CN1784240A - 阿尔茨海默氏病的治疗方法 - Google Patents

阿尔茨海默氏病的治疗方法 Download PDF

Info

Publication number
CN1784240A
CN1784240A CNA2004800125340A CN200480012534A CN1784240A CN 1784240 A CN1784240 A CN 1784240A CN A2004800125340 A CNA2004800125340 A CN A2004800125340A CN 200480012534 A CN200480012534 A CN 200480012534A CN 1784240 A CN1784240 A CN 1784240A
Authority
CN
China
Prior art keywords
peptide
seq
amino acid
acid residues
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800125340A
Other languages
English (en)
Chinese (zh)
Inventor
曼努埃尔·萨拉萨巴里奥
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Zaragoza
Original Assignee
Universidad de Zaragoza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Zaragoza filed Critical Universidad de Zaragoza
Publication of CN1784240A publication Critical patent/CN1784240A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
CNA2004800125340A 2003-05-08 2004-05-03 阿尔茨海默氏病的治疗方法 Pending CN1784240A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200301054 2003-05-08
ES200301054A ES2246105B1 (es) 2003-05-08 2003-05-08 Uso de anticuerpos para el tratamiento de enfermedades amiloideas.

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2008100898940A Division CN101264326A (zh) 2003-05-08 2004-05-03 阿尔茨海默氏病的治疗方法

Publications (1)

Publication Number Publication Date
CN1784240A true CN1784240A (zh) 2006-06-07

Family

ID=32982086

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2004800125340A Pending CN1784240A (zh) 2003-05-08 2004-05-03 阿尔茨海默氏病的治疗方法
CNA2008100898940A Pending CN101264326A (zh) 2003-05-08 2004-05-03 阿尔茨海默氏病的治疗方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2008100898940A Pending CN101264326A (zh) 2003-05-08 2004-05-03 阿尔茨海默氏病的治疗方法

Country Status (19)

