CN102824407B - A kind of Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold and preparation method thereof - Google Patents
A kind of Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold and preparation method thereof.The ratio that the Chinese medicine dripping pills of described treatment arthralgia aggravated by cold comprises parts by weight is principal agent and the substrate of 1:1-1:9; Described principal agent comprises Semen Strychni, Scorpio, Bombyx Batryticatus, Herba Ephedrae, Rhizoma Atractylodis, Olibanum, Myrrha, Radix Cyathulae, Radix Et Caulis Acanthopanacis Senticosi extractum, Radix Glycyrrhizae.First by the mixing of each principal agent composition during preparation, then joined in the substrate of melting, then the mixture of principal agent and substrate is added dropwise in condensed fluid, final drying and get final product.The Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention is with low cost, taking convenience, be easy to carry, have no side effect, and supplements the tcm product dosage form for the treatment of arthralgia aggravated by cold, particularly also has effective fast, remarkable advantage that bioavailability is high.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of Chinese medicine preparation for the treatment of arthralgia aggravated by cold, particularly relate to a kind of Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold and preparation method thereof.
Background technology
Arthralgia aggravated by cold, names of disease of tcm, refer to due to positive QI-insufficiency, the evil combined pathogens of wind, cold, wet and with cold-evil for main invasion and attack human body, cause meridians impatency, QI-blood circulation is smooth, so cause muscle, pain occurs for muscles and bones, joint a class disease, clinical main manifestations is that localized pain, pain are more acute, pain alleviated while getting warmth, pain increase in intensity under coldness etc.Relative to doctor trained in Western medicine saying, arthralgia aggravated by cold mainly comprises rheumatism and gout, such as rheumatic arthritis, rheumatoid arthritis, systemic lupus erythematosus (sle), scleroderma, polymyositis, sciatica, brachial plexus neuralgia, hyperplastic spondylitis, cervical spondylosis, calcanean spur, Kaschin-Beck disease, thromboangiitis obliterans, finger tip arteriospasm disease etc.
The tcm product of existing treatment arthralgia aggravated by cold is much, and what gone on the market is as peaceful in medicinal capsule for treating rheumatalgia, gout Thailand, ZHENGQINGFENGTONGNING capsule (sheet, slow releasing tablet), sea snake for treating arthritis capsule, favour numbness etc.; CN1246348A also discloses a kind of medicinal capsule for treating rheumatalgia and preparation method thereof, this capsule main component comprises Semen Strychni, Sanguis Draxonis, diclofenac, prednisone, ibuprofen, Caulis et folium stauntoniae, indometacin, enteric ABC, compound recipe Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae), can treat the diseases such as rheumatism, rheumatoid arthritis, hyperosteogeny.
The common ground of the said goods is that with oral capsule or tablet be main dosage form, and ubiquity leaches the problems such as the time is long, dissolution is low, absorption difference, dose are large, bioavailability is low, and have a strong impact on drug effect and play, therapeutic effect is not remarkable; Secondly, capsule and tablet owing to there being the technique of granulation, can producing larger dust pollution, not only pollute the environment in preparation process, also can work the mischief to the health of staff; Again, due to reasons such as technologies of preparing, the complex manufacturing of existing capsule and tablet, production cost is higher, and the medicinal cost of patient is improved thereupon, is unfavorable for the ability of seeking medical advice improving extensive patients, is also unfavorable for the raising of social total health level.
Drop pill rises the 1950's a kind of pharmaceutical dosage form studied, in Chinese Pharmacopoeia, drop pill is defined as follows: mean that medical material is through suitable method extraction, purification, concentrated and after mixing with suitable substrate heating and melting, instill in not miscible condensed fluid, shrink condensation and the spherical preparation of spherical or class made.Drop pill is compared with other drug dosage form; production cycle is shorter; quality is more easy to control; both can be made into quick releasing formulation and also can be made into slow releasing preparation; medicine stability, the dissolution rate improving insoluble drug and dissolution can be increased; also can reduce zest and cover bad smell, also have workshop health, advantage that labor protection is good, therefore the application of drop pill in form of Chinese drug is more and more noticeable.The production principle of drop pill is formed through cooling rapidly by medicine and substrate consolute, and therefore the selection of substrate and condensing agent is the key factor preparing drop pill, is limited to technical reason, there is no the report of the Chinese medicine dripping pills about treatment arthralgia aggravated by cold at present.
Summary of the invention
One of the object of the invention is the deficiency for prior art, a kind of Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold is provided, the tcm product dosage form of supplement therapy arthralgia aggravated by cold, for patient provides more more options, and integrate effective fast, bioavailability is high, have no side effect, taking convenience, be easy to carry, the many merits such as cheap.Two of object of the present invention is the preparation method of the Chinese medicine dripping pills providing this treatment arthralgia aggravated by cold.
For one of achieving the above object, the present invention adopts following technical scheme:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, comprise principal agent and substrate; Described principal agent comprises Semen Strychni, Scorpio, Bombyx Batryticatus, Herba Ephedrae, Rhizoma Atractylodis, Olibanum, Myrrha, Radix Cyathulae, Radix Et Caulis Acanthopanacis Senticosi extractum, Radix Glycyrrhizae.
Preferably, described principal agent is 1:1-1:9 with the ratio of the parts by weight of substrate, such as, can be 1:1-1:3,1:2.5-1:6,1:4-1:7.8,1:5.45-1:8.45,1:7-1:9,1:1,1:1.07,1:1.6,1:2,1:2.8,1:3,1:3.4,1:4,1:4.6,1:5,1:5.9,1:6,1:6.2,1:7,1:7.5,1:8,1:8.1,1:9; More preferably 1:3-1:7; Most preferably be 1:5.
Described Semen Strychni is the parts of generic medicinal plants with functions such as removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating, expelling wind and removing dampness, is preferably Semen Strychni Pulveratum in the present invention, and namely Semen Strychni (processed) pulverizes the fine powder of gained.The parts by weight of described Semen Strychni in the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention are preferably 25-75 part, can be such as 25-47.5 part, 32-56.5 part, 42.1-62.1 part, 48-58 part, 54-75 part, 25 parts, 26.4 parts, 29 parts, 30 parts, 33.7 parts, 35 parts, 36.1 parts, 40 parts, 41.8 parts, 45 parts, 47.2 parts, 50 parts, 52 parts, 55 parts, 59.6 parts, 60 parts, 60.4 parts, 63 parts, 65 parts, 68.2 parts, 70 parts, 72.5 parts, 75 parts; More preferably 40-60 part; Most preferably be 48.8 parts.
Described Scorpio is the parts of generic medicinal plants with functions such as endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain, its parts by weight in the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention are preferably 2-12 part, can be such as 2-7.2 part, 4.6-9.5 part, 5.5-8.3 part, 7.9-10 part, 3-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.7 parts, 8 parts, 8.2 parts, 9 parts, 9.5 parts, 10 parts, 10.25 parts, 11.7 parts, 12 parts; More preferably 3-9 part; Most preferably be 6.1 parts.
