CN1283285C - Acne treating ointment - Google Patents

Acne treating ointment Download PDF

Info

Publication number
CN1283285C
CN1283285C CN 200410041396 CN200410041396A CN1283285C CN 1283285 C CN1283285 C CN 1283285C CN 200410041396 CN200410041396 CN 200410041396 CN 200410041396 A CN200410041396 A CN 200410041396A CN 1283285 C CN1283285 C CN 1283285C
Authority
CN
China
Prior art keywords
radix
herba
rhizoma
fructus
ointment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN 200410041396
Other languages
Chinese (zh)
Other versions
CN1593593A (en
Inventor
丁文武
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN 200410041396 priority Critical patent/CN1283285C/en
Publication of CN1593593A publication Critical patent/CN1593593A/en
Application granted granted Critical
Publication of CN1283285C publication Critical patent/CN1283285C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to acne treating ointment which is characterized in that the ointment is prepared through the following steps: adding water to 46 traditional Chinese medicines (such as dodder seed, lycium bark, cape jasmine fruit, etc.) according to parts by weight; boiling and decocting the traditional Chinese medicines until the temperature of 100 DEG C; continuously decocting the traditional Chinese medicines for 30 to 60 minutes, and then filtering out physic liquor; decocting the medicine residues by adding water according to the method, and then filtering out physic liquor; mixing the physic liquor obtained by filtering twice, successively boiling and decocting the mixture by heating until forming ointment; finally, adding right amounts of honey to the ointment. For treating acne diseases, the present invention has the advantages of short period, high cure rate, difficult recurrence and no stimulating or other side effects on skins.

