JP2006525288A - アルツハイマー病治療方法 - Google Patents

アルツハイマー病治療方法 Download PDF

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Publication number
JP2006525288A
JP2006525288A JP2006505607A JP2006505607A JP2006525288A JP 2006525288 A JP2006525288 A JP 2006525288A JP 2006505607 A JP2006505607 A JP 2006505607A JP 2006505607 A JP2006505607 A JP 2006505607A JP 2006525288 A JP2006525288 A JP 2006525288A
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Japan
Prior art keywords
peptide
seq
peptides
terminal
resulting
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Pending
Application number
JP2006505607A
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English (en)
Japanese (ja)
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JP2006525288A5 (https=
Inventor
バーリオ マニュエル サラサ
Original Assignee
ユニバーシダッド デ ザラゴザ
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Publication of JP2006525288A publication Critical patent/JP2006525288A/ja
Publication of JP2006525288A5 publication Critical patent/JP2006525288A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2006505607A 2003-05-08 2004-05-03 アルツハイマー病治療方法 Pending JP2006525288A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200301054A ES2246105B1 (es) 2003-05-08 2003-05-08 Uso de anticuerpos para el tratamiento de enfermedades amiloideas.
PCT/ES2004/000194 WO2004098631A1 (es) 2003-05-08 2004-05-03 Método de tratamiento de la enfermedad de alzheimer

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2011191515A Division JP2012006967A (ja) 2003-05-08 2011-09-02 アルツハイマー病治療方法
JP2014038360A Division JP2014129389A (ja) 2003-05-08 2014-02-28 アルツハイマー病治療方法

Publications (2)

Publication Number Publication Date
JP2006525288A true JP2006525288A (ja) 2006-11-09
JP2006525288A5 JP2006525288A5 (https=) 2007-02-08

Family

ID=32982086

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2006505607A Pending JP2006525288A (ja) 2003-05-08 2004-05-03 アルツハイマー病治療方法
JP2011191515A Pending JP2012006967A (ja) 2003-05-08 2011-09-02 アルツハイマー病治療方法
JP2014038360A Withdrawn JP2014129389A (ja) 2003-05-08 2014-02-28 アルツハイマー病治療方法
JP2016003772A Withdrawn JP2016065100A (ja) 2003-05-08 2016-01-12 アルツハイマー病治療方法
JP2018088643A Pending JP2018119011A (ja) 2003-05-08 2018-05-02 アルツハイマー病治療方法

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2011191515A Pending JP2012006967A (ja) 2003-05-08 2011-09-02 アルツハイマー病治療方法
JP2014038360A Withdrawn JP2014129389A (ja) 2003-05-08 2014-02-28 アルツハイマー病治療方法
JP2016003772A Withdrawn JP2016065100A (ja) 2003-05-08 2016-01-12 アルツハイマー病治療方法
JP2018088643A Pending JP2018119011A (ja) 2003-05-08 2018-05-02 アルツハイマー病治療方法

Country Status (19)

Country Link
US (6) US20090162362A1 (https=)
EP (5) EP2305286A3 (https=)
JP (5) JP2006525288A (https=)
CN (2) CN1784240A (https=)
AT (1) ATE435024T1 (https=)
AU (2) AU2004237373A1 (https=)
BR (1) BRPI0410684A (https=)
CA (1) CA2524571C (https=)
CY (1) CY1109454T1 (https=)
DE (1) DE602004021797D1 (https=)
DK (3) DK2356996T5 (https=)
ES (6) ES2246105B1 (https=)
IL (8) IL171651A (https=)
MX (1) MXPA05010914A (https=)
PL (3) PL2075007T3 (https=)
PT (3) PT1623719E (https=)
RU (2) RU2385161C2 (https=)
SI (1) SI1623719T1 (https=)
WO (1) WO2004098631A1 (https=)

