CN1813999A - Rukuaixiao medicinal prepration for treating breast tumor and preparing method - Google Patents
Rukuaixiao medicinal prepration for treating breast tumor and preparing method Download PDFInfo
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- CN1813999A CN1813999A CNA2005100324302A CN200510032430A CN1813999A CN 1813999 A CN1813999 A CN 1813999A CN A2005100324302 A CNA2005100324302 A CN A2005100324302A CN 200510032430 A CN200510032430 A CN 200510032430A CN 1813999 A CN1813999 A CN 1813999A
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Abstract
The present invention relates to a Rukuaixiao medicine preparation for effectively curing nodules of breast, necrotic mass of breast and swelling of breast and its preparation method. Said Rukuaixiao medicine preparation can be oral liquor, dispersing tablet or effervescent tablet preparation made up by using 6 Chinese medicinal materials of tangerine leaf, salvia root, gleditsia thorn, toosendan fruit, vaccaria seed and earthworm as effective component.
Description
One, technical field:
The present invention relates to a kind of is Rukuaixiao medicinal prepration for treating breast tumor of being prepared from of active component and preparation method thereof with Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Fructus Toosendan, Semen Vaccariae, Pheretima 6 flavor Chinese medicines.Relate in particular to RUKUAIXIAO oral liquid, dispersible tablet, effervescent tablet and preparation method thereof.
Two, background technology:
RUKUAIXIAO PIAN is a kind of Chinese medicine, mainly has depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, dissolving breast mass.Be used for the treatment of depression of liver-QI, qi depression to blood stasis, cyclomastopathy, diseases such as distending pain of the breast.Taken in state-promulgated pharmacopoeia at present.According to the laws and regulations of the relevant new drug of country, change existing pharmaceutical formulation and promptly belong to the new drug research category.The RUKUAIXIAO tablet is traditional Chinese patent medicine tablet, in order to expand the dosage form of this product, is easy to carry and takes, and satisfies people's medication demand better, and the present invention expands as oral liquid and dispersible tablet, effervescent tablet with RUKUAIXIAO tablet prior dosage form.Make medicine improve greatly like this, improved bioavailability, shortened the highest Mlc time of advent, make the curative effect of medicine more remarkable in the intravital infiltration rate of people.
Three, summary of the invention:
The object of the present invention is to provide a kind of preparation for dissipating breast lumps, specifically, is that active component prepares RUKUAIXIAO oral liquid, dispersible tablet and effervescent tablet with Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Fructus Toosendan, Semen Vaccariae, Pheretima 6 flavor Chinese medicines exactly.
Technical scheme of the present invention is:
A kind of preparation for dissipating breast lumps, preparation are meant RUKUAIXIAO oral liquid, dispersible tablet, effervescent tablet, it is characterized in that: formulated by the following traditional Chinese medicines component, its composition by weight is:
Folium Citri tangerinae 412.5-1650 Radix Salviae Miltiorrhizae 412.5-1650 Spina Gleditsiae 275-1100
Fructus Toosendan 275-1100 Semen Vaccariae 275-1100 Pheretima 275-1100
Optimum weight component of the present invention is:
Folium Citri tangerinae 825 Radix Salviae Miltiorrhizaes 825 Spina Gleditsiaes 550
Fructus Toosendan 550 Semen Vaccariae 550 Pheretimas 550
Preparation for dissipating breast lumps of the present invention can be made oral liquid, dispersible tablet and effervescent tablet.
Its preparation method is:
1, RUKUAIXIAO oral liquor:
A, Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Fructus Toosendan, Semen Vaccariae, Pheretima 6 flavor Chinese medicines are cleaned, be up to the standards, standby;
Except that Pheretima, the five tastes such as all the other Folium Citri tangerinae decoct with water secondary in b, the above Six-element, and the 4-12 that decocts amount of water for the 1st time and be Chinese medicine weight doubly, the 4-10 that decocts amount of water for the 2nd time and be Chinese medicine weight doubly, each 1 hour, collecting decoction, filter, concentrate, add Pheretima, mix, with 70% alcohol reflux secondary, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, reclaim ethanol, be condensed into concentrated solution;
C, get concentrated solution and add purified water and correctives, be prepared into oral liquid.
