CN1961071A - 使用可选剪接在真核细胞中表达多肽多聚体的方法和构建物 - Google Patents
使用可选剪接在真核细胞中表达多肽多聚体的方法和构建物 Download PDFInfo
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- CN1961071A CN1961071A CNA2005800156216A CN200580015621A CN1961071A CN 1961071 A CN1961071 A CN 1961071A CN A2005800156216 A CNA2005800156216 A CN A2005800156216A CN 200580015621 A CN200580015621 A CN 200580015621A CN 1961071 A CN1961071 A CN 1961071A
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- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
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- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Neurology (AREA)
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- Neurosurgery (AREA)
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- Immunology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Virology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Physics & Mathematics (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55347804P | 2004-03-15 | 2004-03-15 | |
| US60/553,478 | 2004-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1961071A true CN1961071A (zh) | 2007-05-09 |
Family
ID=34994241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005800156216A Pending CN1961071A (zh) | 2004-03-15 | 2005-03-15 | 使用可选剪接在真核细胞中表达多肽多聚体的方法和构建物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7569362B2 (enExample) |
| EP (1) | EP1733034A4 (enExample) |
| JP (1) | JP2007529223A (enExample) |
| KR (1) | KR20070004026A (enExample) |
| CN (1) | CN1961071A (enExample) |
| AU (1) | AU2005222963B2 (enExample) |
| BR (1) | BRPI0508862A (enExample) |
| CA (1) | CA2559280A1 (enExample) |
| IL (1) | IL178051A (enExample) |
| WO (1) | WO2005089285A2 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105658665A (zh) * | 2013-08-06 | 2016-06-08 | 格兰马克药品股份有限公司 | 表达构建体和用于表达真核细胞中的多肽的方法 |
| CN107881196A (zh) * | 2011-12-22 | 2018-04-06 | 弗·哈夫曼-拉罗切有限公司 | 表达载体组织、新的生产用细胞产生方法及其在重组产生多肽中的用途 |
| CN113302202A (zh) * | 2018-07-17 | 2021-08-24 | 脑若脉仁股份有限公司 | 利用表达胰岛素样生长因子1异构体的脱氧核糖核酸构建体的神经病变的治疗 |
| CN114150021A (zh) * | 2021-11-26 | 2022-03-08 | 武汉枢密脑科学技术有限公司 | 一种包含重叠开放阅读框的基因的表达盒及其在昆虫细胞中的应用 |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2355459B (en) * | 1999-11-29 | 2001-09-26 | Isis Innovation | A dominant conditional lethal genetic system |
| GB2402675B (en) * | 2003-05-12 | 2008-02-20 | Oxitec Ltd | Resistance dilution |
| GB2403475B (en) * | 2003-07-01 | 2008-02-06 | Oxitec Ltd | Stable integrands |
| GB2404382B (en) | 2003-07-28 | 2008-01-30 | Oxitec Ltd | Pest control |
| CA2559280A1 (en) * | 2004-03-15 | 2005-09-29 | Biogen Idec Ma Inc. | Methods and constructs for expressing polypeptide multimers in eukaryotic cells using alternative splicing |
| US20090183269A1 (en) * | 2006-02-10 | 2009-07-16 | Oxitec Limited | Gene expression system using alternative splicing in insects |
| GB2443186A (en) | 2006-10-25 | 2008-04-30 | Oxitec Ltd | Expression system for mediating alternative splicing |
