IL175028A - 2-Aminourealoxazole compounds as tyrosine kinase inhibitors - Google Patents
2-Aminourealoxazole compounds as tyrosine kinase inhibitorsInfo
- Publication number
- IL175028A IL175028A IL175028A IL17502806A IL175028A IL 175028 A IL175028 A IL 175028A IL 175028 A IL175028 A IL 175028A IL 17502806 A IL17502806 A IL 17502806A IL 175028 A IL175028 A IL 175028A
- Authority
- IL
- Israel
- Prior art keywords
- phenyl
- oxazol
- methyl
- pyridin
- ylamino
- Prior art date
Links
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51321403P | 2003-10-23 | 2003-10-23 | |
| PCT/IB2004/003698 WO2005040139A2 (en) | 2003-10-23 | 2004-10-22 | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL175028A0 IL175028A0 (en) | 2006-08-20 |
| IL175028A true IL175028A (en) | 2011-02-28 |
Family
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Family Applications (1)
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|---|---|---|---|
| IL175028A IL175028A (en) | 2003-10-23 | 2006-04-20 | 2-Aminourealoxazole compounds as tyrosine kinase inhibitors |
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| EP (1) | EP1684750B1 (enExample) |
| JP (1) | JP4971797B2 (enExample) |
| CN (1) | CN1950347B (enExample) |
| AT (1) | ATE465731T1 (enExample) |
| AU (1) | AU2004283162B2 (enExample) |
| BR (1) | BRPI0415467A (enExample) |
| CA (1) | CA2542909C (enExample) |
| DK (1) | DK1684750T3 (enExample) |
| HR (1) | HRP20100326T1 (enExample) |
| IL (1) | IL175028A (enExample) |
| NO (1) | NO20062308L (enExample) |
| NZ (1) | NZ546645A (enExample) |
| PL (1) | PL1684750T3 (enExample) |
| WO (1) | WO2005040139A2 (enExample) |
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| WO2005102318A1 (en) * | 2004-04-20 | 2005-11-03 | Ab Science | Use of c-kit inhibitors for treating hiv related diseases |
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| JP2007538064A (ja) * | 2004-05-18 | 2007-12-27 | アブ サイエンス | 化学または生物兵器に曝露された患者を処置するための肥満細胞阻害剤の使用法 |
| WO2005115385A1 (en) * | 2004-05-24 | 2005-12-08 | Ab Science | Use of c-kit inhibitors for treating acne |
| CA2603826C (en) * | 2005-04-04 | 2013-03-12 | Ab Science | Substituted oxazole derivatives and their use as tyrosine kinase inhibitors |
| US20060281788A1 (en) | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| EP1904065A2 (en) * | 2005-07-14 | 2008-04-02 | AB Science | Use of dual c-kit/fgfr3 inhibitors for treating multiple myeloma |
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| KR101367645B1 (ko) | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물 |
| KR101367646B1 (ko) | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나제의 저해제 |
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| GB0625526D0 (en) | 2006-12-18 | 2007-01-31 | Des Enhanced Recovery Ltd | Apparatus and method |
| GB0625191D0 (en) | 2006-12-18 | 2007-01-24 | Des Enhanced Recovery Ltd | Apparatus and method |
| JP2010515708A (ja) * | 2007-01-12 | 2010-05-13 | アブ サイエンス | 代謝拮抗薬およびチロシンキナーゼ阻害剤を用いた固形癌の併用治療 |
| GB0701426D0 (en) * | 2007-01-25 | 2007-03-07 | Univ Sheffield | Compounds and their use |
| GB0709031D0 (en) | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| FR2928150A1 (fr) * | 2008-02-29 | 2009-09-04 | Vetoquinol Sa Sa | Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens |
| EP2145891A1 (en) * | 2008-07-09 | 2010-01-20 | Vetoquinol S.A. | 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials |
| GB0820819D0 (en) | 2008-11-13 | 2008-12-24 | Sareum Ltd | Pharmaceutical compounds |
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| JP5580492B2 (ja) * | 2011-03-01 | 2014-08-27 | エヌファルマコン，エルエルシー | Ｎ−（４−メトキシフェニル）−１−フェニル−１ｈ−ピラゾール−３−アミンおよび関連化合物の使用 |
| US8551992B2 (en) | 2011-05-27 | 2013-10-08 | Neosome Life Sciences, LLC | Aminooxazole inhibitors of cyclin dependent kinases |
| CA2840029C (en) * | 2011-07-27 | 2021-07-20 | Ab Science | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) |
