CN1813827A - Sea-buckthorn chewing tablet and its preparation - Google Patents
Sea-buckthorn chewing tablet and its preparation Download PDFInfo
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- CN1813827A CN1813827A CN 200510031265 CN200510031265A CN1813827A CN 1813827 A CN1813827 A CN 1813827A CN 200510031265 CN200510031265 CN 200510031265 CN 200510031265 A CN200510031265 A CN 200510031265A CN 1813827 A CN1813827 A CN 1813827A
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- fructus hippophae
- chewable tablet
- adjuvant
- hippophae flavone
- flavone
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Abstract
The present invention relates to a chewing tablet made up by using hippophae rhmnoides as raw material. It is characterized by that said invention uses hippophae rhmnoides extract hippophae rhmnoides flavone as main active component, adds the proper medicinal auxiliary materials, such as cane sugar, mannitol, xylitol, lactose, aspartame,microcrystalline cellulose and lubricant and adopts tableting process to prepare the invented chewing tablet.
Description
Technical field:
The present invention relates to medical technical field, be meant that especially a kind of is that raw material is made chewable tablet and preparation technology thereof with the Fructus Hippophae.
Technical background:
Elaeangnaceae plant Fructus Hippophae (Hipplphae rhamnoides L.) is commonly called as " vinegar willow ", " acid thorn " is a kind of plant with nutrition and medicinal dual value, its fruit contains very rich nutrient contents: except that vitamin C, E, K, P etc., also contain multiple medicinal ingredients such as flavone.The traditional Chinese medical science is thought: Fructus Hippophae can go into the heart, lung, spleen, stomach four warps, has tonifying the lung, dissipating blood stasis blood, and effects such as wet refreshment, appetite stimulator fall in sunstroke prevention.According to record in " China book on Chinese herbal medicine ", the functional component of Fructus Hippophae is mainly flavone compound such as isorhamnetin, isorhamnetin glucoside, isorhamnetin Folium Symplocoris Caudatae glucoside, Quercetin, kaempferide etc.A large amount of pharmacological researches show: Fructus Hippophae flavone (Fructus Hippophae extract) can significantly increase the myocardial nutritional flow amount, improve myocardium microcirculation, reduce myocardial oxygen consumption, improve oxygen-resistant ability, prevent the acute ischemic myocardial damage that pituitrin causes, significant antagonism is arranged increasing myocardial oxygen consumption due to the isoproterenol.Clinical practice shows: the Fructus Hippophae flavone preparation has significant curative effect to ischemic heart desease: the effective percentage to patient with angina pectoris reaches 94%, improves the blood supply of cardiac muscle state preferably, promotes cardiac function, is the treatment ischemic heart desease, the ideal medicament of allevating angina pectoris; Can also be used for myocardial ischemia, chronic cardiac insufficiency, prevention of arterial is atherosis, myocardial infarction, cerebral thrombosis etc.The Hippophac Rhamnoides Yellow ketone preparation that has in the market is mainly XINDAKANG PIAN and granule etc., granule must be used mixing in water for oral taking owing to added a large amount of adjuvants, and carry inconvenience, because Fructus Hippophae flavone is the slightly water-soluble material, as raw material, the tablet of making usually has disintegration time long, even phenomenon that can't disintegrate, to cause curative effect to descend, need water to swallow as capsule and conventional tablet in addition, take for the people who is reluctant to take medicine or the people that do not have drinking water at one's side and to have certain difficulty, sea-buckthorn chewing tablet of the present invention has not only solved this problem, and because the oral cavity mastication improves the dispersibility of Fructus Hippophae flavone greatly, thereby help improving the bioavailability of Fructus Hippophae flavone.
Summary of the invention:
Fructus Hippophae (Hippophae rhamnoides L.) is the Elaeangnaceae plant, Fructus Hippophae flavone mainly is contained in its fruit, stem and leaf etc., because Fructus Hippophae flavone soluble,very slightly in water, so it extracts the ethanol extractions that adopt more, method such as the agent of Ministry of Public Health Chinese traditional patent formulation commonly used are contained, XINDAKANG PIAN (WS3-B-2666-97): " get Fructus Hippophae 1000g and be ground into coarse powder; divide heating and refluxing extraction three times with 85% ethanol 9000ml, filtrate recycling ethanol is condensed into dried cream; oil expression again; with ethanol 200ml reflux, reclaim ethanol, be condensed into dried cream; water 1000ml washing is drying to obtain Fructus Hippophae flavone." can make 1000 XINDAKANG PIAN with this Fructus Hippophae flavone 100g or 50g.
The present invention is that active component is made chewable tablet with the Fructus Hippophae flavone, can allocate taste by adding adjuvant, is convenient to take.The general Fructus Hippophae flavone preparation water mode of swallowing, become chewing easily and suck medicine, both increased the mode of taking, can strengthen the dispersion of Fructus Hippophae flavone again, thereby improve its bioavailability.
