CN1950347B - 作为酪氨酸激酶抑制剂的2-氨基芳基噁唑化合物 - Google Patents
作为酪氨酸激酶抑制剂的2-氨基芳基噁唑化合物 Download PDFInfo
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- CN1950347B CN1950347B CN2004800371595A CN200480037159A CN1950347B CN 1950347 B CN1950347 B CN 1950347B CN 2004800371595 A CN2004800371595 A CN 2004800371595A CN 200480037159 A CN200480037159 A CN 200480037159A CN 1950347 B CN1950347 B CN 1950347B
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Classifications
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- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Vascular Medicine (AREA)
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- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51321403P | 2003-10-23 | 2003-10-23 | |
| US60/513,214 | 2003-10-23 | ||
| PCT/IB2004/003698 WO2005040139A2 (en) | 2003-10-23 | 2004-10-22 | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1950347A CN1950347A (zh) | 2007-04-18 |
| CN1950347B true CN1950347B (zh) | 2012-04-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004800371595A Expired - Fee Related CN1950347B (zh) | 2003-10-23 | 2004-10-22 | 作为酪氨酸激酶抑制剂的2-氨基芳基噁唑化合物 |
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| Country | Link |
|---|---|
| US (2) | US7718676B2 (enExample) |
| EP (1) | EP1684750B1 (enExample) |
| JP (1) | JP4971797B2 (enExample) |
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| AT (1) | ATE465731T1 (enExample) |
| AU (1) | AU2004283162B2 (enExample) |
| BR (1) | BRPI0415467A (enExample) |
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| DK (1) | DK1684750T3 (enExample) |
| HR (1) | HRP20100326T1 (enExample) |
| IL (1) | IL175028A (enExample) |
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| NZ (1) | NZ546645A (enExample) |
| PL (1) | PL1684750T3 (enExample) |
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| AU2004251668B2 (en) * | 2003-06-03 | 2008-03-20 | Triad Therapeutics, Inc | 5-membered heterocycle-based p-38 inhibitors |
| WO2005040139A2 (en) * | 2003-10-23 | 2005-05-06 | Ab Science | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
| US8066076B2 (en) | 2004-02-26 | 2011-11-29 | Cameron Systems (Ireland) Limited | Connection system for subsea flow interface equipment |
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| CA2564568A1 (en) * | 2004-04-20 | 2005-11-03 | Ab Science | Use of c-kit inhibitors for treating inflammatory muscle disorders including myositis and muscular dystrophy |
| CA2566104A1 (en) * | 2004-05-18 | 2005-12-01 | Ab Science | Use of mast cells inhibitors for treating patients exposed to chemical or biological weapons |
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| EP1874305B1 (en) * | 2005-04-04 | 2014-08-27 | AB Science | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors |
| US20060281788A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| US20080207572A1 (en) * | 2005-07-14 | 2008-08-28 | Ab Science | Use of Dual C-Kit/Fgfr3 Inhibitors for Treating Multiple Myeloma |
| WO2007076460A2 (en) * | 2005-12-23 | 2007-07-05 | Kalypsys, Inc. | Substituted thiazole ureas useful as inhibitors of protein kinases |
| US8815867B2 (en) | 2006-04-20 | 2014-08-26 | Janssen Pharmaceutica Nv | Inhibitors of c-fms kinase |
| JP5089681B2 (ja) | 2006-04-20 | 2012-12-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ｃ−ｆｍｓキナーゼの阻害剤としての複素環式化合物 |
| US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| NZ572200A (en) * | 2006-04-20 | 2011-09-30 | Janssen Pharmaceutica Nv | Method of inhibiting c-kit kinase |
| GB0618001D0 (en) | 2006-09-13 | 2006-10-18 | Des Enhanced Recovery Ltd | Method |
| US7790756B2 (en) * | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| GB0625526D0 (en) | 2006-12-18 | 2007-01-31 | Des Enhanced Recovery Ltd | Apparatus and method |
| GB0625191D0 (en) | 2006-12-18 | 2007-01-24 | Des Enhanced Recovery Ltd | Apparatus and method |
| ES2606505T3 (es) * | 2007-01-12 | 2017-03-24 | Ab Science | Tratamiento de combinación de cánceres sólidos con antimetabolitos e inhibidores de tirosina quinasa |
| GB0701426D0 (en) * | 2007-01-25 | 2007-03-07 | Univ Sheffield | Compounds and their use |
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
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Also Published As
| Publication number | Publication date |
|---|---|
| PL1684750T3 (pl) | 2010-10-29 |
| US7718676B2 (en) | 2010-05-18 |
| ATE465731T1 (de) | 2010-05-15 |
| HRP20100326T1 (hr) | 2010-10-31 |
| CN1950347A (zh) | 2007-04-18 |
| NO20062308L (no) | 2006-05-22 |
| EP1684750A2 (en) | 2006-08-02 |
| NZ546645A (en) | 2010-02-26 |
| JP4971797B2 (ja) | 2012-07-11 |
| CA2542909C (en) | 2012-07-10 |
| US8110591B2 (en) | 2012-02-07 |
| HK1091134A1 (en) | 2007-01-12 |
| IL175028A0 (en) | 2006-08-20 |
| EP1684750B1 (en) | 2010-04-28 |
| AU2004283162B2 (en) | 2011-12-15 |
| US20100113471A1 (en) | 2010-05-06 |
| BRPI0415467A (pt) | 2006-12-19 |
| JP2007509130A (ja) | 2007-04-12 |
| US20070142390A1 (en) | 2007-06-21 |
| CA2542909A1 (en) | 2005-05-06 |
| WO2005040139A8 (en) | 2006-06-01 |
| DK1684750T3 (da) | 2010-08-09 |
| AU2004283162A1 (en) | 2005-05-06 |
| WO2005040139A3 (en) | 2005-10-13 |
| WO2005040139A2 (en) | 2005-05-06 |
| IL175028A (en) | 2011-02-28 |
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