| GB201202027D0 (en) | 2012-02-06 | 2012-03-21 | Sareum Ltd | Pharmaceutical compounds |
| PL2634185T3 (pl) | 2012-03-02 | 2016-06-30 | Sareum Ltd | Inhibitory kinazy TYK2 |
| JOP20180012A1 (ar) | 2012-08-07 | 2019-01-30 | Janssen Pharmaceutica Nv | عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد |
| US9303046B2 (en) | 2012-08-07 | 2016-04-05 | Janssen Pharmaceutica Nv | Process for the preparation of heterocyclic ester derivatives |
| US20160175302A1 (en) * | 2014-12-17 | 2016-06-23 | Ab Science | Masitinib for treating gastric cancer |
| CA2972239A1 (en) | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| ES2796276T3 (es) * | 2015-02-05 | 2020-11-26 | Ab Science | Compuestos con actividad antitumoral |
| CN107427521B (zh) | 2015-03-27 | 2021-08-03 | 达纳-法伯癌症研究所股份有限公司 | 细胞周期蛋白依赖性激酶的抑制剂 |
| EP4019515A1 (en) | 2015-09-09 | 2022-06-29 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| GB201617871D0 (en) | 2016-10-21 | 2016-12-07 | Sareum Limited | Pharmaceutical compounds |
| JP7590185B2 (ja) | 2018-06-25 | 2024-11-26 | ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド | Ｔａｉｒｅファミリーキナーゼインヒビターおよびそれらの使用 |
| GB201816369D0 (en) | 2018-10-08 | 2018-11-28 | Sareum Ltd | Pharmaceutical compounds |
| CN112480101B (zh) * | 2019-09-12 | 2022-11-25 | 中国科学院上海药物研究所 | 一类irak4激酶抑制剂及其制备和应用 |
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| CN113185511B (zh) * | 2021-05-24 | 2022-04-26 | 中国医学科学院医药生物技术研究所 | 一种嘧啶类化合物及其制备方法和应用 |
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| CA2542909C (en) | 2003-10-23 | 2012-07-10 | Ab Science | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
-
2004
- 2004-10-22 CA CA2542909A patent/CA2542909C/en not_active Expired - Fee Related
- 2004-10-22 AT AT04791783T patent/ATE465731T1/de active
- 2004-10-22 BR BRPI0415467-3A patent/BRPI0415467A/pt not_active IP Right Cessation
- 2004-10-22 CN CN2004800371595A patent/CN1950347B/zh not_active Expired - Fee Related
- 2004-10-22 EP EP04791783A patent/EP1684750B1/en not_active Expired - Lifetime
- 2004-10-22 NZ NZ546645A patent/NZ546645A/en not_active IP Right Cessation
- 2004-10-22 PL PL04791783T patent/PL1684750T3/pl unknown
- 2004-10-22 JP JP2006536215A patent/JP4971797B2/ja not_active Expired - Fee Related
- 2004-10-22 WO PCT/IB2004/003698 patent/WO2005040139A2/en not_active Ceased
- 2004-10-22 HR HR20100326T patent/HRP20100326T1/hr unknown
- 2004-10-22 AU AU2004283162A patent/AU2004283162B2/en not_active Ceased
- 2004-10-22 DK DK04791783.6T patent/DK1684750T3/da active
- 2004-10-22 US US10/576,267 patent/US7718676B2/en not_active Expired - Fee Related
-
2006
- 2006-04-20 IL IL175028A patent/IL175028A/en not_active IP Right Cessation
- 2006-05-22 NO NO20062308A patent/NO20062308L/no not_active Application Discontinuation
-
2010
- 2010-01-11 US US12/654,957 patent/US8110591B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8110591B2 (en) | 2012-02-07 |
| BRPI0415467A (pt) | 2006-12-19 |
| HRP20100326T1 (hr) | 2010-10-31 |
| WO2005040139A8 (en) | 2006-06-01 |
| CA2542909A1 (en) | 2005-05-06 |
| NO20062308L (no) | 2006-05-22 |
| AU2004283162B2 (en) | 2011-12-15 |
| AU2004283162A1 (en) | 2005-05-06 |
| DK1684750T3 (da) | 2010-08-09 |
| EP1684750A2 (en) | 2006-08-02 |
| JP2007509130A (ja) | 2007-04-12 |
| HK1091134A1 (en) | 2007-01-12 |
| US20070142390A1 (en) | 2007-06-21 |
| IL175028A0 (en) | 2006-08-20 |
| NZ546645A (en) | 2010-02-26 |
| CN1950347B (zh) | 2012-04-04 |
| JP4971797B2 (ja) | 2012-07-11 |
| WO2005040139A2 (en) | 2005-05-06 |
| ATE465731T1 (de) | 2010-05-15 |
| CA2542909C (en) | 2012-07-10 |
| US7718676B2 (en) | 2010-05-18 |
| EP1684750B1 (en) | 2010-04-28 |
| CN1950347A (zh) | 2007-04-18 |
| WO2005040139A3 (en) | 2005-10-13 |
| US20100113471A1 (en) | 2010-05-06 |
| PL1684750T3 (pl) | 2010-10-29 |
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