CN1911042A - Compounding sterilizing deodoriferant contg. solid quaternary ammonium salts and its preparation method - Google Patents

Abstract

A disinfecting and deodoring composition in the form of powder, particle, tablet, slow-release tablet, or effervescent tablet for various purposes in various areas is prepared from quaternary ammonium salt compound, stabilizer, adhesive, excipient, chelating agent and metallic corrosion inhibitor.

Description

A kind of solid quaternary ammonium salts compounding sterilizing deodoriferant and preparation method

Technical field

The present invention relates to a kind of solid quaternary ammonium salts compounding sterilizing deodoriferant and preparation method, it relates to, and effervescent agent is instant, the design of slow-release solid prescription, and respective tablets, granule, pulvis and other products manufacturing process technology, being mainly used in human body skin sterilization and removing the disinfecting, deodorizing etc. of the washing of the sterilization of inflammation, pet sterilization and deodorizing, dental appliance, Medical Devices and sterilization, environment thing table, is a kind of more novel disinfecting, deodorizing pharmaceutical preparation.

Background technology

Adopt the existing nearly 200 years history of chlorine compound sterilization, as chlorine water, hypochlorous acid salt, TCCA (Trichloroisocyanuric acid) class, chlorine dioxide class etc., have sterilization rapidly, the characteristics of broad-spectrum high efficacy, but the chemistry and the physical stability of this compounds and the product made are relatively poor, use and retention cycle is subjected to certain condition restriction; The oxidisability of this compounds and excitant are stronger in addition, and human body is produced very strong side effect, and be also bigger to corrosion of metal simultaneously.Under this condition, the range of application and the using dosage of this series products is subjected to many restrictions.People study and have synthesized new generation bactericide-chlorine (bromine) and changed alkylammonium salt for this reason, have the bactericidal activity of more efficient and low excitant, have good washing functions etc. simultaneously, not only can be used as skin, vagina, oral cavity, apparatus and environment sterilization, diminish inflammation and dispel the preparation of bad smell.As USP6899893, adopt chlorine (bromine) to change the combination of alkylammonium salt and poly-phenolic compound etc., be prepared into and be used for treating allergic or inflammatory diseases, also can effectively prevent the infection of Food ﹠ Drink, this compositions display has long-term drug effect effect and high safety.USP6899890, as a kind of bio-adhesive drug delivery system, said composition is a kind of spheroid emulsion, and this emulsion has double-deck physical arrangement, and wherein internal layer is water-soluble, and skin is water-insoluble layer, can carry out effective drug.USP6899865 is a kind of double-deck mouth cavity medicine composition, contains a kind of quaternary ammonium chloride compounds, has the accumulation of good removing oral cavity and dental surface and the effect of peculiar smell.USP6896877 is a kind of detergents and cosmetic composition product, contains polymer and quaternary ammonium salt, is used for handling various footwear things, uses as cleaning agent, disinfectant and eliminating smell agent.More than several external last words each all have significant function and characteristics, has good bactericidal activity, conditioning property and deodorization functions etc., but the general character of these compositions is liquid state or emulsified state, selected quaternary ammonium salt also is a liquid charging stock, so this based composition is inconvenient in the use, troublesome poeration in the metering, be difficult to accurately hold, the keeping and the transport difficulty of product are bigger, be not easy to the individual and carry, fluid product is subject to the oxidation of airborne oxygen institute in addition, and the shelf-life can be subjected to influence to a certain degree, this series products is more serious to metal protection, influences the scope of application etc.

Summary of the invention

A main purpose of the present invention provides a kind of solid quaternary ammonium salts composition, can convenient metering very use, carry, transport and store.

Another main purpose of the present invention provides a kind of solid quaternary ammonium salts composition, can directly apply to the sterilization and the deodorizing of food industry, farming and animal husbandry, medicine, medical industry, public environment, daily life.

