CN1894401B - 从人胚胎干细胞衍生终末分化的多巴胺能神经元 - Google Patents
从人胚胎干细胞衍生终末分化的多巴胺能神经元 Download PDFInfo
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- CN1894401B CN1894401B CN2004800127488A CN200480012748A CN1894401B CN 1894401 B CN1894401 B CN 1894401B CN 2004800127488 A CN2004800127488 A CN 2004800127488A CN 200480012748 A CN200480012748 A CN 200480012748A CN 1894401 B CN1894401 B CN 1894401B
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- Biotechnology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
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- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN269/MUM/2003 | 2003-03-12 | ||
| IN269MU2003 | 2003-03-12 | ||
| US52004803P | 2003-11-14 | 2003-11-14 | |
| US60/520,048 | 2003-11-14 | ||
| PCT/IB2004/001246 WO2004081172A2 (en) | 2003-03-12 | 2004-03-11 | Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1894401A CN1894401A (zh) | 2007-01-10 |
| CN1894401B true CN1894401B (zh) | 2012-05-23 |
Family
ID=34074054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004800127488A Expired - Fee Related CN1894401B (zh) | 2003-03-12 | 2004-03-11 | 从人胚胎干细胞衍生终末分化的多巴胺能神经元 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP4900587B2 (https=) |
| CN (1) | CN1894401B (https=) |
| ZA (1) | ZA200401646B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10227563B2 (en) | 2008-06-06 | 2019-03-12 | Riken | Method for culture of stem cell |
| CN102257386B (zh) * | 2008-10-24 | 2014-12-31 | B.R.A.H.M.S有限公司 | 通过测定标志肽的水平在已患过中风或短暂性缺血性发作的患者中进行预后和风险评估 |
| CN101824399B (zh) * | 2009-03-05 | 2012-05-30 | 中日友好医院 | 从人羊膜上皮细胞中诱导分化出多巴胺能神经元的方法及分离所得神经元的用途 |
| CN101824398B (zh) * | 2009-03-05 | 2012-08-08 | 中日友好医院 | 人羊膜上皮细胞与神经干细胞共培养诱导分化多巴胺能神经元的方法 |
| JP5787370B2 (ja) | 2009-11-05 | 2015-09-30 | 国立研究開発法人理化学研究所 | 幹細胞の分化誘導方法 |
| WO2011108766A1 (en) * | 2010-03-03 | 2011-09-09 | Kyoto University | METHOD FOR DIAGNOSING A PROTEIN MISFOLDING DISEASE USING NERVE CELLS DERIVED FROM iPS CELLS |
| PT2773748T (pt) * | 2011-11-04 | 2020-03-26 | Memorial Sloan Kettering Cancer Center | Neurónios dopaminérgicos (da) do mesencéfalo para enxerto |
| JP6300807B2 (ja) * | 2012-10-16 | 2018-03-28 | メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー | 神経毒素ポリペプチドの生物学的活性の決定のための細胞試験系 |
| AU2014316100B2 (en) * | 2013-09-05 | 2020-11-05 | Eisai R&D Management Co., Ltd. | New method for inducing dopamine-producing neural precursor cells |
| ES2972541T3 (es) * | 2014-09-08 | 2024-06-13 | Riken | Método para producir tejido progenitor cerebeloso |
| CN105087475B (zh) * | 2015-09-17 | 2018-12-04 | 广州赛莱拉干细胞科技股份有限公司 | 一种细胞培养液及其应用以及诱导牙髓干细胞向神经样细胞分化的方法 |
| AU2016335563B2 (en) * | 2015-10-08 | 2022-10-27 | Neurona Therapeutics Inc. | Neural precursor cell populations and uses thereof |
| CA3021628A1 (en) | 2016-04-22 | 2017-10-26 | Kyoto University | Method for producing dopamine-producing neural precursor cells |
