CN1879777A - Blood circulation-invigorating tendon-strengthening preparation and method for preparing same - Google Patents
Blood circulation-invigorating tendon-strengthening preparation and method for preparing same Download PDFInfo
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Abstract
The invention provides a Chinese medicinal composition and preparing process, especially a preparation for treating diseases including arthralgia and myalgia, body anesthesia and hemiparalysis. The preferred dosage type for the preparation includes dripping pills and soft capsules.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of bones and muscles pain that is used for, the whole body is numb, hemiplegia, the prescription of deviation of the mouth with numbness and paralysis and preparation technology thereof.
Background technology:
Bones and muscles pain, the whole body is numb, hemiplegia, deviation of the mouth with numbness and paralysis is clinically to see symptom more, and the traditional Chinese medical science is often taked expelling wind and activating blood circulation, and the means of the strong muscle of strong waist are treated it, and evident in efficacy.Blood circulation-promoting and muscle-strengthening pill is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, mixture, its pill that makes can be used for curing mainly and is used for bones and muscles pain, the whole body is numb, hemiplegia, deviation of the mouth with numbness and paralysis.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
12.5～150 parts of 10～120 parts of Sanguis Draxonis of 100～1200 parts of Flos Carthamis of Radix Aconiti (system)
5～60 parts of 5～60 parts of Myrrhas of 10～120 parts of Olibanums of Eupolyphaga Seu Steleophaga (deoiling) (deoiling)
20～240 parts of 10～120 portions of Radix Cyathulaes of 10～120 portions of Scorpios of Pheretima
10～120 parts of 10～120 parts of Radix Ginsengs of Ramulus Cinnamomi.
Preferably:
50 parts of 40 parts of Sanguis Draxonis of 400 parts of Flos Carthamis of Radix Aconiti (system)
20 parts of 20 parts of Myrrhas of 40 parts of Olibanums of Eupolyphaga Seu Steleophaga (deoiling) (deoiling)
80 parts of 40 portions of Radix Cyathulaes of 40 portions of Scorpios of Pheretima
40 parts of 40 parts of Radix Ginsengs of Ramulus Cinnamomi.
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, capsule, granule, tablet, mixture, fluid extract and extractum, soft extract, powder.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) get Olibanum, Myrrha two flavor medical materials, adopt supercritical extraction: the medical material of pulverizing is dropped in the supercritical extraction reactor, when pressure reaches 35MPa, 55 ℃ of temperature, CO
2Flow is 15～35kg/h, and constant temperature and pressure extraction 1～5h discharging gets extract;
(2) get Flos Carthami, Scorpio, Radix Cyathulae, Radix Ginseng four Chinese medicine material, add ethanol and carry out reflux, extract, 2～4 times, the alcohol solvent consumption is 4～10 times of medical material amount, and concentration of alcohol is 50～90%, return time 0.5～2.0 hour.The ethanol extract concentrating under reduced pressure gets ethanol extraction;
(3) with the residue after the above supercritical extraction and the medicinal residues behind the ethanol extraction and Radix Aconiti, Eupolyphaga Seu Steleophaga, Pheretima, Ramulus Cinnamomi, extracting in water 2～4 times, amount of water is 4～10 times, each extraction time is 0.5～3 hour, merge extractive liquid,, filter, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 8～48 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, water extract;
(4) getting Sanguis Draxonis powder is broken in the above back adding of the 200 orders said extracted thing.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Sanguis Draxonis, Olibanum, Myrrha, Radix Ginseng and break into fine powder, standby;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and granule.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, analgesic test
Mice is divided into four groups at random, 10 every group.The blank group is irritated stomach (ig) 0.2ml/10g distilled water, indometacin group ig (0.013g/kg) indometacin suspension 0.2ml/10g, technology 1., 2. extractum group consumption such as table 1.Four groups of mice ig every day administration 1 time, totally 7 days, only inject 0.8% acetum 0.2ml/ in 60 minutes pneumoretroperitoneums of administration in the 7th day, observe every mice and cause the time of turning round body because of pain for the first time, the results are shown in Table 1.