Described Bombyx Batryticatus is the parts of generic medicinal plants with functions such as relieving spasm by subduing liver-wind, wind-expelling pain-stopping, dissipating phlegm and resolving masses, is preferably Bombyx Batryticatus (parched with bran) in the present invention, and namely warp and Testa Tritici stir the Bombyx Batryticatus of the process of preparing Chinese medicine, the Chinese medicine processing method that described parched with bran is well known to those skilled in the art.The parts by weight of described Bombyx Batryticatus in the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention are preferably 2-12 part, can be such as 2-4.1 part, 3.9-7.6 part, 6.5-9 part, 8.1-10.3 part, 7-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.7 parts, 8 parts, 8.7 parts, 9 parts, 9.5 parts, 10 parts, 10.2 parts, 11.4 parts, 12 parts; More preferably 3-9 part; Most preferably be 6.1 parts.
Described Herba Ephedrae is the parts of generic medicinal plants with functions such as diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema, its parts by weight in the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention are preferably 2-12 part, can be such as 2-7.7 part, 4.6-6.4 part, 8.5-10.9 part, 3.1-11 part, 7-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.8 parts, 8 parts, 8.3 parts, 9 parts, 9.5 parts, 10 parts, 10.1 parts, 11.9 parts, 12 parts; More preferably 3-9 part; Most preferably be 6.1 parts.
Described Rhizoma Atractylodis are the parts of generic medicinal plants with functions such as drying damp and strengthening spleen, expelling wind and cold, in the present invention preferred parched with bran Rhizoma Atractylodis, namely through and Testa Tritici stir the Rhizoma Atractylodis of the process of preparing Chinese medicine, the Chinese medicine processing method that described parched with bran is well known to those skilled in the art.The parts by weight of described Rhizoma Atractylodis in the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention are preferably 2-12 part, can be such as 2-8 part, 5.6-9.2 part, 7.5-11.5 part, 9.1-10 part, 4.8-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.65 parts, 8 parts, 8.6 parts, 9 parts, 9.5 parts, 10 parts, 10.8 parts, 11.1 parts, 12 parts; More preferably 3-9 part; Most preferably be 6.1 parts.
Described Olibanum has regulating qi and activating blood, eases pain, chases after the parts of generic medicinal plants of function such as poison, is preferably Olibanum (processed) in the present invention.The parts by weight of described Olibanum in the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention are preferably 2-12 part, can be such as 2-8.3 part, 3.9-7 part, 5.5-9 part, 7-11.1 part, 10-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.7 parts, 8 parts, 8.4 parts, 9 parts, 9.6 parts, 10 parts, 10.7 parts, 11.3 parts, 12 parts; More preferably 3-9 part; Most preferably be 6.1 parts.
Described Myrrha is the parts of generic medicinal plants with functions such as loose blood blood stasis removing, subduing swelling and relieving pain, is preferably Myrrha (processed) in the present invention.The parts by weight of described Myrrha in the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention are preferably 2-12 part, can be such as 2-4.5 part, 3-7.6 part, 6.5-9.8 part, 8.1-10.9 part, 5-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.7 parts, 8 parts, 8.2 parts, 9 parts, 9.5 parts, 10 parts, 10.3 parts, 11.5 parts, 12 parts; More preferably 3-9 part; Most preferably be 6.1 parts.
Described Radix Cyathulae be have dispel the wind, dampness removing, stimulate the menstrual flow, the parts of generic medicinal plants of the function such as to invigorate blood circulation, its parts by weight in the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention are preferably 2-12 part, can be such as 2-8.3 part, 4.7-9.7 part, 5.5-8.5 part, 2.1-10 part, 7.4-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.4 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 7.6 parts, 8 parts, 8.7 parts, 9 parts, 9.5 parts, 10 parts, 10.8 parts, 11.2 parts, 12 parts; More preferably 3-9 part; Most preferably be 6.1 parts.
Described Radix Et Caulis Acanthopanacis Senticosi extractum is formed through alcohol reflux is concentrated by Chinese crude drug Radix Et Caulis Acanthopanacis Senticosi, by be purchased or self-control approach obtains, has the function such as replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.The parts by weight of described Radix Et Caulis Acanthopanacis Senticosi extractum in the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention are preferably 0.5-5 part, can be such as 0.5-2.1 part, 0.75-3.08 part, 1.1-3.5 part, 2.6-4.8 part, 3.7-5 part, 0.5 part, 0.6 part, 0.83 part, 1 part, 1.2 parts, 1.44 parts, 1.5 parts, 1.89 parts, 2 parts, 2.07 parts, 2.3 parts, 2.5 parts, 2.75 parts, 3 parts, 3.16 parts, 3.6 parts, 3.9 parts, 4 parts, 4.05 parts, 4.4 parts, 4.5 parts, 4.82 parts, 5 parts; More preferably 1-4 part; Most preferably be 2.4 parts.
Described Radix Glycyrrhizae is the parts of generic medicinal plants with functions such as invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain and coordinating the actions of various ingredients in a prescription, its parts by weight in the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention are preferably 2-12 part, can be such as 2-6.3 part, 5.7-8.1 part, 7.5-9.5 part, 3.1-10 part, 4.9-12 part, 2 parts, 2.5 parts, 3 parts, 3.1 parts, 3.5 parts, 4 parts, 4.9 parts, 5 parts, 5.3 parts, 6 parts, 6.5 parts, 7 parts, 7.4 parts, 7.6 parts, 8 parts, 8.8 parts, 9 parts, 9.5 parts, 10 parts, 10.1 parts, 11.7 parts, 12 parts; More preferably 3-9 part; Most preferably be 6.1 parts.
Described substrate is that those skilled in the art pass through to be purchased or self-control approach any one substrate for the preparation of drop pill obtainable, has absorptive tissue transudate, accelerates the effect of rate of releasing drug; Be preferably water-soluble base; The combination of preferred any one or at least two kinds in sodium lauryl sulphate, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, PEG 8000, PEG20000 further; Described combination is sodium lauryl sulphate/Macrogol 2000, Macrogol 4000/PEG 8000, sodium lauryl sulphate/polyethylene glycol 6000, Macrogol 2000/polyethylene glycol 6000/PEG 8000, sodium lauryl sulphate/Macrogol 4000/polyethylene glycol 6000/PEG20000 etc. such as; Most preferably be Macrogol 2000 and/or Macrogol 4000.
In sum, the technical scheme after optimization of the present invention is:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, the ratio comprising parts by weight is principal agent and the substrate of 1:1-1:9; Described principal agent comprises following composition by weight: Semen Strychni Pulveratum 25-75 part, Scorpio 2-12 part, Bombyx Batryticatus (parched with bran) 2-12 part, Herba Ephedrae 2-12 part, parched with bran Rhizoma Atractylodis 2-12 part, Olibanum (processed) 2-12 part, Myrrha (processed) 2-12 part, Radix Cyathulae 2-12 part, Radix Et Caulis Acanthopanacis Senticosi extractum 0.5-5 part, Radix Glycyrrhizae 2-12 part; Described substrate is water-soluble base.
