CN1972696B - 用于治疗rna依赖性rna病毒感染的核苷氨基磷酸芳基酯 - Google Patents

用于治疗rna依赖性rna病毒感染的核苷氨基磷酸芳基酯 Download PDF

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Publication number
CN1972696B
CN1972696B CN2005800211514A CN200580021151A CN1972696B CN 1972696 B CN1972696 B CN 1972696B CN 2005800211514 A CN2005800211514 A CN 2005800211514A CN 200580021151 A CN200580021151 A CN 200580021151A CN 1972696 B CN1972696 B CN 1972696B
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Prior art keywords
rna
hydrogen
hcv
alkyl
virus
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Expired - Fee Related
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CN2005800211514A
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Chinese (zh)
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CN1972696A (zh
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M·麦科斯
D·B·奥尔森
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Merck Sharp & Dohme LLC
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Merck Sharp & Dohme LLC
Merck and Co Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CN2005800211514A 2004-06-24 2005-06-20 用于治疗rna依赖性rna病毒感染的核苷氨基磷酸芳基酯 Expired - Fee Related CN1972696B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US58266704P 2004-06-24 2004-06-24
US60/582,667 2004-06-24
US61974604P 2004-10-18 2004-10-18
US60/619,746 2004-10-18
PCT/US2005/021684 WO2006012078A2 (en) 2004-06-24 2005-06-20 Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection

Publications (2)

Publication Number Publication Date
CN1972696A CN1972696A (zh) 2007-05-30
CN1972696B true CN1972696B (zh) 2010-08-11

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CN2005800211514A Expired - Fee Related CN1972696B (zh) 2004-06-24 2005-06-20 用于治疗rna依赖性rna病毒感染的核苷氨基磷酸芳基酯

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US (1) US20070265222A1 (enExample)
EP (1) EP1773355B1 (enExample)
JP (1) JP5080973B2 (enExample)
CN (1) CN1972696B (enExample)
AU (1) AU2005267421B2 (enExample)
CA (1) CA2571079A1 (enExample)
WO (1) WO2006012078A2 (enExample)

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US20070265222A1 (en) 2007-11-15
CN1972696A (zh) 2007-05-30
EP1773355B1 (en) 2014-06-25
AU2005267421A1 (en) 2006-02-02
AU2005267421B2 (en) 2010-06-03
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