| FR3058892B1 (fr) * | 2016-11-23 | 2021-04-09 | Univ Bordeaux | Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere |
| EP3551748B1 (en) * | 2016-12-12 | 2022-07-13 | Health and Biotech France (H&B France) | Perinatal tissue derived mesenchymal stem cells: method of preparation and uses thereof |
| JPWO2020054647A1 (ja) * | 2018-09-14 | 2021-11-11 | 学校法人慶應義塾 | アストロサイトの製造方法 |
| CN111304167B (zh) * | 2018-12-12 | 2024-03-26 | 上海泉眼生物科技有限公司 | 人源脂肪干细胞来源的神经元前体细胞及其制备方法和应用 |
| CN113439120B (zh) * | 2019-01-22 | 2025-02-14 | 高丽大学校产学协力团 | 用于将神经干细胞分化为星形胶质细胞的基于直接细胞转化的方法 |
| CN114606188A (zh) * | 2019-03-06 | 2022-06-10 | 安徽中盛溯源生物科技有限公司 | 一种中脑多巴胺能神经前体细胞的制备方法及其应用 |
| CN110257332A (zh) * | 2019-07-08 | 2019-09-20 | 广东省赛莱拉干细胞研究院 | 一种诱导间充质干细胞分化成为多巴胺能神经元的培养基以及方法 |
| CN110669143B (zh) * | 2019-10-10 | 2021-05-14 | 中国人民解放军军事科学院军事医学研究院 | 一种短肽及其应用 |
| CN114657119B (zh) * | 2022-03-16 | 2023-10-20 | 广东省农业科学院动物科学研究所 | 一种初生仔猪肠神经胶质细胞的分离和原代培养方法 |
| CN115591025B (zh) * | 2022-11-09 | 2024-01-02 | 深圳先进技术研究院 | 神经调控器件、制备方法及其应用 |
| KR20250108745A (ko) | 2022-12-02 | 2025-07-15 | 누와셀 바이오테크놀로지 코., 엘티디. | 중뇌 도파민 작동성 전구 세포의 제조를 위한 배양 배지, 코팅 매트릭스 및 방법 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277820B1 (en) * | 1998-04-09 | 2001-08-21 | Genentech, Inc. | Method of dopaminergic and serotonergic neuron formation from neuroprogenitor cells |
| WO2003000868A1 (en) * | 2001-06-21 | 2003-01-03 | Geron Corporation | Dopaminergic neurons and proliferation-competent precursor cells for treating parkinson's disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5943533B2 (ja) * | 2000-05-17 | 2016-07-06 | アステリアス バイオセラピューティクス インコーポレイテッド | 神経前駆細胞の集団 |
| WO2002086073A2 (en) * | 2001-04-20 | 2002-10-31 | Memorial Sloan-Kettering Cancer Center | Generation of differentiated tissue from nuclear transfer embryonic stem cells and methods of use |
-
2004
- 2004-03-01 ZA ZA200401646A patent/ZA200401646B/xx unknown
- 2004-03-11 CN CN2004800127488A patent/CN1894401B/zh not_active Expired - Fee Related
- 2004-03-11 JP JP2006506517A patent/JP4900587B2/ja not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277820B1 (en) * | 1998-04-09 | 2001-08-21 | Genentech, Inc. | Method of dopaminergic and serotonergic neuron formation from neuroprogenitor cells |
| WO2003000868A1 (en) * | 2001-06-21 | 2003-01-03 | Geron Corporation | Dopaminergic neurons and proliferation-competent precursor cells for treating parkinson's disease |
Non-Patent Citations (2)
| Title |
|---|
| Alexandra Rolletschek et al..Differentiation of embryonic stem cell-derived dopaminergicneurons is enhanced by survival-promoting factors.Mechanisms of Development105.2001,10594-95. * |
| WO 03000868 A1,说明书第11页第18行至第12页22行. |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4900587B2 (ja) | 2012-03-21 |
| CN1894401A (zh) | 2007-01-10 |
| JP2006521807A (ja) | 2006-09-28 |
| ZA200401646B (en) | 2004-06-07 |
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Granted publication date: 20120523 Termination date: 20130311 |