Technical scheme after the present invention optimizes further is:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, the ratio comprising parts by weight is principal agent and the substrate of 1:3-1:7; Described principal agent comprises following composition by weight: Semen Strychni Pulveratum 40-60 part, Scorpio 3-9 part, Bombyx Batryticatus (parched with bran) 3-9 part, Herba Ephedrae 3-9 part, parched with bran Rhizoma Atractylodis 3-9 part, Olibanum (processed) 3-9 part, Myrrha (processed) 3-9 part, Radix Cyathulae 3-9 part, Radix Et Caulis Acanthopanacis Senticosi extractum 1-4 part, Radix Glycyrrhizae 3-9 part; Described substrate is selected from the combination of any one or at least two kinds in sodium lauryl sulphate, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, PEG 8000, PEG20000.
The optimized technical scheme of the present invention is:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, the ratio comprising parts by weight is principal agent and the substrate of 1:5; Described principal agent comprises following composition by weight: Semen Strychni Pulveratum 48.8 parts, Scorpio 6.1 parts, Bombyx Batryticatus (parched with bran) 6.1 parts, 6.1 parts, Herba Ephedrae, parched with bran Rhizoma Atractylodis 6.1 parts, Olibanum (processed) 6.1 parts, Myrrha (processed) 6.1 parts, Radix Cyathulae 6.1 parts, Radix Et Caulis Acanthopanacis Senticosi extractum 2.4 parts, 6.1 parts, Radix Glycyrrhizae; Described substrate is Macrogol 2000 and/or Macrogol 4000.
" comprising " of the present invention, mean it except described component, can also contain other components, these other components give the Chinese medicine dripping pills of described treatment arthralgia aggravated by cold with different characteristics.In addition, " comprising " of the present invention, can also replace with enclosed " being " or " by ... make ".
For achieve the above object two, the present invention adopts following technical scheme:
Treat a preparation method for the Chinese medicine dripping pills of arthralgia aggravated by cold, comprise the steps:
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, after cold drying, mixed powder is broken into fine powder, for subsequent use.
Preferably, described cold drying refers to carries out drying at the temperature of 50-70 DEG C, can be such as 50-58.5 DEG C, 54.2-67 DEG C, 63.5-70 DEG C, 50 DEG C, 51 DEG C, 52.5 DEG C, 53 DEG C, 55 DEG C, 57.8 DEG C, 59 DEG C, 60 DEG C, 61.7 DEG C, 62 DEG C, 64.3 DEG C, 65 DEG C, 66.4 DEG C, 68 DEG C, 69.1 DEG C, 70 DEG C; More preferably 55-65 DEG C; Most preferably be 60 DEG C.
Preferably, described fine powder crosses No. 8 sieves.
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water, decoction liquor is filtered, concentrate, cool.
Preferably, the number of times of described decoction is 1-3 time, such as, can be 1 time, 2 times, 3 times; More preferably 2 times.
Preferably, described decoction each time is 0.5-3h, such as, can be 0.5-1.2h, 0.71-1.63h, 1.45-2.7h, 1.9-2.82h, 2.6-3h, 0.5h, 0.6h, 0.8h, 0.94h, 1h, 1.05h, 1.1h, 1.3h, 1.5h, 1.68h, 1.7h, 1.84h, 2h, 2.17h, 2.3h, 2.4h, 2.5h, 2.76h, 2.9h, 3h; More preferably 1-2h; Most preferably be 1.5h.
Preferably, described concentrated referring to is concentrated into the relative density 1.00-1.35 when 50-85 DEG C, such as relative density 1.35 during relative density 1.21,85 DEG C during relative density 1.3,80.1 DEG C during relative density 1.24,75 DEG C during relative density 1.25,70 DEG C during relative density 1.14,65 DEG C during relative density 1.18,60 DEG C during relative density 1.00,55 DEG C during relative density 1.33,50 DEG C when relative density 1.12,75-85 DEG C when relative density 1.05,54.5-79 DEG C during 50-62 DEG C; More preferably relative density 1.1-1.2 during 52-72 DEG C; Relative density 1.15 when most preferably being 56 DEG C.
Preferably, be cooled to described in and be cooled to room temperature.Cooling can effectively prevent next step add the volatilization loss of ethanol.
(3) in step (2) cooled decoction liquor, add ethanol, static, filter, obtain refined liquid after reclaiming ethanol, refined liquid is concentrated to obtain extract, for subsequent use.
Preferably, the addition of described ethanol is make alcohol content in the decoction liquor after adding ethanol reach 10-85wt%, such as, can be 10-37wt%, 18.2-57.4wt%, 46-76wt%, 51.3-61.3wt%, 69-85wt%, 10wt%, 12.4wt%, 15wt%, 20wt%, 25wt%, 30wt%, 35wt%, 40wt%, 41.8wt%, 45wt%, 50wt%, 55wt%, 60wt%, 65wt%, 67.2wt%, 70wt%, 75wt%, 80wt%, 85wt%; More preferably 50-80wt%; Most preferably be 75wt%.
Preferably, the described standing time is 4-48h, such as, can be 4-11h, 7.5-26.5h, 14-28.3h, 22-39h, 33-48h, 4h, 5h, 6.8h, 9.5h, 10h, 12.5h, 15h, 20h, 21.7h, 23.6h, 25h, 28h, 30h, 30.2h, 32h, 34.7h, 35h, 36.3h, 40h, 41h, 43.5h, 45h; More preferably 12-36h; Most preferably be 24h.
Preferably, described concentrating refers to that being concentrated into the relative density when 50-90 DEG C is 1.00-1.45, such as, when can be 50-62 DEG C relative density 1.00-1.20, relative density 1.05-1.35 during 55-75 DEG C, 64.8-84.8 DEG C time relative density 1.1-1.2, relative density 1.08-1.36 during 73-83 DEG C, relative density 1.25-1.45 during 81-90 DEG C, relative density 1.00 when 50 DEG C, relative density 1.18 when 55 DEG C, relative density 1.14 when 60 DEG C, relative density 1.25 when 65 DEG C, relative density 1.24 when 70 DEG C, relative density 1.4 when 75 DEG C, relative density 1.23 when 80.1 DEG C, relative density 1.35 when 85 DEG C, relative density 1.45 when 90 DEG C, more preferably relative density 1.1-1.3 during 52-72 DEG C, relative density 1.2 when most preferably being 56 DEG C.
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, for subsequent use.
Preferably, described fine powder crosses No. 8 sieves.
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, for subsequent use.
Preferably, described fine powder crosses No. 8 sieves.
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture.