Table 1 pair mice acetic acid causes pain and turns round the influence of body (x ± s)
| Group | Dosage (g/kg) | Number of elements | The body time (s) appears turning round for the first time |
| Blank group indometacin group technology is 2. extractum group of extractum group technology 1. | - 0.013 0.020 0.028 | 10 10 10 10 | 213.5±76.3 486.5±186.8 ** 432.4±103.1 ** 350.8±112.6 * |
Annotate: expression and blank group ratio,
*P＜0.01,
*P＜0.05
By table 1 as seen, three groups of mices of irritating the stomach treatment all have in various degree to prolong the average time that writhing response occurs.Indometacin group and technology 1. extractum group and distilled water group relatively have highly significant difference (P＜0.01); Technology 2. extractum group and distilled water group more also there were significant differences (P＜0.05); But technology 2. extractum group is obvious not as the indometacin effect, two groups of P＜0.05 relatively, and 1. technology do not have significant difference between extractum group and the indometacin.Illustrate that this medicine has obvious inhibition acetic acid (chemical substance stimulation) to cause the effect of mice pain.
2, to the microcirculatory influence of rat mesentery
Get SD rat 150～200g,
♀ half and half, is divided into four groups at random, 8 every group, be respectively the blank group, ligustrazine group, technology 1., 2. extractum group.Rat oral gavage was handled after 20 days fasting 14 hours, but can't help water, pentobarbital sodium 40mg/kg, intraperitoneal injection of anesthesia, back of the body position is fixing, the right lower abdomen cropping, and vertical shape is cut 3cm open, carefully pull out one section intestinal loop, be tiled on the lucite perfusion Xiao Chi, stud is fixed, 37 ℃ of slow perfusions of Rockwell liquid, XG-5 type microscope amplifies 20 * 2 times and observes blood capillary, field of excursion, and with high voltage mercury lamp (GC 2.50) as cold light source, the relevant index of observed and recorded, drip 1 of 0.1% norepinephrine liquid (about 50 μ g) then, observe relevant microcirculation index again: 1. blood capillary site crossing number; 2. blood flow peripheral speed: 0 grade: as seen blood capillary does not pass through 0 fen but there is the blood cell; The I level: idol has hemocyte to pass through, 1 minute; The II level: hemocyte is full of tube chamber, sluggish flow, 2 minutes; The III level: blood flow is very fast, is linear, 3 minutes; The IV level: can not differentiate hemocyte, flow velocity is very fast, 4 minutes.3. blood flow attitude: 0 grade: achroacyte is assembled (linear flow), 4 minutes; I level: 2-3 cell aggregation becomes graininess, do not influence flow velocity (grain linear flow), 3 minutes; II level: 4-6 cell aggregation becomes the coarse granule shape, visible void shape (line grain stream) in the tube chamber, 2 minutes; The III level: hemocyte is gathered into lumps and influences velocity of blood flow (grain stream, grain unhurried current), 1 minute; The IV level: blood flow stops or forming microthrombus, and bright section (grain pendulum stream or stagnation) arranged in the tube chamber, 0 minute, the results are shown in Table 2.
The table 2 pair microcirculatory influence of rat mesentery live body (x ± s, n=8)
| Group | Dosage (g/kg) | Flow velocity (μ m/s) | The flow velocity average integral | The fluidised form average integral | Crossing net is counted |
| Blank group indocin group technology is 2. medicinal extract group of medicinal extract group technology 1. | - 0.4 0.010 0.014 | Preceding 1355.7 ± 402.3 backs 458.4 ± 342.6 *Preceding 1465.3 ± 288.1 backs 824.4 ± 384.2 △Preceding 1401.2 ± 387.1 backs 912.8 ± 403.7 △Preceding 1301.2 ± 487.2 backs 713.4 ± 316.5 * | 3.14±0.98 1.12±1.31 * 3.98±0.64 1.90±0.71 △ 3.65±0.79 2.35±0.86 △ 3.16±0.81 1.89±0.68 △ | 3.32±1.06 1.02±1.13 * 3.54±0.82 1.99±0.83 △ 3.49±0.74 2.38±0.69 △ 3.38±1.17 1.97±0.56 * | 3.5±1.06 1.5±0.89 * 3.6±1.60 3.2±1.30 ▲ 4.1±1.07 3.6±1.11 △▲ 4.1±0.88 3.3±0.75 ▲ |
Annotate: expression is compared before dripping NA with matched group,
*P＜0.01,
△P＜0.05; Expression is compared after dripping NA with matched group,
▲P＜0.05
3, rat paw edema test
Get 32 of rats, be divided into four groups at random, 8 every group, be respectively blank group, prednisolone acetate group, technology 1., 2. extractum group.Rat after 30 minutes, causes inflammation (every 0.1ml) with sufficient sole of the foot of 3% formaldehyde injection in administration in the morning in the 10th day according to table 3ig administration 10 days, measures and causes first and second natural feet sole of the foot diameter of scorching back, and the difference of left and right sides diameter is the swelling degree, the results are shown in Table 3.