Description

A kind of ointment for the treatment of acne
Technical field
The present invention relates to a kind of outer applying ointment, exactly is a kind of ointment for the treatment of acne.
Background technology
Acne are a kind of dermatosiss common among the youth, at present, acne patient day by day all increases, and the skincare product ubiquity of treatment acne not only that treatment cycle is long, cure rate is extremely low in the prior art, and ubiquity uses the medicine of harm skin healths such as hormone, antibiotic in the medicine, occur xerosis cutis, skin lesion after the medication, peel, be prone to serious allergic symptom, redness is very itched, and easily recurrence has dependency after the medication, patient's old complaint is not gone and add new disease, agonizing.
Summary of the invention
The objective of the invention is provides a kind of treatment cycle short to people, non-stimulated and other side effect to skin, the ointment of the treatment acne of difficult recurrence.
The present invention is made by following material medicine, and its composition by weight is:
Semen Cuscutae 30~50 Cortex Lycii 20~40 Fructus Gardeniaes 40~60
Cortex Acanthopancis 40~60 Rhizoma Chuanxiongs 20~40 Bombyx Batryticatus 40~60
The Fructus Kochiae 10~30 Fructus Forsythiaes 20~40 Radix Ampelopsis 20~40
Radix Rubiae 20~40 Radixs Angelicae Dahuricae 30~50 Rhizoma Atractylodis Macrocephalaes 40~60
Flos Magnoliae 40~60 Semen Armeniacae Amarums 20~40 Rhizoma Corydalis 40~60
Lignum Sappan 35~55 Rhizoma Cimicifugaes 50~70 Fructus Trichosanthis 100~130
Cortex Moutan 40~60 Flos Campsiss 30~60 Flos Carthamis 50~70
Rhizoma Et Radix Notopterygii 20~40 Radix Salviae Miltiorrhizaes 40~60 Herba Asaris 10~30
Semen Ginkgo 30~50 Herba Ephedraes 50~70 Radix Saposhnikoviaes 20~40
Radix Cucubali 40~60 Radix Scrophulariaes 30~50 Ramulus Cinnamomi 20~40
Radix Scutellariae 20~40 Radix Dipsacis 40~60 Rhizoma Coptidis 10~30
Radix Asparagi 50~70 Semen Benincasaes 40~60 Herba Verbenae 50~70
Herba Patriniae 50~70 Rhizoma Typhoniis 30~50 Herba Taraxacis 40~60
Flos Lonicerae 30~50 Semen Euphorbiaes 10~30 Herba Portulacaes 20~40
Radix Angelicae Pubescentis 20~40 Fructus Crataegis 20~40 Herba Senecionis Scandentiss 30~50
Herba Polygalae Japonicae 30~50.
Composition by weight is:
Semen Cuscutae 40 Cortex Lycii 30 Fructus Gardeniaes 50 Cortex Acanthopanciss 50
Rhizoma Chuanxiong 30 Bombyx Batryticatus 50 Fructus Kochiae 20 Fructus Forsythiaes 30
Radix Ampelopsis 30 Radix Rubiaes 30 Radixs Angelicae Dahuricae 40 Rhizoma Atractylodis Macrocephalaes 50
Flos Magnoliae 50 Semen Armeniacae Amarums 30 Rhizoma Corydalis 50 Lignum Sappans 45
Rhizoma Cimicifugae 60 Fructus Trichosanthis 120 Cortex Moutans 50 Flos Campsiss 40
Flos Carthami 60 Rhizoma Et Radix Notopterygiis 30 Radix Salviae Miltiorrhizaes 50 Herba Asaris 20
Semen Ginkgo 40 Herba Ephedraes 60 Radix Saposhnikoviaes 30 Radix Cucubalis 50
Radix Scrophulariae 40 Ramulus Cinnamomi 30 Radix Scutellariae 30 Radix Dipsacis 50
Rhizoma Coptidis 20 Radix Asparagi 60 Semen Benincasaes 50 Herba Verbenae 60
Herba Patriniae 60 Rhizoma Typhoniis 40 Herba Taraxacis 50 Flos Loniceraes 40
Semen Euphorbiae 20 Herba Portulacaes 30 Radix Angelicae Pubescentiss 30 Fructus Crataegis 30
Herba Senecionis Scandentis 40 Herba Polygalae Japonicae 40.
Preparation method is:
(1) takes by weighing required component, add decocting in water and endure, continue to endure 30~60 minutes after-filtration and go out medicinal liquid to 100 ℃ of temperature;
(2) with above-mentioned filter medicinal residues add decocting in water and endure to 100 ℃ of temperature, continue to endure 30~60 minutes after-filtration and go out medicinal liquid;
(3) twice medicinal liquid Hybrid Heating boiled endure, after becoming cream, add proper honey and promptly get ointment.
The principle of above Chinese medicine preparation treatment is a heat-clearing and toxic substances removing, activating blood circulation to dissipate blood stasis, disinfection and deinsectization, dispeling the wind, it is cold to remove, softening hardness and disperse swelling is declared scared capsule, hole skin, the oil-control secretion, strengthen metabolism, speckle dispelling removes trace, Glycerin, and this medicine took effect to the treatment of acne in 24 hours, effective percentage is 100%, and cure rate is more than 90%.Through to 190 routine acne disease patient clinical treatments so far, given sufficient confirmation from 2000.