(7) take the substrate of formula ratio, be placed in container and carry out heating in water bath, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stirs, and obtains the fused solution containing medicine and substrate.
Preferably, the temperature of described heating in water bath is 70-90 DEG C, can be such as 70-74.3 DEG C, 73.5-82 DEG C, 75-85 DEG C, 79.1-89.1 DEG C, 88-90 DEG C, 70 DEG C, 71 DEG C, 72 DEG C, 72.5 DEG C, 73 DEG C, 74.7 DEG C, 75 DEG C, 76 DEG C, 77.2 DEG C, 78.4 DEG C, 80 DEG C, 81.5 DEG C, 83.6 DEG C, 84 DEG C, 86.9 DEG C, 87 DEG C, 89.5 DEG C, 90 DEG C; More preferably 75-85 DEG C; Most preferably be 80 DEG C.
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 70-90 DEG C, in condensation column, the temperature of condensing agent remains on-5-40 DEG C, is placed in the water dropper tank of pill dripping machine by the fused solution that step (7) obtains, and is added dropwise in the condensing agent in condensation column by water dropper.
Described water dropper temperature remains on 70-90 DEG C, can be such as 70-78.3 DEG C, 73.5-84 DEG C, 77-87 DEG C, 80.1-88 DEG C, 83.2-90 DEG C, 70 DEG C, 71.5 DEG C, 72 DEG C, 73.2 DEG C, 74.7 DEG C, 75 DEG C, 76 DEG C, 77.2 DEG C, 78.4 DEG C, 80 DEG C, 81.5 DEG C, 83.6 DEG C, 84 DEG C, 86.9 DEG C, 87 DEG C, 89.5 DEG C, 90 DEG C; More preferably 75-85 DEG C; Most preferably be 80 DEG C.
The temperature of condensing agent remains on-5-40 DEG C, can be such as-5-5 DEG C ,-3.5-14 DEG C, 0.7-27 DEG C, 10.1-30 DEG C, 6.2-40 DEG C ,-5 DEG C ,-4 DEG C ,-2 DEG C, 0 DEG C, 1 DEG C, 3.8 DEG C, 6 DEG C, 9.2 DEG C, 10 DEG C, 12.4 DEG C, 15 DEG C, 18.5 DEG C, 20 DEG C, 25 DEG C, 26.9 DEG C, 30 DEG C, 32 DEG C, 39.5 DEG C, 40 DEG C; More preferably 0-5 DEG C; Most preferably be 1-2 DEG C.
Preferably, described condensing agent is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil; Described combination is liquid paraffin/soybean oil, soybean oil/methyl-silicone oil, liquid paraffin/methyl-silicone oil, liquid paraffin/soybean oil/methyl-silicone oil such as; More preferably methyl-silicone oil.
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the condensing agent on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention.
In sum, the technical scheme after optimization of the present invention is:
Treat a preparation method for the Chinese medicine dripping pills of arthralgia aggravated by cold, comprise the steps:
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, at the temperature of 50-70 DEG C after drying, mixed powder is broken into fine powder, for subsequent use;
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 1-3 time, each 0.5-3h, merge decoction liquor, filter, be concentrated into the relative density 1.00-1.35 when 50-85 DEG C, cooling;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 10-85wt%, static 4-48h, filter, obtain refined liquid after reclaiming ethanol, it is 1.00-1.45 that refined liquid is concentrated into the relative density when 50-90 DEG C, obtain extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) substrate of formula ratio is taken, be placed in container and carry out heating in water bath at the temperature of 70-90 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stir, obtain the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 70-90 DEG C, in condensation column, the temperature of condensing agent remains on-5-40 DEG C, the fused solution that step (7) obtains is placed in the water dropper tank of pill dripping machine, be added dropwise in the condensing agent in condensation column by water dropper, described condensing agent is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the condensing agent on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention.
Technical scheme after the present invention optimizes further is:
Treat a preparation method for the Chinese medicine dripping pills of arthralgia aggravated by cold, comprise the steps:
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, at the temperature of 55-65 DEG C after drying, mixed powder is broken into fine powder, for subsequent use;
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 1-3 time, each 1-2h, merge decoction liquor, filter, be concentrated into the relative density 1.1-1.2 when 52-72 DEG C, be cooled to room temperature;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 50-80wt%, static 12-36h, filter, obtain refined liquid after reclaiming ethanol, refined liquid is concentrated into the relative density 1.1-1.3 when 52-72 DEG C, obtains extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) substrate of formula ratio is taken, be placed in container and carry out heating in water bath at the temperature of 75-85 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stir, obtain the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 75-85 DEG C, in condensation column, the temperature of condensing agent remains on 0-5 DEG C, the fused solution that step (7) obtains is placed in the water dropper tank of pill dripping machine, be added dropwise in the condensing agent in condensation column by water dropper, described condensing agent is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the condensing agent on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention.
The optimized technical scheme of the present invention is:
Treat a preparation method for the Chinese medicine dripping pills of arthralgia aggravated by cold, comprise the steps:
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, at the temperature of 60 DEG C after drying, mixed powder is broken into fine powder, crosses No. 8 sieves, for subsequent use;
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 2 times, each 1.5h, merge decoction liquor, filter, be concentrated into relative density 1.15 56 DEG C time, be cooled to room temperature;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 75wt%, static 24h, filter, obtain refined liquid after reclaiming ethanol, refined liquid is concentrated into relative density 1.2 56 DEG C time, obtains extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross No. 8 sieves, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses No. 8 sieves, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) take the substrate of formula ratio, be placed in container and carry out heating in water bath at the temperature of 80 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stirs, and obtains the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 80 DEG C, in condensation column, the temperature of condensing agent methyl-silicone oil remains on 1-2 DEG C, is placed in the water dropper tank of pill dripping machine, is added dropwise in methyl-silicone oil by water dropper by the fused solution that step (7) obtains;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the methyl-silicone oil on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention.
The present invention is by rational formula and meticulous technological design, with cheap cost and method simple and easy to control prepare effective fast, bioavailability is high, taking convenience, be convenient to go out to carry, the Chinese medicine dripping pills of the treatment arthralgia aggravated by cold of safe without toxic side effect, function is mainly expelling wind and removing dampness, subduing swelling and relieving pain, the various numbness be applicable to caused by Cold-dampness are sick, clinically for muscles and bones arthralgia, swelling, numbness, weigh, joint stuffiness, chance are cold the disease such as to increase the weight of and all achieve good therapeutic effect.The Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention, supplements the tcm product dosage form for the treatment of arthralgia aggravated by cold, has enriched the selection of arthralgia aggravated by cold disease patient, particularly had significant curative effect for rheumatism, rheumatoid.
