CN101743977B - Bactericidal composition containing hexaconazole and probenazole - Google Patents
Bactericidal composition containing hexaconazole and probenazole Download PDFInfo
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- CN101743977B CN101743977B CN2010100030672A CN201010003067A CN101743977B CN 101743977 B CN101743977 B CN 101743977B CN 2010100030672 A CN2010100030672 A CN 2010100030672A CN 201010003067 A CN201010003067 A CN 201010003067A CN 101743977 B CN101743977 B CN 101743977B
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- probenazole
- azoles alcohol
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- azoles
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- WHHIPMZEDGBUCC-UHFFFAOYSA-N probenazole Chemical compound C1=CC=C2C(OCC=C)=NS(=O)(=O)C2=C1 WHHIPMZEDGBUCC-UHFFFAOYSA-N 0.000 title claims abstract description 112
- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 20
- STMIIPIFODONDC-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(O)(CCCC)CN1C=NC=N1 STMIIPIFODONDC-UHFFFAOYSA-N 0.000 title abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 30
- 239000000375 suspending agent Substances 0.000 claims abstract description 25
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 17
- 241000221785 Erysiphales Species 0.000 claims abstract description 16
- 206010039509 Scab Diseases 0.000 claims abstract description 8
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 4
- 235000013311 vegetables Nutrition 0.000 claims abstract description 4
- 150000003851 azoles Chemical class 0.000 claims description 101
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 99
- 238000009736 wetting Methods 0.000 claims description 26
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 239000003899 bactericide agent Substances 0.000 abstract description 4
- 241000123650 Botrytis cinerea Species 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 42
- 239000002131 composite material Substances 0.000 description 18
- 230000003449 preventive effect Effects 0.000 description 18
- 238000012360 testing method Methods 0.000 description 18
- 239000000575 pesticide Substances 0.000 description 9
- 240000008067 Cucumis sativus Species 0.000 description 8
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
- 239000002270 dispersing agent Substances 0.000 description 7
- 230000002195 synergetic effect Effects 0.000 description 7
- 239000000080 wetting agent Substances 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 229920005646 polycarboxylate Polymers 0.000 description 6
- -1 polyoxyethylene Polymers 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 229920002472 Starch Polymers 0.000 description 5
- 238000012271 agricultural production Methods 0.000 description 5
- 239000000440 bentonite Substances 0.000 description 5
- 229910000278 bentonite Inorganic materials 0.000 description 5
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 5
- 229910021641 deionized water Inorganic materials 0.000 description 5
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- 235000019698 starch Nutrition 0.000 description 5
- 241000220223 Fragaria Species 0.000 description 4
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- 235000011363 Fragaria x ananassa Nutrition 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229920001732 Lignosulfonate Polymers 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
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- 235000014443 Pyrus communis Nutrition 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
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- 238000011835 investigation Methods 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 230000001018 virulence Effects 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 206010067482 No adverse event Diseases 0.000 description 3
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 3
- 240000003377 Shepherdia canadensis Species 0.000 description 3
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- 239000002518 antifoaming agent Substances 0.000 description 3
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- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000233679 Peronosporaceae Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003905 agrochemical Substances 0.000 description 2
- 150000004996 alkyl benzenes Chemical class 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 229940077388 benzenesulfonate Drugs 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
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- 150000007942 carboxylates Chemical class 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
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- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
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- 229920001285 xanthan gum Polymers 0.000 description 2
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- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 1
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
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- 230000006540 mitochondrial respiration Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
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- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000004308 thiabendazole Substances 0.000 description 1
- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
- 229960004546 thiabendazole Drugs 0.000 description 1
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Abstract
The invention relates to a bactericide composition with synergy. The composition contains hexaconazole and probenazole serving as effective active components, wherein the weight ratio of hexaconazole to probenazole is 1-40:80-5, the effective active components is added with additives and excipient and prepared into wet powder, water dispersible granules or suspending agents. The composition is mainly used to prevent and control powdery mildew, botrytis cinerea and scab of vegetables and fruit trees.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of bactericidal composition that contains own azoles alcohol and probenazole.
Technical background
Own azoles alcohol (hexaconazole) is the triazole bactericidal agent of Syngenta Co.,Ltd's exploitation.Molecular formula: C
14H
17Cl
2N
3O, chemical name: (RS)-2-(2,4 dichloro benzene base)-1-(1H-1,2,4-triazol-1-yl)-oneself-2-alcohol.