Sea-buckthorn chewing tablet of the present invention is main functional component with Fructus Hippophae flavone mainly, used main adjuvant is the pharmaceutic adjuvant that improves mouthfeel, increases chewable tablet mouldability and hardness, as mannitol, sucrose, xylitol, lactose aspartame, Herba Menthae essence, citric acid, malic acid, starch and cellulose family are as microcrystalline Cellulose, methylcellulose, hydroxypropyl celluloses etc. add the flowability that an amount of fluidizer (micropowder silica gel) and lubricant (magnesium stearate) can increase powder in the tabletting process.Used preparation method can adopt the dry process of direct powder compression, or adopt suitable adhesive as (concentration is generally 1～5%) or ethanol water moistenings such as starch slurry, PVP, HPMC, crossing 8～24 mesh sieves granulates, 60～70 ℃ of oven dry, again with the magnesium stearate mix homogeneously, granulate the compacting chewable tablet with 12～40 mesh sieves.This is the wet method tabletting.
Dry granulation is crossed 100 mesh sieves usually with Fructus Hippophae flavone and pharmaceutic adjuvant pulverize separately, and mix homogeneously adds the moderate lubrication agent and directly goes up the machine tabletting.
The ratio of Fructus Hippophae flavone and pharmaceutic adjuvant is (100～500) in the sea-buckthorn chewing tablet: (400～800), used pharmaceutic adjuvant generally adds in proportion with its role in the chewable tablet preparation process, wherein improve sucrose, mannitol, xylitol, lactose and the acidic flavoring agent of mouthfeel and essence etc., can be one or more mixture, its gross weight should account for used adjuvant total amount more than 1/2.
Sea-buckthorn chewing tablet of the present invention can further specify by the following example, but the present invention is not subjected to the restriction of following enforcement:
The used Fructus Hippophae flavone of the following example is meant in the contained standard XINDAKANG PIAN of Ministry of Public Health Chinese traditional patent formulation preparation (WS3-B-2666-97) that its preparation method is seen this standard in order to the raw material Fructus Hippophae flavone of preparation XINDAKANG PIAN.
Embodiment 1:
Prescription: Fructus Hippophae flavone 100g
Lactose 140g
Microcrystalline Cellulose 200g
Mannitol 50g
Micropowder silica gel 10g
Amount to 500g
Above each component by above-mentioned prescription mix homogeneously, is pressed into chewable tablet by dry method
Embodiment 2:
Prescription: Fructus Hippophae flavone 100g
Sucrose 58g
Mannitol 130g
Microcrystalline Cellulose 200g
Aspartame 4g
Micropowder silica gel 3g
Magnesium stearate 5g
Amount to 500g
More than add sweeting agent in the prescription to improve mouthfeel, add an amount of fluidizer and lubricant to increase the flowability of powder, mannitol, Icing Sugar and microcrystalline Cellulose are filler.
Adopt direct powder compression, preparation technology is as follows: take by weighing various adjuvants by recipe quantity, mix homogeneously adds Fructus Hippophae flavone, mix homogeneously, tabletting.
Embodiment 3:
Prescription: Fructus Hippophae flavone 100g
Sucrose 237g
Lactose 79g
Mannitol 79g
Magnesium stearate 5g
Amount to 500g
Get Fructus Hippophae flavone and adjuvant (all crossing 80 mesh sieves) mix homogeneously by above-mentioned prescription, with 85% ethanol moistening system soft material, 20 mesh sieves are granulated, 60～70 ℃ of dryings, and 20 mesh sieve granulate add magnesium stearate, and tabletting gets 1000 tablet chewable tablets.
Embodiment 4:
Prescription: Fructus Hippophae flavone 350g
Sucrose 200g
Microcrystalline Cellulose 80g
Citric acid 10g
Micropowder silica gel 50g
Magnesium stearate 10g
Amount to 690g
By above-mentioned prescription, according to wet granulation, binding agent adopts 85% ethanol, is pressed into chewable tablet.
Embodiment 5:
Prescription: Fructus Hippophae flavone 100g
Xylitol 200g
Lactose 100g
Microcrystalline Cellulose 70g
Malic acid 5g
Micropowder silica gel 20g
The beautiful 5g of stearic acid
Amount to 500g
By above-mentioned prescription, according to wet granulation, binding agent is that 1%PVP alcoholic solution (concentration of alcohol is 80%) is pressed into chewable tablet.
Claims (6)
1, a kind of is the chewable tablet that raw material is made with the Fructus Hippophae.
2, the chewable tablet of claim 1 is characterized in that: contain the active component Fructus Hippophae flavone, the part by weight of Fructus Hippophae flavone and adjuvant (100～500) in the chewable tablet: (400～800).