Now by the clinical treatment situation of the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention, details are as follows:
(1) for the clinical treatment of arthralgia aggravated by cold patient:
1, physical data:
Arthralgia aggravated by cold patient 180 example, wherein man 99 example, female 81 example, age 20-65 year, the course of disease 3 months-23 years.Main clinical manifestation is tract pain or the swelling such as joint, skin, muscles and bones, and morning, stiff, numbness weighed, or joint stuffiness, very then joint swelling deformation, tetanic unfavorable, amyotrophy etc.Physico-chemical examination is shown in that anti-" O " increases, or erythrocyte sedimentation rate speeds, or rheumatoid factor positive.The visible sclerotin infringement of x-ray.150 routine patients are divided into treatment group 100 example (man 55 example, female 45 example) and matched group 80 example (man 44 example, female 36 example) at random, and two groups of Genders, age, the course of disease, ill-distribution are basically identical, without statistical number difference.
2, Therapeutic Method:
Treatment group: the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention, oral, one time 1,2 times on the one.
Matched group: medicinal capsule for treating rheumatalgia (Hengba Pharmaceutical Co., Ltd., Guizhou, the accurate word Z20054248 of traditional Chinese medicines), oral, one time 2,2 times on the one.
Be all 1 course for the treatment of with 2 weeks, 1 course for the treatment of of patients whose symptoms were less severe's medication, symptom comparatively severe one medication 2-3 course for the treatment of.
3, curative effect index:
Cure: symptom all disappears, functional activity recovers normal, and main doctor trained in Western medicine physical and chemical index inspection such as anti-" O ", erythrocyte sedimentation rate, rheumatoid factor etc. is all normal, and x-ray loses sclerotin infringement.
Effective: symptomatology is eliminated or cardinal symptom is eliminated, and function of joint is recovered substantially, can participate in normal work or physical labor, main doctor trained in Western medicine physical and chemical index such as anti-" O ", erythrocyte sedimentation rate, rheumatoid factor etc. checks normal.
Effective: cardinal symptom is eliminated substantially, function of joint is substantially recovered or is had made marked progress, and main doctor trained in Western medicine physical and chemical index inspection such as anti-" O ", erythrocyte sedimentation rate, rheumatoid factor etc. makes moderate progress.
Invalid: compared with before treatment, each side is all without progressive.
4, therapeutic outcome: (as shown in table 1)
Table 1
| Cure | Effective | Effectively | Invalid | Total effective rate | |
| Treatment group | 57（57%） | 30（30%） | 11（11%） | 2（2%） | 98% |
| Matched group | 42（52.5%） | 23（28.75%） | 10（12.5%） | 5（6.25%） | 93.75% |
As can be seen from Table 1, medicine of the present invention, compared with contrast medicine, all achieves and significantly improves in cure rate, obvious effective rate and total effective rate.
(2) for the clinical treatment of rheumatism, rheumatoid patient
1, physical data:
Rheumatism, rheumatoid patient 150 example, wherein man 64 example, female 86 example, age 22-67 year, course of disease 0.5-21.Be divided into treatment group 90 example (man 38 example, female 52 example) and matched group 60 example (man 26 example, female 34 example) at random, two groups of Genders, age, the course of disease, ill-distribution are basically identical, without statistical number difference.
2, Therapeutic Method:
Treatment group: the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention, oral, one time 1,2 times on the one.
Matched group: medicinal capsule for treating rheumatalgia (Hengba Pharmaceutical Co., Ltd., Guizhou, the accurate word Z20054248 of traditional Chinese medicines), oral, one time 2,2 times on the one.
Be all 1 course for the treatment of with 2 weeks, 1 course for the treatment of of patients whose symptoms were less severe's medication, symptom comparatively severe one medication 2-3 course for the treatment of.
3, curative effect index:
Cure: symptom all disappears, functional activity recovers normal, and the inspection of main doctor trained in Western medicine physical and chemical index is normal.
Effective: symptomatology is eliminated or cardinal symptom is eliminated, and function of joint is recovered substantially, can participate in normal work or physical labor, main doctor trained in Western medicine physical and chemical index is normal.
Effective: cardinal symptom is eliminated substantially, major joint function is substantially recovered or is had made marked progress, and the inspection of main doctor trained in Western medicine physical and chemical index makes moderate progress.
Invalid: compared with before treatment, each side is all without progressive.
4, therapeutic outcome: (as shown in table 2)
Table 2
| Cure | Effective | Effectively | Invalid | Total effective rate | |
| Treatment group | 53（58.89%） | 31（34.44%） | 5（5.56%） | 1（1.11%） | 98.89% |
| Matched group | 32（53.33%） | 19（31.67%） | 6（10%） | 3（5%） | 95% |
As can be seen from Table 2, medicine of the present invention, compared with contrast medicine, is significantly improving for all achieving in rheumatism, rheumatoid cure rate, obvious effective rate and total effective rate.
Below in conjunction with embodiment, the present invention is described in further detail.But following embodiment is only simple and easy example of the present invention, does not represent or limits the scope of the present invention, and interest field of the present invention is as the criterion with claims.
Detailed description of the invention
For better the present invention being described, be convenient to understand technical scheme of the present invention, existing with several groups of specific embodiments, just the preparation method of Bitongning drop pill of the present invention is described further.
Embodiment 1:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, the ratio comprising parts by weight is principal agent and the substrate of 1:5; Described principal agent comprises following composition by weight: Semen Strychni Pulveratum 48.8 parts, Scorpio 6.1 parts, Bombyx Batryticatus (parched with bran) 6.1 parts, 6.1 parts, Herba Ephedrae, parched with bran Rhizoma Atractylodis 6.1 parts, Olibanum (processed) 6.1 parts, Myrrha (processed) 6.1 parts, Radix Cyathulae 6.1 parts, Radix Et Caulis Acanthopanacis Senticosi extractum 2.4 parts, 6.1 parts, Radix Glycyrrhizae; Described substrate is Macrogol 2000.
The preparation method of the Chinese medicine dripping pills of above-mentioned treatment arthralgia aggravated by cold, comprises the steps:
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, at the temperature of 60 DEG C after drying, mixed powder is broken into fine powder, crosses No. 8 sieves, for subsequent use;
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 2 times, each 1.5h, merge decoction liquor, filter, be concentrated into relative density 1.15 56 DEG C time, be cooled to room temperature;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 75wt%, static 24h, filter, obtain refined liquid after reclaiming ethanol, refined liquid is concentrated into relative density 1.2 56 DEG C time, obtains extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross No. 8 sieves, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses No. 8 sieves, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) take the substrate of formula ratio, be placed in container and carry out heating in water bath at the temperature of 80 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stirs, and obtains the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 80 DEG C, in condensation column, the temperature of condensing agent methyl-silicone oil remains on 1-2 DEG C, is placed in the water dropper tank of pill dripping machine, is added dropwise in methyl-silicone oil by water dropper by the fused solution that step (7) obtains;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the methyl-silicone oil on surface, dry.