One, clinical data: among the 190 routine acne disease patients:
Suffer from Semen setariae shape acne 85 examples, male's 45 examples wherein, women's 40 examples, at 15~30 years old age, the course of disease is 2~3 years, uses this ointment to put on the skin in 1st three times, and 7~15 days transference cures were consolidated the treatment of applying ointment through 7~15 days, and all recurrence is not seen in healings in half a year.
Suffer from blackhead and be mingled with numerous pustule acne 35 examples, male's 20 examples wherein, women's 15 examples, at 30~45 years old age, the course of disease is 10~15 years, use this ointment to put on the skin in 1st three times, transference cure after 7~20 days was consolidated the treatment of applying ointment through 7~20 days, found wherein 32 routine patient's recoveries from illness, do not see recurrence in half a year, 3 routine patients have significant curative effect.
Suffer from pustule type acne 30 examples, male's 20 examples wherein, women's 10 examples, at 16~25 years old age, the course of disease 6 months~2 years uses this ointment to put on the skin in 1st three times, and transference cure after 7~20 days was consolidated the treatment of applying ointment through 7~20 days, and all recurrence is not seen in healings in half a year.
Suffer from pimple acne 20 examples, male's 12 examples wherein, women's 8 examples, at 35~45 years old age, the course of disease 3 months~6 months uses this ointment to put on the skin in 1st three times, and transference cure after 7~15 days was consolidated the treatment of applying ointment through 7~15 days, and all recurrence is not seen in healings in half a year.
Suffer from cyst acne 20 examples, male's 10 examples wherein, women's 10 examples, 18~38 years old age, the course of disease 1~10 year used this ointment to put on the skin in 1st three times, and symptom disappeared substantially in 7~20 days, consolidated the treatment of applying ointment through 7~20 days, find wherein 18 routine patient's recoveries from illness, do not see recurrence half a year, 2 routine patients have significant curative effect.
Two, clinical data summary sheet:
Title Case load The recovery from illness significant curative effect
The example number Cure rate (%) The example number Cure rate (%)
Semen setariae shape type 85 85 100
The blackhead type 35 32 91.4 3 8.6
Pustule type 30 30 100
The pimple powder 20 20 100
Cyst type 20 18 90 2 10
Add up to 190 185 97.4 5 2.6
Effect of the present invention
1, the present invention does not contain any hormone, and therefore non-stimulated and other side effect to skin xerosis cutis, skin lesion, decortication, allergy, redness can not occur, itch after the medication.
1, the present invention is used for the treatment of the acne disease, treatment cycle is short, the high and difficult recurrence of cure rate.
2, material medicine amount of the present invention is bigger, thus to treating for skin disease scope also broad, not only can control the acne disease, but also can be used for treating comedo, rosacea, facial blue or green, purple, black, the anaphylaxis redness is itched, dermatitis, tinea, pigmentation, the wrinkle removing of whitening.Freckle, chloasma also there is certain desalination effect.
The specific embodiment
Embodiment 1