2, RUKUAIXIAO dispersible tablet preparation method:
A, Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Fructus Toosendan, Semen Vaccariae, Pheretima 6 flavor Chinese medicines are cleaned, be up to the standards, standby;
Except that Pheretima, the five tastes such as all the other Folium Citri tangerinae decoct with water secondary in b, the above Six-element, and the 4-12 that decocts amount of water for the 1st time and be Chinese medicine weight doubly, the 4-10 that decocts amount of water for the 2nd time and be Chinese medicine weight doubly, each 1 hour, collecting decoction, filter, concentrate, add Pheretima, mix, with 70% alcohol reflux secondary, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, reclaim ethanol, be condensed into concentrated solution; Being evaporated to relative density is the clear paste of 1.20～1.25 (75～80 ℃);
C, with clear paste simmer down to dried cream powder, add an amount of filler and part disintegrating agent, granulate drying, granulate with binding agent or wetting agent; Add mix homogeneously tablettings such as an amount of disintegrating agent and lubricant again, promptly get dispersible tablet; Make film-coated dispersion tablet through art for coating again.
Above-mentioned described disintegrating agent is: one or more of crospolyvinylpyrrolidone or Sodium Hydroxymethyl Stalcs or low-substituted hydroxypropyl cellulose or crosslinked Carboxymethyl cellulose sodium.
Binding agent is: one or several of the alcoholic solution of 45-90% or starch slurry or polyvinylpyrrolidone alcoholic solution.The best is the alcoholic solution of 2-4% polyvinylpyrrolidone and 55%.
Lubricant is: magnesium stearate or micropowder silica gel or Pulvis Talci.
Filler is: one or several of starch or lactose or microcrystalline Cellulose or precoking starch.
3, RUKUAIXIAO effervescent tablet preparation method
A, Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Fructus Toosendan, Semen Vaccariae, Pheretima 6 flavor Chinese medicines are cleaned, be up to the standards, standby;
B, get in the above Six-element except that Pheretima, the five tastes such as all the other Folium Citri tangerinae decoct with water secondary, and the 4-12 that decocts amount of water for the 1st time and be Chinese medicine weight doubly, the 4-10 that decocts amount of water for the 2nd time and be Chinese medicine weight doubly, each 1 hour, collecting decoction, filter, concentrate, add Pheretima, mix, with 70% alcohol reflux secondary, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, reclaim ethanol, be condensed into concentrated solution; Being evaporated to relative density is the clear paste of 1.20～1.25 (75～80 ℃);
Add an amount of starch, dextrin, polyethylene glycol 6000, saccharin sodium, stevioside, magnesium stearate in c, the clear paste, in the Pulvis Talci one or several, mix homogeneously, add the carbon dioxide source of acid source and effervescent tablet in addition again, continue abundant mix homogeneously, drying, make particulate, compacting is in blocks, and drying promptly gets the RUKUAIXIAO effervescent tablet.
Acid source is citric acid, L MALIC ACID, adipic acid, potassium citrate dihydrogen, Soluble tartar., fumaric acid sodium, can add wherein one or several.
The carbon dioxide source of effervescent tablet is: sodium bicarbonate, potassium bicarbonate, calcium carbonate can add wherein one or several.
The ratio of effervescent tablet Chinese medicine of the present invention, adjuvant is as follows:
Drug extract 10-50%
Carbon dioxide source 11-35%
Acid source 16-35%
Saccharin sodium 0.1-2%
Pulvis Talci 0.4-3%
The invention has the advantages that, overcome the disintegrating procedue of tablet at gastric, be that oral liquid or dispersible tablet effervescent tablet all make medicine be absorbed rapidly in the intestines and stomach, make effective ingredient in blood, reach effective Mlc in the short period of time, improved bioavailability, made the product curative effect more remarkable.