The present invention mainly adopts the pharmaceutical technology technology, and quaternary ammonium salt through suitable processing, is carried out Combined Processing in conjunction with other moulding dressing, stabilizing agent, effervescent agent etc., or makes various shaped articles by pharmaceutical machine.The quality percentage composition of each component of the present composition is:

Ethylenediamine tetra-acetic acid and salt 0.20%-6%

Polyphosphate 0.2%-10%

Lubricant 0.01%-3%

Inorganic acid and salt 0.5%-9% thereof

Benzoic acid and salt 0.5%-10% thereof

Carbonate 1%-50%

Polymer 1%-12%

Organic acid 0.1%-35%

Zinc compound 0.05%-4%

Sulphate 6%-70%

Corrosion inhibiter 0.01%-5%

Quaternary ammonium salt 0.01%-55%

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, wherein component ethylenediamine tetra-acetic acid and salt, as chela and agent and synergist, it can be ethylenediamine tetra-acetic acid, ethylenediamine tetrem disodium, tetrasodium ethylenediamine tetraacetate, B,EDTA, amino trimethylene methyl acid phosphate five sodium or their mixture, is preferably disodium ethylene diamine tetraacetate; Its shared mass percent is 0.20%-6%, is preferably 0.50%-3%.

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, wherein contained component polyphosphate are as chela and agent and cleaning agent, and it can be tripolyphosphate, five Quadrafos, pyrophosphate or their mixture; Described polyphosphate can be sylvite, sodium salt or calcium salt, is preferably sodium salt; Its shared mass percent is 0.2%-10%, is preferably 0.50%-8%.

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, wherein contained lubricant composition, can in granulation and compression molding process, bring into play good action, described lubricant can be fine silica powder, talcum powder, zinc stearate, dolomol, lauryl sodium sulfate, fine titanium dioxide powder or their mixture, is preferably fine silica powder; Its shared mass percent is 0.01%-3%, is preferably 0.1%-2%.

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, wherein contained component inorganic acid and salt thereof, it can be positive silicic acid and salt, metasilicic acid and salt thereof, boric acid and salt thereof or their mixture, is preferably the mixture of boric acid or boric acid and salt thereof; Described inorganic acid salt can be sylvite, sodium salt or calcium salt, is preferably sodium salt; Its shared mass percent is 0.5%-9%, is preferably 1%-8%.As auxiliary elements such as solid forming, lubricated and fillings.

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, wherein contained component benzoic acid and salt thereof, benzoic salt can be Sodium Benzoate, Potassium Benzoate, calcium benzoate, magnesium benzoate, zinc benzoate or their mixture, is preferably benzoic acid and sodium benzoate; Its shared mass percent is 0.5%-10%, is preferably 1%-7%.Mainly as auxiliary materials such as excipient, fillings.

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, wherein contained component carbonate are as effervescent agent and forming agent, and it can be subcarbonate or acid carbonate or their mixture; Described carbonate or acid carbonate can be sylvite, sodium salt, calcium salt, magnesium salts, are preferably sodium salt; Its shared mass percent is 1%-50%, is preferably 5%-35%.

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, wherein contained component polymer can be methylcellulose, ethyl cellulose, propyl cellulose, cellulose acetate, hydroxymethyl-propyl cellulose, carboxymethyl cellulose, sodium carboxymethylcellulose, sodium carboxymethyl starch, microcrystalline cellulose, cellulose acetate-phthalate, polyvinyl alcohol 400, polyvinyl alcohol 4000, polyvinylpyrrolidone or their mixture, is preferably carboxymethyl cellulose and sodium salt; Its shared mass percent is 1%-12%, is preferably 2%-8%.Mainly as auxiliary materials such as excipient, bonding, carrier, absorption.

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, wherein contained component organic acid, it can be oxalic acid, glutaric acid, sulfamic acid, citric acid, malic acid, tartaric acid or their mixture; Be preferably sulfamic acid and tartaric acid; Its shared mass percent is 0.1%-35%, is preferably 1%-30%.Regulate auxiliary element as acid effervescent agent and pH value.

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, wherein contained component zinc compound, it can be zinc oxide, zinc chloride, zinc citrate, zinc sulphate, zinc nitrate, trbasic zinc phosphate or their mixture, is preferably zinc sulphate; Its shared mass percent is 0.05%-4%, is preferably 0.1%-3%.Auxiliary element as pulvis, granule and effervescent tablet.

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, wherein contained component sulphate cpd, it can be potassium sulphate, sodium sulphate, calcium sulphate, aluminum sulfate, strontium sulfate, lithium sulfate, ammonium sulfate or their mixture, is preferably sodium sulphate and calcium sulphate; Its shared mass percent is 6%-70%, is preferably 10%-60%.Packing material and auxiliary element as pulvis, granule and effervescent tablet, sustained-release tablet etc.

