CN1909925A - 一种免疫佐剂 - Google Patents
一种免疫佐剂 Download PDFInfo
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- CN1909925A CN1909925A CNA2005800027003A CN200580002700A CN1909925A CN 1909925 A CN1909925 A CN 1909925A CN A2005800027003 A CNA2005800027003 A CN A2005800027003A CN 200580002700 A CN200580002700 A CN 200580002700A CN 1909925 A CN1909925 A CN 1909925A
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- levamisol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (1)
- 权利要求1、 一种免疫佐剂, 是左旋咪唑, 或左旋咪唑的衍生物, 或左旋咪唑或左旋 咪唑衍生物与下述至少一种物质组成的组合物: 白油、 甘油、 油酸、 双十八垸 基二甲基溴化铵或皂素。2、 根据权利要求 1所述的免疫佐剂, 其特征在于: 所述免疫佐剂是左旋咪 唑或左旋咪唑衍生物。3、 根据权利要求 1所述的免疫佐剂, 其特征在于: 所述免疫佐剂是左旋咪 唑或左旋咪唑衍生物与白油的组合物。4、 根据权利要求 1所述的免疫佐剂, 其特征在于: 所述免疫佐剂是左旋咪 唑或左旋咪唑衍生物与甘油的组合物。5、 根据权利要求 1所述的免疫佐剂, 其特征在于: 所述免疫佐剂是左旋咪 唑或左旋咪唑衍生物与油酸的组合物。6、 根据权利要求 1所述的免疫佐剂, 其特征在于: 所述免疫佐剂是左旋咪 唑或左旋咪唑衍生物与双十八烷基二甲基溴化铵的组合物。7、 根据权利要求 1所述的免疫佐剂, 其特征在于: 所述免疫佐剂是左旋咪 唑或左旋咪唑衍生物与皂素的组合物。8、 根据权利要求 1-7中任一所述的免疫佐剂, 其特征在于: 所述左旋咪唑 衍生物为盐酸左旋咪唑或磷酸左旋咪唑。9、 根据权利要求 1-7中任一所述的免疫佐剂, 其特征在于: 所述白油为食 品用白油或注射用白油。10、 根据权利要求 3的免疫佐剂, 其特征在于: 所述白油与左旋咪唑或左旋 咪唑衍生物的质量比为 20:1至 1:20。11、 根据权利要求 10的免疫佐剂, 其特征在于: 所述白油与左旋咪唑或左 旋咪唑衍生物的质量比为 10:1至 1:1。12、 根据权利要求 4的免疫佐剂, 其特征在于: 所述甘油与左旋咪唑或左旋 咪唑衍生物的质量比为 5:1至 1:5。 '13、 根据权利要求 12的免疫佐剂, 其特征在于: 所述甘油与左旋咪唑或左 旋咪唑衍生物的质量比为 2:1至 1:2。14、 根据权利要求 5的免疫佐剂, 其特征在于: 所述油酸与左旋咪唑或左旋 咪唑衍生物的质量比为 5:1至 1:5。15、 根据权利要求 14的免疫佐剂, 其特征在于: 所述油酸与左旋咪唑或左 旋咪唑衍生物的质量比为 2:1至 1:2。 16、 根据权利要求 6的免疫佐剂, 其特征在于: 所述双十八烷基二甲基溴化 铵与左旋咪唑或左旋咪唑衍生物的质量比为 20:1至 1:20。17、 根据权利要求 16的免疫佐剂, 其特征在于: 所述双十八垸基二甲基溴 化铵与左旋咪唑或左旋咪唑衍生物的质量比为 10:1至 1:5。18、 根据权利要求 7的免疫佐剂, 其特征在于: 所述皂素与左旋咪唑或左旋 咪唑衍生物的质量比为 20:1至 1:20。19、 根据权利要求 18的免疫佐剂, 其特征在于: 所述皂素与左旋咪唑或左 旋咪唑衍生物的质量比为 10: 1至 1: 5。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2005800027003A CN1909925B (zh) | 2004-02-20 | 2005-01-19 | 一种免疫佐剂 |
Applications Claiming Priority (4)
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CN200410039190 | 2004-02-20 | ||
CN200410039190.4 | 2004-02-20 | ||
PCT/CN2005/000084 WO2005079842A1 (fr) | 2004-02-20 | 2005-01-19 | Adjuvant immunologique |
CN2005800027003A CN1909925B (zh) | 2004-02-20 | 2005-01-19 | 一种免疫佐剂 |
Publications (2)
Publication Number | Publication Date |
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CN1909925A true CN1909925A (zh) | 2007-02-07 |
CN1909925B CN1909925B (zh) | 2010-10-13 |
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CN2005800027003A Active CN1909925B (zh) | 2004-02-20 | 2005-01-19 | 一种免疫佐剂 |