The influence of table 3 pair rat paw edema (x ± s)
| Group | Dosage (g/kg) | Cause scorching back swelling degree (cm) | |
| 24 hours | 48 hours | ||
| Blank group prednisone acetate group technology is 2. extractum group of extractum group technology 1. | - 0.1 0.010 0.014 | 0.998±0.324 0.652±0.124 * 0.702±0.153 * 0.701±0.169 * | 0.726±0.341 0.529±0.194 0.422±0.186 * 0.531±0.172 |
Annotate:
*Expression and blank group ratio, P＜0.05
Rat causes scorching back first day at formaldehyde, and three administration group pedal swelling degree are all light than the blank group, and its swelling degree is significantly less than blank group (P＜0.05).The foot sole of the foot causes scorching back second day, and three administration group swelling degree still all are lower than matched group, but have only 1. extractum group significance of technology.As seen, two extractum groups have with the suitable resist inflammation on repercussive function of prednisolone acetate, and technology 1. extractum group action time than the positive control group leader.
4, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment bones and muscles pain, the whole body is numb, hemiplegia, the medicine of diseases such as deviation of the mouth with numbness and paralysis, and change preparation technology, can obviously strengthen its expelling wind and activating blood circulation, clinical efficacies such as the strong muscle of strong waist, its hypotoxicity in addition, prolonged application safety, therefore, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Radix Aconiti (system) 100g Flos Carthami 10g Sanguis Draxonis 12.5g
Eupolyphaga Seu Steleophaga 10g Olibanum (deoiling) 5g Myrrha (deoiling) 5g
Pheretima 10g Scorpio 10g Radix Cyathulae 20g
Ramulus Cinnamomi 10g Radix Ginseng 10g
PEG4000 50g
Make 1000 balls
Preparation method:
(1) get Olibanum, Myrrha two flavor medical materials, adopt supercritical extraction: the medical material of pulverizing is dropped in the supercritical extraction reactor, when pressure reaches 35MPa, 55 ℃ of temperature, CO
2Flow is 15～35kg/h, and constant temperature and pressure extraction 3h discharging gets extract;
(2) get Flos Carthami, Scorpio, Radix Cyathulae, Radix Ginseng four Chinese medicine material, add ethanol and carry out reflux, extract, 3 times, the alcohol solvent consumption is 8 times of medical material amount, and concentration of alcohol is 80%, return time 1.0 hours.The ethanol extract concentrating under reduced pressure gets ethanol extraction;
(3) with the residue after the above supercritical extraction and the medicinal residues behind the ethanol extraction and Radix Aconiti, Eupolyphaga Seu Steleophaga, Pheretima, Ramulus Cinnamomi, extracting in water 3 times, amount of water are 6 times, each extraction time is 1.5 hours, and merge extractive liquid, filters, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 24 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, water extract;
(4) getting Sanguis Draxonis powder is broken in the above back adding of the 200 orders said extracted thing;
(5) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Radix Aconiti (system) 100g Flos Carthami 10g Sanguis Draxonis 12.5g
Eupolyphaga Seu Steleophaga 10g Olibanum (deoiling) 5g Myrrha (deoiling) 5g
Pheretima 10g Scorpio 10g Radix Cyathulae 20g
Ramulus Cinnamomi 10g Radix Ginseng 10g
PEG4000 50g
Make 1000
Preparation method:
(1) get Olibanum, Myrrha two flavor medical materials, adopt supercritical extraction: the medical material of pulverizing is dropped in the supercritical extraction reactor, when pressure reaches 35MPa, 55 ℃ of temperature, CO
2Flow is 15～35kg/h, and constant temperature and pressure extraction 3h discharging gets extract;
(2) get Flos Carthami, Scorpio, Radix Cyathulae, Radix Ginseng four Chinese medicine material, add ethanol and carry out reflux, extract, 3 times, the alcohol solvent consumption is 8 times of medical material amount, and concentration of alcohol is 80%, return time 1.0 hours.The ethanol extract concentrating under reduced pressure gets ethanol extraction;