Own azoles alcohol belongs to sterol demethylation inhibitor, destroys and stop the biosynthesis of the cell membrane important composition composition ergosterol of germ, causes cell membrane not form, and makes germ dead.Suction in the tool, protection and therapeutic activity.
Probenazole (thiabendazole) belongs to benzimidazole, and molecular formula is C
10H
7N
3S, chemical name: α-(4-thiazolyl)-1H-benzimidazole.
Probenazole belongs to benzimidazole, and mechanism of action is to suppress mitochondrial respiration of fungi and cell proliferation.Inhale conduction in having, root is executed the conduction of Shi Nengxiang top, but can not conduct to base.Antibacterial activity is limited to sac fungi, basidiomycetes, imperfect fungus, and to oomycetes and zygomycete non-activity.
No matter be own azoles alcohol, probenazole or other efficient germicides, long-term use separately makes disease develop immunity to drugs easily, causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of different effects mechanism is carried out composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in the production application, judge this composite be synergistic effect or antagonism.Complex role is more significantly filled a prescription, and can obviously improve preventive effect, reduces the dosage of agricultural chemicals greatly, also can enlarge fungicidal spectrum, improves germicidal efficiency.Own azoles alcohol is different with the probenazole mechanism of action, and mutual composite have good synergistic effect within the specific limits.And composite about own azoles alcohol and probenazole do not see relevant report at present at home and abroad as yet.
Summary of the invention
The objective of the invention is to propose a kind ofly have synergistic function, use cost is low, preventive effect is good contains the bactericidal composition of own azoles alcohol and probenazole.
The present invention realizes through following technical scheme:
A kind of bactericidal composition that contains own azoles alcohol and probenazole, wherein own azoles alcohol is 1～40: 80～5 with the probenazole weight ratio.
The described bactericidal composition that contains own azoles alcohol and probenazole, wherein own azoles alcohol is 1～30: 70～10 with the weight ratio of probenazole.
The described bactericidal composition that contains own azoles alcohol and probenazole, wherein own azoles alcohol is 1～20: 60～20 with the weight ratio of probenazole.
The described bactericidal composition that contains own azoles alcohol and probenazole, wherein the effective active component content accounts for 10～80% of gross weight.
The described bactericidal composition that contains own azoles alcohol and probenazole is processed wetting powder, water dispersible granules or suspending agent.
When processing wetting powder, composition comprises following constituent content: own azoles alcohol 1～40%, probenazole 5～80%, dispersant 5～10%, wetting agent 2～10%, filler 8～90%.
Own azoles alcohol, probenazole, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, promptly can be made into own azoles alcohol probenazole wetting powder product.
When processing water dispersible granules, composition comprises following constituent content: own azoles alcohol 1～40%, probenazole 5～80%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, filler 10～90%.
Own azoles alcohol, probenazole, dispersant, wetting agent, disintegrant, filler etc. are obtained the particle diameter that needs through comminution by gas stream together, obtain the materials of granulating.It is interior through after granulation and the drying to expect that article are quantitatively sent the fluidized bed granulation dryer to, makes own azoles alcohol probenazole water dispersible granules product.
Comprise following constituent content when composition is processed suspending agent: own azoles alcohol 1～40%, probenazole 5～50%, dispersant 2～10%, wetting agent 2～10%, antifoaming agent 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, deionized water add to 100%.
Dispersant, wetting agent, antifoaming agent, thickener, antifreeze in the above-mentioned formulation material are mixed through high speed shear; Add own azoles alcohol, probenazole; Ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes own azoles alcohol probenazole suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, in phonetic one or more of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, the soapberry powder.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, the polyethylene glycol.
Described antifoaming agent is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, the C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, the polyethylene glycol.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, the aluminium chloride.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Composition of the present invention is mainly used in powdery mildew, gray mold, the scab of control vegetables and fruit tree.
Beneficial effect of the present invention: own azoles alcohol of (1) present composition effective active composition and probenazole belong to the bactericide of two kinds of different effects mechanism, and both are mixed each other and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single agent, and dosage is little; (3) the present invention not with an organic solvent is not difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to powdery mildew, gray mold, the scab of vegetables and fruit tree.
Embodiment
The present invention is explained further that the percentage among the embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the invention is the method that adopts Toxicity Determination and field trial to combine.
