CN1256130C - Preparation of Chinese traditional medicine for curing skin disease - Google Patents

Abstract

The present invention relates to a traditional Chinese medicinal preparation for treating skin diseases, which more specifically is Chinese patent medicine prepared from Chinese herbal medicine as raw material. The present invention is prepared from fineleaf schizonepeta herb, ledebouriella root, cicada slough, garter snake, stiff silkorm, densefruit pittany root-bark, lightyellow sophora root, water plantain, gypsum, common anemarrhena rhizome, angelica, rehmanniae and radix glycyrrhiza, and the present invention is in the form of any preparations disclosed in pharmacy. The present invention has the compatibility characteristics that the present invention focuses on expelling wind and is a product for eliminating heat, dispelling dampness, nourishing the blood and dredging channels; the present invention aims to eliminate pathogen and strengthen vital qi, and the present invention can eliminate wind, dispell dampness and nourish the blood so as to expel wind. Therefore, rheumatism is cured, the blood vessel is regulated, and pruritus automatically disappears. The present invention has the advantages of reasonable, effective and safe formula, easy acquirement of raw material, low cost and obvious social benefit and economic benefit after industrialized production.

Description

The dermopathic Chinese medicine preparation of a kind of treatment

One, technical field

The present invention relates to the dermopathic Chinese medicine preparation of a kind of treatment, specifically is the Chinese patent medicine of feedstock production with the Chinese herbal medicine.

Two, background technology

Dermatosiss such as eczema, dermatitis, urticaria, skin pruritus are dermatology common disease, frequently-occurring disease, treat rather thorny.The present medicine that uses mostly takes effect slowly, the course of treatment is long, can not remove old complaint, easily recurrence, and the part medicine also has certain toxic and side effects, and not retrieving in the prior art has good therapeutic effect to above-mentioned dermatosis, and the Chinese medicine that has no side effect.

Three, summary of the invention

The object of the present invention is to provide a kind of Chinese medicine preparation that above-mentioned dermatosis is had good therapeutic effect and has no side effect.

For achieving the above object, it is that feedstock production becomes a kind of Chinese patent medicine that the present invention adopts multiple Chinese herbal medicine.It is made up of the component of following parts by weight:

Herba Schizonepetae 500-600 Radix Saposhnikoviae 500-600 Periostracum Cicadae 300-360

Zaocys 500-600 Bombyx Batryticatus 500-600 Cortex Dictamni 750-900

Radix Sophorae Flavescentis 750-900 Rhizoma Alismatis 500-600 Gypsum Fibrosum 1500-1800

Rhizoma Anemarrhenae 500-600 Radix Angelicae Sinensis 1000-1200 Radix Rehmanniae 1000-1200

Radix Glycyrrhizae 300-360.

The optimization formula of preparation Chinese medicine preparation of the present invention is:

Herba Schizonepetae 530-580 Radix Saposhnikoviae 500-550 Periostracum Cicadae 300-330

Zaocys 550-600 Bombyx Batryticatus 530-580 Cortex Dictamni 800-850

Radix Sophorae Flavescentis 800-850 Rhizoma Alismatis 500-550 Gypsum Fibrosum 1600-1700

Rhizoma Anemarrhenae 530-580 Radix Angelicae Sinensis 1000-1100 Radix Rehmanniae 1100-1200

Radix Glycyrrhizae 330-360.

Chinese medicine preparation of the present invention can be said dosage form on any pharmaceutics, as: granule, tablet, capsule, oral liquid, pill, syrup agent, buccal tablet, effervescent tablet, dispersible tablet.

