CN1764458A - 作为黑皮质素－4受体激动剂的双环哌啶衍生物 - Google Patents
作为黑皮质素－4受体激动剂的双环哌啶衍生物 Download PDFInfo
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- CN1764458A CN1764458A CNA2004800082186A CN200480008218A CN1764458A CN 1764458 A CN1764458 A CN 1764458A CN A2004800082186 A CNA2004800082186 A CN A2004800082186A CN 200480008218 A CN200480008218 A CN 200480008218A CN 1764458 A CN1764458 A CN 1764458A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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| DE (1) | DE602004028228D1 (fr) |
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| EP2083831B1 (fr) | 2006-09-22 | 2013-12-25 | Merck Sharp & Dohme Corp. | Procédé de traitement utilisant des inhibiteurs de synthèse d'acide gras |
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| TR201815292T4 (tr) | 2007-11-05 | 2018-11-21 | Board Of Supervisors Of Louisiana State Univ And Agriculture And Mechanical College | İnsüli̇n duyarliliğinin tedavi̇si̇nde melanokorti̇nleri̇n kullanimi. |
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| BR0108965A (pt) * | 2000-03-03 | 2002-11-26 | Ortho Mcneil Pharm Inc | Derivados de 3-(diarilmetileno)-8-azabiciclo[3,2,1]octano |
| JP2003527444A (ja) | 2000-03-23 | 2003-09-16 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体アゴニストとして作用するスピロピペリジン誘導体 |
| JP2003528088A (ja) | 2000-03-23 | 2003-09-24 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体作働薬としての置換ピペリジン類 |
| CA2410597A1 (fr) | 2000-05-30 | 2001-12-06 | Merck & Co., Inc. | Agonistes du recepteur de la melanocortine |
| CA2432988A1 (fr) | 2001-01-23 | 2002-08-01 | Cristina Garcia-Paredes | Agonistes de recepteurs de melanocortine |
| DE60205465T2 (de) | 2001-01-23 | 2006-04-20 | Eli Lilly And Co., Indianapolis | Piperazinderivate als agonisten des melanocortin-rezeptors |
| US7157463B2 (en) | 2001-01-23 | 2007-01-02 | Eli Lilly And Company | Substituted piperidines/piperazines as melanocortin receptor agonists |
| CA2439119A1 (fr) * | 2001-02-28 | 2002-09-06 | Merck & Co., Inc. | Derives acyles de la piperidine agonistes du recepteur 4 de la melacortine |
| MXPA03007785A (es) | 2001-02-28 | 2003-12-08 | Merck & Co Inc | Derivados de piperidina acilados como agonistas del receptor de melanocortina 4. |
| EP1372653B1 (fr) | 2001-02-28 | 2006-10-04 | Merck & Co., Inc. | Derives de piperidine acyles utilises comme agonistes du recepteur de la melanocortine-4 |
| CA2453609C (fr) | 2001-07-18 | 2010-05-04 | Merck & Co., Inc. | Derives de piperidine pontee utilises comme agonistes du recepteur de la melanocortine |
| US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
| HUP0202001A2 (hu) * | 2002-06-14 | 2005-08-29 | Sanofi-Aventis | DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok |
| WO2004078717A1 (fr) * | 2003-03-03 | 2004-09-16 | Merck & Co., Inc. | Derives de piperazine acylee tenant lieu d'agonistes du recepteur de la melanocortine-4 |
| JP2006528180A (ja) | 2003-07-22 | 2006-12-14 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン−４受容体作働薬としてのピペリジン誘導体 |
| US7649002B2 (en) | 2004-02-04 | 2010-01-19 | Pfizer Inc | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists |
-
2004
- 2004-03-22 DE DE602004028228T patent/DE602004028228D1/de not_active Expired - Lifetime
- 2004-03-22 JP JP2006507449A patent/JP2006521359A/ja not_active Ceased
- 2004-03-22 EP EP04758182A patent/EP1610789B1/fr not_active Expired - Lifetime
- 2004-03-22 AU AU2004226452A patent/AU2004226452B2/en not_active Ceased
- 2004-03-22 CN CNA2004800082186A patent/CN1764458A/zh active Pending
- 2004-03-22 CA CA002519939A patent/CA2519939A1/fr not_active Abandoned
- 2004-03-22 AT AT04758182T patent/ATE474577T1/de not_active IP Right Cessation
- 2004-03-22 WO PCT/US2004/008711 patent/WO2004087159A1/fr active Application Filing
- 2004-03-22 US US10/548,782 patent/US7276520B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2519939A1 (fr) | 2004-10-14 |
| ATE474577T1 (de) | 2010-08-15 |
| EP1610789A1 (fr) | 2006-01-04 |
| US20060194780A1 (en) | 2006-08-31 |
| US7276520B2 (en) | 2007-10-02 |
| EP1610789B1 (fr) | 2010-07-21 |
| EP1610789A4 (fr) | 2008-02-27 |
| DE602004028228D1 (de) | 2010-09-02 |
| WO2004087159A1 (fr) | 2004-10-14 |
| AU2004226452A1 (en) | 2004-10-14 |
| JP2006521359A (ja) | 2006-09-21 |
| AU2004226452B2 (en) | 2008-07-24 |
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