, and Bluetooth. At the same time, the fluorescence immunoassay analyzer is equipped with a remote communication interface and protocol to connect to the server, which can realize remote monitoring and data sharing. Function, by monitoring the changes of the equipment to give early warning of the health status of the equipment, and take corresponding measures in time; on the other hand, because of the data sharing, the macro operating status of the equipment can be statistically analyzed to find and discover the overall system of the equipment The characteristics of the product, including the defects in the design, the defects in the use process, the characteristics of the samples, and the user habits, etc., play a very important role in the big data analysis of the product.

[0063] The above are only the preferred embodiments of the application, and do not limit the scope of the application. Under the application concept of the application, the equivalent structure transformations made by using the content of the specification and drawings of the application, or directly/ Indirect applications in other related technical fields are included in the scope of patent protection of this application. Summary of the invention

technical problem

The solution to the problem

The beneficial effects of the invention

Claims

[Claim 1] An optical sampling module with both sampling width and accuracy, characterized in that it comprises a photocell, a signal collector connected to the photocell, a processor and a sampling resistor; one end of the sampling resistor is connected to the signal collector There are N compensation resistors connected in series with the photovoltaic cell at the other end, and a switch is connected in parallel at both ends of each compensation resistor, and the control end of the switch is connected to the processor; when the processor outputs a low level, the switch is turned off and the compensation resistor is connected Into the sampling resistor to increase the resistance of the signal collector during sampling; when the processor outputs a high level, the switch is turned on to compensate for the resistance short circuit to reduce the resistance of the signal collector during sampling.

[Claim 2] The optical sampling module with both sampling width and accuracy according to claim 1, wherein the switch is a triode, the input end and the output end of the triode are connected to both ends of the compensation resistor, and the The control end of the triode is connected with the processor.

[Claim 3] A fluorescence immunoassay analyzer for measuring various blood indicators on the surface of a test card and printing the indicators, characterized by comprising the optical sampling module according to claim 1, a housing, a printer, and a display screen, An automatic card ejection mechanism and a main control board; the housing is provided with a bayonet inlet and a card outlet; the optical sampling module, the automatic card ejection mechanism, the main control board and the printer are respectively arranged in the housing, the optical sampling module, The display screen, the automatic card ejection mechanism and the printer are respectively electrically connected to the main control board; the automatic card ejection mechanism includes a bottom plate, a sliding rail, a sliding mechanism, a stop mechanism and a card pushing mechanism; the bottom plate is provided with a strip shape The card ejecting slide is fixed under the bottom plate, and the top of the card ejecting slide is open and corresponding to the hollow portion. The card ejecting slide has a first end and a second opposite to the first end. The first end is provided with a slideway opening for the test card to enter and exit, the slideway opening is docked with the bayonet inlet, and the slideway opening is docked with the bayonet outlet; the slide rail is installed on the bottom plate and is arranged near the hollow portion The sliding mechanism is movably mounted on the sliding rail and can move in the direction of the sliding rail, and the test card can be placed on the sliding mechanism; the optical sampling module is set directly above the sliding rail through a bracket, and the optical sampling module It is used to measure various index parameters of blood on the surface of the test card and transfer the index parameters to the main control board. After receiving the index parameters, the main control board controls the printer to print the index parameters; the gear mechanism is fixed on the bottom plate and close to the back The position of the second end of the card slide, when the sliding mechanism moves to a position close to the second end of the card ejecting slide, blocks the test card from continuing to move, The test card is dropped into the card ejecting slide; the card pushing mechanism is installed on the sliding mechanism and partially extends into the card ejecting slide, so that when the sliding mechanism moves along the second end of the card ejecting slide to the first end, The test card is pushed out from the exit of the card ejecting slide to realize automatic card eject.

[Claim 4] The fluorescence immunoassay analyzer according to claim 3, characterized in that, a code scanning module for scanning code test card information is further provided in the housing, and the code scanning module is electrically connected to the main control board The code scanning module scans the information of the test card information, and transmits the information to the main control board, and the main control board hole printer prints the test card information.

[Claim 5] The fluorescence immunoassay analyzer of claim 3, wherein the main control board is provided with a number of slots, and a WIFI module and a 4G module are inserted in the slots.

[Claim 6] The fluorescence immunoassay analyzer of claim 3, wherein the sliding mechanism is a card tray slider, and the card tray slider is formed along the sliding rail with a storage that can accommodate a test card The receiving groove is located above the card ejecting slide, and one end of the receiving groove is formed with a discharge opening provided at the same end as the slide opening of the card ejecting slide.

[Claim 7] The fluorescence immunoassay analyzer according to claim 6, wherein the gear mechanism is a baffle, a retreat is formed in the middle of the baffle, and a side of the baffle close to the slide rail is provided with a Abutting the stop block of the test card.

[Claim 8] The fluorescence immunoassay analyzer of claim 7, wherein the card pushing mechanism is a pushing plate, and a gap is reserved between the pushing plate and the bottom of the card ejecting slide, and the gap is smaller than Or equal to the thickness of the test card.

[Claim 9] The fluorescence immunoassay analyzer of claim 8, wherein the push plate is provided with a curved push part on one side of the push plate for pushing the test card.

[Claim 10] The fluorescence immunoassay analyzer of claim 9, wherein the automatic card ejection mechanism further comprises a driving mechanism installed on the bottom plate, and the driving mechanism drives the card holder slider to move along the slide rail. Reciprocating direction.