Practice example one: own azoles alcohol is composite to the powdery mildew of cucumber Toxicity Determination with probenazole
Test medicine provides by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation.
After the effective inhibition concentration scope of each medicament was confirmed in prerun, each medicament was established 5 dosage respectively by active constituent content and is handled, and established the clear water contrast.Carry out with reference to " agricultural chemicals indoor bioassay test rule bactericide ", adopt the mycelial growth rate method to measure the virulence of medicament powdery mildew of cucumber.Measure colony diameter with the right-angled intersection method behind the 72h, calculate and respectively handle clean amount of growth, mycelial growth inhibition rate.
Clean amount of growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates the EC of every kind of medicament thus
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is an antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is following:
Wherein: a, b are respectively the pure and mild probenazole of own azoles shared ratio in combination
A is own azoles alcohol
B is a probenazole
Result of the test is as shown in table 1:
The own azoles alcohol of table 1, probenazole and composite toxicity test analysis of results table thereof to powdery mildew of cucumber
Can know that by table 1 own azoles alcohol, probenazole are to the EC of powdery mildew of cucumber
50Be respectively 0.15mg/L and 53.28mg/L.The virulence of own azoles alcohol is higher than the virulence of probenazole.Own azoles alcohol is respectively 1.66,1.89,2.06,1.86,1.54 with 1: 1,1: 5,1: 10,1: 20,1: 30 synergy ratio of probenazole proportioning; Explain that pure being mixed in the scope at 1: 1～1: 20 with probenazole of own azoles all shows obvious synergistic effect; Wherein synergy ratio SR is maximum when own azoles alcohol is 1: 10 with the probenazole weight ratio, and synergistic effect is the most obvious.
Practice example two and implement the prescription example
Embodiment 1 80% own azoles alcohol probenazole wetting powder
Own azoles alcohol 30%, probenazole 50%, polycarboxylate 5%, neopelex 3%, soapberry powder 2%, white carbon 10%, mixture carries out comminution by gas stream, makes 80% own azoles alcohol probenazole wetting powder.
Embodiment 2 70% own azoles alcohol probenazole wetting powders
Own azoles alcohol 20%, probenazole 50%, lignosulfonates 5%, spaonin powder 3%, white carbon 7%, diatomite 15%, mixture carries out comminution by gas stream, makes 70% own azoles alcohol probenazole wetting powder.
Embodiment 3 60% own azoles alcohol probenazole wetting powders
Own azoles alcohol 15%, probenazole 45%, alkylphenol-polyethenoxy are phonetic 5%, neopelex 3%, white carbon 12%, bentonite 20%, and mixture carries out comminution by gas stream, makes 60% own azoles alcohol probenazole wetting powder.
Embodiment 4 50% own azoles alcohol probenazole wetting powders
Own azoles alcohol 8%, probenazole 42%, lignosulfonates 5%, wetting and penetrating agent F 3%, white carbon 12%, bentonite 30%, mixture carries out comminution by gas stream, makes 50% own azoles alcohol probenazole wetting powder.
Embodiment 5 80% own azoles alcohol probenazole water dispersible granules
Own azoles alcohol 10%, probenazole 70%, alkylphenol-polyethenoxy are phonetic 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, starch 10%, mixed 80% own azoles alcohol probenazole water dispersible granules.
Embodiment 6 65% own azoles alcohol probenazole water dispersible granules
Own azoles alcohol 5%, probenazole 60%, polycarboxylate 3%, polyoxyethylene carboxylate 3%, lauryl sodium sulfate 4%, sodium bicarbonate 3%, starch 22%, mixed 65% own azoles alcohol probenazole water dispersible granules.
Embodiment 7 50% own azoles alcohol probenazole water dispersible granules
Own azoles alcohol 4%, probenazole 46%, alkylphenol-polyethenoxy are phonetic 5%, dodecyl benzene sulfonate 3%, starch 20%, bentonite 22%, mixed 50% own azoles alcohol probenazole water dispersible granules.
Embodiment 8 15% own azoles alcohol probenazole water dispersible granules
Own azoles alcohol 5%, probenazole 10%, alkylphenol-polyethenoxy are phonetic 4%, DBSA 4%, ammonium sulfate 5%, starch 20%, diatomite 52%, mixed 15% own azoles alcohol probenazole water dispersible granules.