(3) with the residue after the above supercritical extraction and the medicinal residues behind the ethanol extraction and Radix Aconiti, Eupolyphaga Seu Steleophaga, Pheretima, Ramulus Cinnamomi, extracting in water 3 times, amount of water are 6 times, each extraction time is 1.5 hours, and merge extractive liquid, filters, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 24 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, water extract;
(4) getting Sanguis Draxonis powder is broken in the above back adding of the 200 orders said extracted thing;
(5) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Radix Aconiti (system) 1200g Flos Carthami 120g Sanguis Draxonis 150g
Eupolyphaga Seu Steleophaga 120g Olibanum (deoiling) 60g Myrrha (deoiling) 60g
Pheretima 120g Scorpio 120g Radix Cyathulae 240g
Ramulus Cinnamomi 120g Radix Ginseng 120g
Make 1000g
Preparation method:
(1) get Sanguis Draxonis, Olibanum, Myrrha, Radix Ginseng and break into fine powder, standby;
(2) get Flos Carthami, Scorpio, Radix Cyathulae three flavor medical materials, add ethanol and carry out reflux, extract, 3 times, the alcohol solvent consumption is 8 times of medical material amount, and concentration of alcohol is 80%, return time 1.0 hours.The ethanol extract concentrating under reduced pressure gets ethanol extraction;
(3) with the residue after the above supercritical extraction and the medicinal residues behind the ethanol extraction and Radix Aconiti, Eupolyphaga Seu Steleophaga, Pheretima, Ramulus Cinnamomi, extracting in water 3 times, amount of water are 6 times, each extraction time is 1.5 hours, and merge extractive liquid, filters, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 24 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, water extract;
(4) above active component is merged, add aspartame 5.0g, dextrin 170.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Radix Aconiti (system) 100g Flos Carthami 10g Sanguis Draxonis 12.5g
Eupolyphaga Seu Steleophaga 10g Olibanum (deoiling) 5g Myrrha (deoiling) 5g
Pheretima 10g Scorpio 10g Radix Cyathulae 20g
Ramulus Cinnamomi 10g Radix Ginseng 10g
Make 1000
Preparation method:
(1) get Sanguis Draxonis, Olibanum, Myrrha, Radix Ginseng and break into fine powder, standby;
(2) get Flos Carthami, Scorpio, Radix Cyathulae three flavor medical materials, add ethanol and carry out reflux, extract, 3 times, the alcohol solvent consumption is 8 times of medical material amount, and concentration of alcohol is 80%, return time 1.0 hours.The ethanol extract concentrating under reduced pressure gets ethanol extraction;
(3) with the residue after the above supercritical extraction and the medicinal residues behind the ethanol extraction and Radix Aconiti, Eupolyphaga Seu Steleophaga, Pheretima, Ramulus Cinnamomi, extracting in water 3 times, amount of water are 6 times, each extraction time is 1.5 hours, and merge extractive liquid, filters, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 24 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, water extract;
(4) above active component is merged, add aspartame 3.0g, mannitol 130.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
12.5～150 parts of 10～120 parts of Sanguis Draxonis of 100～1200 parts of Flos Carthamis of Radix Aconiti (system)
5～60 parts of 5～60 parts of Myrrhas of 10～120 parts of Olibanums of Eupolyphaga Seu Steleophaga (deoiling) (deoiling)
20～240 parts of 10～120 portions of Radix Cyathulaes of 10～120 portions of Scorpios of Pheretima
10～120 parts of 10～120 parts of Radix Ginsengs of Ramulus Cinnamomi.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
50 parts of 40 parts of Sanguis Draxonis of 400 parts of Flos Carthamis of Radix Aconiti (system)
20 parts of 20 parts of Myrrhas of 40 parts of Olibanums of Eupolyphaga Seu Steleophaga (deoiling) (deoiling)
80 parts of 40 portions of Radix Cyathulaes of 40 portions of Scorpios of Pheretima
40 parts of 40 parts of Radix Ginsengs of Ramulus Cinnamomi.