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, it can be petroleum sodium sulfonate, methylbenzotrazole, ethyl BTA, sulfydryl BTA, imidazoles woods or their mixture for wherein contained component corrosion inhibiter; Be preferably methylbenzotrazole; Its shared mass percent is 0.01%-5%, is preferably 0.05%-3%.Part as the metal inhibitor of pulvis, granule, effervescent tablet and sustained-release tablet.

A kind of as mentioned above solid quaternary ammonium salts compounding sterilizing deodoriferant, wherein contained component quaternary ammonium salt, it can be benzalkonium bromide, benzalkonium chloride, dodecyl dimethyl ethylbenzene oxygen ethyl ammonium bromide, two certain herbaceous plants with big flowers base alkyl dimethyl ammonium chloride, two dodecyl dimethyl ammonium chloride, two myristyl alkyl dimethyl ammonium chloride, Varisoft 432PPG, benzethonium chloride and benzene rope bromine ammonium or their mixture, is preferably benzethonium chloride and benzene rope bromine ammonium; Its shared mass percent is 0.01%-55%, is preferably 0.1%-50%.Part as deodorizing, sterilization and the disinfectant of pulvis, granule, effervescent tablet and sustained release agent.

Preparation technology's method of the present composition:

Aforesaid a kind of solid quaternary ammonium salts compounding sterilizing deodoriferant is the basic amount according to prescription, pulverize respectively, cross the 60-100 mesh sieve, it is dry under 80-110 ℃ of condition to put into thermal cycle drying box temperature control then respectively, and the time is controlled at was advisable in 8-12 hour, measure moisture then, according to the accurate weighing of formula ratio, put into 30 minutes married operations of grooved or three-dimensional hybrid device, accurately measure content after, can further process respectively again according to the different dosage form of follow-up required preparation.

A, instant type pulvis: can directly pack, seal and be finished product.

B, instant type granule: can adopt suitable solvent, binder to adopt wet method, also can adopt dry method to pass through comminutor, make the effervescence granular of various particle diameters, respectively packing.

C, dissolving tablet: by granulation respectively, also can adopt dry powder direct tabletting earlier,, select different punch dies again,, make the suitable product of hardness and intensity by adjusting the pressure of machine by selecting different tablet press machines such as rotary 25,33,40 stamping machines for use.Sheet is heavy can be 0.5 gram/sheet, 1.0 gram/sheets, 1.50 gram/sheets, 2 gram/sheets, 3 gram/sheets.

D, slowly-releasing lozenge: can adopt macromolecular material such as adhesive, excipient, lubricant etc. in certain solvent, to mix, by machine kneading, granulation, oven dry, by the extrusion modling of oil pressure system heavy stone used as an anchor machine, sheet heavily is 20 gram/sheets, 100 gram/sheets, 200 gram/sheets, 300 gram/sheets etc. again.

Solid instant preparation of the present invention can pass through a certain amount of water, ethanol, polyalcohol or the dissolving of other polar solvent respectively, in 3-10 minute, form the aqueous solution of clear, have than the accurate activity medicament contg, promptly realize solid quaternary ammonium salts compounding sterilizing deodoriferant manufacture process of the present invention.

Solid sustained-release preparation of the present invention can place it in the container of certain volume, put into certain amount of solvent, solid sustained-release preparation physical state in solvent is constant substantially, and the disinfecting, deodorizing factor can slowly keep certain amount to discharge from system, and life cycle can reach 10-60 days.

Embodiment

Embodiment 1

A kind of sustained release preparation of solid quaternary ammonium salts compounding sterilizing deodoriferant, the mass percent of its each component is:

Ethylenediamine tetra-acetic acid 0.90%

Potassium polyphosphate 5%

Fine silica powder 0.1%

Sodium silicate 0.5%

Benzoic acid 0.5%

Calcium carbonate 15%

Carboxymethyl cellulose 5%

Oxalic acid 6.4%

Zinc chloride 0.5%

Calcium sulphate 56%

Petroleum sodium sulfonate 0.1%

Benzalkonium chloride 10%

Optimize embodiment 1

Disodium ethylene diamine tetraacetate 2%

Sodium polyphosphate 5%

Fine silica powder 2%

Boric acid 1%

Sodium Benzoate 1%

Calcium carbonate 11%

Carboxymethyl cellulose 5%

Tartaric acid 1%

Zinc sulphate 0.5%

Calcium sulphate 59%

Methylbenzotrazole 0.2%

Benzalkonium chloride 12.3%

Embodiment 2

A kind of dissolution formulation of solid quaternary ammonium salts compounding sterilizing deodoriferant, the mass percent of its each component is:

