CN102824407A - Traditional Chinese medicine dropping pill for treating arthritis and preparation method for traditional Chinese medicine dropping pill - Google Patents

Abstract

The invention relates to a traditional Chinese medicine dropping pill for treating arthritis and a preparation method for the traditional Chinese medicine dropping pill. The traditional Chinese medicine dropping pill for treating the arthritis comprises the main drugs and a substrate, wherein the ratio of the main drugs to the substrate is (1:1)-(1:9) in parts by weight. The main drugs comprise nux vomica, scorpio, stiff silkworm, ephedra, rhizoma atractylodis, frankincense, myrrh, medicinal cyathula root, acanthopanax extract and liquorice. The preparation method for the traditional Chinese medicine dropping pill comprises the following steps of: firstly, mixing all main drugs to obtain a mixture; then, adding the mixture to the molten substrate; then, dropping the mixture of the main drugs and the substrate into condensate; and finally, drying to obtain the traditional Chinese medicine dropping pill. The traditional Chinese medicine dropping pill for treating the arthritis is low in cost and convenient in taking, convenient in carrying and has no toxic and side effects, and traditional Chinese medicine product preparation formulations for treating the arthritis are supplemented. Especially, the traditional Chinese medicine dropping pill also has the obvious advantages of rapid effect and high bioavailability.

Description

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine preparation of treating arthralgia aggravated by cold, particularly relate to a kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold and preparation method thereof.

Background technology

Arthralgia aggravated by cold; Names of disease of tcm is meant because positive QI-insufficiency, wind, cold, damp combined pathogens and be main invasion and attack human bodies with cold-evil; Cause the meridians impatency; QI-blood circulation is not smooth, and then causes that one type of disease of pain, clinical localized pain, pain play, pain alleviated while getting warmth, the pain increase in intensity under coldness etc. of mainly showing as take place for muscle, muscles and bones, joint.With respect to the doctor trained in Western medicine saying; Arthralgia aggravated by cold mainly comprises rheumatism and gout, for example rheumatic arthritis, rheumatoid arthritis, systemic lupus erythematosus (sle), scleroderma, polymyositis, sciatica, brachial plexus neuralgia, hyperplastic spondylitis, cervical spondylosis, calcanean spur, Kaschin-Beck disease, thromboangiitis obliterans, finger tip arteriospasm disease or the like.

The tcm product of existing treatment arthralgia aggravated by cold is much, and what gone on the market is peaceful etc. like medicinal capsule for treating rheumatalgia, gout Thailand, ZHENGQINGFENGTONGNING capsule (sheet, slow releasing tablet), sea snake for treating arthritis capsule, favour numbness; CN 1246348A also discloses a kind of medicinal capsule for treating rheumatalgia and preparation method thereof; This capsule main component comprises Semen Strychni, Sanguis Draxonis, diclofenac, prednisone, ibuprofen, Caulis et folium stauntoniae, indometacin, enteric ABC, compound recipe Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), can treat diseases such as rheumatism, rheumatoid arthritis, hyperosteogeny.

The common ground of the said goods is that with oral capsule or tablet be main dosage form, and ubiquity dissolves long, the problems such as dissolution is low, absorption difference, dose is big, bioavailability is low of time of loosing, and has a strong impact on the drug effect performance, and therapeutic effect is not remarkable; Secondly, capsule and tablet because the technology of granulation is arranged, can produce bigger dust pollution in the preparation process, not only pollute the environment, and also can staff's health be worked the mischief; Once more, owing to reasons such as technologies of preparing, the complex manufacturing of existing capsule and tablet, production cost is higher, makes patient's medicinal cost improve thereupon, is unfavorable for improving the ability of seeking medical advice of extensive patients, also is unfavorable for the raising of social total health level.

Drop pill is a kind of pharmaceutical dosage form that rises research the 1950's; In the Chinese Pharmacopoeia with drop pill definition as follows: mean medical material through appropriate method extraction, purification, concentrate and with the substrate heating and melting mixing that suits after; Splash in the not miscible condensed fluid, shrink condensation and the spherical or type spherical preparation processed.Drop pill is compared with the other drug dosage form; Production cycle is shorter, and quality is more easy to control, both can be made into quick releasing formulation and also can be made into slow releasing preparation; Can increase the dissolution rate and the dissolution of medicine stability, raising insoluble drug; Also can reduce zest and cover bad smell, also have workshop health, advantage that labor protection is good, so the application of drop pill in form of Chinese drug be more and more noticeable.The production principle of drop pill is to be formed through cooling rapidly by medicine and substrate consolute, so the selection of substrate and condensing agent is the key factor of preparation drop pill, is limited to technical reason, still has nothing to do at present in the report of the Chinese medicine dripping pills of treating arthralgia aggravated by cold.

Summary of the invention

One of the object of the invention is the deficiency to prior art; A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold is provided; The tcm product dosage form of supplement therapy arthralgia aggravated by cold; For the patient provides more more options, and integrate that produce effects is fast, bioavailability is high, have no side effect, taking convenience, be easy to carry, numerous advantages such as cheap.Two of the object of the invention is to provide the method for preparing of the Chinese medicine dripping pills of this treatment arthralgia aggravated by cold.

For one of achieving the above object, the present invention adopts following technical scheme:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold comprises principal agent and substrate; Said principal agent comprises Semen Strychni, Scorpio, Bombyx Batryticatus, Herba Ephedrae, Rhizoma Atractylodis, Olibanum, Myrrha, Radix Cyathulae, Radix Et Caulis Acanthopanacis Senticosi extractum, Radix Glycyrrhizae.

Preferably; Said principal agent is 1:1-1:9 with the ratio of the parts by weight of substrate, for example can be 1:1-1:3,1:2.5-1:6,1:4-1:7.8,1:5.45-1:8.45,1:7-1:9,1:1,1:1.07,1:1.6,1:2,1:2.8,1:3,1:3.4,1:4,1:4.6,1:5,1:5.9,1:6,1:6.2,1:7,1:7.5,1:8,1:8.1,1:9; Further be preferably 1:3-1:7; Most preferably be 1:5.

