CN1899301A - Anti-parasite medicine for aquatic cultication - Google Patents
Anti-parasite medicine for aquatic cultication Download PDFInfo
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- CN1899301A CN1899301A CN 200610014754 CN200610014754A CN1899301A CN 1899301 A CN1899301 A CN 1899301A CN 200610014754 CN200610014754 CN 200610014754 CN 200610014754 A CN200610014754 A CN 200610014754A CN 1899301 A CN1899301 A CN 1899301A
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- parasite
- avilamycin
- parasiticidal
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Abstract
The parasiticidal medicine for aquatic cultivation is antibiotic medicine for killing parasite in aquatic animals. Each unit of the parasiticidal medicine contains abamectin 0.05-0.5 weight portions, mebendazole 5-15 weight portions and zeolite powder 70-90 weight portions. The parasiticidal medicine is white powder, has the features of lasting acting, high safety and small dosage, and may be used to replace abamectin in killing arthropods and worms in aquatic animals. It has no drug resistance, and may be taken by aquatic animals or spread in water.
Description
Technical field
The present invention relates to a kind of antibiotics that is used for aquaculture, be specially adapted to kill the parasite in the aquatic animal.
Background technology
Before the present invention realized, avilamycin (Abamectin) preparation extensively was used for fishing animal husbandry at home and abroad as the broad-spectrum high efficacy antiparasitic, obtains preferable evaluation.Yet because the lasting use of this agent, cause many endoparasite and ectoparasites, particularly segmental appendage class and Vermes parasite develop immunity to drugs year by year, and cause that drug effect falls sharply even invalid, aquatic animal body surface and gill entozoa are again to break out one of the most severe, that harm is maximum disease in the aquaculture in addition, thereby cause domestic and international relevant expert's very big concern, and seek and overcome or slow down drug-fast effective measures.
Avilamycin belongs to a kind of macrolide disaccharidase compounds, many parasites is had tag and stomach poison function, and particularly nematicide and arthropod all have the good effect of killing.But to cestode, trematodiasis, and protozoacide invalid.Can be used for fish, shrimp, Eriocheir sinensis and raise together with pool parasite killing, can kill anthelmintics such as Fish spiny-headed worm, dactylogyrider, Gyrodactylus.Its its mechanism of action is to disturb the nervous physiology activity, stimulates to discharge gamma aminobutyric acid and cause its nerve conduction and be suppressed and paralyse to cause and get killed.But since life-time service, corresponding receptors bind in medicine and the parasite cell, affinity reduces, and its drug susceptibility weakens, and subtracts to imitate or inefficacy thereupon.The protein of the internal energy elimination medicine of parasite cell again and enzymatic activity raise, and make the also generation generation succession according to legend effectively of its dominant gene, thereby have produced indomitable Drug resistance, and it is invalid fully finally to cause medicine.
Summary of the invention
The objective of the invention is to, a kind of anti-parasite medicine that is used for aquaculture is provided, be specially adapted to kill the parasite in the aquatic animal, thereby solved the Drug resistance problem that exists in the above-mentioned background technology.
Contain commercially available avilamycin 0.05-0.5 part in the unit of the present invention component by weight, also contain mebendazole 5-15 part and zeolite powder 70-90 part.During making, can get each component respectively according to above-mentioned ratio, then mix homogeneously get final product the off-white powder preparation finished product of colorless and odorless.
Every 2-3 mu during use (1 meter of the depth of water) uses preparation 100g of the present invention, can directly be spilled into the water body from the outside.
In preparation of the present invention, the general content of the pure product of avilamycin is white or little yellow crystalline powder more than 98%.Under low dosage multiple parasite in various pests and the animal body all had and efficiently kill activity, particularly nematicide and arthropod all have the good effect of killing to endoparasite and ectoparasite.But to cestode, trematodiasis, and protozoacide invalid.Can be used for fish, shrimp, Eriocheir sinensis and raise together with pool parasite killing, can kill anthelmintics such as Fish spiny-headed worm, dactylogyrider, Gyrodactylus.Avilamycin belongs to a kind of macrolide disaccharidase compounds, and it has many parasites tags and stomach poison function, and its mechanism of action is to disturb the nervous physiology activity, stimulates to discharge gamma aminobutyric acid and cause its nerve conduction and be suppressed and paralyse to cause and get killed.
Mebendazole is white, off-white color or micro-yellow powder.Can cause that polypide enterocyte slurry microtubule disappears, the utilization that can irreversiblely suppress polypide to glucose causes polypide glycogen and adenosine triphosphate to exhaust, and the polypide growth promoter is obstructed, and maybe can prolong retaining of the interior hydrolytic enzyme of cell, thereby quickens the dissolving of polypide cortex.Be the anthelmintic drug of efficient, wide spectrum, low toxicity, be commonly used to kill the eel silk trematodiasis of parasitic European eel inside and outside, genus Pseudodactylogrus from Anguilla anguilla, Gyrodactylus and fish carp louse etc.