The traditional Chinese medical science thinks that dermatosiss such as eczema, dermatitis, urticaria, skin pruritus are itching skin disease, how by the heresy invasion and attack human body of wind heat or rheumatism, the contamination blood vessels, interior must not catharsis, must not reach thoroughly outward, strongly fragrant between the skin space between skin and muscles due to." all wind of itching " is main so control should dispelling wind antipruritic, and it is auxilliary cooperating removing damp-heat, nourshing blood and promoting blood circulation.XIAOFENG SAN has that dispelling wind nourishes blood, the effect of removing damp-heat, is the classics recipe of motherland's traditional medicine treatment rubella, eczema." control wind and control blood, blood sector-style earlier " from going out.The present invention is on the basis of XIAOFENG SAN, deduct Fructus Cannabis, the Fructus Arctii of intestine moistening, laxation, add with the stronger Zaocys of dispelling wind for relieving itching effect, Bombyx Batryticatus, to strengthen the merit of dispelling wind and removing obstruction in the collateral, using pungent drugs for dispersion and bitter drugs for purgation space between skin and muscles, the Cortex Dictamni that dispels the wind with detoxifcation dehumidifying substitutes the Rhizoma Atractylodis of warm-dryness syndrome, replace Caulis Akebiae with the Rhizoma Alismatis that the strong promoting diuresis to eliminate damp pathogen effect of expelling the heat-evil is arranged, the product of reusing blood nourishing acupuncture-stimulatings such as Radix Rehmanniae, Radix Angelicae Sinensis are to help dispelling wind, thereby its dispelling wind nourishes blood, the effect of removing damp-heat is more obvious than XIAOFENG SAN, have antibacterial, the anti-allergy action of stronger antiinflammatory, thereby clinical efficacy is remarkable.The present invention is made up of medicines such as Radix Saposhnikoviae, Bombyx Batryticatus, Radix Angelicae Sinensis, Gypsum Fibrosum, has that dispelling wind nourishes blood, the effect of removing damp-heat, mainly is applicable to the dermatosis of wind heat and damp-heat syndrome, and is particularly remarkable to wind heat or eczema due to dampness-heat, dermatitis, urticaria and skin pruritus curative effect.Dialectical main points are the erythema pimple, ooze out erosion, scarlet or pale red welt scratch, light red tongue is yellow or yellow greasy, floating and rapid pulse, stringy and rolling pulse or sliding number.

Herba Schizonepetae, Radix Saposhnikoviae, Periostracum Cicadae are monarch drug in the present invention's prescription.

Herba Schizonepetae suffering, flat, tepor.Return lung, Liver Channel.Have expelling pathogenic wind from the body surface, the antipruritic effect of rash.

Radix Saposhnikoviae suffering, sweet, tepor.Return bladder, liver, spleen channel.Have expelling pathogenic wind from the body surface, win wet antipruritic effect.Be the patient with susceptibility to wind pathogen principal agent, the profit agent in the medicine that dispels the wind.

Periostracum Cicadae is sweet, cold.Return lung, Liver Channel.Have dispelling wind and heat pathogens, rash is antipruritic, the effect of the expelling wind to relieve convulsion.

Three medicines share, and are total to the long memorial wind, relieving exterior syndrome, and victory wets antipruritic effect and is monarch drug.

Zaocys, Bombyx Batryticatus, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Alismatis are ministerial drug altogether.

Zaocys is sweet, flat.Return Liver Channel.Have dispel the wind, the effect of collateral dredging, arresting convulsion.

Bombyx Batryticatus becomes, suffering, flat.Return liver, lung meridian, have that dispelling wind is antipruritic, the effect of endogenous wind stopping relieving convulsion.

Cortex Dictamni hardship, cold.Return spleen, stomach warp, have heat-clearing and toxic substances removing, the effect of dehumidifying dispelling wind for relieving itching.

Radix Sophorae Flavescentis hardship, cold.GUIXIN, liver, stomach, Da Tang, urinary bladder channel have the effect of heat clearing and damp drying, wind dispelling insecticide.

Rhizoma Alismatis is sweet, light, cold.Return kidney, urinary bladder channel.Has stronger promoting diuresis to eliminate damp pathogen.The effect of clearing away damp-heat from lower-JIAO.

Zaocys, Bombyx Batryticatus dispelling wind and removing obstruction in the collateral, using pungent drugs for dispersion and bitter drugs for purgation space between skin and muscles; Cortex Dictamni detoxifcation dehumidifying, dispelling wind for relieving itching, Radix Sophorae Flavescentis heat clearing and damp drying, Rhizoma Alismatis is oozed dampness removing heat.More than five medicines work in coordination, have dispelling wind for relieving itching, the effect of detoxifcation dehumidifying is assisted the monarch drug expelling wind and dampness and is ministerial drug.

Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, Radix Rehmanniae are adjuvant drug.

Gypsum Fibrosum suffering, sweet, Great Cold.Attach to the lung and stomach meridians, have clearing away heat-fire, the effect that relieving restlessness is quenched the thirst is the key medicine of the clear branch excess-heat that loses heart.