Said Semen Strychni is the conventional Chinese medicine material with functions such as removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating, expelling wind and removing dampness, is preferably Semen Strychni Pulveratum in the present invention, and promptly Semen Strychni (processed) is pulverized the fine powder of gained.The parts by weight of said Semen Strychni in the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention are preferably 25-75 part, for example can be 25-47.5 part, 32-56.5 part, 42.1-62.1 part, 48-58 part, 54-75 part, 25 parts, 26.4 parts, 29 parts, 30 parts, 33.7 parts, 35 parts, 36.1 parts, 40 parts, 41.8 parts, 45 parts, 47.2 parts, 50 parts, 52 parts, 55 parts, 59.6 parts, 60 parts, 60.4 parts, 63 parts, 65 parts, 68.2 parts, 70 parts, 72.5 parts, 75 parts; Further be preferably 40-60 part; Most preferably be 48.8 parts.

Said Scorpio is the conventional Chinese medicine material with functions such as endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; Its parts by weight in the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention are preferably 2-12 part, for example can be 2-7.2 part, 4.6-9.5 part, 5.5-8.3 part, 7.9-10 part, 3-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.7 parts, 8 parts, 8.2 parts, 9 parts, 9.5 parts, 10 parts, 10.25 parts, 11.7 parts, 12 parts; Further be preferably 3-9 part; Most preferably be 6.1 parts.

Said Bombyx Batryticatus is the conventional Chinese medicine material with functions such as relieving spasm by subduing liver-wind, wind-expelling pain-stopping, dissipating phlegm and resolving masses, is preferably Bombyx Batryticatus (parched with bran) in the present invention, and promptly warp and Testa Tritici stir the Bombyx Batryticatus of the process of preparing Chinese medicine, the Chinese medicine processing method that said parched with bran is well known to those skilled in the art.The parts by weight of said Bombyx Batryticatus in the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention are preferably 2-12 part, for example can be 2-4.1 part, 3.9-7.6 part, 6.5-9 part, 8.1-10.3 part, 7-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.7 parts, 8 parts, 8.7 parts, 9 parts, 9.5 parts, 10 parts, 10.2 parts, 11.4 parts, 12 parts; Further be preferably 3-9 part; Most preferably be 6.1 parts.

Said Herba Ephedrae is the conventional Chinese medicine material with functions such as diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema; Its parts by weight in the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention are preferably 2-12 part, for example can be 2-7.7 part, 4.6-6.4 part, 8.5-10.9 part, 3.1-11 part, 7-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.8 parts, 8 parts, 8.3 parts, 9 parts, 9.5 parts, 10 parts, 10.1 parts, 11.9 parts, 12 parts; Further be preferably 3-9 part; Most preferably be 6.1 parts.

Said Rhizoma Atractylodis are the conventional Chinese medicine materials with function such as drying damp and strengthening spleen, expelling wind and cold, preferred in the present invention parched with bran Rhizoma Atractylodis, and promptly warp and Testa Tritici stir the Rhizoma Atractylodis of the process of preparing Chinese medicine, the Chinese medicine processing method that said parched with bran is well known to those skilled in the art.The parts by weight of said Rhizoma Atractylodis in the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention are preferably 2-12 part, for example can be 2-8 part, 5.6-9.2 part, 7.5-11.5 part, 9.1-10 part, 4.8-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.65 parts, 8 parts, 8.6 parts, 9 parts, 9.5 parts, 10 parts, 10.8 parts, 11.1 parts, 12 parts; Further be preferably 3-9 part; Most preferably be 6.1 parts.

Said Olibanum is the conventional Chinese medicine material that has regulating qi and activating blood, eases pain, chases after functions such as poison, is preferably Olibanum (processed) in the present invention.The parts by weight of said Olibanum in the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention are preferably 2-12 part, for example can be 2-8.3 part, 3.9-7 part, 5.5-9 part, 7-11.1 part, 10-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.7 parts, 8 parts, 8.4 parts, 9 parts, 9.6 parts, 10 parts, 10.7 parts, 11.3 parts, 12 parts; Further be preferably 3-9 part; Most preferably be 6.1 parts.

Said Myrrha is the conventional Chinese medicine material with functions such as diffusing blood blood stasis removing, subduing swelling and relieving pain, is preferably Myrrha (processed) in the present invention.The parts by weight of said Myrrha in the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention are preferably 2-12 part, for example can be 2-4.5 part, 3-7.6 part, 6.5-9.8 part, 8.1-10.9 part, 5-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.7 parts, 8 parts, 8.2 parts, 9 parts, 9.5 parts, 10 parts, 10.3 parts, 11.5 parts, 12 parts; Further be preferably 3-9 part; Most preferably be 6.1 parts.

Said Radix Cyathulae be have dispel the wind, the conventional Chinese medicine material of dampness removing, function such as stimulate the menstrual flow, invigorate blood circulation; Its parts by weight in the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention are preferably 2-12 part, for example can be 2-8.3 part, 4.7-9.7 part, 5.5-8.5 part, 2.1-10 part, 7.4-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.6 parts, 8 parts, 8.7 parts, 9 parts, 9.5 parts, 10 parts, 10.8 parts, 11.2 parts, 12 parts; Further be preferably 3-9 part; Most preferably be 6.1 parts.

Said Radix Et Caulis Acanthopanacis Senticosi extractum is to be concentrated through alcohol reflux by the Chinese crude drug Radix Et Caulis Acanthopanacis Senticosi to form, and can have functions such as replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization through being purchased or the acquisition of self-control approach.The parts by weight of said Radix Et Caulis Acanthopanacis Senticosi extractum in the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention are preferably 0.5-5 part, for example can be 0.5-2.1 part, 0.75-3.08 part, 1.1-3.5 part, 2.6-4.8 part, 3.7-5 part, 0.5 part, 0.6 part, 0.83 part, 1 part, 1.2 parts, 1.44 parts, 1.5 parts, 1.89 parts, 2 parts, 2.07 parts, 2.3 parts, 2.5 parts, 2.75 parts, 3 parts, 3.16 parts, 3.6 parts, 3.9 parts, 4 parts, 4.05 parts, 4.4 parts, 4.5 parts, 4.82 parts, 5 parts; Further be preferably 1-4 part; Most preferably be 2.4 parts.