Component takes by weighing Semen Cuscutae 30g by weight, Cortex Lycii 20g, Fructus Gardeniae 40g, Cortex Acanthopancis 40g, Rhizoma Chuanxiong 20g, Bombyx Batryticatus 40g, Fructus Kochiae 10g, Fructus Forsythiae 20g, Radix Ampelopsis 20g, Radix Rubiae 20g, Radix Angelicae Dahuricae 30g, Rhizoma Atractylodis Macrocephalae 40g, Flos Magnoliae 40g, Semen Armeniacae Amarum 20g, Rhizoma Corydalis 40g, Lignum Sappan 35g, Rhizoma Cimicifugae 50g, Fructus Trichosanthis 100g, Cortex Moutan 40g, Flos Campsis 30g, Flos Carthami 50g, Rhizoma Et Radix Notopterygii 20g, Radix Salviae Miltiorrhizae 40g, Herba Asari 10g, Semen Ginkgo 30g, Herba Ephedrae 50g, Radix Saposhnikoviae 20g, Radix Cucubali 40g, Radix Scrophulariae 30g, Ramulus Cinnamomi 20g, Radix Scutellariae 20g, Radix Dipsaci 40g, Rhizoma Coptidis 10g, Radix Asparagi 50g, Semen Benincasae 40, Herba Verbenae 50g, Herba Patriniae 50g, Rhizoma Typhonii 30g, Herba Taraxaci 40g, Flos Lonicerae 30g, Semen Euphorbiae 10g, Herba Portulacae 20g, Radix Angelicae Pubescentis 20g, Fructus Crataegi 20g, Herba Senecionis Scandentis 30g, Herba Polygalae Japonicae 30g puts into container, adds water and crosses powder, is heated to 100 ℃ and boils and endure 30~60 minutes after-filtration and go out medicinal liquid; Medicinal residues are added water cross powder, be heated to 100 ℃ and boil and endure 30~60 minutes after-filtration and go out medicinal liquid; Twice medicinal liquid mixing post-heating boiled endure,, add proper honey again and make anticorrosion usefulness, bottle at last, seal, sell until becoming paste.
Embodiment 2
Component takes by weighing Semen Cuscutae 40g by weight, Cortex Lycii 30g, Fructus Gardeniae 50g, Cortex Acanthopancis 50g, Rhizoma Chuanxiong 30g, Bombyx Batryticatus 50g, Fructus Kochiae 20g, Fructus Forsythiae 30g, Radix Ampelopsis 30g, Radix Rubiae 30g, Radix Angelicae Dahuricae 40g, Rhizoma Atractylodis Macrocephalae 50g, Flos Magnoliae 50g, Semen Armeniacae Amarum 30g, Rhizoma Corydalis 50g, Lignum Sappan 45g, Rhizoma Cimicifugae 60g, Fructus Trichosanthis 120g, Cortex Moutan 50g, Flos Campsis 40g, Flos Carthami 60g, Rhizoma Et Radix Notopterygii 30g, Radix Salviae Miltiorrhizae 50g, Herba Asari 20g, Semen Ginkgo 40g, Herba Ephedrae 60g, Radix Saposhnikoviae 30g, Radix Cucubali 50g, Radix Scrophulariae 40g, Ramulus Cinnamomi 30g, Radix Scutellariae 30g, Radix Dipsaci 50g, Rhizoma Coptidis 20g, Radix Asparagi 60g, Semen Benincasae 50g, Herba Verbenae 60g, Herba Patriniae 60g, Rhizoma Typhonii 40g, Herba Taraxaci 50g, Flos Lonicerae 40g, Semen Euphorbiae 20g, Herba Portulacae 30g, Radix Angelicae Pubescentis 30g, Fructus Crataegi 30g, Herba Senecionis Scandentis 40g, Herba Polygalae Japonicae 40g puts into container, adds water and crosses powder, is heated to 100 ℃ and boils and endure 30~60 minutes after-filtration and go out medicinal liquid; Medicinal residues are added water cross powder, be heated to 100 ℃ and boil and endure 30~60 minutes after-filtration and go out medicinal liquid; Twice medicinal liquid mixing post-heating boiled endure,, add proper honey again and make anticorrosion usefulness, bottle at last, seal, sell until becoming paste.
Embodiment 3
Component takes by weighing Semen Cuscutae 50g by weight, Cortex Lycii 40g, Fructus Gardeniae 60g, Cortex Acanthopancis 60g, Rhizoma Chuanxiong 40g, Bombyx Batryticatus 60g, Fructus Kochiae 30g, Fructus Forsythiae 40g, Radix Ampelopsis 40g, Radix Rubiae 40g, Radix Angelicae Dahuricae 50g, Rhizoma Atractylodis Macrocephalae 60g, Flos Magnoliae 60g, Semen Armeniacae Amarum 40g, Rhizoma Corydalis 60g, Lignum Sappan 55g, Rhizoma Cimicifugae 70g, Fructus Trichosanthis 130g, Cortex Moutan 60g, Flos Campsis 60g, Flos Carthami 70g, Rhizoma Et Radix Notopterygii 40g, Radix Salviae Miltiorrhizae 60g, Herba Asari 30g, Semen Ginkgo 50g, Herba Ephedrae 70g, Radix Saposhnikoviae 40g, Radix Cucubali 60g, Radix Scrophulariae 50g, Ramulus Cinnamomi 40g, Radix Scutellariae 40g, Radix Dipsaci 60g, Rhizoma Coptidis 30g, Radix Asparagi 70g, Semen Benincasae 60g, Herba Verbenae 70g, Herba Patriniae 70g, Rhizoma Typhonii 50g, Herba Taraxaci 60g, Flos Lonicerae 50g, Semen Euphorbiae 30g, Herba Portulacae 40g, Radix Angelicae Pubescentis 40g, Fructus Crataegi 40g, Herba Senecionis Scandentis 50g, Herba Polygalae Japonicae 50g puts into container, adds water and crosses powder, is heated to 100 ℃ and boils and endure 30~60 minutes after-filtration and go out medicinal liquid; Medicinal residues are added water cross powder, be heated to 100 ℃ and boil and endure 30~60 minutes after-filtration and go out medicinal liquid; Twice medicinal liquid mixing post-heating boiled endure,, add proper honey again and make anticorrosion usefulness, bottle at last, seal, sell until becoming paste.