Country Link
US (6) US20090162362A1 (https=)
EP (5) EP2305286A3 (https=)
JP (5) JP2006525288A (https=)
CN (2) CN1784240A (https=)
AT (1) ATE435024T1 (https=)
AU (2) AU2004237373A1 (https=)
BR (1) BRPI0410684A (https=)
CA (1) CA2524571C (https=)
CY (1) CY1109454T1 (https=)
DE (1) DE602004021797D1 (https=)
DK (3) DK2356996T5 (https=)
ES (6) ES2246105B1 (https=)
IL (8) IL171651A (https=)
MX (1) MXPA05010914A (https=)
PL (3) PL2075007T3 (https=)
PT (3) PT1623719E (https=)
RU (2) RU2385161C2 (https=)
SI (1) SI1623719T1 (https=)
WO (1) WO2004098631A1 (https=)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
ES2246105B1 (es) * 2003-05-08 2007-03-01 Araclon Biotech, S.L. Uso de anticuerpos para el tratamiento de enfermedades amiloideas.
BRPI0513959A (pt) 2004-07-30 2008-05-20 Rinat Neuroscience Corp anticorpos dirigidos contra o peptìdeo beta-amilóide, suas composições farmacêuticas, kit e métodos de fabricação dos mesmos
PE20061323A1 (es) 2005-04-29 2007-02-09 Rinat Neuroscience Corp Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos
RU2432362C2 (ru) 2005-11-30 2011-10-27 Эбботт Лэборетриз Моноклональные антитела и их применения
PL2289909T3 (pl) 2005-11-30 2015-04-30 Abbvie Inc Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał
SG10201404801YA (en) 2005-12-12 2014-09-26 Ac Immune Sa Monoclonal antibody
NZ574188A (en) * 2006-07-14 2012-05-25 Ac Immune Sa Humanized antibody against amyloid beta
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
EP2124952A2 (en) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
AU2008220785B2 (en) 2007-03-01 2013-02-21 Vivoryon Therapeutics N.V. New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
US8048420B2 (en) * 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) * 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
SG178809A1 (en) * 2007-10-05 2012-03-29 Genentech Inc Use of anti-amyloid beta antibody in ocular diseases
RS53174B (sr) * 2007-10-05 2014-06-30 Genentech Inc. Upotreba antiamiloidnog beta antitela u slučaju oboljenja oka
EP2149380A1 (en) * 2008-07-29 2010-02-03 Medivet Pharma, S.L. Veterinary immunotherapy compositions for the Aged Related Cognitive Dysfunction.
EP2258398A1 (en) 2009-05-26 2010-12-08 Araclón Biotech, S. L. Albumin-amyloid peptide conjugates and uses thereof
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
WO2011070174A1 (en) 2009-12-11 2011-06-16 Araclon Biotech, S.L. Methods and reagents for improved detection of amyloid beta peptides
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
ES2684475T3 (es) 2010-04-15 2018-10-03 Abbvie Inc. Proteínas que se unen a beta amiloide
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
CA2805414C (en) * 2010-07-14 2020-07-07 Merck Sharp & Dohme Corp. Anti-addl monoclonal antibody and uses thereof
RU2607368C2 (ru) * 2010-07-30 2017-01-10 Ац Иммуне С.А. Безопасные и функциональные гуманизированные антитела
CN103298833B (zh) 2010-08-14 2015-12-16 Abbvie公司 β淀粉样蛋白结合蛋白
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
EP3027205A4 (en) 2013-07-28 2017-07-19 Qantu Therapeutics, Inc. Vaccine formulations that induce a th2 immune response
ES2571055B1 (es) * 2016-02-15 2016-12-28 Araclon Biotech, S.L. Conjugado amiloide y usos y procedimientos del mismo
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
PL237739B1 (pl) 2018-06-06 2021-05-17 Univ Gdanski Genisteina do zastosowania do leczenia choroby Alzheimera
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
WO2021242776A2 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339014C (en) * 1987-10-08 1997-03-25 Ronald E. Majocha Antibodies to a4 amyloid peptide
AU5525090A (en) * 1989-04-14 1990-11-16 Research Foundation For Mental Hygiene, Inc. Monoclonal antibody to amyloid peptide
ATE153534T1 (de) 1990-04-27 1997-06-15 John Mcmichael Verfahren und zusammensetzung zur behandlung von erkrankungen des zns hervorgerufen durch abnormales beta-amyloid-protein
EP0683234B2 (en) * 1993-01-25 2007-06-06 Takeda Chemical Industries, Ltd. Antibody against beta-amyloid or their derivative and use thereof
US7427392B1 (en) * 1994-11-14 2008-09-23 Elan Pharmaceuticals, Inc. Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau
US8173127B2 (en) * 1997-04-09 2012-05-08 Intellect Neurosciences, Inc. Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof
US7964192B1 (en) * 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
US6905686B1 (en) * 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
TWI239847B (en) * 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
CA2340394A1 (en) * 1998-08-20 2000-03-02 Jorge R. Barrio Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles
UA81216C2 (en) * 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
EP1975179A1 (en) * 2001-12-26 2008-10-01 Araclon Biotech, S.L. Polyclonal antibodies, preparation method thereof and use of same
EP1371986A1 (en) * 2002-06-06 2003-12-17 ABETA GmbH Diagnosis of Alzheimer's disease based on the hAbeta42:hAbeta40 ratio
CA2487528A1 (en) * 2002-07-24 2004-02-12 Innogenetics N.V. Prevention, treatment and diagnosis of diseases associated with beta-amyloid formation and/or aggregation
ES2201929B1 (es) * 2002-09-12 2005-05-16 Araclon Biotech, S.L. Anticuerpos policlonales, metodo de preparacion y uso de los mismos.
MXPA05003621A (es) * 2002-10-09 2005-10-19 Rinat Neuroscience Corp Metodos de tratamiento de la enfermedad de alzheimer usando anticuerpos dirigidos contra el peptido beta amiloide y composiciones de los mismos.
MXPA05008156A (es) * 2003-02-01 2005-09-30 Neuralab Ltd Inmunizacion activa para generar anticuerpos para beta-a soluble.
ES2246105B1 (es) * 2003-05-08 2007-03-01 Araclon Biotech, S.L. Uso de anticuerpos para el tratamiento de enfermedades amiloideas.