Said Radix Glycyrrhizae is the conventional Chinese medicine material with functions such as invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain and coordinating the actions of various ingredients in a prescription; Its parts by weight in the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention are preferably 2-12 part, for example can be 2-6.3 part, 5.7-8.1 part, 7.5-9.5 part, 3.1-10 part, 4.9-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.3 parts, 6 parts, 6.5 parts, 7 parts, 7.4 parts, 7.6 parts, 8 parts, 8.8 parts, 9 parts, 9.5 parts, 10 parts, 10.1 parts, 11.7 parts, 12 parts; Further be preferably 3-9 part; Most preferably be 6.1 parts.

Said substrate for those skilled in the art through being purchased or obtainable any one of self-control approach is used to prepare the substrate of drop pill, have the absorptive tissue transudate, accelerate the effect of rate of releasing drug; Be preferably water-soluble base; The combination of further preferred any one or at least two kinds in sodium lauryl sulphate, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, Polyethylene Glycol 8000, cetomacrogol 1000 0; Said combination is sodium lauryl sulphate/Macrogol 2000, Macrogol 4000/Polyethylene Glycol 8000, sodium lauryl sulphate/polyethylene glycol 6000, Macrogol 2000/polyethylene glycol 6000/Polyethylene Glycol 8000, sodium lauryl sulphate/Macrogol 4000/polyethylene glycol 6000/cetomacrogol 1000 0 etc. for example; Most preferably be Macrogol 2000 and/or Macrogol 4000.

In sum, the technical scheme after the optimization of the present invention is:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold, the ratio that comprises parts by weight are principal agent and the substrate of 1:1-1:9; Said principal agent comprises following composition by weight: Semen Strychni Pulveratum 25-75 part, Scorpio 2-12 part, Bombyx Batryticatus (parched with bran) 2-12 part, Herba Ephedrae 2-12 part, parched with bran Rhizoma Atractylodis 2-12 part, Olibanum (processed) 2-12 part, Myrrha (processed) 2-12 part, Radix Cyathulae 2-12 part, Radix Et Caulis Acanthopanacis Senticosi extractum 0.5-5 part, Radix Glycyrrhizae 2-12 part; Said substrate is water-soluble base.

Technical scheme after the present invention further optimizes is:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold, the ratio that comprises parts by weight are principal agent and the substrate of 1:3-1:7; Said principal agent comprises following composition by weight: Semen Strychni Pulveratum 40-60 part, Scorpio 3-9 part, Bombyx Batryticatus (parched with bran) 3-9 part, Herba Ephedrae 3-9 part, parched with bran Rhizoma Atractylodis 3-9 part, Olibanum (processed) 3-9 part, Myrrha (processed) 3-9 part, Radix Cyathulae 3-9 part, Radix Et Caulis Acanthopanacis Senticosi extractum 1-4 part, Radix Glycyrrhizae 3-9 part; Said substrate is selected from the combination of any one or at least two kinds in sodium lauryl sulphate, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, Polyethylene Glycol 8000, the cetomacrogol 1000 0.

The optimized technical scheme of the present invention is:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold, the ratio that comprises parts by weight are principal agent and the substrate of 1:5; Said principal agent comprises following composition by weight: 48.8 parts of Semen Strychni Pulveratums, 6.1 parts of Scorpios, 6.1 parts of Bombyx Batryticatus (parched with bran), 6.1 parts in Herba Ephedrae, 6.1 parts of parched with bran Rhizoma Atractylodis, 6.1 parts of Olibanum (processed)s, 6.1 parts of Myrrha (processed)s, 6.1 parts of Radix Cyathulaes, 2.4 parts of Radix Et Caulis Acanthopanacis Senticosi extractums, 6.1 parts in Radix Glycyrrhizae; Said substrate is Macrogol 2000 and/or Macrogol 4000.

" comprising " of the present invention, mean it except that said component, can also contain other components, the Chinese medicine dripping pills that these other components are given said treatment arthralgia aggravated by cold is with different characteristic.In addition, " comprising " of the present invention, can also replace with enclosed " being " or " by ... process ".

For achieve the above object two, the present invention adopts following technical scheme:

A kind of method for preparing of treating the Chinese medicine dripping pills of arthralgia aggravated by cold comprises the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the cold drying, mixed powder is broken into fine powder, and is subsequent use.

Preferably; Said cold drying is meant carries out drying under 50-70 ℃ temperature, for example can be 50-58.5 ℃, 54.2-67 ℃, 63.5-70 ℃, 50 ℃, 51 ℃, 52.5 ℃, 53 ℃, 55 ℃, 57.8 ℃, 59 ℃, 60 ℃, 61.7 ℃, 62 ℃, 64.3 ℃, 65 ℃, 66.4 ℃, 68 ℃, 69.1 ℃, 70 ℃; Further be preferably 55-65 ℃; Most preferably be 60 ℃.

Preferably, said fine powder is crossed sieve No. 8.

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water, decoction liquor is filtered, is concentrated, cooling.

Preferably, the number of times of said decoction is 1-3 time, for example can be 1 time, 2 times, 3 times; Further be preferably 2 times.

Preferably; Each time of said decoction is 0.5-3h, for example can be 0.5-1.2h, 0.71-1.63h, 1.45-2.7h, 1.9-2.82h, 2.6-3h, 0.5h, 0.6h, 0.8h, 0.94h, 1h, 1.05h, 1.1h, 1.3h, 1.5h, 1.68h, 1.7h, 1.84h, 2h, 2.17h, 2.3h, 2.4h, 2.5h, 2.76h, 2.9h, 3h; Further be preferably 1-2h; Most preferably be 1.5h.

Preferably; Said concentrate be meant and be concentrated into relative density 1.00-1.35 in the time of 50-85 ℃, for example relative density 1.35 during 1.21,85 ℃ of relative densities during 1.3,80.1 ℃ of relative densities during 1.24,75 ℃ of relative densities during 1.25,70 ℃ of relative densities during 1.14,65 ℃ of relative densities during 1.18,60 ℃ of relative densities during 1.00,55 ℃ of relative densities during 1.33,50 ℃ of relative densities when relative density 1.12 when relative density 1.05 50-62 ℃ time the, 54.5-79 ℃, 75-85 ℃; Relative density 1.1-1.2 when further being preferably 52-72 ℃; Relative density 1.15 when most preferably being 56 ℃.