Embodiment 9 50% own azoles alcohol probenazole suspending agents
Own azoles alcohol 10%, probenazole 40%, alkyl benzene sulfonate calcium salt 5%, Sodium Polyacrylate 2%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, mixed 50% own azoles alcohol probenazole suspending agent.
Embodiment 10 30% own azoles alcohol probenazole suspending agents
Own azoles alcohol 4%, probenazole 26%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mixed 30% own azoles alcohol probenazole suspending agent.
Embodiment 11 21% own azoles alcohol probenazole suspending agents
Own azoles alcohol 1%, probenazole 20%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mixed 21% own azoles alcohol probenazole suspending agent.
Embodiment 12 10% own azoles alcohol probenazole suspending agents
Own azoles alcohol 5%, probenazole 5%, polycarboxylate 2%, Nekal BX 2%, C10-20 saturated fat acid compounds 0.1%, polyethylene glycol 0.5%, ethylene glycol 4%, deionized water add to 100%, mixed 10% own azoles alcohol probenazole suspending agent.
Embodiment uses three own azoles alcohol and the probenazole and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
This EE is in suburb, Pucheng County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 40% probenazole wetting powder (commercial), 10% hexaconazole suspending agent (commercial).
The investigation pear scab state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 3 times.Investigated the apple mildew disease index respectively and calculated preventive effect in 7 days, 14 days, 30 days after the dispenser for the third time.Experimental result is as follows:
The own azoles alcohol of table 2, probenazole and the composite pear scab test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 80% own azoles alcohol probenazole wetting powder | 8000 times | 91.34 | 94.24 | 94.17 |
| 65% own azoles alcohol probenazole water dispersible granules | 2400 times | 90.27 | 93.57 | 94.35 |
| 30% own azoles alcohol probenazole suspending agent | 1500 times | 88.81 | 92.31 | 94.13 |
| 40% probenazole wetting powder | 1200 times | 60.13 | 65.14 | 64.82 |
| 10% hexaconazole suspending agent | 2500 times | 66.51 | 71.64 | 70.18 |
Can be found out that by table 2 can effectively prevent and treat pear scab after own azoles alcohol and probenazole are composite, control efficiency all is superior to contrasting medicament, the lasting period is long.In the test scope of medication, the target crop is had no adverse effects.
Practice example four: own azoles alcohol and the probenazole and the composite control grape grey mould test of pesticide effectiveness thereof
This EE is in suburb, Ningxia Province Yinchuan City, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 40% probenazole wetting powder (commercial), 10% hexaconazole suspending agent (commercial).
The investigation grape grey mould state of an illness before the medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in per 7 days once is total to dispenser 2 times.Investigated the downy mildew of garpe disease index respectively and calculated preventive effect in 7 days, 14 days, 30 days after the dispenser for the second time.Experimental result is as follows:
The own azoles alcohol of table 3, probenazole and the composite control grape grey mould test of pesticide effectiveness thereof
| Handle medicament | Extension rate | 7 days preventive effects (%) behind the last medicine | 14 days preventive effects (%) behind the last medicine | 30 days preventive effects (%) behind the last medicine |
| 70% own azoles alcohol probenazole wetting powder | 6500 times | 89.36 | 96.05 | 95.57 |
| 50% own azoles alcohol probenazole water dispersible granules | 2000 times | 88.54 | 95.16 | 93.35 |
| 21% own azoles alcohol probenazole suspending agent | 500 times | 89.55 | 94.91 | 93.27 |
| 40% probenazole wetting powder | 1000 times | 63.28 | 66.30 | 65.38 |
| 10% hexaconazole suspending agent | 3000 times | 75.36 | 82.42 | 81.42 |
Can find out by table 3, ability effectively preventing downy mildew of garpe after own azoles alcohol and probenazole are composite, control efficiency all is superior to contrasting medicament, and dosage is little, and the lasting period is long.In the test scope of medication, the target crop there is not harm.
Practice example five: own azoles alcohol, probenazole and the composite control powdery mildew of strawberry test of pesticide effectiveness thereof
This EE is in area just outside a city gate town, Qian County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 40% probenazole wetting powder (commercial), 10% hexaconazole suspending agent (commercial).