Embodiment 2:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, the ratio comprising parts by weight is principal agent and the substrate of 1:2; Described principal agent comprises following composition by weight: Semen Strychni Pulveratum 42 parts, Scorpio 7 parts, Bombyx Batryticatus (parched with bran) 7 parts, 7 parts, Herba Ephedrae, parched with bran Rhizoma Atractylodis 7 parts, Olibanum (processed) 7 parts, Myrrha (processed) 7 parts, Radix Cyathulae 7 parts, Radix Et Caulis Acanthopanacis Senticosi extractum 2 parts, 7 parts, Radix Glycyrrhizae; Described substrate is Macrogol 4000 and the polyethylene glycol 6000 of mass ratio 1:1.
The preparation method of the Chinese medicine dripping pills of above-mentioned treatment arthralgia aggravated by cold, comprises the steps:
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, at the temperature of 60 DEG C after drying, mixed powder is broken into fine powder, crosses No. 8 sieves, for subsequent use;
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 2 times, each 1h, merge decoction liquor, filter, be concentrated into relative density 1.15 56 DEG C time, be cooled to room temperature;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 75wt%, static 24h, filter, obtain refined liquid after reclaiming ethanol, refined liquid is concentrated into relative density 1.2 56 DEG C time, obtains extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross No. 8 sieves, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses No. 8 sieves, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) take the substrate of formula ratio, be placed in container and carry out heating in water bath at the temperature of 80 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stirs, and obtains the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 80 DEG C, in condensation column, the temperature of condensing agent methyl-silicone oil remains on 1-4 DEG C, is placed in the water dropper tank of pill dripping machine, is added dropwise in methyl-silicone oil by water dropper by the fused solution that step (7) obtains;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the methyl-silicone oil on surface, dry.
Embodiment 3:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, the ratio comprising parts by weight is principal agent and the substrate of 1:3; Described principal agent comprises following composition by weight: Semen Strychni Pulveratum 49 parts, Scorpio 6 parts, Bombyx Batryticatus (parched with bran) 6 parts, 6 parts, Herba Ephedrae, parched with bran Rhizoma Atractylodis 6 parts, Olibanum (processed) 6 parts, Myrrha (processed) 6 parts, Radix Cyathulae 6 parts, Radix Et Caulis Acanthopanacis Senticosi extractum 3 parts, 6 parts, Radix Glycyrrhizae; Described substrate is Macrogol 4000.
The preparation method of the Chinese medicine dripping pills of above-mentioned treatment arthralgia aggravated by cold, comprises the steps:
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, at the temperature of 60 DEG C after drying, mixed powder is broken into fine powder, crosses No. 8 sieves, for subsequent use;
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 2 times, each 1h, merge decoction liquor, filter, be concentrated into relative density 1.15 56 DEG C time, be cooled to room temperature;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 75wt%, static 24h, filter, obtain refined liquid after reclaiming ethanol, refined liquid is concentrated into relative density 1.2 56 DEG C time, obtains extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross No. 8 sieves, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses No. 8 sieves, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) take the substrate of formula ratio, be placed in container and carry out heating in water bath at the temperature of 80 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stirs, and obtains the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 80 DEG C, in condensation column, the temperature of condensing agent liquid paraffin remains on 1-2 DEG C, is placed in the water dropper tank of pill dripping machine, is added dropwise in liquid paraffin by water dropper by the fused solution that step (7) obtains;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the liquid paraffin on surface, dry.
Embodiment 4:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, the ratio comprising parts by weight is principal agent and the substrate of 1:3; Described principal agent comprises following composition by weight: Semen Strychni Pulveratum 50 parts, Scorpio 6 parts, Bombyx Batryticatus (parched with bran) 6 parts, 6 parts, Herba Ephedrae, parched with bran Rhizoma Atractylodis 6 parts, Olibanum (processed) 6 parts, Myrrha (processed) 6 parts, Radix Cyathulae 6 parts, Radix Et Caulis Acanthopanacis Senticosi extractum 2 parts, 6 parts, Radix Glycyrrhizae; Described substrate is polyethylene glycol 6000.
The preparation method of the Chinese medicine dripping pills of above-mentioned treatment arthralgia aggravated by cold, comprises the steps:
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, at the temperature of 60 DEG C after drying, mixed powder is broken into fine powder, crosses No. 8 sieves, for subsequent use;
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 2 times, each 1h, merge decoction liquor, filter, be concentrated into relative density 1.15 56 DEG C time, be cooled to room temperature;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 75wt%, static 24h, filter, obtain refined liquid after reclaiming ethanol, refined liquid is concentrated into relative density 1.2 56 DEG C time, obtains extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross No. 8 sieves, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses No. 8 sieves, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) take the substrate of formula ratio, be placed in container and carry out heating in water bath at the temperature of 80 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stirs, and obtains the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 80 DEG C, in condensation column, the temperature of condensing agent soybean oil remains on 1-2 DEG C, is placed in the water dropper tank of pill dripping machine, is added dropwise in soybean oil by water dropper by the fused solution that step (7) obtains;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the soybean oil on surface, dry.
Embodiment 5:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, the ratio comprising parts by weight is principal agent and the substrate of 1:7; Described principal agent comprises following composition by weight: Semen Strychni Pulveratum 40 parts, Scorpio 3 parts, Bombyx Batryticatus (parched with bran) 3 parts, 3 parts, Herba Ephedrae, parched with bran Rhizoma Atractylodis 3 parts, Olibanum (processed) 3 parts, Myrrha (processed) 3 parts, Radix Cyathulae 3 parts, Radix Et Caulis Acanthopanacis Senticosi extractum 1 part, 3 parts, Radix Glycyrrhizae; Described substrate is sodium lauryl sulphate.
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, at the temperature of 65 DEG C after drying, mixed powder is broken into fine powder, for subsequent use;
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 3 times, each 1h, merge decoction liquor, filter, be concentrated into relative density 1.2 72 DEG C time, be cooled to room temperature;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 80wt%, static 36h, filter, obtain refined liquid after reclaiming ethanol, refined liquid is concentrated into relative density 1.3 72 DEG C time, obtains extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) take the substrate of formula ratio, be placed in container and carry out heating in water bath at the temperature of 85 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stirs, and obtains the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 85 DEG C, in condensation column, the temperature of condensing agent liquid paraffin remains on 5 DEG C, is placed in the water dropper tank of pill dripping machine by the fused solution that step (7) obtains, and is added dropwise in the liquid paraffin in condensation column by water dropper;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the liquid paraffin on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention.
Embodiment 6:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, the ratio comprising parts by weight is principal agent and the substrate of 1:3; Described principal agent comprises following composition by weight: Semen Strychni Pulveratum 60 parts, Scorpio 9 parts, Bombyx Batryticatus (parched with bran) 9 parts, 9 parts, Herba Ephedrae, parched with bran Rhizoma Atractylodis 9 parts, Olibanum (processed) 9 parts, Myrrha (processed) 9 parts, Radix Cyathulae 9 parts, Radix Et Caulis Acanthopanacis Senticosi extractum 4 parts, 9 parts, Radix Glycyrrhizae; Described substrate is PEG20000.