Preferably, said being cooled to is cooled to room temperature.Cooling can prevent effectively that next step from adding alcoholic acid volatilization loss.

(3) in the cooled decoction liquor of step (2), add ethanol, static, filter, reclaim behind the ethanol refined liquid, refined liquid concentrate extract, subsequent use.

Preferably; Said alcoholic acid addition is to make to contain the alcohol amount in the decoction liquor that adds behind the ethanol and reach 10-85wt%, for example can be 10-37wt%, 18.2-57.4wt%, 46-76wt%, 51.3-61.3wt%, 69-85wt%, 10wt%, 12.4wt%, 15wt%, 20wt%, 25wt%, 30wt%, 35wt%, 40wt%, 41.8wt%, 45wt%, 50wt%, 55wt%, 60wt%, 65wt%, 67.2wt%, 70wt%, 75wt%, 80wt%, 85wt%; Further be preferably 50-80wt%; Most preferably be 75wt%.

Preferably; The said time of leaving standstill is 4-48h, for example can be 4-11h, 7.5-26.5h, 14-28.3h, 22-39h, 33-48h, 4h, 5h, 6.8h, 9.5h, 10h, 12.5h, 15h, 20h, 21.7h, 23.6h, 25h, 28h, 30h, 30.2h, 32h, 34.7h, 35h, 36.3h, 40h, 41h, 43.5h, 45h; Further be preferably 12-36h; Most preferably be 24h.

Preferably; Said concentrate be meant and be concentrated into that relative density is 1.00-1.45 in the time of 50-90 ℃, relative density 1.25-1.45 in the time of relative density 1.08-1.36 in the time of relative density 1.1-1.2 in the time of relative density 1.05-1.35 in the time of relative density 1.00-1.20 in the time of for example can being 50-62 ℃, 55-75 ℃, 64.8-84.8 ℃, 73-83 ℃, 81-90 ℃, relative density 1.45 during 1.35,90 ℃ of relative densities during 1.23,85 ℃ of relative densities during 1.4,80.1 ℃ of relative densities during 1.24,75 ℃ of relative densities during 1.25,70 ℃ of relative densities during 1.14,65 ℃ of relative densities during 1.18,60 ℃ of relative densities during 1.00,55 ℃ of relative densities 50 ℃ the time; Relative density 1.1-1.3 when further being preferably 52-72 ℃; Relative density 1.2 when most preferably being 56 ℃.

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, subsequent use.

Preferably, said fine powder is crossed sieve No. 8.

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, and is subsequent use.

Preferably, said fine powder is crossed sieve No. 8.

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture.

(7) take by weighing the substrate of formula ratio, place and carry out heating in water bath in the container, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate.

Preferably; The temperature of said heating in water bath is 70-90 ℃, for example can be 70-74.3 ℃, 73.5-82 ℃, 75-85 ℃, 79.1-89.1 ℃, 88-90 ℃, 70 ℃, 71 ℃, 72 ℃, 72.5 ℃, 73 ℃, 74.7 ℃, 75 ℃, 76 ℃, 77.2 ℃, 78.4 ℃, 80 ℃, 81.5 ℃, 83.6 ℃, 84 ℃, 86.9 ℃, 87 ℃, 89.5 ℃, 90 ℃; Further be preferably 75-85 ℃; Most preferably be 80 ℃.

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 70-90 ℃; The temperature of condensing agent remains on-5-40 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the condensing agent in the condensation column through water dropper.

Said water dropper temperature remains on 70-90 ℃, for example can be 70-78.3 ℃, 73.5-84 ℃, 77-87 ℃, 80.1-88 ℃, 83.2-90 ℃, 70 ℃, 71.5 ℃, 72 ℃, 73.2 ℃, 74.7 ℃, 75 ℃, 76 ℃, 77.2 ℃, 78.4 ℃, 80 ℃, 81.5 ℃, 83.6 ℃, 84 ℃, 86.9 ℃, 87 ℃, 89.5 ℃, 90 ℃; Further be preferably 75-85 ℃; Most preferably be 80 ℃.

The temperature of condensing agent remains on-5-40 ℃, for example can be-5-5 ℃ ,-3.5-14 ℃, 0.7-27 ℃, 10.1-30 ℃, 6.2-40 ℃ ,-5 ℃ ,-4 ℃ ,-2 ℃, 0 ℃, 1 ℃, 3.8 ℃, 6 ℃, 9.2 ℃, 10 ℃, 12.4 ℃, 15 ℃, 18.5 ℃, 20 ℃, 25 ℃, 26.9 ℃, 30 ℃, 32 ℃, 39.5 ℃, 40 ℃; Further be preferably 0-5 ℃; Most preferably be 1-2 ℃.

Preferably, said condensing agent is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil; Said combination is liquid paraffin/soybean oil, soybean oil/methyl-silicone oil, liquid paraffin/methyl-silicone oil, liquid paraffin/soybean oil/methyl-silicone oil for example; Further be preferably methyl-silicone oil.

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the condensing agent on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.

In sum, the technical scheme after the optimization of the present invention is:

A kind of method for preparing of treating the Chinese medicine dripping pills of arthralgia aggravated by cold comprises the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 50-70 ℃ the temperature, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 1-3 time, each 0.5-3h merges decoction liquor, filters, is concentrated into relative density 1.00-1.35 in the time of 50-85 ℃, cooling;

(3) in the cooled decoction liquor of step (2), add ethanol, make the alcohol amount of containing in the decoction liquor reach 10-85wt%, static 4-48h; Filter, reclaim behind the ethanol refined liquid, refined liquid is concentrated into that relative density is 1.00-1.45 in the time of 50-90 ℃; Get extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio; Place in the container and under 70-90 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion; Stir, obtain containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 70-90 ℃; The temperature of condensing agent remains on-5-40 ℃ in the condensation column; The fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the condensing agent in the condensation column through water dropper, and said condensing agent is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the condensing agent on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.

Technical scheme after the present invention further optimizes is:

A kind of method for preparing of treating the Chinese medicine dripping pills of arthralgia aggravated by cold comprises the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 55-65 ℃ the temperature, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 1-3 time, each 1-2h merges decoction liquor, filters, is concentrated into relative density 1.1-1.2 in the time of 52-72 ℃, is cooled to room temperature;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 50-80wt%, static 12-36h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into relative density 1.1-1.3 in the time of 52-72 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio; Place in the container and under 75-85 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion; Stir, obtain containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 75-85 ℃; The temperature of condensing agent remains on 0-5 ℃ in the condensation column; The fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the condensing agent in the condensation column through water dropper, and said condensing agent is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the condensing agent on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.