Claims (3)

1, a kind of ointment for the treatment of acne is characterized in that being made by following material medicine, and its composition by weight is:
Semen Cuscutae 30~50 Cortex Lycii 20~40 Fructus Gardeniaes 40~60
Cortex Acanthopancis 40~60 Rhizoma Chuanxiongs 20~40 Bombyx Batryticatus 40~60
The Fructus Kochiae 10~30 Fructus Forsythiaes 20~40 Radix Ampelopsis 20~40
Radix Rubiae 20~40 Radixs Angelicae Dahuricae 30~50 Rhizoma Atractylodis Macrocephalaes 40~60
Flos Magnoliae 40~60 Semen Armeniacae Amarums 20~40 Rhizoma Corydalis 40~60
Lignum Sappan 35~55 Rhizoma Cimicifugaes 50~70 Fructus Trichosanthis 100~130
Cortex Moutan 40~60 Flos Campsiss 30~60 Flos Carthamis 50~70
Rhizoma Et Radix Notopterygii 20~40 Radix Salviae Miltiorrhizaes 40~60 Herba Asaris 10~30
Semen Ginkgo 30~50 Herba Ephedraes 50~70 Radix Saposhnikoviaes 20~40
Radix Cucubali 40~60 Radix Scrophulariaes 30~50 Ramulus Cinnamomi 20~40
Radix Scutellariae 20~40 Radix Dipsacis 40~60 Rhizoma Coptidis 10~30
Radix Asparagi 50~70 Semen Benincasaes 40~60 Herba Verbenae 50~70
Herba Patriniae 50~70 Rhizoma Typhoniis 30~50 Herba Taraxacis 40~60
Flos Lonicerae 30~50 dried gold 10~30 Herba Portulacaes 20~40
Radix Angelicae Pubescentis 20~40 Fructus Crataegis 20~40 Herba Senecionis Scandentiss 30~50
Herba Polygalae Japonicae 30~50.
2, a kind of ointment for the treatment of acne according to claim 1 is characterized in that composition by weight is:
Semen Cuscutae 40 Cortex Lycii 30 Fructus Gardeniaes 50 Cortex Acanthopanciss 50
Rhizoma Chuanxiong 30 Bombyx Batryticatus 50 Fructus Kochiae 20 Fructus Forsythiaes 30
Radix Ampelopsis 30 Radix Rubiaes 30 Radixs Angelicae Dahuricae 40 Rhizoma Atractylodis Macrocephalaes 50
Flos Magnoliae 50 Semen Armeniacae Amarums 30 Rhizoma Corydalis 50 Lignum Sappans 45
Rhizoma Cimicifugae 60 Fructus Trichosanthis 120 Cortex Moutans 50 Flos Campsiss 40
Flos Carthami 60 Rhizoma Et Radix Notopterygiis 30 Radix Salviae Miltiorrhizaes 50 Herba Asaris 20
Semen Ginkgo 40 Herba Ephedraes 60 Radix Saposhnikoviaes 30 Radix Cucubalis 50
Radix Scrophulariae 40 Ramulus Cinnamomi 30 Radix Scutellariae 30 Radix Dipsacis 50
Rhizoma Coptidis 20 Radix Asparagi 60 Semen Benincasaes 50 Herba Verbenae 60
Herba Patriniae 60 Rhizoma Typhoniis 40 Herba Taraxacis 50 Flos Loniceraes 40
A thousand pieces of gold 20 Herba Portulacaes 30 Radix Angelicae Pubescentiss 30 Fructus Crataegis 30
Herba Senecionis Scandentis 40 Herba Polygalae Japonicae 40.
3, a kind of preparation method for the treatment of the ointment of acne according to claim 1 and 2 the steps include:
(1) takes by weighing required component, add decocting in water and endure, continue to endure 30~60 minutes after-filtration and go out medicinal liquid to 100 ℃ of temperature;
(2) with above-mentioned filter medicinal residues add decocting in water and endure to 100 ℃ of temperature, continue to endure 30~60 minutes after-filtration and go out medicinal liquid;
(3) twice medicinal liquid Hybrid Heating boiled endure, after becoming cream, add proper honey and promptly get ointment.
CN 200410041396 2004-07-13 2004-07-13 Acne treating ointment Expired - Fee Related CN1283285C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 200410041396 CN1283285C (en) 2004-07-13 2004-07-13 Acne treating ointment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN 200410041396 CN1283285C (en) 2004-07-13 2004-07-13 Acne treating ointment