Investigation powdery mildew of strawberry state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
The own azoles alcohol of table 4, probenazole and the composite control powdery mildew of strawberry test of pesticide effectiveness thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the medicine for the second time | 14 days preventive effects (%) behind the medicine for the second time |
| 60% own azoles alcohol probenazole wetting powder | 10 gram/mus | 91.72 | 96.08 |
| 80% own azoles alcohol probenazole water dispersible granules | 15 gram/mus | 90.38 | 95.43 |
| 50% own azoles alcohol probenazole suspending agent | 12 gram/mus | 89.53 | 94.83 |
| 40% probenazole wetting powder | 45/ mu | 63.44 | 66.34 |
| 10% hexaconazole suspending agent | 15 gram/mus | 80.28 | 85.45 |
Can find out that by table 4 can effectively prevent and treat powdery mildew of strawberry after own azoles alcohol and probenazole are composite and take place, control efficiency all is superior to contrasting medicament, in this test scope of medication, the target crop is had no adverse effects.
Practice example six: own azoles alcohol, probenazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
This EE is in the Gaoling County, Shaanxi Province, and test medicine is researched and developed, provided by Shaanxi means of agricultural production trade Co., Ltd of U.S. nation, contrast medicament 40% probenazole wetting powder (commercial), 10% hexaconazole suspending agent (commercial).
Investigation powdery mildew of cucumber state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before the medicine, in the their early stage dispenser, dispenser in per 7 days once is total to dispenser 2 times, investigates disease index respectively and calculates preventive effect in 7 days, 14 days after the dispenser for the second time.Experimental result is as follows:
The own azoles alcohol of table 5, probenazole and the composite powdery mildew of cucumber test of pesticide effectiveness of preventing and treating thereof
| Handle medicament | The preparation dosage | 7 days preventive effects (%) behind the medicine for the second time | 14 days preventive effects (%) behind the medicine for the second time |
| 50% own azoles alcohol probenazole wetting powder | 10 gram/mus | 91.72 | 96.08 |
| 15% own azoles alcohol probenazole water dispersible granules | 40 gram/mus | 90.38 | 95.43 |
| 10% own azoles alcohol probenazole suspending agent | 50 gram/mus | 89.53 | 94.83 |
| 40% probenazole wetting powder | 45 gram/mus | 68.47 | 72.34 |
| 10% hexaconazole suspending agent | 15 gram/mus | 79.28 | 85.45 |
Can find out that by table 5 can effectively prevent and treat powdery mildew of cucumber after own azoles alcohol and probenazole are composite and take place, control efficiency all is superior to contrasting medicament, in this test scope of medication, the target crop is had no adverse effects.
Claims (5)
1. a bactericidal composition that contains own azoles alcohol and probenazole is characterized in that the own azoles alcohol of bactericidal composition effective active composition and the weight ratio of probenazole are 1: 1～1: 20.
2. the bactericidal composition that contains own azoles alcohol and probenazole according to claim 1, it is characterized in that: wherein the effective active component content accounts for 1～90% of gross weight.
3. the bactericidal composition that contains own azoles alcohol and probenazole according to claim 2, it is characterized in that: wherein the effective active component content accounts for 10～80% of gross weight.
4. the bactericidal composition that contains own azoles alcohol and probenazole according to claim 1, it is characterized in that: bactericidal composition is processed wetting powder, water dispersible granules or suspending agent.
5. the purposes that the bactericidal composition that contains own azoles alcohol and probenazole according to claim 1 is used to prevent and treat vegetables and fruit diseases, described disease is powdery mildew, gray mold, scab.
Priority Applications (1)
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| CN2010100030672A CN101743977B (en) | 2010-01-05 | 2010-01-05 | Bactericidal composition containing hexaconazole and probenazole |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010100030672A CN101743977B (en) | 2010-01-05 | 2010-01-05 | Bactericidal composition containing hexaconazole and probenazole |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5597840A (en) * | 1994-07-07 | 1997-01-28 | Ciba-Geigy Corporation | Microemulsion formulation for injection into trees |
| CN101069511A (en) * | 2006-05-09 | 2007-11-14 | 陶氏农业科学公司 | Stabilized fungus-killing agent composition |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5597840A (en) * | 1994-07-07 | 1997-01-28 | Ciba-Geigy Corporation | Microemulsion formulation for injection into trees |
| CN101069511A (en) * | 2006-05-09 | 2007-11-14 | 陶氏农业科学公司 | Stabilized fungus-killing agent composition |
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