The optimized technical scheme of the present invention is:

A kind of method for preparing of treating the Chinese medicine dripping pills of arthralgia aggravated by cold comprises the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 60 ℃ the temperature, crosses sieve No. 8, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 2 times, each 1.5h merges decoction liquor, filters, is concentrated into relative density 1.15 in the time of 56 ℃, is cooled to room temperature;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 75wt%, static 24h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into relative density 1.2 in the time of 56 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross sieve No. 8, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses sieve No. 8, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio, place in the container and under 80 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 80 ℃; The temperature of condensing agent methyl-silicone oil remains on 1-2 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the methyl-silicone oil through water dropper;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the methyl-silicone oil on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.

The present invention is through rational formula and meticulous technological design; With less cost and method simple and easy to control prepare that produce effects is fast, bioavailability is high, taking convenience, be convenient to go out to carry, the Chinese medicine dripping pills of the treatment arthralgia aggravated by cold of safe without toxic side effect; Function is mainly expelling wind and removing dampness; Subduing swelling and relieving pain is applicable to that the various numbness due to the cold-damp resistance network are sick, clinically for muscles and bones arthralgia, swelling, numbness, weighing, joint stuffiness, chance are cold disease such as increases the weight of and all obtained good therapeutic effect.The Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention has been replenished the tcm product dosage form of treating arthralgia aggravated by cold, has enriched arthralgia aggravated by cold disease patient's selection, particularly has significant curative effect for rheumatism, rheumatoid.

Details are as follows for the clinical treatment situation of existing Chinese medicine dripping pills with treatment arthralgia aggravated by cold of the present invention:

(1) for arthralgia aggravated by cold patient's clinical treatment:

1, physical data:

Arthralgia aggravated by cold patient's 180 examples, wherein male 99 examples, women 81 examples, age 20-65 year, the course of disease 3 months-23 years.Main clinical manifestation is position pain or swelling such as joint, skin, muscles and bones, and morning, stiff, numbness weighed, or joint stuffiness, and very then joint swelling deformation is tetanic unfavorable, amyotrophy etc.Physico-chemical examination is seen, and anti-" O " increases, or erythrocyte sedimentation rate speeds, or rheumatoid factor is positive.The visible sclerotin infringement of X line.150 routine patients are divided into treatment at random and organize 100 examples (male 55 examples, women 45 examples) and matched group 80 examples (male 44 examples, women 36 examples), and two groups of patient's sexes, age, the course of disease, diseases are planted distribution basically identical, no statistical number difference.

2, Therapeutic Method:

The treatment group: the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention, oral, one time 1,2 times on the one.

Matched group: medicinal capsule for treating rheumatalgia (Hengba Pharmaceutical Co., Ltd., Guizhou, the accurate word Z20054248 of traditional Chinese medicines), oral, one time 2,2 times on the one.

Be 1 course of treatment all with 2 weeks, 1 course of treatment of patients whose symptoms were less severe's medication, 2-3 course of treatment of the heavier person's medication of symptom.

3, curative effect index:

Cure: symptom all disappears, and it is normal that functional activity recovers, and main doctor trained in Western medicine physical and chemical index inspections such as anti-" O ", erythrocyte sedimentation rate, rheumatoid factor are all normal, and the X line loses the sclerotin infringement.

Produce effects: symptomatology is eliminated or cardinal symptom is eliminated, and function of joint is recovered basically, can participate in operate as normal and work, and main doctor trained in Western medicine physical and chemical index inspections such as anti-" O ", erythrocyte sedimentation rate, rheumatoid factor are normal basically.

Effectively: cardinal symptom is eliminated basically, and function of joint is recovered basically or had made marked progress, and main doctor trained in Western medicine physical and chemical index inspections such as anti-" O ", erythrocyte sedimentation rate, rheumatoid factor make moderate progress.

Invalid: with the treatment before compare, each side does not all have progress.

4, therapeutic outcome: (as shown in table 1)

Table 1

	Cure	Produce effects	Effectively	Invalid	Total effective rate
						The treatment group	?57（57%）	30（30%）	?11（11%）	2（2%）	98%
Matched group	?42（52.5%）	23（28.75%）	?10（12.5%）	5（6.25%）	93.75%

Can find out that from table 1 medicine of the present invention is compared with the contrast medicine, is all obtaining obvious raising aspect cure rate, obvious effective rate and the total effective rate.

(2) for the clinical treatment of rheumatism, rheumatoid patient

1, physical data:

Rheumatism, rheumatoid patient 150 examples, wherein male 64 examples, women 86 examples, age 22-67 year, course of disease 0.5-21.Be divided into treatment at random and organize 90 examples (male 38 examples, women 52 examples) and matched group 60 examples (male 26 examples, women 34 examples), two groups of patient's sexes, age, the course of disease, diseases are planted distribution basically identical, no statistical number difference.

2, Therapeutic Method:

The treatment group: the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention, oral, one time 1,2 times on the one.

Matched group: medicinal capsule for treating rheumatalgia (Hengba Pharmaceutical Co., Ltd., Guizhou, the accurate word Z20054248 of traditional Chinese medicines), oral, one time 2,2 times on the one.

Be 1 course of treatment all with 2 weeks, 1 course of treatment of patients whose symptoms were less severe's medication, 2-3 course of treatment of the heavier person's medication of symptom.

3, curative effect index:

Cure: symptom all disappears, and it is normal that functional activity recovers, and main doctor trained in Western medicine physical and chemical index inspection is normal.

Produce effects: symptomatology is eliminated or cardinal symptom is eliminated, and function of joint is recovered basically, can participate in operate as normal and work, and main doctor trained in Western medicine physical and chemical index is normal basically.

Effectively: cardinal symptom is eliminated basically, and main function of joint is recovered basically or had made marked progress, and main doctor trained in Western medicine physical and chemical index inspection makes moderate progress.

Invalid: with the treatment before compare, each side does not all have progress.