Also Published As

Publication number Publication date
US20170260234A1 (en) 2017-09-14
DK2356996T5 (da) 2013-08-26
EP1623719B1 (en) 2009-07-01
IL207876A0 (en) 2011-07-31
ES2246178B1 (es) 2007-03-01
IL207877A (en) 2013-03-24
ES2246105A1 (es) 2006-02-01
US20110262458A1 (en) 2011-10-27
RU2005134351A (ru) 2006-04-27
IL207881A0 (en) 2011-07-31
EP2305286A3 (en) 2011-11-09
EP1623719A1 (en) 2006-02-08
PT2075007E (pt) 2013-08-23
SI1623719T1 (sl) 2009-12-31
ES2423590T3 (es) 2013-09-23
IL207879A (en) 2013-02-28
JP2012006967A (ja) 2012-01-12
RU2009148539A (ru) 2011-06-27
EP2356996B9 (en) 2013-08-28
BRPI0410684A (pt) 2006-06-20
EP2356996B1 (en) 2013-06-26
JP2014129389A (ja) 2014-07-10
PL1623719T3 (pl) 2010-11-30
EP2305286A2 (en) 2011-04-06
IL207877A0 (en) 2011-07-31
ES2329369T3 (es) 2009-11-25
EP2075007B1 (en) 2013-05-22
AU2011200170B2 (en) 2011-09-01
ES2423281T3 (es) 2013-09-19
IL207879A0 (en) 2011-07-31
IL207875A (en) 2013-02-28
IL207880A0 (en) 2011-07-31
ES2246178A1 (es) 2006-02-01
JP2016065100A (ja) 2016-04-28
DK2075007T3 (da) 2013-07-29
RU2385161C2 (ru) 2010-03-27
ES2246177A1 (es) 2006-02-01
DK2356996T3 (da) 2013-07-22
PL2356996T3 (pl) 2013-09-30
US20200140488A1 (en) 2020-05-07
DK1623719T3 (da) 2009-11-09
CN101264326A (zh) 2008-09-17
ES2246177B1 (es) 2007-03-01
ATE435024T1 (de) 2009-07-15
EP2356996A1 (en) 2011-08-17
AU2011200170C1 (en) 2012-03-22
EP2075007A2 (en) 2009-07-01
CA2524571C (en) 2017-01-10
PL2075007T3 (pl) 2013-09-30
MXPA05010914A (es) 2006-03-21
WO2004098631A1 (es) 2004-11-18
US20090162362A1 (en) 2009-06-25
EP2082747A3 (en) 2010-01-13
DE602004021797D1 (de) 2009-08-13
PT1623719E (pt) 2009-10-08
CY1109454T1 (el) 2014-08-13
EP2082747A2 (en) 2009-07-29
IL207878A0 (en) 2011-07-31
PT2356996E (pt) 2013-08-23
ES2246105B1 (es) 2007-03-01
IL207875A0 (en) 2011-07-31
AU2004237373A1 (en) 2004-11-18
US20140044725A1 (en) 2014-02-13
JP2006525288A (ja) 2006-11-09
CA2524571A1 (en) 2004-11-18
IL171651A (en) 2011-11-30
RU2526155C2 (ru) 2014-08-20
IL207876A (en) 2013-03-24
AU2011200170A1 (en) 2011-02-03
JP2018119011A (ja) 2018-08-02
IL207881A (en) 2013-02-28
US20210214394A1 (en) 2021-07-15
IL207878A (en) 2013-02-28
EP2075007A3 (en) 2009-11-11
IL207880A (en) 2013-02-28
EP2075007B9 (en) 2013-09-04

Similar Documents

Publication Publication Date Title
CN1784240A (zh) 阿尔茨海默氏病的治疗方法
CN1249085C (zh) 诱导对β淀粉状蛋白和淀粉状蛋白沉积物的免疫反应、与β淀粉状蛋白同源的免疫源性但非淀粉状蛋白源性合成肽
RU2375374C2 (ru) Домены и эпитопы менингококкового белка nmb1870
CN101043901A (zh) 预防和治疗阿尔茨海默病的方法
CN1826354A (zh) 预防和治疗阿尔茨海默病(ad)的方法
CN101080421A (zh) 抗体以及其利用
CN1568329A (zh) 一种用于预防和治疗阿尔兹海默氏病的具有免疫原性的肽组合物
CN1659187A (zh) 融合铁蛋白在疫苗和其他方面的应用
CN1541225A (zh) 识别β淀粉样肽的人源化抗体
CN1391580A (zh) 肽
CN101052417A (zh) 突触核蛋白病以及淀粉样变性病的预防和治疗
CN1917898A (zh) 用于治疗非典型肺部感染的血管活性肠肽的生物活性物质
CN1874787A (zh) 预防/治疗hbv感染和hbv介导疾病的组合物
CN1231262C (zh) 载脂蛋白b－100表位的模拟肽、其多联体和修饰肽,以及含有这些肽的疫苗组合物
CN1529754A (zh) 一种针对hbv s-表面抗原的单克隆抗体可变区及编码它的基因
CN1657102A (zh) 基于表位的SARS－Cov基因疫苗及其构建
HK1088548A (en) Alzheimer's disease treatment method
CN1634978A (zh) Sars病毒hla－a2限制性表位多肽及其应用
CN1657626A (zh) 抗真菌多肽及其制备方法
CN1280310C (zh) 具有防治流感作用的融合蛋白及其编码基因与应用
CN1238382C (zh) 中华绒螯蟹蜕皮抑制激素1蛋白
CN1073603A (zh) 用于治疗急性胰腺炎的缓激肽拮抗物
CN1903878A (zh) 抗SARS病毒人源性抗体lgG Fab片段
CN1330662A (zh) 幽门螺杆菌抗原
CN1300315C (zh) 奶牛之犊牛前胸腺素基因及其克隆方法与应用

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: ALLEYKLAN BIOISYSTECH CO., LTD.

Free format text: FORMER OWNER: UNIV ZARAGOZA

Effective date: 20060721

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20060721

Address after: Zaragoza

Applicant after: Univ Zaragoza

Address before: Zaragoza

Applicant before: Univ Zaragoza

REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1088548

Country of ref document: HK

C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Open date: 20060607

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1088548

Country of ref document: HK