Four, the specific embodiment:
Embodiment 1:a, get Folium Citri tangerinae 825g Radix Salviae Miltiorrhizae 825g Spina Gleditsiae 550g Fructus Toosendan 550g Semen Vaccariae 550g Pheretima 550g
Except that Pheretima, the five tastes such as all the other Folium Citri tangerinae decoct with water secondary in b, the above Six-element, and the 4-12 that decocts amount of water for the 1st time and be Chinese medicine weight doubly, the 4-10 that decocts amount of water for the 2nd time and be Chinese medicine weight doubly, each 1 hour, collecting decoction, filter, filtrate is concentrated into 1100ml, adds Pheretima, mix, with 70% alcohol reflux secondary, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, reclaim ethanol, be condensed into concentrated solution;
C, get concentrated solution and add purified water and correctives, make 10000 milliliters of RUKUAIXIAO oral liquids.
Embodiment 2:a, get Folium Citri tangerinae 825g Radix Salviae Miltiorrhizae 825g Spina Gleditsiae 550g Fructus Toosendan 550g Semen Vaccariae 550g Pheretima 550g
Except that Pheretima, the five tastes such as all the other Folium Citri tangerinae decoct with water secondary in b, the above Six-element, and the 4-12 that decocts amount of water for the 1st time and be Chinese medicine weight doubly, the 4-10 that decocts amount of water for the 2nd time and be Chinese medicine weight doubly, each 1 hour, collecting decoction, filter, filtrate is concentrated into 1100ml, adds Pheretima, mix, with 70% alcohol reflux secondary, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, reclaim ethanol, be condensed into concentrated solution; Being evaporated to relative density is the clear paste of 1.20～1.25 (75～80 ℃);
C, with clear paste simmer down to dried cream powder, add an amount of filler and part disintegrating agent, granulate drying, granulate with binding agent or wetting agent; Add mix homogeneously tablettings such as an amount of disintegrating agent and lubricant again, make 1000 dispersible tablets; Make film-coated dispersion tablet through art for coating again.
Embodiment 3:a, get Folium Citri tangerinae 825g Radix Salviae Miltiorrhizae 825g Spina Gleditsiae 550g Fructus Toosendan 550g Semen Vaccariae 550g Pheretima 550g
B, get in the above Six-element except that Pheretima, the five tastes such as all the other Folium Citri tangerinae decoct with water secondary, and the 4-12 that decocts amount of water for the 1st time and be Chinese medicine weight doubly, the 4-10 that decocts amount of water for the 2nd time and be Chinese medicine weight doubly, each 1 hour, collecting decoction, filter, filtrate is concentrated into 1100ml, adds Pheretima, mix, with 70% alcohol reflux secondary, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, reclaim ethanol, be condensed into concentrated solution; Being evaporated to relative density is the clear paste of 1.20～1.25 (75～80 ℃);
Add an amount of starch, dextrin, polyethylene glycol 6000, saccharin sodium, stevioside, magnesium stearate in c, the clear paste, in the Pulvis Talci one or several, mix homogeneously, add the carbon dioxide source of acid source and effervescent tablet in addition again, continue abundant mix homogeneously, drying, make particulate, compacting is in blocks, and drying is made 1000 RUKUAIXIAO effervescent tablets.
Embodiment 4: get Folium Citri tangerinae 412.5g Radix Salviae Miltiorrhizae 412.5g Spina Gleditsiae 275g Fructus Toosendan 275g Semen Vaccariae 275g Pheretima 275g
By the preparation method of RUKUAIXIAO oral liquid in the technique scheme and dispersible tablet effervescent tablet, make 10000 milliliters of RUKUAIXIAO oral liquids or 1000 dispersible tablets or 1000 effervescent tablets.