Rhizoma Anemarrhenae hardship, sweet, cold.Return lung, stomach, kidney channel.Has clearing away heat-fire, nourshing Yin and drynsessmoistening prescription effect.But supernatant lung-fire, middle clearing stomach fire, following clear kidney fire.

Radix Angelicae Sinensis is sweet, hot, warm.Return liver, the heart, spleen channel.Effect with nourshing blood and promoting blood circulation collateral dredging.

Radix Rehmanniae is sweet, bitter, cold.GUIXIN, liver, kidney channel have the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, are the key medicine of removing heat from blood yin nourishing.

Gypsum Fibrosum, the Rhizoma Anemarrhenae, clearing away heat-fire, Radix Angelicae Sinensis, Radix Rehmanniae nourshing blood and promoting blood circulation collateral dredging, more than four medicines be adjuvant drug altogether, the dispel the wind detoxifcation dehumidifying of auxiliary monarch-minister drug.

Radix Glycyrrhizae is sweet, flat.GUIXIN, lung, spleen, stomach warp.Function with invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, mitigation property of medicine, the above all medicines that are in harmonious proportion are messenger drug.

Compatibility characteristics of the present invention to be dispeling the wind, and the product of compatibility heat clearing away, damp eliminating, blood nourishing acupuncture-stimulating are eliminating evilly taken into account with setting upright, can the expelling wind and removing dampness collateral dredging, can nourish blood again to help dispelling wind, and rheumatism is removed, blood vessels are in harmonious proportion, and then pruritus is from ending.

In recent years, routine case surplus the present invention collects 1000 was altogether carried out clinical observation on the therapeutic effect.These cases are the out-patient, and wherein the male accounts for 58%, the women accounts for 42%, age 8-70 year, 35 years old mean age, the course of disease 1 thoughtful 20 years, average 10 years.Wherein eczema, dermatitis patients account for total case load 50% (acute, subacute eczema accounts for 80% of eczema, dermatitis case, chronic eczema account for eczema, dermatitis case 20%), urticaria accounts for 30% of total case, skin pruritus accounts for 20% of total case, is wind heat or damp-heat type.Subjective symptoms shows as pruritus, and erythra shows as erythema, pimple, oozes out erosion, scarlet or pale red welt, scratch, infiltration or lichen sampleization.Light red tongue is yellow or yellow greasy, floating and rapid pulse, stringy and rolling pulse or sliding number.

Therapeutic Method: greater than 13 years old, decoct 1 time sooner or later respectively took traditional Chinese medicine every day; Less than 13 years old, decoct (dosage reduces by half) 1 time sooner or later respectively took traditional Chinese medicine every day.

Curative effect determinate standard:

Cure: clinical symptoms, sign complete obiteration;

Produce effects: (＞60%) is obviously improved or alleviated to clinical symptoms, sign;

Take a turn for the better: clinical symptoms, sign make moderate progress (＞20%)

Invalid: clinical symptoms, sign no change or deterioration;

Recurrence: after the healing, erythra occurs at former position.

Effective percentage adds produce effects for curing.

Medication is carried out efficacy evaluation after 2 weeks, and the case after the healing carries out following up a case by regular visits to half a year, and the result is as follows:

Eczematous dermatitis: after 1 week of taking medicine, the erythema color is thin out, the pimple decreased number, and infiltration or lichenization skin lesion alleviate to some extent, and rotten to the corn, sepage disappears, and pruritus obviously alleviates; Took medicine for 2 weeks, erythra disappears substantially, pruritus transference cure, cure rate 56%, effective percentage 88%, relapse rate 10%.

Urticaria: take medicine after 1 week, pruritus alleviates, and idol has new breakout; Take medicine after 2 weeks, do not have new breakout, pruritus transference cure, cure rate 52%, effective percentage 84%, relapse rate 8%.

Skin pruritus: take medicine after 1 week, pruritus obviously alleviates; Take medicine after 2 weeks pruritus transference cure, cure rate 50%, effective percentage 83%, relapse rate 9%.

In above-mentioned therapeutic process, only a few patient takes medicine, and the back is even stomach discomfort, the symptom of laxativeness, but can stand, do not influence treatment.Most patients have no adverse reaction.

In sum, we think that the present invention fills a prescription to form certain reasonability is arranged, effectiveness, safety, and raw material is easy to get, and cost is relatively low, after carrying out industrialization and producing, will produce obvious social and economic benefit.