4, therapeutic outcome: (as shown in table 2)

Table 2

	Cure	Produce effects	Effectively	Invalid	Total effective rate
						The treatment group	53（58.89%）	31（34.44%）	5（5.56%）	1（1.11%）	98.89%
Matched group	32（53.33%）	19（31.67%）	6（10%）	3（5%）	95%

Can find out that from table 2 medicine of the present invention is compared with the contrast medicine, aspect rheumatism, rheumatoid cure rate, obvious effective rate and total effective rate, is all obtaining obvious raising.

Below in conjunction with embodiment the present invention is done further explain.But following embodiment only is a simple and easy example of the present invention, does not represent or limits rights protection scope of the present invention, and interest field of the present invention is as the criterion with claims.

The specific embodiment

For the present invention is described better, be convenient to understand technical scheme of the present invention, existing with several groups of specific embodiments, be described further with regard to the method for preparing of Bitongning drop pill of the present invention.

Embodiment 1:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold, the ratio that comprises parts by weight are principal agent and the substrate of 1:5; Said principal agent comprises following composition by weight: 48.8 parts of Semen Strychni Pulveratums, 6.1 parts of Scorpios, 6.1 parts of Bombyx Batryticatus (parched with bran), 6.1 parts in Herba Ephedrae, 6.1 parts of parched with bran Rhizoma Atractylodis, 6.1 parts of Olibanum (processed)s, 6.1 parts of Myrrha (processed)s, 6.1 parts of Radix Cyathulaes, 2.4 parts of Radix Et Caulis Acanthopanacis Senticosi extractums, 6.1 parts in Radix Glycyrrhizae; Said substrate is Macrogol 2000.

The method for preparing of the Chinese medicine dripping pills of above-mentioned treatment arthralgia aggravated by cold comprises the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 60 ℃ the temperature, crosses sieve No. 8, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 2 times, each 1.5h merges decoction liquor, filters, is concentrated into relative density 1.15 in the time of 56 ℃, is cooled to room temperature;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 75wt%, static 24h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into relative density 1.2 in the time of 56 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross sieve No. 8, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses sieve No. 8, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio, place in the container and under 80 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 80 ℃; The temperature of condensing agent methyl-silicone oil remains on 1-2 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the methyl-silicone oil through water dropper;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the methyl-silicone oil on surface, drying.

Embodiment 2:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold, the ratio that comprises parts by weight are principal agent and the substrate of 1:2; Said principal agent comprises following composition by weight: 42 parts of Semen Strychni Pulveratums, 7 parts of Scorpios, 7 parts of Bombyx Batryticatus (parched with bran), 7 parts in Herba Ephedrae, 7 parts of parched with bran Rhizoma Atractylodis, 7 parts of Olibanum (processed)s, 7 parts of Myrrha (processed)s, 7 parts of Radix Cyathulaes, 2 parts of Radix Et Caulis Acanthopanacis Senticosi extractums, 7 parts in Radix Glycyrrhizae; Said substrate is Macrogol 4000 and the polyethylene glycol 6000 of mass ratio 1:1.

The method for preparing of the Chinese medicine dripping pills of above-mentioned treatment arthralgia aggravated by cold comprises the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 60 ℃ the temperature, crosses sieve No. 8, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 2 times, each 1h merges decoction liquor, filters, is concentrated into relative density 1.15 in the time of 56 ℃, is cooled to room temperature;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 75wt%, static 24h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into relative density 1.2 in the time of 56 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross sieve No. 8, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses sieve No. 8, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio, place in the container and under 80 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 80 ℃; The temperature of condensing agent methyl-silicone oil remains on 1-4 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the methyl-silicone oil through water dropper;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the methyl-silicone oil on surface, drying.

Embodiment 3:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold, the ratio that comprises parts by weight are principal agent and the substrate of 1:3; Said principal agent comprises following composition by weight: 49 parts of Semen Strychni Pulveratums, 6 parts of Scorpios, 6 parts of Bombyx Batryticatus (parched with bran), 6 parts in Herba Ephedrae, 6 parts of parched with bran Rhizoma Atractylodis, 6 parts of Olibanum (processed)s, 6 parts of Myrrha (processed)s, 6 parts of Radix Cyathulaes, 3 parts of Radix Et Caulis Acanthopanacis Senticosi extractums, 6 parts in Radix Glycyrrhizae; Said substrate is Macrogol 4000.

The method for preparing of the Chinese medicine dripping pills of above-mentioned treatment arthralgia aggravated by cold comprises the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 60 ℃ the temperature, crosses sieve No. 8, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 2 times, each 1h merges decoction liquor, filters, is concentrated into relative density 1.15 in the time of 56 ℃, is cooled to room temperature;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 75wt%, static 24h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into relative density 1.2 in the time of 56 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross sieve No. 8, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses sieve No. 8, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio, place in the container and under 80 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 80 ℃; The temperature of condensing agent liquid paraffin remains on 1-2 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the liquid paraffin through water dropper;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the liquid paraffin on surface, drying.

Embodiment 4:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold, the ratio that comprises parts by weight are principal agent and the substrate of 1:3; Said principal agent comprises following composition by weight: 50 parts of Semen Strychni Pulveratums, 6 parts of Scorpios, 6 parts of Bombyx Batryticatus (parched with bran), 6 parts in Herba Ephedrae, 6 parts of parched with bran Rhizoma Atractylodis, 6 parts of Olibanum (processed)s, 6 parts of Myrrha (processed)s, 6 parts of Radix Cyathulaes, 2 parts of Radix Et Caulis Acanthopanacis Senticosi extractums, 6 parts in Radix Glycyrrhizae; Said substrate is polyethylene glycol 6000.

The method for preparing of the Chinese medicine dripping pills of above-mentioned treatment arthralgia aggravated by cold comprises the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 60 ℃ the temperature, crosses sieve No. 8, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 2 times, each 1h merges decoction liquor, filters, is concentrated into relative density 1.15 in the time of 56 ℃, is cooled to room temperature;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 75wt%, static 24h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into relative density 1.2 in the time of 56 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross sieve No. 8, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses sieve No. 8, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio, place in the container and under 80 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 80 ℃; The temperature of condensing agent soybean oil remains on 1-2 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the soybean oil through water dropper;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the soybean oil on surface, drying.