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, at the temperature of 55 DEG C after drying, mixed powder is broken into fine powder, for subsequent use;
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 1 time, each 2h, merge decoction liquor, filter, be concentrated into relative density 1.1 52 DEG C time, be cooled to room temperature;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 50wt%, static 12h, filter, obtain refined liquid after reclaiming ethanol, refined liquid is concentrated into relative density 1.1 52 DEG C time, obtains extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) take the substrate of formula ratio, be placed in container and carry out heating in water bath at the temperature of 75 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stirs, and obtains the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 75 DEG C, in condensation column, the temperature of condensing agent soybean oil remains on 0 DEG C, is placed in the water dropper tank of pill dripping machine by the fused solution that step (7) obtains, and is added dropwise in the soybean oil in condensation column by water dropper;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the soybean oil on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention.
Embodiment 7:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, the ratio comprising parts by weight is principal agent and the substrate of 1:9; Described principal agent comprises following composition by weight: Semen Strychni Pulveratum 75 parts, Scorpio 12 parts, Bombyx Batryticatus (parched with bran) 12 parts, 12 parts, Herba Ephedrae, parched with bran Rhizoma Atractylodis 12 parts, Olibanum (processed) 12 parts, Myrrha (processed) 12 parts, Radix Cyathulae 12 parts, Radix Et Caulis Acanthopanacis Senticosi extractum 5 parts, 12 parts, Radix Glycyrrhizae; Described substrate is polyethylene glycol 6000 and the PEG 8000 of mass ratio 2:1.
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, at the temperature of 70 DEG C after drying, mixed powder is broken into fine powder, for subsequent use;
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 3 times, each 0.5h, merge decoction liquor, filter, be concentrated into relative density 1.35 85 DEG C time, cooling;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 85wt%, static 48h, filter, obtain refined liquid after reclaiming ethanol, it is 1.45 that refined liquid is concentrated into relative density 90 DEG C time, obtains extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) take the substrate of formula ratio, be placed in container and carry out heating in water bath at the temperature of 90 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stirs, and obtains the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 90 DEG C, in condensation column, the temperature of condensing agent liquid paraffin remains on 40 DEG C, is placed in the water dropper tank of pill dripping machine by the fused solution that step (7) obtains, and is added dropwise in the liquid paraffin in condensation column by water dropper;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the liquid paraffin on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention.
Embodiment 8:
Treat a Chinese medicine dripping pills for arthralgia aggravated by cold, the ratio comprising parts by weight is principal agent and the substrate of 1:1; Described principal agent comprises following composition by weight: Semen Strychni Pulveratum 25 parts, Scorpio 2 parts, Bombyx Batryticatus (parched with bran) 2 parts, 2 parts, Herba Ephedrae, parched with bran Rhizoma Atractylodis 2 parts, Olibanum (processed) 2 parts, Myrrha (processed) 2 parts, Radix Cyathulae 2 parts, Radix Et Caulis Acanthopanacis Senticosi extractum 0.5 part, 2 parts, Radix Glycyrrhizae; Described substrate is Macrogol 4000 and the PEG 8000 of mass ratio 1:2.
(1) take the Scorpio of formula ratio, Rhizoma Atractylodis, Olibanum, Myrrha, at the temperature of 50 DEG C after drying, mixed powder is broken into fine powder, for subsequent use;
(2) take the Bombyx Batryticatus of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 1 time, each 3h, merge decoction liquor, filter, be concentrated into relative density 1.00 50 DEG C time, cooling;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 10wt%, static 4h, filter, obtain refined liquid after reclaiming ethanol, it is 1.00 that refined liquid is concentrated into relative density 50 DEG C time, obtains extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) take the substrate of formula ratio, be placed in container and carry out heating in water bath at the temperature of 70 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stirs, and obtains the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 70 DEG C, in condensation column, the temperature of condensing agent methyl-silicone oil remains on-5 DEG C, is placed in the water dropper tank of pill dripping machine by the fused solution that step (7) obtains, and is added dropwise in the methyl-silicone oil in condensation column by water dropper;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the methyl-silicone oil on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold of the present invention.
It should be noted that and understand, when not departing from the spirit and scope of the present invention required by accompanying claim, various amendment and improvement can be made to the present invention of foregoing detailed description.Therefore, the scope of claimed technical scheme is not by the restriction of given any specific exemplary teachings.
Applicant states, above content is in conjunction with concrete preferred implementation further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to protection scope of the present invention.
Claims (9)
1. treat a Chinese medicine dripping pills for arthralgia aggravated by cold, it is characterized in that, comprise principal agent and substrate; Described principal agent is made up of Semen Strychni Pulveratum, Scorpio, Bombyx Batryticatus (parched with bran), Herba Ephedrae, parched with bran Rhizoma Atractylodis, Olibanum (processed), Myrrha (processed), Radix Cyathulae, Radix Et Caulis Acanthopanacis Senticosi extractum, Radix Glycyrrhizae;
Described principal agent is grouped into by the one-tenth of following parts by weight: Semen Strychni Pulveratum 25-75 part, Scorpio 2-12 part, Bombyx Batryticatus (parched with bran) 2-12 part, Herba Ephedrae 2-12 part, parched with bran Rhizoma Atractylodis 2-12 part, Olibanum (processed) 2-12 part, Myrrha (processed) 2-12 part, Radix Cyathulae 2-12 part, Radix Et Caulis Acanthopanacis Senticosi extractum 0.5-5 part, Radix Glycyrrhizae 2-12 part;
Described principal agent is 1:5-1:9 with the ratio of the parts by weight of substrate;
Described Chinese medicine dripping pills is made as follows:
(1) take the Scorpio of formula ratio, parched with bran Rhizoma Atractylodis, Olibanum (processed), Myrrha (processed), at the temperature of 50-70 DEG C after drying, mixed powder is broken into fine powder, for subsequent use;
(2) take the Bombyx Batryticatus (parched with bran) of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 1-3 time, each 0.5-3h, merge decoction liquor, filter, be concentrated into the relative density 1.00-1.35 when 50-85 DEG C, cooling;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 10-85wt%, static 4-48h, filter, obtain refined liquid after reclaiming ethanol, it is 1.00-1.45 that refined liquid is concentrated into the relative density when 50-90 DEG C, obtain extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) substrate of formula ratio is taken, be placed in container and carry out heating in water bath at the temperature of 70-90 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stir, obtain the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 70-90 DEG C, in condensation column, the temperature of condensing agent remains on-5 ~ 40 DEG C, the fused solution that step (7) obtains is placed in the water dropper tank of pill dripping machine, be added dropwise in the condensing agent in condensation column by water dropper, described condensing agent is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the condensing agent on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold.
2. the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold according to claim 1, is characterized in that, described principal agent is 1:5-1:7 with the ratio of the parts by weight of substrate.