Tetrasodium ethylenediamine tetraacetate 6%

PTPP 10%

Talcum powder 0.01%

Sodium tetraborate 1%

Sodium Benzoate 10%

Sodium bicarbonate 30%

Sodium carboxymethylcellulose 2%

Sulfamic acid 15%

Zinc sulphate 4%

Potassium sulphate 20.89%

Propyl group BTA 0.1%

Benzene rope bromine ammonium 1%

Optimize embodiment 2

Disodium ethylene diamine tetraacetate 3%

Sodium phosphate trimer 8%

Fine silica powder 0.01%

Boric acid 8%

Sodium Benzoate 7%

Sodium bicarbonate 30%

Sodium carboxymethylcellulose 2%

Tartaric acid 15%

Zinc sulphate 3%

Sodium sulphate 22.89%

Methylbenzotrazole 0.1%

Benzethonium chloride 1%

The design of this individual system is mainly reflected in the design of the input technology (being sustained release) to fungicide active ingredient, reaches this purpose by adjusting auxiliary element.That is to say by adjusting the proportioning of composition, the useful effect medicine is come out fast or with slower VELOCITY DIFFUSION, enter solution system, form final product.

The present composition, mainly reach its deodorizing purpose by its good sterilization and bacteriostatic activity, be embodied in the elimination that each bacterioid that rots is grown in thorough elimination, the adsorption component in the composition can effectively bind the stink molecular beam simultaneously, prevent its diffusion, more help removing.

Acute toxicity: the present composition drips in the eye of rabbit and flushing immediately by 1%, 5% valid density, find to stimulate phenomenon, can not produce the stimulation phenomenon in the valid density of mouse mucous membrane tissue irritation test process 0.1%.The valid density of employing 0.6% does not produce stimulation to the Skin-test of dog and rabbit.

Chronic toxicity: adopt 0.005%, 0.01%, 0.05% valid density to add one-year age in the food of dog to, find to grow up and the existence anomaly, and blood and pathological change.

The effect data (1 minute action time) of the killing microorganisms of table-1 present composition

The microorganism classification	Active matter valid density	Kill logarithm value
			Staphylococcus aureus Escherichia coli Candida albicans Pseudomonas aeruginosa	0.1％ 0.1％ 0.1％ 0.1％	5 5 5 5

The valid density data of the killing microorganisms of table-2 present compositions

The microorganism classification	Active matter valid density	The active matter dilution ratio
			Staphylococcus aureus cholera salmonella pseudomonas aeruginosa	0.005％ 0.005％ 0.1％	1∶2000 1∶2000 1∶1000

The inhibition growth of microorganism active ingredient dilution ratio data of table-3 present compositions

The microorganism classification	The dilution ratio of active active ingredient
			Antibacterial ratio	Maximum antibacterial ratio
	Green pus streptococcus viridans streptococci Escherichia coli cholera salmonella poultry salmonella Candida albicans black-koji mould pseudomonas aeruginosa Lactobacillus casei S. cervisiae trichophyta	1∶40000 1∶200000 1∶15000 1∶30000 1∶30000 1∶300000 1∶400 1∶8000 1∶40000 1∶90000 1∶2000			1∶40000 1∶300000 1∶15000 1∶30000 1∶30000 1∶600000 1∶800 1∶8000 1∶80000 1∶90000 1∶4000

Invention is summed up

A kind of solid quaternary ammonium salts compounding sterilizing deodoriferant of the present invention, adopt the solid drugs technology of preparing, have good disintegration, dispersion and slow-release capability and more excellent anti-performance of hard water, can be applied to sterilization and deodorizing that joy place, dental appliance and artificial tooth, human body skin, clothing, pet are washed in industrial production, family, hospital's apparatus and environment, leisure center, haircut. Prove that from the Theoretical Design of deodorizing and the actual effect that reaches its deodorizing is fundamentally to remove microorganism and organic bad smell, rather than simple physics hides, the present composition is with atomizer spray or with rag, mop wiping, can remove fast the bad smell in decomposed odour, public place, kitchen, bathroom, and can be not residual itself smell and toxicity; Also have in addition the effect of algal grown in control swimming pool and other pond, can be applied to civilian and industrial aspect. The aspects such as the individual carries from storing, transporting and consuming, use procedure is measured and convenient, the present composition has many-sided value.

