CN1939920A - 东罂粟碱类化合物及其医药用途 - Google Patents
东罂粟碱类化合物及其医药用途 Download PDFInfo
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- CN1939920A CN1939920A CN200510105828.4A CN200510105828A CN1939920A CN 1939920 A CN1939920 A CN 1939920A CN 200510105828 A CN200510105828 A CN 200510105828A CN 1939920 A CN1939920 A CN 1939920A
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Abstract
Description
编号 | 剂量(mg/kg) | 镇痛(%) |
丁丙诺啡 | 1.1 | 40 |
Ia-1·HCl | 0.0005 | 40.1 |
0.001 | 74.5 | |
Ia-2·HCl | 5 | 70.2 |
10 | 71.4 | |
Ia-3·HCl | 2.5 | 68.6 |
5 | 100 | |
Ia-4·HCl | 10 | 75.8 |
20 | 100 | |
Ib-1·HCl | 0.005 | 64.0 |
0.010 | 93.4 | |
Ib-2 | 5 | 45.4 |
10 | 40.2 | |
Ib-3·HCl | 20 | 42.7 |
40 | 33.7 | |
Ib-4 | 10 | 38.6 |
20 | 35.2 | |
Ic-1 | 0.1 | 92.3 |
0.5 | 100 |
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2005101058284A CN1939920B (zh) | 2005-09-29 | 2005-09-29 | 东罂粟碱类化合物及其医药用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN2005101058284A CN1939920B (zh) | 2005-09-29 | 2005-09-29 | 东罂粟碱类化合物及其医药用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1939920A true CN1939920A (zh) | 2007-04-04 |
CN1939920B CN1939920B (zh) | 2011-08-31 |
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Application Number | Title | Priority Date | Filing Date |
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CN2005101058284A Expired - Fee Related CN1939920B (zh) | 2005-09-29 | 2005-09-29 | 东罂粟碱类化合物及其医药用途 |
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CN (1) | CN1939920B (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102112479A (zh) * | 2008-07-30 | 2011-06-29 | 普渡制药公司 | 丁丙诺啡类似物 |
US8232397B2 (en) | 2008-09-30 | 2012-07-31 | Mallinckrodt Llc | Processes for the production of buprenorphine with reduced impurity formation |
US8269006B2 (en) | 2008-09-30 | 2012-09-18 | Mallinckrodt Llc | Processes for the selective amination of ketomorphinans |
US8273887B2 (en) | 2008-09-30 | 2012-09-25 | Mallinckrodt Llc | Processes for synthesis of opiate alkaloid derivatives |
CN108530452A (zh) * | 2017-03-01 | 2018-09-14 | 泰州华元医药科技有限公司 | 新型高效抗成瘾药物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2230154A1 (de) * | 1972-06-21 | 1974-01-17 | Boehringer Sohn Ingelheim | N-(heteroaryl-methyl)-6,14-endoaetheno7alpha-hydroxyalkyl-tetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung |
CN1233645C (zh) * | 2001-09-14 | 2005-12-28 | 中国人民解放军军事医学科学院毒物药物研究所 | 新的东罂粟碱衍生物及其医药用途 |
-
2005
- 2005-09-29 CN CN2005101058284A patent/CN1939920B/zh not_active Expired - Fee Related
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102112479A (zh) * | 2008-07-30 | 2011-06-29 | 普渡制药公司 | 丁丙诺啡类似物 |
US8530494B2 (en) | 2008-07-30 | 2013-09-10 | Purdue Pharma Lp | Buprenophine analogs |
CN102112479B (zh) * | 2008-07-30 | 2014-10-29 | 普渡制药公司 | 丁丙诺啡类似物 |
US8232397B2 (en) | 2008-09-30 | 2012-07-31 | Mallinckrodt Llc | Processes for the production of buprenorphine with reduced impurity formation |
US8269006B2 (en) | 2008-09-30 | 2012-09-18 | Mallinckrodt Llc | Processes for the selective amination of ketomorphinans |
US8273887B2 (en) | 2008-09-30 | 2012-09-25 | Mallinckrodt Llc | Processes for synthesis of opiate alkaloid derivatives |
CN108530452A (zh) * | 2017-03-01 | 2018-09-14 | 泰州华元医药科技有限公司 | 新型高效抗成瘾药物 |
CN108530452B (zh) * | 2017-03-01 | 2023-02-03 | 泰州华元医药科技有限公司 | 高效抗成瘾药物 |
Also Published As
Publication number | Publication date |
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CN1939920B (zh) | 2011-08-31 |
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C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhong Bohua Inventor after: Gong Zehui Inventor after: Wang Jingyan Inventor after: Yu Gang Inventor after: Liu Chunhe Inventor after: Wu Bo Inventor after: Shi Weiguo Inventor after: Zhang Zhenqing Inventor after: Xie Jianwei Inventor before: Zhong Bohua Inventor before: Gong Zehui Inventor before: Wang Jingyan Inventor before: Yu Gang Inventor before: Liu Chunhe Inventor before: Wu Bo |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHONG BOHUA GONG ZEHUI WANG JINGYAN YU GANG LIU CHUNHE WU BO TO: ZHONG BOHUA GONG ZEHUI WANG JINGYAN YU GANG LIU CHUNHE WU BO SHI WEIGUO ZHANG ZHENQING XIE JIANWEI |
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C14 | Grant of patent or utility model | ||
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110831 Termination date: 20210929 |