Four, the specific embodiment

Embodiment 1, take by weighing raw material by following prescription and be prepared (kilogram):

Herba Schizonepetae 500 Radix Saposhnikoviaes 600 Periostracum Cicadaes 360 Zaocyss 600 Bombyx Batryticatus 500

Cortex Dictamni 900 Radix Sophorae Flavescentiss 900 Rhizoma Alismatis 500 Gypsum Fibrosum 1500 Rhizoma Anemarrhenaes 600

Radix Angelicae Sinensis 1200 Radix Rehmanniae 1000 Radix Glycyrrhizaes 300.

Embodiment 2, take by weighing raw material by following prescription and be prepared (kilogram):

Herba Schizonepetae 550 Radix Saposhnikoviaes 525 Periostracum Cicadaes 320 Zaocyss 570 Bombyx Batryticatus 550

Cortex Dictamni 840 Radix Sophorae Flavescentiss 830 Rhizoma Alismatis 520 Gypsum Fibrosum 1650 Rhizoma Anemarrhenaes 560

Radix Angelicae Sinensis 1060 Radix Rehmanniae 1150 Radix Glycyrrhizaes 350.

Embodiment 3, take by weighing raw material by following prescription and be prepared (kilogram):

Herba Schizonepetae 580 Radix Saposhnikoviaes 520 Periostracum Cicadaes 340 Zaocyss 530 Bombyx Batryticatus 590

Cortex Dictamni 860 Radix Sophorae Flavescentiss 770 Rhizoma Alismatis 525 Gypsum Fibrosum 1760 Rhizoma Anemarrhenaes 510

Radix Angelicae Sinensis 1150 Radix Rehmanniae 1100 Radix Glycyrrhizaes 300.

Herba Schizonepetae in the above-mentioned three assembly sides, Radix Saposhnikoviae, Periostracum Cicadae is extracted volatile oil, the volatile oil beta-cyclodextrin inclusion compound, aqueous solution after distillation device is in addition collected, medicinal residues and Zaocys, Bombyx Batryticatus, Cortex Dictamni, Radix Sophorae Flavescentis, Rhizoma Alismatis, Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Angelicae Sinensis, Radix Rehmanniae, the Radix Glycyrrhizae merging decocts with water secondary, each 2 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and are evaporated to about 1.10 (50 ℃) of relative density, add ethanol and make that to contain the alcohol amount be 65%, left standstill 24 hours, filter, filtrate recycling ethanol, and continue to be evaporated to the clear paste that relative density is 1.30 (80 ℃), add adjuvant, mixing is made granule, drying, with above-mentioned volatile oil beta cyclodextrin inclusion complex mix homogeneously, promptly get granule.Adopt conventional preparation technology, Chinese medicine preparation of the present invention also can be made into said dosage form on other any pharmaceutics, as: tablet, capsule, oral liquid, pill, syrup agent, buccal tablet, effervescent tablet, dispersible tablet.

Claims (3)

1, the dermopathic Chinese medicine preparation of a kind of treatment is characterized in that its effective ingredient is made up of the component of following parts by weight:

Herba Schizonepetae 500-600 Radix Saposhnikoviae 500-600 Periostracum Cicadae 300-360

Zaocys 500-600 Bombyx Batryticatus 500-600 Cortex Dictamni 750-900

Radix Sophorae Flavescentis 750-900 Rhizoma Alismatis 500-600 Gypsum Fibrosum 1500-1800

Rhizoma Anemarrhenae 500-600 Radix Angelicae Sinensis 1000-1200 Radix Rehmanniae 1000-1200

Radix Glycyrrhizae 300-360.

2, the dermopathic Chinese medicine preparation of treatment according to claim 1 is characterized in that its effective ingredient is made up of the component of following parts by weight:

Herba Schizonepetae 530-580 Radix Saposhnikoviae 500-550 Periostracum Cicadae 300-330

Zaocys 550-600 Bombyx Batryticatus 530-580 Cortex Dictamni 800-850

Radix Sophorae Flavescentis 800-850 Rhizoma Alismatis 500-550 Gypsum Fibrosum 1600-1700

Rhizoma Anemarrhenae 530-580 Radix Angelicae Sinensis 1000-1100 Radix Rehmanniae 1100-1200

Radix Glycyrrhizae 330-360.

3, the dermopathic Chinese medicine preparation of treatment according to claim 1 and 2 is characterized in that, it can be said dosage form on any pharmaceutics.