3, the chewable tablet of claim 1 is characterized in that Fructus Hippophae through Fructus Hippophae flavone and additive of tablet mix homogeneously that extraction obtains, with dry method or wet granulation mode, is pressed into chewable tablet.
4, the dry method of claim 3 is meant the method with the mixed material direct compression of Fructus Hippophae flavone and adjuvant.
5, the wet granulation in the claim 3 is meant Fructus Hippophae flavone is mixed with adjuvant, with 1～5% binding agent (as starch slurry, PVP, HPMC etc.) or ethanol water moistening, crossing 8～24 mesh sieves granulates, 60～70 ℃ of oven dry, again with the magnesium stearate mix homogeneously, granulate the compacting chewable tablet with 12～40 mesh sieves.
6, the chewable tablet in the claim 3, it is characterized in that containing pharmaceutic adjuvant, pharmaceutic adjuvant is mannitol, sucrose, lactose, xylitol, aspartame, Herba Menthae essence, citric acid, malic acid, magnesium stearate, micropowder silica gel, starch, cellulose family (microcrystalline Cellulose, methylcellulose, hydroxypropyl cellulose).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510031265 CN1813827A (en) | 2005-02-04 | 2005-02-04 | Sea-buckthorn chewing tablet and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510031265 CN1813827A (en) | 2005-02-04 | 2005-02-04 | Sea-buckthorn chewing tablet and its preparation |
Publications (1)
| Publication Number | Publication Date |
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| CN1813827A true CN1813827A (en) | 2006-08-09 |
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| CN 200510031265 Pending CN1813827A (en) | 2005-02-04 | 2005-02-04 | Sea-buckthorn chewing tablet and its preparation |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720726A (en) * | 2013-11-22 | 2014-04-16 | 镇江市丹徒区南山溪园茶叶专业合作社 | Processing technology of folium ginkgo chewable tablets |
| CN103783369A (en) * | 2014-01-22 | 2014-05-14 | 天益食品（徐州）有限公司 | Burdock chewable tablet and preparation method thereof |
| CN104222729A (en) * | 2014-09-19 | 2014-12-24 | 中国科学院西北高原生物研究所 | Sea-buckthorn royal jelly buccal tablet and production method thereof |
| CN104257893A (en) * | 2014-10-13 | 2015-01-07 | 上海海虹实业(集团)巢湖今辰药业有限公司 | Preparation method of fructus mume and green tea antidiarrheal chewable tablet |
| CN106176841A (en) * | 2016-08-17 | 2016-12-07 | 四川理工学院 | A kind of Penthorum chinense whole part mixing chewable tablet and preparation method thereof |
| CN108851071A (en) * | 2018-09-17 | 2018-11-23 | 青海清华博众生物技术有限公司 | Sea-buckthorn VP alimentation composition and its preparation method and application |
| CN110384720A (en) * | 2018-04-17 | 2019-10-29 | 西南民族大学 | A kind of hippophae rhamnoides compositions and its preparation method and application |
| CN114052254A (en) * | 2021-12-01 | 2022-02-18 | 成都华西康健生物工程有限公司 | Sea-buckthorn chewable tablet and preparation method thereof |
-
2005
- 2005-02-04 CN CN 200510031265 patent/CN1813827A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720726A (en) * | 2013-11-22 | 2014-04-16 | 镇江市丹徒区南山溪园茶叶专业合作社 | Processing technology of folium ginkgo chewable tablets |
| CN103783369A (en) * | 2014-01-22 | 2014-05-14 | 天益食品（徐州）有限公司 | Burdock chewable tablet and preparation method thereof |
| CN103783369B (en) * | 2014-01-22 | 2015-09-30 | 天益食品（徐州）有限公司 | A kind of burdock chewable tablets and preparation method thereof |
| CN104222729A (en) * | 2014-09-19 | 2014-12-24 | 中国科学院西北高原生物研究所 | Sea-buckthorn royal jelly buccal tablet and production method thereof |
| CN104257893A (en) * | 2014-10-13 | 2015-01-07 | 上海海虹实业(集团)巢湖今辰药业有限公司 | Preparation method of fructus mume and green tea antidiarrheal chewable tablet |
| CN106176841A (en) * | 2016-08-17 | 2016-12-07 | 四川理工学院 | A kind of Penthorum chinense whole part mixing chewable tablet and preparation method thereof |
| CN110384720A (en) * | 2018-04-17 | 2019-10-29 | 西南民族大学 | A kind of hippophae rhamnoides compositions and its preparation method and application |
| CN108851071A (en) * | 2018-09-17 | 2018-11-23 | 青海清华博众生物技术有限公司 | Sea-buckthorn VP alimentation composition and its preparation method and application |
| CN114052254A (en) * | 2021-12-01 | 2022-02-18 | 成都华西康健生物工程有限公司 | Sea-buckthorn chewable tablet and preparation method thereof |
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