Publications (2)

Publication Number Publication Date
CN1593593A CN1593593A (en) 2005-03-16
CN1283285C true CN1283285C (en) 2006-11-08

Family

ID=34665035

Family Applications (1)

Application Number Title Priority Date Filing Date
CN 200410041396 Expired - Fee Related CN1283285C (en) 2004-07-13 2004-07-13 Acne treating ointment

Country Status (1)

Country Link
CN (1) CN1283285C (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101829262A (en) * 2010-04-27 2010-09-15 徐晓玉 Heat-clearing fire-reducing, yin-nourishing and body fluid-inviting solid agent for food and medicinal two-purposes
CN102813854B (en) * 2012-09-10 2014-07-16 山东大学齐鲁医院 Chinese herbal medicine paste used for treating acne
CN103536787B (en) * 2013-09-30 2015-12-23 王纯治 A kind of Chinese medicinal formulae of Acne treatment
CN103933320A (en) * 2014-04-30 2014-07-23 王海云 Cosmetic for treating rosacea and preparation method thereof
CN103932964A (en) * 2014-04-30 2014-07-23 王海云 Skin care product for treating chloasma and preparation method thereof
CN106334141A (en) * 2016-09-13 2017-01-18 佛山市顺德区宝铜金属科技有限公司 Traditional Chinese medicine for removing acne and eliminating sores

Also Published As

Publication number Publication date
CN1593593A (en) 2005-03-16

Similar Documents

Publication Publication Date Title
CN1317027C (en) Chinese medicine for treating depression
CN1742939A (en) Medicine for treating pulmonary fibrosis and preparing method
CN1087625C (en) Traditional Chinese medicine preparation for treating colitis
CN1283285C (en) Acne treating ointment
CN102225100A (en) Chinese medicinal formulation for treating cardiovascular and cerebrovascular diseases and preparation process of products thereof
CN1686085A (en) Bath lotion for chilblain nursing and preparation method thereof
CN101703742B (en) Preparation method of granules for treating acne caused by qi deficiency causing blood stasis and phlegm-heat stagnation
CN103656051A (en) Traditional Chinese medicine for treating diabetes
CN109674960A (en) A kind of preparation of water seedling Chinese herbal treatment gout
CN1256130C (en) Preparation of Chinese traditional medicine for curing skin disease
CN1895593A (en) Medicine for treating acne and its preparation
CN106943485B (en) Traditional Chinese medicine compound preparation for treating anemia caused by blood heat bleeding and preparation method
CN1169555C (en) A Chinese medicinal decoction pill for treating hepatitis B
CN1199679C (en) Medicine for nourishing yin and fortifying kidney, benefiting qi and fortifying spleen , and its preparation method
CN100540025C (en) Treat Parkinsonian Chinese medicine preparation and preparation method thereof
CN1211426A (en) Medicine for treating diabetes
CN101036692A (en) Application of radix codonopsis and radix astragali in the preparing of medicine for curing diabetes mellitus
CN1285367C (en) Medicinal preparation for treating diabetes and its preparation method
CN100345568C (en) Chinese-medicinal preparation for treating prostatic disease
CN101485845A (en) Chinese medicine for treating diabetes
CN101062348A (en) Ganoerma lucidum capusule for reducing blood sugar
CN102258713A (en) Chinese medicinal composition for preventing and treating metabolic diseases
CN101194940A (en) Anti-inflammation medicament for treating toothache and preparation method thereof
CN1899528B (en) Chinese patented medicine for treating psoriasis
CN101485776A (en) Compound flow-dredging brain-protecting soybean milk preparation for persons in middle and old age

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee