CN1805966B - 作为抗病毒核苷酸类似物的含膦酸酯基团的嘧啶化合物 - Google Patents

作为抗病毒核苷酸类似物的含膦酸酯基团的嘧啶化合物 Download PDF

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Publication number
CN1805966B
CN1805966B CN2004800168859A CN200480016885A CN1805966B CN 1805966 B CN1805966 B CN 1805966B CN 2004800168859 A CN2004800168859 A CN 2004800168859A CN 200480016885 A CN200480016885 A CN 200480016885A CN 1805966 B CN1805966 B CN 1805966B
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compound
group
independently
amino
formula
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Expired - Lifetime
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CN2004800168859A
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English (en)
Chinese (zh)
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CN1805966A (zh
Inventor
J·M·R·巴尔扎里尼
E·D·A·德克莱尔克
D·霍茨科娃
A·霍利
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Katholieke Universiteit Leuven
Czech Academy of Sciences CAS
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Katholieke Universiteit Leuven
Czech Academy of Sciences CAS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2004800168859A 2003-06-16 2004-06-16 作为抗病毒核苷酸类似物的含膦酸酯基团的嘧啶化合物 Expired - Lifetime CN1805966B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47889303P 2003-06-16 2003-06-16
US60/478,893 2003-06-16
PCT/CZ2004/000034 WO2004111064A1 (en) 2003-06-16 2004-06-16 Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs

Publications (2)

Publication Number Publication Date
CN1805966A CN1805966A (zh) 2006-07-19
CN1805966B true CN1805966B (zh) 2013-03-13

Family

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Family Applications (1)

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CN2004800168859A Expired - Lifetime CN1805966B (zh) 2003-06-16 2004-06-16 作为抗病毒核苷酸类似物的含膦酸酯基团的嘧啶化合物

Country Status (15)

Country Link
US (2) US7115592B2 (https=)
EP (1) EP1644389B1 (https=)
JP (2) JP5280631B2 (https=)
KR (1) KR101102815B1 (https=)
CN (1) CN1805966B (https=)
AT (1) ATE496056T1 (https=)
AU (1) AU2004247305B2 (https=)
CA (1) CA2527805C (https=)
DE (1) DE602004031115D1 (https=)
DK (1) DK1644389T3 (https=)
EA (1) EA011948B1 (https=)
IL (1) IL172015A (https=)
NZ (1) NZ543864A (https=)
SI (1) SI1644389T1 (https=)
WO (1) WO2004111064A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1906971A2 (en) * 2005-07-27 2008-04-09 Gilead Sciences, Inc. Antiviral compounds
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
WO2011027222A2 (en) 2009-09-02 2011-03-10 Novartis Ag Immunogenic compositions including tlr activity modulators
EP2558466A4 (en) 2010-04-14 2013-11-13 Univ California PHOSPHONATES WITH REDUCED TOXICITY FOR THE TREATMENT OF VIRUS INFECTIONS
WO2012031045A2 (en) * 2010-08-31 2012-03-08 Chimerix, Inc. Phosphonate ester derivatives and methods of synthesis thereof
AU2011295853A1 (en) * 2010-09-01 2013-04-04 Irm Llc Adsorption of immunopotentiators to insoluble metal salts
WO2012079035A1 (en) 2010-12-10 2012-06-14 Sigmapharm Laboratories, Llc Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs
WO2012117377A1 (en) 2011-03-02 2012-09-07 Novartis Ag Combination vaccines with lower doses of antigen and/or adjuvant
EP3578563B1 (en) 2011-12-22 2021-04-14 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
MX372965B (es) 2012-03-08 2020-04-01 Glaxosmithkline Biologicals Sa Formulaciones adyuvadas de vacunas de difteria, tetanos y tos ferina (dtp) de refuerzo.
CN103665043B (zh) * 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
CN102796138B (zh) * 2012-09-07 2014-10-22 山东大学 (2-(3-甲硫基-1,2,4-噻二嗪)乙氧基)甲基膦酸酯类衍生物及其制备与应用
SG10201800188SA (en) 2013-03-15 2018-02-27 Univ California Acyclic nucleoside phosphonate diesters
CN111808136B (zh) 2014-09-15 2024-06-11 加利福尼亚大学董事会 核苷酸类似物
EP3350191B9 (en) 2015-09-15 2021-12-22 The Regents of the University of California Nucleotide analogs
KR20250052378A (ko) 2022-07-21 2025-04-18 안티바 바이오사이언시즈, 인크. Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태

Citations (1)

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WO2003002580A1 (en) * 2001-06-29 2003-01-09 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity

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CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
US4740365A (en) * 1984-04-09 1988-04-26 Toyo Boseki Kabushiki Kaisha Sustained-release preparation applicable to mucous membrane in oral cavity
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
US4725233A (en) * 1985-10-30 1988-02-16 Jens Planert Device for removing crowns, bridges, and similar structures from the stumps of teeth
US5141752A (en) 1986-05-09 1992-08-25 Alza Corporation Delayed drug delivery device
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
NZ222553A (en) 1986-11-18 1991-07-26 Bristol Myers Co Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions
CA2001715C (en) 1988-11-14 1999-12-28 Muzammil M. Mansuri Carbocyclic nucleosides and nucleotides
US5098443A (en) * 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
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US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
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JPH05509307A (ja) * 1990-07-19 1993-12-22 ビーチャム・グループ・パブリック・リミテッド・カンパニー プリンの抗ウイルス性ホスホノ―アルケン誘導体
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WO2003002580A1 (en) * 2001-06-29 2003-01-09 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity

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Kger K ET AL.Synthesis of New Acyclic Pyrimidine Nucleoside Analogs asPotential Antiviral Drugs.J.Med.Chem37.1994,373057-3061. *

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Publication number Publication date
US20060241081A1 (en) 2006-10-26
IL172015A (en) 2016-07-31
WO2004111064A1 (en) 2004-12-23
EP1644389A1 (en) 2006-04-12
JP2012153731A (ja) 2012-08-16
CA2527805A1 (en) 2004-12-23
NZ543864A (en) 2009-10-30
ATE496056T1 (de) 2011-02-15
US20050075318A1 (en) 2005-04-07
DE602004031115D1 (de) 2011-03-03
EA200600046A1 (ru) 2006-06-30
US7115592B2 (en) 2006-10-03
JP5280631B2 (ja) 2013-09-04
CN1805966A (zh) 2006-07-19
CA2527805C (en) 2012-08-21
AU2004247305B2 (en) 2010-02-18
KR101102815B1 (ko) 2012-01-05
KR20060041182A (ko) 2006-05-11
IL172015A0 (en) 2009-02-11
HK1088013A1 (en) 2006-10-27
EA011948B1 (ru) 2009-06-30
SI1644389T1 (sl) 2011-06-30
JP2006527702A (ja) 2006-12-07
AU2004247305A1 (en) 2004-12-23
DK1644389T3 (da) 2011-05-09
EP1644389B1 (en) 2011-01-19

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Granted publication date: 20130313