Embodiment 5: get Folium Citri tangerinae 412.5g Radix Salviae Miltiorrhizae 412.5g Spina Gleditsiae 275g Fructus Toosendan 275g Semen Vaccariae 275g Pheretima 275g
By the preparation method of RUKUAIXIAO oral liquid in the technique scheme and dispersible tablet effervescent tablet, make 5000 milliliters of RUKUAIXIAO oral liquids or 500 dispersible tablets or 500 effervescent tablets.
Embodiment 6: get Folium Citri tangerinae 412.5g Radix Salviae Miltiorrhizae 412.5g Spina Gleditsiae 275g Fructus Toosendan 275g Semen Vaccariae 275g Pheretima 275g
By the preparation method of RUKUAIXIAO oral liquid in the technique scheme and dispersible tablet effervescent tablet, make 2500 milliliters of RUKUAIXIAO oral liquids or 250 dispersible tablets or 250 effervescent tablets.
Claims (6)
1, a kind of preparation for dissipating breast lumps, preparation is meant RUKUAIXIAO oral liquid, dispersible tablet, effervescent tablet, it is characterized in that: formulated by the following traditional Chinese medicines component, its composition by weight is:
Folium Citri tangerinae 412.5-1650 Radix Salviae Miltiorrhizae 412.5-1650 Spina Gleditsiae 275-1100
Fructus Toosendan 275-1100 Semen Vaccariae 275-1100 Pheretima 275-1100
Optimum weight component of the present invention is:
Folium Citri tangerinae 825 Radix Salviae Miltiorrhizaes 825 Spina Gleditsiaes 550
Fructus Toosendan 550 Semen Vaccariae 550 Pheretimas 550
2, preparation for dissipating breast lumps according to claim 1 is characterized in that:
The RUKUAIXIAO oral liquor:
A, Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Fructus Toosendan, Semen Vaccariae, Pheretima 6 flavor Chinese medicines are cleaned, be up to the standards, standby;
Except that Pheretima, the five tastes such as all the other Folium Citri tangerinae decoct with water secondary in b, the above Six-element, and the 4-12 that decocts amount of water for the 1st time and be Chinese medicine weight doubly, the 4-10 that decocts amount of water for the 2nd time and be Chinese medicine weight doubly, each 1 hour, collecting decoction, filter, concentrate, add Pheretima, mix, with 70% alcohol reflux secondary, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, reclaim ethanol, be condensed into concentrated solution;
C, get concentrated solution and add purified water and correctives, be prepared into oral liquid.
3, preparation for dissipating breast lumps according to claim 1 is characterized in that:
RUKUAIXIAO dispersible tablet preparation method:
A, Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Fructus Toosendan, Semen Vaccariae, Pheretima 6 flavor Chinese medicines are cleaned, be up to the standards, standby;
Except that Pheretima, the five tastes such as all the other Folium Citri tangerinae decoct with water secondary in b, the above Six-element, and the 4-12 that decocts amount of water for the 1st time and be Chinese medicine weight doubly, the 4-10 that decocts amount of water for the 2nd time and be Chinese medicine weight doubly, each 1 hour, collecting decoction, filter, concentrate, add Pheretima, mix, with 70% alcohol reflux secondary, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, reclaim ethanol, be condensed into concentrated solution; Being evaporated to relative density is the clear paste of 1.20～1.25 (75～80 ℃);
C, with clear paste simmer down to dried cream powder, add an amount of filler and part disintegrating agent, granulate drying, granulate with binding agent or wetting agent; Add mix homogeneously tablettings such as an amount of disintegrating agent and lubricant again, promptly get dispersible tablet; Make film-coated dispersion tablet through art for coating again.
4, preparation for dissipating breast lumps according to claim 1 is characterized in that:
RUKUAIXIAO effervescent tablet preparation method:
A, Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Fructus Toosendan, Semen Vaccariae, Pheretima 6 flavor Chinese medicines are cleaned, be up to the standards, standby;
B, get in the above Six-element except that Pheretima, the five tastes such as all the other Folium Citri tangerinae decoct with water secondary, and the 4-12 that decocts amount of water for the 1st time and be Chinese medicine weight doubly, the 4-10 that decocts amount of water for the 2nd time and be Chinese medicine weight doubly, each 1 hour, collecting decoction, filter, concentrate, add Pheretima, mix, with 70% alcohol reflux secondary, 2 hours for the first time, 1 hour for the second time, filter merging filtrate, reclaim ethanol, be condensed into concentrated solution; Being evaporated to relative density is the clear paste of 1.20～1.25 (75～80 ℃);
Add an amount of starch, dextrin, polyethylene glycol 6000, saccharin sodium, stevioside, magnesium stearate in c, the clear paste, in the Pulvis Talci one or several, mix homogeneously, add the carbon dioxide source of acid source and effervescent tablet in addition again, continue abundant mix homogeneously, drying, make particulate, compacting is in blocks, and drying promptly gets the RUKUAIXIAO effervescent tablet.
5, preparation for dissipating breast lumps according to claim 3 is characterized in that:
The disintegrating agents of dispersible tablets is: one or more of crospolyvinylpyrrolidone or Sodium Hydroxymethyl Stalcs or low-substituted hydroxypropyl cellulose or crosslinked Carboxymethyl cellulose sodium;
Binding agent is: one or several of the alcoholic solution of 45-90% or starch slurry or polyvinylpyrrolidone alcoholic solution; The best is the alcoholic solution of 2-4% polyvinylpyrrolidone and 55%;
Lubricant is: magnesium stearate or micropowder silica gel or Pulvis Talci;
Filler is: one or several of starch or lactose or microcrystalline Cellulose or precoking starch.
6, preparation for dissipating breast lumps according to claim 4 is characterized in that:
Acid source in the effervescent tablet is citric acid, L MALIC ACID, adipic acid, potassium citrate dihydrogen, Soluble tartar., fumaric acid sodium, can add wherein one or several;
The carbon dioxide source of effervescent tablet is: sodium bicarbonate, potassium bicarbonate, calcium carbonate can add wherein one or several;
The ratio of effervescent tablet Chinese medicine, adjuvant is as follows:
Drug extract 10-50%
Carbon dioxide source 11-35%
Acid source 16-35%
Saccharin sodium 0.1-2%
Pulvis Talci 0.4-3%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005100324302A CN1813999A (en) | 2005-11-22 | 2005-11-22 | Rukuaixiao medicinal prepration for treating breast tumor and preparing method |
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| CNA2005100324302A CN1813999A (en) | 2005-11-22 | 2005-11-22 | Rukuaixiao medicinal prepration for treating breast tumor and preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943662B (en) * | 2006-10-18 | 2010-05-12 | 北京亚东生物制药有限公司 | Preparation method of the Chinese traditional medicinal composition granules for treating galactophore disease and its products |
| CN102000182B (en) * | 2007-04-03 | 2012-12-05 | 北京亚东生物制药有限公司 | Preparation method of traditional Chinese medicinal soft capsules for treating breast diseases and product thereof |
| CN102973698A (en) * | 2012-12-18 | 2013-03-20 | 西安碑林药业股份有限公司 | Traditional Chinese medicine preparation for treating hyperplasia of mammary glands |
-
2005
- 2005-11-22 CN CNA2005100324302A patent/CN1813999A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943662B (en) * | 2006-10-18 | 2010-05-12 | 北京亚东生物制药有限公司 | Preparation method of the Chinese traditional medicinal composition granules for treating galactophore disease and its products |
| CN102000182B (en) * | 2007-04-03 | 2012-12-05 | 北京亚东生物制药有限公司 | Preparation method of traditional Chinese medicinal soft capsules for treating breast diseases and product thereof |
| CN102973698A (en) * | 2012-12-18 | 2013-03-20 | 西安碑林药业股份有限公司 | Traditional Chinese medicine preparation for treating hyperplasia of mammary glands |
| CN102973698B (en) * | 2012-12-18 | 2014-03-26 | 西安碑林药业股份有限公司 | Traditional Chinese medicine preparation for treating hyperplasia of mammary glands |
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Open date: 20060809 |