3. the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold according to claim 2, is characterized in that, described principal agent is 1:5 with the ratio of the parts by weight of substrate.
4. the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold according to claim 1, is characterized in that, described substrate is water-soluble base.
5. according to the Chinese medicine dripping pills of the treatment arthralgia aggravated by cold one of claim 1-4 Suo Shu, it is characterized in that, described principal agent is grouped into by the one-tenth of following parts by weight: Semen Strychni Pulveratum 40-60 part, Scorpio 3-9 part, Bombyx Batryticatus (parched with bran) 3-9 part, Herba Ephedrae 3-9 part, parched with bran Rhizoma Atractylodis 3-9 part, Olibanum (processed) 3-9 part, Myrrha (processed) 3-9 part, Radix Cyathulae 3-9 part, Radix Et Caulis Acanthopanacis Senticosi extractum 1-4 part, Radix Glycyrrhizae 3-9 part; Described substrate is selected from the combination of any one or at least two kinds in sodium lauryl sulphate, Macrogol 2000, Macrogol 4000, polyethylene glycol 6000, PEG 8000, PEG20000.
6. the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold according to claim 5, it is characterized in that, described principal agent is grouped into by the one-tenth of following parts by weight: Semen Strychni Pulveratum 48.8 parts, Scorpio 6.1 parts, Bombyx Batryticatus (parched with bran) 6.1 parts, 6.1 parts, Herba Ephedrae, parched with bran Rhizoma Atractylodis 6.1 parts, Olibanum (processed) 6.1 parts, Myrrha (processed) 6.1 parts, Radix Cyathulae 6.1 parts, Radix Et Caulis Acanthopanacis Senticosi extractum 2.4 parts, 6.1 parts, Radix Glycyrrhizae; Described substrate is Macrogol 2000 and/or Macrogol 4000.
7., according to the preparation method of the Chinese medicine dripping pills of the treatment arthralgia aggravated by cold one of claim 1-6 Suo Shu, it is characterized in that, comprise the steps:
(1) take the Scorpio of formula ratio, parched with bran Rhizoma Atractylodis, Olibanum (processed), Myrrha (processed), at the temperature of 50-70 DEG C after drying, mixed powder is broken into fine powder, for subsequent use;
(2) take the Bombyx Batryticatus (parched with bran) of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 1-3 time, each 0.5-3h, merge decoction liquor, filter, be concentrated into the relative density 1.00-1.35 when 50-85 DEG C, cooling;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 10-85wt%, static 4-48h, filter, obtain refined liquid after reclaiming ethanol, it is 1.00-1.45 that refined liquid is concentrated into the relative density when 50-90 DEG C, obtain extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) substrate of formula ratio is taken, be placed in container and carry out heating in water bath at the temperature of 70-90 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stir, obtain the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 70-90 DEG C, in condensation column, the temperature of condensing agent remains on-5 ~ 40 DEG C, the fused solution that step (7) obtains is placed in the water dropper tank of pill dripping machine, be added dropwise in the condensing agent in condensation column by water dropper, described condensing agent is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the condensing agent on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold.
8. the preparation method of the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold according to claim 7, is characterized in that, comprise the steps:
(1) take the Scorpio of formula ratio, parched with bran Rhizoma Atractylodis, Olibanum (processed), Myrrha (processed), at the temperature of 55-65 DEG C after drying, mixed powder is broken into fine powder, for subsequent use;
(2) take the Bombyx Batryticatus (parched with bran) of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 1-3 time, each 1-2h, merge decoction liquor, filter, be concentrated into the relative density 1.1-1.2 when 52-72 DEG C, be cooled to room temperature;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 50-80wt%, static 12-36h, filter, obtain refined liquid after reclaiming ethanol, refined liquid is concentrated into the relative density 1.1-1.3 when 52-72 DEG C, obtain extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) substrate of formula ratio is taken, be placed in container and carry out heating in water bath at the temperature of 75-85 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stir, obtain the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 75-85 DEG C, in condensation column, the temperature of condensing agent remains on 0-5 DEG C, the fused solution that step (7) obtains is placed in the water dropper tank of pill dripping machine, be added dropwise in the condensing agent in condensation column by water dropper, described condensing agent is selected from the combination of any one or at least two kinds of liquid paraffin, soybean oil, methyl-silicone oil;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the condensing agent on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold.
9. preparation method according to claim 8, is characterized in that, comprises the steps:
(1) take the Scorpio of formula ratio, parched with bran Rhizoma Atractylodis, Olibanum (processed), Myrrha (processed), at the temperature of 60 DEG C after drying, mixed powder is broken into fine powder, crosses No. 8 sieves, for subsequent use;
(2) take the Bombyx Batryticatus (parched with bran) of formula ratio, Herba Ephedrae, Radix Cyathulae, Radix Glycyrrhizae, decoct with water 2 times, each 1.5h, merge decoction liquor, filter, be concentrated into relative density 1.15 56 DEG C time, be cooled to room temperature;
(3) in step (2) cooled decoction liquor, add ethanol, make alcohol content in decoction liquor reach 75wt%, static 24h, filter, obtain refined liquid after reclaiming ethanol, refined liquid is concentrated into relative density 1.2 56 DEG C time, obtains extract, for subsequent use;
(4) take the Semen Strychni Pulveratum of formula ratio, be ground into fine powder, cross No. 8 sieves, for subsequent use;
(5) take the Radix Et Caulis Acanthopanacis Senticosi extractum of formula ratio, crushed after being dried becomes fine powder, crosses No. 8 sieves, for subsequent use;
(6) fine powder that extract step (3) obtained and (1), (4), (5) obtain is mixed homogeneously, and obtains principal agent mixture;
(7) substrate of formula ratio is taken, be placed in container and carry out heating in water bath at the temperature of 80 DEG C, the substrate heated while stirring in container, to its complete melting, adds the principal agent mixture of step (6), stir, obtain the fused solution containing medicine and substrate;
(8) temperature control system of pill dripping machine is adjusted, the water dropper temperature of pill dripping machine is made to remain on 80 DEG C, in condensation column, the temperature of condensing agent methyl-silicone oil remains on 1-2 DEG C, the fused solution that step (7) obtains is placed in the water dropper tank of pill dripping machine, is added dropwise in methyl-silicone oil by water dropper;
(9) from pill dripping machine outlet, the drop pill shrinking molding is taken out, absorb the methyl-silicone oil on surface, after drying, namely obtain the Chinese medicine dripping pills for the treatment of arthralgia aggravated by cold.
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Effective date of registration: 20160804 Address after: 158417 Jixi City, Heilongjiang city of Hulin province (Xigang Street West Revolutionary Committee) Patentee after: Heilongjiang Wusuli River Pharmaceutical Co., Ltd. Address before: Haping Road Development Zone in Harbin City, Heilongjiang province 150060 District Bohai Road No. 39 Patentee before: Wang Xiaoyu |