Claims (9)

1. solid quaternary ammonium salts compounding sterilizing deodoriferant and preparation method, it is characterized in that, quaternary ammonium salt, stabilizing agent, binder, excipients, chelating agent, metal inhibitor by solid state are formed, and it can be can control the formulation that active ingredient discharges with pulvis, granule, tablet, sustained release agent and effervescent agent etc.Unified packaged form is adopted in preparation, and its composition main component is constructed as follows by mass percentage:

Ethylenediamine tetra-acetic acid and salt 0.20%-6%

Polyphosphate 0.2%-10%

Lubricant 0.01%-3%

Inorganic acid and salt 0.5%-9% thereof

Benzoic acid and salt 0.5%-10% thereof

Carbonate 1%-50%

Polymer 1%-12%

Organic acid 0.1%-35%

Zinc compound 0.05%-4%

Sulphate 6%-70%

Corrosion inhibiter 0.01%-5%

Quaternary ammonium salt 0.01%-55%.

2. according to described a kind of solid quaternary ammonium salts compounding sterilizing deodoriferant of claim 1 and preparation method, it is characterized in that, it can be ethylenediamine tetra-acetic acid, ethylenediamine tetrem disodium, tetrasodium ethylenediamine tetraacetate, B,EDTA, amino trimethylene methyl acid phosphate five sodium or their mixture to contain a kind of ethylenediamine tetra-acetic acid and salt, is preferably disodium ethylene diamine tetraacetate; Its shared mass percent is 0.20%-6%, is preferably 0.50%-3%.Contain a kind of polyphosphate as chelating and cleaning agent, it can be tripolyphosphate, five Quadrafos, pyrophosphate or their mixture; Described polyphosphate can be sylvite, sodium salt or calcium salt, is preferably sodium salt; Its shared mass percent is 0.2%-10%, is preferably 0.50%-8%.

3. according to described a kind of solid quaternary ammonium salts compounding sterilizing deodoriferant of claim 1 and preparation method, it is characterized in that, contain a kind of lubricant, can be fine silica powder, talcum powder, zinc stearate, dolomol, lauryl sodium sulfate, fine titanium dioxide powder or their mixture, be preferably fine silica powder; Its shared mass percent is 0.01%-3%, is preferably 0.1%-2%.Contain a kind of inorganic acid and salt thereof, it can be positive silicic acid and salt, metasilicic acid and salt thereof, boric acid and salt thereof or their mixture, is preferably the mixture of boric acid or boric acid and salt thereof; Described inorganic acid salt can be sylvite, sodium salt or calcium salt, is preferably sodium salt; Its shared mass percent is 0.5%-9%, is preferably 1%-8%.

4. according to claim 1, it is characterized in that a kind of solid quaternary ammonium salts compounding sterilizing deodoriferant and preparation method, contain a kind of benzoic acid and salt thereof, benzoate can be Sodium Benzoate, Potassium Benzoate, calcium benzoate, magnesium benzoate, zinc benzoate or their mixture, is preferably benzoic acid and sodium benzoate; Its shared mass percent is 0.5%-10%, is preferably 1%-7%.Contain a kind of carbonate as effervescent agent and forming agent, it can be subcarbonate or acid carbonate or their mixture; Described carbonate or acid carbonate can be sylvite, sodium salt, calcium salt, magnesium salts, are preferably sodium salt; Its shared mass percent is 1%-50%, is preferably 5%-35%.