| EA200802061A1 (ru) | 2006-03-28 | 2009-04-28 | Байоджен Айдек Эмэй Инк. | Антитело или его фрагмент, специфично связывающееся с рецептором 1 инсулиноподобного фактора роста (igf-r1) (варианты), композиция на его основе, полинуклеотид, кодирующий вариабельную область антитела (варианты), содержащие полинуклеотид композиция (варианты) и вектор, содержащая вектор клетка-хозяин (варианты), способ продуцирования антитела или его фрагмента (варианты) и способ лечения гиперпролиферативного заболевания у животного организма |
| EP2018430A1 (en) * | 2006-05-16 | 2009-01-28 | Millegen | Method for expressing polypeptides in eukaryotic cells using alternative splicing |
| KR101202498B1 (ko) * | 2006-05-17 | 2012-11-16 | 에프. 호프만-라 로슈 아게 | 폴리펩티드 생성 세포 |
| US20080045419A1 (en) * | 2006-08-18 | 2008-02-21 | University Of North Texas Health Science Center At Fort Worth | Screening Assay |
| MX2010004007A (es) * | 2007-10-15 | 2010-06-15 | Chugai Pharmaceutical Co Ltd | Metodo para la produccion de un anticuerpo. |
| WO2009059235A2 (en) * | 2007-11-01 | 2009-05-07 | Facet Biotech Corporation | Immunoglobulin display vectors |
| KR100907221B1 (ko) * | 2009-01-22 | 2009-07-10 | 한국과학기술원 | 새로운 조성의 황색 발광 Ce3+부활 칼슘 실리케이트 황색형광체를 포함하는 백색 발광 다이오드 |
| WO2011125833A1 (ja) | 2010-03-31 | 2011-10-13 | 学校法人 慶應義塾 | 生体分子相互作用解析ツールの構成とそれを用いた解析方法 |
| US9220774B2 (en) | 2011-11-01 | 2015-12-29 | Bionomics Inc. | Methods of treating cancer by administering anti-GPR49 antibodies |
| AU2012332588B2 (en) | 2011-11-01 | 2017-09-07 | Bionomics, Inc. | Methods of blocking cancer stem cell growth |
| WO2013067060A1 (en) | 2011-11-01 | 2013-05-10 | Bionomics, Inc. | Anti-gpr49 antibodies |
| AU2012332587B2 (en) | 2011-11-01 | 2017-02-23 | Bionomics, Inc. | Antibodies and methods of treating cancer |
| GB2500113A (en) | 2012-03-05 | 2013-09-11 | Oxitec Ltd | Arthropod male germline gene expression system |
| GB201303932D0 (en) | 2013-03-05 | 2013-04-17 | Oxitec Ltd | Muscle actin promoter |
| AU2014246731A1 (en) * | 2013-03-30 | 2015-11-19 | Usha Biotech Limited | Methods and constructs for expressing biologically active proteins in mammalian cells |
| EP3126397B1 (en) | 2014-04-04 | 2020-01-29 | Bionomics, Inc. | Humanized antibodies that bind lgr5 |
| GB2526867A (en) | 2014-06-05 | 2015-12-09 | Oxitec Ltd | Gene expression system |
| AU2017239038B2 (en) | 2016-03-22 | 2024-06-27 | Bionomics Inc | Administration of an anti-LGR5 monoclonal antibody |
| WO2018029534A1 (en) | 2016-08-12 | 2018-02-15 | Oxitec Ltd. | A self-limiting, sex-specific gene and methods of using |
| EP3472198B1 (en) | 2016-09-29 | 2020-03-04 | H. Hoffnabb-La Roche Ag | Improved method for selecting polypeptide producing cells |
| AR117409A1 (es) | 2018-03-29 | 2021-08-04 | Oxitec Ltd | Noctuidas autolimitantes |
| WO2021041924A2 (en) * | 2019-08-30 | 2021-03-04 | Baylor College Of Medicine | System for regulating gene expression |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2759053A1 (de) * | 1977-12-30 | 1979-07-12 | Uhlin | Verfahren zum herstellen von genprodukten von plasmid-dns |
| GB2048894A (en) * | 1979-05-11 | 1980-12-17 | Gist Brocades Nv | Plasmid |
| JPS58192900A (ja) * | 1982-05-04 | 1983-11-10 | Ajinomoto Co Inc | 複合プラスミド |