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CN (1) | CN1909925B (zh) |
WO (1) | WO2005079842A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102186502A (zh) * | 2008-08-19 | 2011-09-14 | 惠氏有限责任公司 | 免疫学组合物 |
CN104248760A (zh) * | 2013-12-16 | 2014-12-31 | 普莱柯生物工程股份有限公司 | 一种疫苗组合物及其制备方法和应用 |
CN111467488A (zh) * | 2020-04-17 | 2020-07-31 | 内蒙古必威安泰生物科技有限公司 | 一种水溶性复合免疫佐剂及其应用 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102416177A (zh) * | 2011-12-12 | 2012-04-18 | 天津瑞普高科生物药业有限公司 | 鸡新城疫-h9亚型禽流感二联双佐剂灭活疫苗及其制备方法 |
RU2014102939A (ru) * | 2013-02-05 | 2015-08-10 | Нитто Денко Корпорейшн | Вакцинная композиция для чрескожного введения |
CN104667273B (zh) * | 2015-02-06 | 2017-11-10 | 吉林正业生物制品股份有限公司 | 疫苗佐剂及其在制备新城疫灭活疫苗中的应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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ZA803063B (en) * | 1979-05-31 | 1981-05-27 | Ici Australia Ltd | Process |
CN1391954A (zh) * | 2002-07-09 | 2003-01-22 | 新疆大学生命科学与技术学院 | 增强核酸疫苗免疫的组合物及其生产方法和使用方法 |
-
2005
- 2005-01-19 WO PCT/CN2005/000084 patent/WO2005079842A1/zh active Application Filing
- 2005-01-19 CN CN2005800027003A patent/CN1909925B/zh active Active
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102186502A (zh) * | 2008-08-19 | 2011-09-14 | 惠氏有限责任公司 | 免疫学组合物 |
CN102186502B (zh) * | 2008-08-19 | 2014-07-16 | 佐蒂斯W有限责任公司 | 免疫学组合物 |
CN104248760A (zh) * | 2013-12-16 | 2014-12-31 | 普莱柯生物工程股份有限公司 | 一种疫苗组合物及其制备方法和应用 |
CN104248760B (zh) * | 2013-12-16 | 2021-07-23 | 普莱柯生物工程股份有限公司 | 一种疫苗组合物及其制备方法和应用 |
CN111467488A (zh) * | 2020-04-17 | 2020-07-31 | 内蒙古必威安泰生物科技有限公司 | 一种水溶性复合免疫佐剂及其应用 |
CN111467488B (zh) * | 2020-04-17 | 2023-09-01 | 内蒙古必威安泰生物科技有限公司 | 一种水溶性复合免疫佐剂及其应用 |
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Publication number | Publication date |
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CN1909925B (zh) | 2010-10-13 |
WO2005079842A1 (fr) | 2005-09-01 |
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Effective date of registration: 20160802 Address after: 527400 Yunfu City, Xinxing County Province, the new town of North East embankment road, No. 6 Patentee after: GUANGDONG WENS DAHUANONG BIOTECHNOLOGY CO., LTD. Address before: 527400 Yunfu City, Xinxing County Province, the new town of North East embankment road, No. 6 Patentee before: Guangdong Dahuanong Animal Health Products Co., Ltd. |