Zeolite: unique mineral structure, its structure is three-dimensional silicon-oxy tetrahedron and three-dimensional aluminum-oxygen tetrahedron, these tetrahedrons are arranged in the crystalline framework with definite shape according to certain rules.The hole of zeolite crystal inside and the volume of passage account for the over half of crystal cumulative volume, and the internal surface area of a gram zeolite hole and passage can reach 500～1000 square metres.It has very strong adsorptivity this loose structure decision.Adsorbable a large amount of polar molecule (as ammonia, carbon dioxide, hydrogen sulfide etc.) that has, every mu of depth of water is used zeolite powder (200 order) 50kg for 1 meter, can remove ammonia nitrogen 95% in the water, purifies water, and alleviating changes the water phenomenon.When TAN in the shrimp pond surpass to allow one times of content, promptly reach 1.2mg/L, use zeolite 16mg/L to handle after, can make pond water ammonia-nitrogen content reduce to safe concentration.Using zeolite powder in the product of the present invention mainly is the stability of utilizing zeolite powder, as the carrier of avilamycin and mebendazole.
Preparation of the present invention is an off-white powder shape material, than the avilamycin activity in the background technology higher effect is arranged, and characteristics such as tool is lasting, safety, consumption are low, can replace simple avilamycin becomes anti-inside and outside arthropod and the parasitic medicine of Vermes extremely, and has solved the Drug resistance problem of using simple avilamycin in the background technology and producing effectively.Preparation of the present invention can effectively be killed on the aquatic animal body surface and the gill parasitic anthelmintic such as dactylogyrider, Gyrodactylus, spiny-headed worm, fish carp louse etc., and arthropod such as Cyclop, violent water flea, Diaptomus etc. can be taken orally, also can directly splash in the culturing pool body.
Embodiment
Below in conjunction with specific embodiment the present invention is elaborated:
Embodiment 1
After 0.4 part of commercially available avilamycin, 15 parts of mebendazoles and 70 parts of abundant mixing of zeolite powder, get the white powder finished product of colorless and odorless.
Embodiment 2
After 0.1 part of commercially available avilamycin, 5 parts of mebendazoles and 70 parts of abundant mixing of zeolite powder, get the white powder finished product of colorless and odorless.
Embodiment 3
After 0.05 part of commercially available avilamycin, 10 parts of mebendazoles and 80 parts of abundant mixing of zeolite powder, get the white powder finished product of colorless and odorless.
Embodiment 4
After 0.3 part of commercially available avilamycin, 5 parts of mebendazoles and 85 parts of abundant mixing of zeolite powder, get the white powder finished product of colorless and odorless.
Embodiment 5
After 0.2 part of commercially available avilamycin, 15 parts of mebendazoles and 90 parts of abundant mixing of zeolite powder, get the white powder finished product of colorless and odorless.
Embodiment 6
After 0.5 part of commercially available avilamycin, 15 parts of mebendazoles and 75 parts of abundant mixing of zeolite powder, get the white powder finished product of colorless and odorless.
The test example
The sloping Cyprinus carpio of the big stream in Baodi county, Tianjin, crucian carp, Aristichthys nobilis, silver carp are raised together with the pond and break out finger mid-June
The sloping Cyprinus carpio of the big stream in Baodi county, Tianjin, crucian carp, Aristichthys nobilis, silver carp are raised together with the pond and break out doctylogyrosis mid-June, fish gill portion is especially serious, cause fish at water surface play, do not eat food, the raiser uses metrifonate, consumption is a 500g/ mu. rice, fish play phenomenon alleviates after 2 days, begin food, but microscopy finds to also have 2-3 tail dactylogyrider in each visual field, uses the relapse rate of this type of disease of metrifonate more than 70% through investigation, and use preparation of the present invention, 50g/ mu. rice, microscopy after 2 days, the dactylogyrider in the visible visual field is dead to be decomposed.Apply on a large scale through the raiser, cure rate reaches more than 95%.
Claims (2)
1. an anti-parasite medicine that is used for aquaculture contains avilamycin 0.05-0.5 part by weight in its unit component, it is characterized in that also containing in its unit component mebendazole 5-15 part and zeolite powder 70-90 part.
2. the anti-parasite medicine that is used for aquaculture according to claim 1 is characterized in that described anti-parasite medicine is the off-white powder preparation of colorless and odorless.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610014754 CN1899301A (en) | 2006-07-11 | 2006-07-11 | Anti-parasite medicine for aquatic cultication |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610014754 CN1899301A (en) | 2006-07-11 | 2006-07-11 | Anti-parasite medicine for aquatic cultication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1899301A true CN1899301A (en) | 2007-01-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610014754 Pending CN1899301A (en) | 2006-07-11 | 2006-07-11 | Anti-parasite medicine for aquatic cultication |
Country Status (1)
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| CN (1) | CN1899301A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127263A (en) * | 2013-02-28 | 2013-06-05 | 张丽香 | Drug for treating oyster perkinsus disease |
| CN103518753A (en) * | 2013-10-16 | 2014-01-22 | 曾立雄 | Novel compound preparation capable of killing dactylogyrus and improving water quality |
| CN111387222A (en) * | 2019-09-12 | 2020-07-10 | 浙江海洋大学 | Spindle water flea eliminating agent |
-
2006
- 2006-07-11 CN CN 200610014754 patent/CN1899301A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127263A (en) * | 2013-02-28 | 2013-06-05 | 张丽香 | Drug for treating oyster perkinsus disease |
| CN103518753A (en) * | 2013-10-16 | 2014-01-22 | 曾立雄 | Novel compound preparation capable of killing dactylogyrus and improving water quality |
| CN111387222A (en) * | 2019-09-12 | 2020-07-10 | 浙江海洋大学 | Spindle water flea eliminating agent |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20070124 |