CN1827604A - 硝基化合物及其在培美曲塞制备中的应用 - Google Patents
硝基化合物及其在培美曲塞制备中的应用 Download PDFInfo
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- CN1827604A CN1827604A CN 200610043441 CN200610043441A CN1827604A CN 1827604 A CN1827604 A CN 1827604A CN 200610043441 CN200610043441 CN 200610043441 CN 200610043441 A CN200610043441 A CN 200610043441A CN 1827604 A CN1827604 A CN 1827604A
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CNB2006100434415A CN100379729C (zh) | 2006-04-06 | 2006-04-06 | 硝基化合物及其在培美曲塞制备中的应用 |
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CNB2006100434415A CN100379729C (zh) | 2006-04-06 | 2006-04-06 | 硝基化合物及其在培美曲塞制备中的应用 |
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CN1827604A true CN1827604A (zh) | 2006-09-06 |
CN100379729C CN100379729C (zh) | 2008-04-09 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010031357A1 (zh) * | 2008-09-22 | 2010-03-25 | 重庆医药工业研究院有限责任公司 | 培美曲塞二酸的新晶型及其制备方法 |
CN106749270A (zh) * | 2016-11-29 | 2017-05-31 | 上海天慈生物谷生物工程有限公司 | 一种抗叶酸小分子化学药物的合成方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101624379B (zh) * | 2009-07-29 | 2011-04-27 | 苏州永拓医药科技有限公司 | 一种2-氯-4,6-二甲氧基-1,3,5-三嗪的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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NO169490C (no) * | 1988-03-24 | 1992-07-01 | Takeda Chemical Industries Ltd | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater |
US5254687A (en) * | 1991-12-04 | 1993-10-19 | The Trustees Of Princeton University | Process for the preparation of pyrrolo[2,3-d]pyrimidines |
IL135190A (en) * | 1997-09-26 | 2005-03-20 | Lilly Co Eli | Processes and intermediates useful to make antifolates |
US6066732A (en) * | 1998-08-21 | 2000-05-23 | The Trustees Of Princeton University | Process for the preparation of pyrrolo[2,3-d]pyrimidines |
CN100344615C (zh) * | 2004-11-25 | 2007-10-24 | 重庆医药工业研究院有限责任公司 | 制备N-(吡咯并[2,3-d]嘧啶-5-基)酰基谷氨酸衍生物的方法及中间体 |
CN100395246C (zh) * | 2005-06-15 | 2008-06-18 | 江苏豪森药业股份有限公司 | 用于制造叶酸拮抗剂及其中间体的方法 |
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2006
- 2006-04-06 CN CNB2006100434415A patent/CN100379729C/zh active Active
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010031357A1 (zh) * | 2008-09-22 | 2010-03-25 | 重庆医药工业研究院有限责任公司 | 培美曲塞二酸的新晶型及其制备方法 |
AU2009295094B2 (en) * | 2008-09-22 | 2012-11-01 | Chongqing Pharmaceutical Research Institute Co., Ltd. | New crystalline forms of pemetrexed diacid, and preparations thereof |
US8324382B2 (en) | 2008-09-22 | 2012-12-04 | Chongqing Pharmaceutical Research Institute Co., Ltd. | Crystalline forms of Pemetrexed diacid, and preparations thereof |
CN101684121B (zh) * | 2008-09-22 | 2013-04-03 | 重庆医药工业研究院有限责任公司 | 培美曲塞二酸的新晶型及其制备方法 |
CN106749270A (zh) * | 2016-11-29 | 2017-05-31 | 上海天慈生物谷生物工程有限公司 | 一种抗叶酸小分子化学药物的合成方法 |
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C14 | Grant of patent or utility model | ||
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EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Qilu Pharmaceutical (Hainan) Co., Ltd.|Qilu Pharmaceutical (Hainan) Co., Ltd. Assignor: Henan Tianyuan Kangze Pharmaceutical Technology Co., Ltd.| Henan Tianyuan Kangze Pharmaceutical Technology Co., Ltd. Contract fulfillment period: 2009.7.5 to 2014.7.5 contract change Contract record no.: 2009460000010 Denomination of invention: Nitro compounds and their application in preparation of pemetrexed Granted publication date: 20080409 License type: Exclusive license Record date: 2009.9.21 |
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Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.7.5 TO 2014.7.5; CHANGE OF CONTRACT Name of requester: QILU PHARMACEUTICAL (HAINAN) CO., LTD. QILU PHARMA Effective date: 20090921 |
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Owner name: QILU PHARMACEUTICAL (HAINAN) CO., LTD. Free format text: FORMER OWNER: HENAN TIANYUAN KANGZE PHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20130708 |
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Effective date of registration: 20130708 Address after: 570314 -A, Nanhai Avenue, national hi tech Development Zone, Hainan, Haikou, 273 Patentee after: Qilu Pharmaceutical (Hainan) Co.,Ltd. Address before: 570314 -A, Nanhai Avenue, national hi tech Development Zone, Hainan, Haikou, 273 Patentee before: Henan Tianyuan Kangze Pharmaceutical Technology Co., Ltd. |