Embodiment 5:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold, the ratio that comprises parts by weight are principal agent and the substrate of 1:7; Said principal agent comprises following composition by weight: 40 parts of Semen Strychni Pulveratums, 3 parts of Scorpios, 3 parts of Bombyx Batryticatus (parched with bran), 3 parts in Herba Ephedrae, 3 parts of parched with bran Rhizoma Atractylodis, 3 parts of Olibanum (processed)s, 3 parts of Myrrha (processed)s, 3 parts of Radix Cyathulaes, 1 part of Radix Et Caulis Acanthopanacis Senticosi extractum, 3 parts in Radix Glycyrrhizae; Said substrate is sodium lauryl sulphate.

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 65 ℃ the temperature, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 3 times, each 1h merges decoction liquor, filters, is concentrated into relative density 1.2 in the time of 72 ℃, is cooled to room temperature;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 80wt%, static 36h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into relative density 1.3 in the time of 72 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio, place in the container and under 85 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 85 ℃; The temperature of condensing agent liquid paraffin remains on 5 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the liquid paraffin in the condensation column through water dropper;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the liquid paraffin on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.

Embodiment 6:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold, the ratio that comprises parts by weight are principal agent and the substrate of 1:3; Said principal agent comprises following composition by weight: 60 parts of Semen Strychni Pulveratums, 9 parts of Scorpios, 9 parts of Bombyx Batryticatus (parched with bran), 9 parts in Herba Ephedrae, 9 parts of parched with bran Rhizoma Atractylodis, 9 parts of Olibanum (processed)s, 9 parts of Myrrha (processed)s, 9 parts of Radix Cyathulaes, 4 parts of Radix Et Caulis Acanthopanacis Senticosi extractums, 9 parts in Radix Glycyrrhizae; Said substrate is cetomacrogol 1000 0.

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 55 ℃ the temperature, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 1 time, each 2h merges decoction liquor, filters, is concentrated into relative density 1.1 in the time of 52 ℃, is cooled to room temperature;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 50wt%, static 12h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into relative density 1.1 in the time of 52 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio, place in the container and under 75 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 75 ℃; The temperature of condensing agent soybean oil remains on 0 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the soybean oil in the condensation column through water dropper;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the soybean oil on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.

Embodiment 7:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold, the ratio that comprises parts by weight are principal agent and the substrate of 1:9; Said principal agent comprises following composition by weight: 75 parts of Semen Strychni Pulveratums, 12 parts of Scorpios, 12 parts of Bombyx Batryticatus (parched with bran), 12 parts in Herba Ephedrae, 12 parts of parched with bran Rhizoma Atractylodis, 12 parts of Olibanum (processed)s, 12 parts of Myrrha (processed)s, 12 parts of Radix Cyathulaes, 5 parts of Radix Et Caulis Acanthopanacis Senticosi extractums, 12 parts in Radix Glycyrrhizae; Said substrate is polyethylene glycol 6000 and the Polyethylene Glycol 8000 of mass ratio 2:1.

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 70 ℃ the temperature, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 3 times, each 0.5h merges decoction liquor, filters, is concentrated into relative density 1.35 in the time of 85 ℃, cooling;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 85wt%, static 48h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into that relative density is 1.45 in the time of 90 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio, place in the container and under 90 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 90 ℃; The temperature of condensing agent liquid paraffin remains on 40 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the liquid paraffin in the condensation column through water dropper;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the liquid paraffin on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.

Embodiment 8:

A kind of Chinese medicine dripping pills of treating arthralgia aggravated by cold, the ratio that comprises parts by weight are principal agent and the substrate of 1:1; Said principal agent comprises following composition by weight: 25 parts of Semen Strychni Pulveratums, 2 parts of Scorpios, 2 parts of Bombyx Batryticatus (parched with bran), 2 parts in Herba Ephedrae, 2 parts of parched with bran Rhizoma Atractylodis, 2 parts of Olibanum (processed)s, 2 parts of Myrrha (processed)s, 2 parts of Radix Cyathulaes, 0.5 part of Radix Et Caulis Acanthopanacis Senticosi extractum, 2 parts in Radix Glycyrrhizae; Said substrate is Macrogol 4000 and the Polyethylene Glycol 8000 of mass ratio 1:2.

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 50 ℃ the temperature, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 1 time, each 3h merges decoction liquor, filters, is concentrated into relative density 1.00 in the time of 50 ℃, cooling;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 10wt%, static 4h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into that relative density is 1.00 in the time of 50 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio, place in the container and under 70 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 70 ℃; The temperature of condensing agent methyl-silicone oil remains on-5 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the methyl-silicone oil in the condensation column through water dropper;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the methyl-silicone oil on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.

Should be noted that and understand, under the situation that does not break away from the desired the spirit and scope of the present invention of accompanying Claim, can make various modifications and improvement the present invention of above-mentioned detailed description.Therefore, the scope of the technical scheme of requirement protection does not receive the restriction of given any specific exemplary teachings.

Applicant's statement, above content are to combine concrete preferred implementation to the further explain that the present invention did, and can not assert that practical implementation of the present invention is confined to these explanations.For the those of ordinary skill of technical field under the present invention, under the prerequisite that does not break away from the present invention's design, can also make some simple deduction or replace, all should be regarded as belonging to protection scope of the present invention.

Claims (10)

1. a Chinese medicine dripping pills of treating arthralgia aggravated by cold is characterized in that, comprises principal agent and substrate; Said principal agent comprises Semen Strychni, Scorpio, Bombyx Batryticatus, Herba Ephedrae, Rhizoma Atractylodis, Olibanum, Myrrha, Radix Cyathulae, Radix Et Caulis Acanthopanacis Senticosi extractum, Radix Glycyrrhizae.

2. the Chinese medicine dripping pills of treatment arthralgia aggravated by cold according to claim 1 is characterized in that, said principal agent is 1:1-1:9 with the ratio of the parts by weight of substrate, is preferably 1:3-1:7, most preferably is 1:5.