| US5043270A (en) * | 1989-03-31 | 1991-08-27 | The Board Of Trustees Of The Leland Stanford Junior University | Intronic overexpression vectors |
| SG84484A1 (en) * | 1991-02-25 | 2001-11-20 | Ciba Geigy Ag | Improved yeast vectors |
| US5587308A (en) * | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| US5561053A (en) * | 1994-08-05 | 1996-10-01 | Genentech, Inc. | Method for selecting high-expressing host cells |
| CA2309344A1 (en) * | 1997-11-12 | 1999-05-20 | Valentis, Inc. | Expression plasmids for multiepitope nucleic acid-based vaccines |
| US6228360B1 (en) * | 1998-08-19 | 2001-05-08 | Ajinomoto Co., Inc. | Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody |
| US6900010B2 (en) * | 1999-01-25 | 2005-05-31 | Musc Foundation For Research Development | Compositions and methods for detecting human immunodeficiency virus |
| WO2000075342A1 (fr) * | 1999-06-04 | 2000-12-14 | Nippon Institute For Biological Science | Nouveau vecteur plasmidique |
| JP2006512061A (ja) * | 2002-11-14 | 2006-04-13 | ジェネンテック・インコーポレーテッド | イントロン融合コンストラクトおよび高発現産生細胞系を選択するための使用方法 |
| MXPA05008523A (es) * | 2003-02-14 | 2005-10-20 | Biogen Idec Inc | Un casete de expresion y vector para la expresion transitoria o estable de moleculas exogenas. |
| CA2559280A1 (en) * | 2004-03-15 | 2005-09-29 | Biogen Idec Ma Inc. | Methods and constructs for expressing polypeptide multimers in eukaryotic cells using alternative splicing |
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- 2005-03-15 CA CA002559280A patent/CA2559280A1/en not_active Abandoned
- 2005-03-15 KR KR1020067021005A patent/KR20070004026A/ko not_active Ceased
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- 2005-03-15 EP EP05730385A patent/EP1733034A4/en not_active Withdrawn
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2006
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2009
- 2009-06-05 US US12/479,144 patent/US20100009410A1/en not_active Abandoned
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107881196A (zh) * | 2011-12-22 | 2018-04-06 | 弗·哈夫曼-拉罗切有限公司 | 表达载体组织、新的生产用细胞产生方法及其在重组产生多肽中的用途 |
| CN105658665A (zh) * | 2013-08-06 | 2016-06-08 | 格兰马克药品股份有限公司 | 表达构建体和用于表达真核细胞中的多肽的方法 |
| CN113302202A (zh) * | 2018-07-17 | 2021-08-24 | 脑若脉仁股份有限公司 | 利用表达胰岛素样生长因子1异构体的脱氧核糖核酸构建体的神经病变的治疗 |
| CN113302202B (zh) * | 2018-07-17 | 2024-01-30 | 赫利世弥斯株式会社 | 利用表达胰岛素样生长因子1异构体的脱氧核糖核酸构建体的神经病变的治疗 |
| CN114150021A (zh) * | 2021-11-26 | 2022-03-08 | 武汉枢密脑科学技术有限公司 | 一种包含重叠开放阅读框的基因的表达盒及其在昆虫细胞中的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005222963B2 (en) | 2009-10-29 |
| KR20070004026A (ko) | 2007-01-05 |
| WO2005089285A2 (en) | 2005-09-29 |
| US7569362B2 (en) | 2009-08-04 |
| AU2005222963A1 (en) | 2005-09-29 |
| IL178051A (en) | 2010-12-30 |
| US20100009410A1 (en) | 2010-01-14 |
| EP1733034A4 (en) | 2010-01-20 |
| CA2559280A1 (en) | 2005-09-29 |
| BRPI0508862A (pt) | 2007-09-04 |
| US20050221430A1 (en) | 2005-10-06 |
| WO2005089285A3 (en) | 2006-01-19 |
| IL178051A0 (en) | 2006-12-31 |
| EP1733034A2 (en) | 2006-12-20 |
| JP2007529223A (ja) | 2007-10-25 |
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