5. according to described a kind of solid quaternary ammonium salts compounding sterilizing deodoriferant of claim 1 and preparation method, it is characterized in that, contain a kind of polymer, can be methylcellulose, ethyl cellulose, propyl cellulose, cellulose acetate, hydroxymethyl-propyl cellulose, carboxymethyl cellulose, sodium carboxymethylcellulose, sodium carboxymethyl starch, microcrystalline cellulose, cellulose acetate-phthalate, polyvinyl alcohol 400, polyvinyl alcohol 4000, polyvinylpyrrolidone or their mixture, be preferably carboxymethyl cellulose and sodium salt; Its shared mass percent is 1%-12%, is preferably 2%-8%.Contain a kind of organic acid, it can be oxalic acid, glutaric acid, sulfamic acid, citric acid, malic acid, tartaric acid or their mixture; Be preferably sulfamic acid and tartaric acid; Its shared mass percent is 0.1%-35%, is preferably 1%-30%.

6. according to described a kind of solid quaternary ammonium salts compounding sterilizing deodoriferant of claim 1 and preparation method, it is characterized in that, contain a kind of zinc compound, it can be zinc oxide, zinc chloride, zinc citrate, zinc sulphate, zinc nitrate, trbasic zinc phosphate or their mixture, is preferably zinc sulphate; Its shared mass percent is 0.05%-4%, is preferably 0.1%-3%.Contain a kind of sulphate cpd, it can be potassium sulphate, sodium sulphate, calcium sulphate, aluminum sulfate, strontium sulfate, lithium sulfate, ammonium sulfate or their mixture, is preferably sodium sulphate and calcium sulphate; Its shared mass percent is 6%-70%, is preferably 10%-60%.

7. according to described a kind of solid quaternary ammonium salts compounding sterilizing deodoriferant of claim 1 and preparation method, it is characterized in that, contain a kind of corrosion inhibiter, it can be petroleum sodium sulfonate, methylbenzotrazole, ethyl BTA, sulfydryl BTA, imidazoles woods or their mixture; Be preferably methylbenzotrazole; Its shared mass percent is 0.01%-5%, is preferably 0.05%-3%.

8. according to described a kind of solid quaternary ammonium salts compounding sterilizing deodoriferant of claim 1 and preparation method, it is characterized in that, contain a kind of component quaternary ammonium salt, it can be benzalkonium bromide, benzalkonium chloride, dodecyl dimethyl ethylbenzene oxygen ethyl ammonium bromide, two certain herbaceous plants with big flowers base alkyl dimethyl ammonium chloride, two dodecyl dimethyl ammonium chloride, two myristyl alkyl dimethyl ammonium chloride, Varisoft 432PPG, benzethonium chloride and benzene rope bromine ammonium or their mixture, is preferably benzethonium chloride and benzene rope bromine ammonium; Its shared mass percent is 0.01%-55%, is preferably 0.1%-50%.

9. according to described a kind of solid quaternary ammonium salts compounding sterilizing deodoriferant of claim 1 and preparation method, it is characterized in that, formation requirement according to present composition mass percent, promptly according to the basic amount of prescription, pulverize respectively, cross the 60-100 mesh sieve, it is dry under 80-110 ℃ of condition to put into thermal cycle drying box temperature control then respectively, and the time is controlled at was advisable in 8-12 hour, measured moisture then, according to the accurate weighing of formula ratio, put into 30 minutes married operations of grooved or three-dimensional hybrid device, accurately measure content after, can be according to the different dosage form of follow-up required preparation, further process respectively again, be prepared as follows:

A, instant type pulvis: can directly pack, seal and be finished product.

B, instant type granule: can adopt suitable solvent, binder to adopt wet method, also can adopt dry method to pass through comminutor, make the effervescence granular of various particle diameters, respectively packing.

C, dissolving tablet: by granulation respectively, also can adopt dry powder direct tabletting earlier,, select different punch dies again,, make the suitable product of hardness and intensity by adjusting the pressure of machine by selecting different tablet press machines such as rotary 25,33,40 stamping machines for use.Sheet is heavy can be 0.5 gram/sheet, 1.0 gram/sheets, 1.50 gram/sheets, 2 gram/sheets, 3 gram/sheets.

D, slowly-releasing lozenge: can adopt macromolecular material such as adhesive, excipient, lubricant etc. in certain solvent, to mix, by machine kneading, granulation, oven dry, by the extrusion modling of oil pressure system heavy stone used as an anchor machine, sheet heavily is 20 gram/sheets, 100 gram/sheets, 200 gram/sheets, 300 gram/sheets etc. again.