3. the Chinese medicine dripping pills of treatment arthralgia aggravated by cold according to claim 1 and 2; It is characterized in that said principal agent comprises following composition by weight: Semen Strychni Pulveratum 25-75 part, Scorpio 2-12 part, Bombyx Batryticatus (parched with bran) 2-12 part, Herba Ephedrae 2-12 part, parched with bran Rhizoma Atractylodis 2-12 part, Olibanum (processed) 2-12 part, Myrrha (processed) 2-12 part, Radix Cyathulae 2-12 part, Radix Et Caulis Acanthopanacis Senticosi extractum 0.5-5 part, Radix Glycyrrhizae 2-12 part; Said substrate is water-soluble base.

4. according to the Chinese medicine dripping pills of the described treatment arthralgia aggravated by cold of one of claim 1-3; It is characterized in that said principal agent comprises following composition by weight: Semen Strychni Pulveratum 40-60 part, Scorpio 3-9 part, Bombyx Batryticatus (parched with bran) 3-9 part, Herba Ephedrae 3-9 part, parched with bran Rhizoma Atractylodis 3-9 part, Olibanum (processed) 3-9 part, Myrrha (processed) 3-9 part, Radix Cyathulae 3-9 part, Radix Et Caulis Acanthopanacis Senticosi extractum 1-4 part, Radix Glycyrrhizae 3-9 part; Said substrate is selected from the combination of any one or at least two kinds in sodium lauryl sulphate, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, Polyethylene Glycol 8000, the cetomacrogol 1000 0.

5. according to the Chinese medicine dripping pills of the described treatment arthralgia aggravated by cold of one of claim 1-4; It is characterized in that said principal agent comprises following composition by weight: 48.8 parts of Semen Strychni Pulveratums, 6.1 parts of Scorpios, 6.1 parts of Bombyx Batryticatus (parched with bran), 6.1 parts in Herba Ephedrae, 6.1 parts of parched with bran Rhizoma Atractylodis, 6.1 parts of Olibanum (processed)s, 6.1 parts of Myrrha (processed)s, 6.1 parts of Radix Cyathulaes, 2.4 parts of Radix Et Caulis Acanthopanacis Senticosi extractums, 6.1 parts in Radix Glycyrrhizae; Said substrate is Macrogol 2000 and/or Macrogol 4000.

6. according to the method for preparing of the Chinese medicine dripping pills of the described treatment arthralgia aggravated by cold of claim 1-5, it is characterized in that, comprise the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the cold drying, mixed powder is broken into fine powder, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water, decoction liquor is filtered, is concentrated, cooling;

(3) in the cooled decoction liquor of step (2), add ethanol, static, filter, reclaim behind the ethanol refined liquid, refined liquid concentrate extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio, place and carry out heating in water bath in the container, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 70-90 ℃; The temperature of condensing agent remains on-5-40 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the condensing agent in the condensation column through water dropper;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the condensing agent on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.

7. method for preparing according to claim 6 is characterized in that, condensing agent described in the step (8) is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil.

8. according to claim 6 or 7 described method for preparinies, it is characterized in that, comprise the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 50-70 ℃ the temperature, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 1-3 time, each 0.5-3h merges decoction liquor, filters, is concentrated into relative density 1.00-1.35 in the time of 50-85 ℃, cooling;

(3) in the cooled decoction liquor of step (2), add ethanol, make the alcohol amount of containing in the decoction liquor reach 10-85wt%, static 4-48h; Filter, reclaim behind the ethanol refined liquid, refined liquid is concentrated into that relative density is 1.00-1.45 in the time of 50-90 ℃; Get extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio; Place in the container and under 70-90 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion; Stir, obtain containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 70-90 ℃; The temperature of condensing agent remains on-5-40 ℃ in the condensation column; The fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the condensing agent in the condensation column through water dropper, and said condensing agent is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the condensing agent on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.

9. according to the method for preparing of the Chinese medicine dripping pills of the described treatment arthralgia aggravated by cold of one of claim 6-8, it is characterized in that, comprise the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 55-65 ℃ the temperature, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 1-3 time, each 1-2h merges decoction liquor, filters, is concentrated into relative density 1.1-1.2 in the time of 52-72 ℃, is cooled to room temperature;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 50-80wt%, static 12-36h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into relative density 1.1-1.3 in the time of 52-72 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio; Place in the container and under 75-85 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion; Stir, obtain containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 75-85 ℃; The temperature of condensing agent remains on 0-5 ℃ in the condensation column; The fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the condensing agent in the condensation column through water dropper, and said condensing agent is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the condensing agent on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.

10. according to the described method for preparing of one of claim 6-9, it is characterized in that, comprise the steps:

(1) take by weighing Scorpio, Rhizoma Atractylodis, Olibanum, the Myrrha of formula ratio, after the drying, mixed powder is broken into fine powder under 60 ℃ the temperature, crosses sieve No. 8, and is subsequent use;

(2) take by weighing Bombyx Batryticatus, Herba Ephedrae, Radix Cyathulae, the Radix Glycyrrhizae of formula ratio, decocte with water 2 times, each 1.5h merges decoction liquor, filters, is concentrated into relative density 1.15 in the time of 56 ℃, is cooled to room temperature;

(3) in the cooled decoction liquor of step (2), add ethanol, make to contain alcohol amount in the decoction liquor and reach 75wt%, static 24h filters, reclaim behind the ethanol refined liquid, refined liquid is concentrated into relative density 1.2 in the time of 56 ℃, extract, subsequent use;

(4) take by weighing the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross sieve No. 8, subsequent use;

(5) take by weighing the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses sieve No. 8, and is subsequent use;

(6) with step (3) extract that obtains and the fine powder mix homogeneously that (1), (4), (5) obtain, get the principal agent mixture;

(7) take by weighing the substrate of formula ratio, place in the container and under 80 ℃ temperature, carry out heating in water bath, the substrate in the container that heats while stirring adds the principal agent mixture of step (6) to its complete fusion, stirs, and obtains containing the fused solution of medicine and substrate;

(8) temperature control system of adjustment drop pill machine; Make the water dropper temperature of drop pill machine remain on 80 ℃; The temperature of condensing agent methyl-silicone oil remains on 1-2 ℃ in the condensation column, and the fused solution that step (7) is obtained places in the water dropper jar of drop pill machine, splashes in the methyl-silicone oil through water dropper;

(9) export the drop pill that will shrink molding from the drop pill machine and take out, absorb the methyl-silicone oil on surface, promptly get the Chinese medicine dripping pills of treatment arthralgia aggravated by cold of the present invention after the drying.