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BRPI0513959A (pt) 2004-07-30 2008-05-20 Rinat Neuroscience Corp anticorpos dirigidos contra o peptìdeo beta-amilóide, suas composições farmacêuticas, kit e métodos de fabricação dos mesmos
PE20061323A1 (es) 2005-04-29 2007-02-09 Rinat Neuroscience Corp Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos
RU2432362C2 (ru) 2005-11-30 2011-10-27 Эбботт Лэборетриз Моноклональные антитела и их применения
PL2289909T3 (pl) 2005-11-30 2015-04-30 Abbvie Inc Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał
SG10201404801YA (en) 2005-12-12 2014-09-26 Ac Immune Sa Monoclonal antibody
NZ574188A (en) * 2006-07-14 2012-05-25 Ac Immune Sa Humanized antibody against amyloid beta
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
EP2124952A2 (en) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
AU2008220785B2 (en) 2007-03-01 2013-02-21 Vivoryon Therapeutics N.V. New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
US8048420B2 (en) * 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) * 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
SG178809A1 (en) * 2007-10-05 2012-03-29 Genentech Inc Use of anti-amyloid beta antibody in ocular diseases
RS53174B (sr) * 2007-10-05 2014-06-30 Genentech Inc. Upotreba antiamiloidnog beta antitela u slučaju oboljenja oka
EP2149380A1 (en) * 2008-07-29 2010-02-03 Medivet Pharma, S.L. Veterinary immunotherapy compositions for the Aged Related Cognitive Dysfunction.
EP2258398A1 (en) 2009-05-26 2010-12-08 Araclón Biotech, S. L. Albumin-amyloid peptide conjugates and uses thereof
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
WO2011070174A1 (en) 2009-12-11 2011-06-16 Araclon Biotech, S.L. Methods and reagents for improved detection of amyloid beta peptides
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
ES2684475T3 (es) 2010-04-15 2018-10-03 Abbvie Inc. Proteínas que se unen a beta amiloide
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
CA2805414C (en) * 2010-07-14 2020-07-07 Merck Sharp & Dohme Corp. Anti-addl monoclonal antibody and uses thereof
RU2607368C2 (ru) * 2010-07-30 2017-01-10 Ац Иммуне С.А. Безопасные и функциональные гуманизированные антитела
CN103298833B (zh) 2010-08-14 2015-12-16 Abbvie公司 β淀粉样蛋白结合蛋白
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
EP3027205A4 (en) 2013-07-28 2017-07-19 Qantu Therapeutics, Inc. Vaccine formulations that induce a th2 immune response
ES2571055B1 (es) * 2016-02-15 2016-12-28 Araclon Biotech, S.L. Conjugado amiloide y usos y procedimientos del mismo
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
PL237739B1 (pl) 2018-06-06 2021-05-17 Univ Gdanski Genisteina do zastosowania do leczenia choroby Alzheimera
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
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JP2002502802A (ja) * 1997-12-02 2002-01-29 ニューララブ リミテッド アミロイド形成疾患の予防および処置

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Publication number Publication date
US20170260234A1 (en) 2017-09-14
DK2356996T5 (da) 2013-08-26
EP1623719B1 (en) 2009-07-01
IL207876A0 (en) 2011-07-31
ES2246178B1 (es) 2007-03-01
IL207877A (en) 2013-03-24
ES2246105A1 (es) 2006-02-01
US20110262458A1 (en) 2011-10-27
RU2005134351A (ru) 2006-04-27
IL207881A0 (en) 2011-07-31
EP2305286A3 (en) 2011-11-09
EP1623719A1 (en) 2006-02-08
PT2075007E (pt) 2013-08-23
SI1623719T1 (sl) 2009-12-31
ES2423590T3 (es) 2013-09-23
IL207879A (en) 2013-02-28
JP2012006967A (ja) 2012-01-12
RU2009148539A (ru) 2011-06-27
EP2356996B9 (en) 2013-08-28
BRPI0410684A (pt) 2006-06-20
EP2356996B1 (en) 2013-06-26
JP2014129389A (ja) 2014-07-10
PL1623719T3 (pl) 2010-11-30
EP2305286A2 (en) 2011-04-06
IL207877A0 (en) 2011-07-31
ES2329369T3 (es) 2009-11-25
EP2075007B1 (en) 2013-05-22
AU2011200170B2 (en) 2011-09-01
ES2423281T3 (es) 2013-09-19
IL207879A0 (en) 2011-07-31
IL207875A (en) 2013-02-28
IL207880A0 (en) 2011-07-31
ES2246178A1 (es) 2006-02-01
JP2016065100A (ja) 2016-04-28
DK2075007T3 (da) 2013-07-29
RU2385161C2 (ru) 2010-03-27
CN1784240A (zh) 2006-06-07
ES2246177A1 (es) 2006-02-01
DK2356996T3 (da) 2013-07-22
PL2356996T3 (pl) 2013-09-30
US20200140488A1 (en) 2020-05-07
DK1623719T3 (da) 2009-11-09
CN101264326A (zh) 2008-09-17
ES2246177B1 (es) 2007-03-01
ATE435024T1 (de) 2009-07-15
EP2356996A1 (en) 2011-08-17
AU2011200170C1 (en) 2012-03-22
EP2075007A2 (en) 2009-07-01
CA2524571C (en) 2017-01-10
PL2075007T3 (pl) 2013-09-30
MXPA05010914A (es) 2006-03-21
WO2004098631A1 (es) 2004-11-18
US20090162362A1 (en) 2009-06-25
EP2082747A3 (en) 2010-01-13
DE602004021797D1 (de) 2009-08-13
PT1623719E (pt) 2009-10-08
CY1109454T1 (el) 2014-08-13
EP2082747A2 (en) 2009-07-29
IL207878A0 (en) 2011-07-31
PT2356996E (pt) 2013-08-23
ES2246105B1 (es) 2007-03-01
IL207875A0 (en) 2011-07-31
AU2004237373A1 (en) 2004-11-18
US20140044725A1 (en) 2014-02-13
CA2524571A1 (en) 2004-11-18
IL171651A (en) 2011-11-30
RU2526155C2 (ru) 2014-08-20
IL207876A (en) 2013-03-24
AU2011200170A1 (en) 2011-02-03
JP2018119011A (ja) 2018-08-02
IL207881A (en) 2013-02-28
US20210214394A1 (en) 2021-07-15
IL207878A (en) 2013-02-28
EP2075007A3 (en) 2009-11-11
IL207880A (en) 2013-02-28
EP2075007B9 (en) 2013-09-04

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