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, capsule, granule, tablet, mixture, fluid extract and extractum, soft extract, powder.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get Olibanum, Myrrha two flavor medical materials, adopt supercritical extraction: the medical material of pulverizing is dropped in the supercritical extraction reactor, when pressure reaches 35MPa, 55 ℃ of temperature, the C02 flow is 15～35kg/h, constant temperature and pressure extraction 1～5h discharging, extract;
(2) get Flos Carthami, Scorpio, Radix Cyathulae, Radix Ginseng four Chinese medicine material, add ethanol and carry out reflux, extract, 2～4 times, the alcohol solvent consumption is 4～10 times of medical material amount, and concentration of alcohol is 50～90%, return time 0.5～2.0 hour.The ethanol extract concentrating under reduced pressure gets ethanol extraction;
(3) with the residue after the above supercritical extraction and the medicinal residues behind the ethanol extraction and Radix Aconiti, Eupolyphaga Seu Steleophaga, Pheretima, Ramulus Cinnamomi, extracting in water 2～4 times, amount of water is 4～10 times, each extraction time is 0.5～3 hour, merge extractive liquid,, filter, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 8～48 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, water extract;
(4) getting Sanguis Draxonis powder is broken in the above back adding of the 200 orders said extracted thing.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Sanguis Draxonis, Olibanum, Myrrha, Radix Ginseng and break into fine powder, standby;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and granule.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) get Olibanum, Myrrha two flavor medical materials, adopt supercritical extraction: the medical material of pulverizing is dropped in the supercritical extraction reactor, when pressure reaches 35MPa, 55 ℃ of temperature, CO
2Flow is 15～35kg/h, and constant temperature and pressure extraction 1～5h discharging gets extract;
(2) get Flos Carthami, Scorpio, Radix Cyathulae, Radix Ginseng four Chinese medicine material, add ethanol and carry out reflux, extract, 2～4 times, the alcohol solvent consumption is 4～10 times of medical material amount, and concentration of alcohol is 50～90%, return time 0.5～2.0 hour.The ethanol extract concentrating under reduced pressure gets ethanol extraction;
(3) with the residue after the above supercritical extraction and the medicinal residues behind the ethanol extraction and Radix Aconiti, Eupolyphaga Seu Steleophaga, Pheretima, Ramulus Cinnamomi, extracting in water 2～4 times, amount of water is 4～10 times, each extraction time is 0.5～3 hour, merge extractive liquid,, filter, filtrate decompression is concentrated into the clear paste of relative density 1.18～1.22 (50 ℃ of surveys), put coldly, add ethanol and make and contain alcohol amount and reach 50～80%, stir evenly, left standstill 8～48 hours, get supernatant and reclaim ethanol to be concentrated into relative density be 1.15～1.30 (50), drying, water extract;
(4) getting Sanguis Draxonis powder is broken in the above back adding of the 200 orders said extracted thing.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Sanguis Draxonis, Olibanum, Myrrha, Radix Ginseng and break into fine powder, standby;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and granule.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610081149 CN1879777A (en) | 2006-05-18 | 2006-05-18 | Blood circulation-invigorating tendon-strengthening preparation and method for preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610081149 CN1879777A (en) | 2006-05-18 | 2006-05-18 | Blood circulation-invigorating tendon-strengthening preparation and method for preparing same |
Publications (1)
| Publication Number | Publication Date |
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| CN1879777A true CN1879777A (en) | 2006-12-20 |
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| CN 200610081149 Pending CN1879777A (en) | 2006-05-18 | 2006-05-18 | Blood circulation-invigorating tendon-strengthening preparation and method for preparing same |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102824407A (en) * | 2012-09-07 | 2012-12-19 | 王小宇 | Traditional Chinese medicine dropping pill for treating arthritis and preparation method for traditional Chinese medicine dropping pill |
| CN115364151A (en) * | 2022-09-13 | 2022-11-22 | 上海市静安区中医医院 | Traditional Chinese medicine composition for treating hemiplegia after stroke and application thereof |
-
2006
- 2006-05-18 CN CN 200610081149 patent/CN1879777A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102824407A (en) * | 2012-09-07 | 2012-12-19 | 王小宇 | Traditional Chinese medicine dropping pill for treating arthritis and preparation method for traditional Chinese medicine dropping pill |
| CN102824407B (en) * | 2012-09-07 | 2016-01-20 | 王小宇 | A kind of Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold and preparation method thereof |
| CN115364151A (en) * | 2022-09-13 | 2022-11-22 | 上海市静安区中医医院 | Traditional Chinese medicine composition for treating hemiplegia after stroke and application thereof |
| CN115364151B (en) * | 2022-09-13 | 2023-10-24 | 上海市静安区中医医院 | Traditional Chinese medicine composition for treating hemiplegia after apoplexy and application thereof |
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