CN1703229B - 治疗前列腺和其他癌的组合物和其制备药物的用途 - Google Patents

治疗前列腺和其他癌的组合物和其制备药物的用途 Download PDF

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CN1703229B
CN1703229B CN2003801009272A CN200380100927A CN1703229B CN 1703229 B CN1703229 B CN 1703229B CN 2003801009272 A CN2003801009272 A CN 2003801009272A CN 200380100927 A CN200380100927 A CN 200380100927A CN 1703229 B CN1703229 B CN 1703229B
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hsp27
seq
composition
antisense
oligonucleotide
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CN1703229A (zh
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M·E·格利夫
P·罗基
M·西奈夫斯基
E·贝拉尔特
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University of British Columbia
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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CN2003801009272A 2002-10-02 2003-10-02 治疗前列腺和其他癌的组合物和其制备药物的用途 Expired - Fee Related CN1703229B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41585902P 2002-10-02 2002-10-02
US60/415,859 2002-10-02
US46395203P 2003-04-18 2003-04-18
US60/463,952 2003-04-18
PCT/CA2003/001588 WO2004030660A2 (en) 2002-10-02 2003-10-02 Compositions for treatment of prostate and other cancers

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CN1703229A CN1703229A (zh) 2005-11-30
CN1703229B true CN1703229B (zh) 2011-01-05

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JP (2) JP5127138B2 (enExample)
KR (1) KR101142080B1 (enExample)
CN (1) CN1703229B (enExample)
AT (1) ATE465743T1 (enExample)
AU (1) AU2003278028B2 (enExample)
CA (1) CA2498026C (enExample)
DE (1) DE60332363D1 (enExample)
DK (1) DK1545561T3 (enExample)
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IL (1) IL167621A (enExample)
MX (1) MXPA05003551A (enExample)
NO (2) NO338310B1 (enExample)
NZ (1) NZ538841A (enExample)
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ538841A (en) * 2002-10-02 2006-10-27 Univ British Columbia Compositions for reducing hsp27 for the treatment of prostate and other cancers
US20060188508A1 (en) * 2005-02-17 2006-08-24 Cohen Stanley N Methods and compositions for modulating angiogenesis
WO2007025229A2 (en) * 2005-08-25 2007-03-01 Isis Pharmaceuticals, Inc. Compositions and their uses directed to hsp27
JP2009532017A (ja) * 2006-02-10 2009-09-10 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア ＰＴＤ／ＣＰＰＳへのｄｓＲＮＡ結合ドメイン融合体によるｓｉＲＮＡの導入可能な送達
US8242258B2 (en) * 2006-12-03 2012-08-14 Agilent Technologies, Inc. Protecting groups for RNA synthesis
US9381209B2 (en) * 2007-03-05 2016-07-05 The University Of British Columbia Treatment of squamous cell carcinoma with HSP27 antisense oligonucleotides and radiotherapy
WO2008112218A2 (en) 2007-03-12 2008-09-18 Antigen Express, Inc. Li-rnai involved li suppression in cancer immunotherapy
CA2656577A1 (en) * 2008-04-14 2009-10-14 The University Of British Columbia Method for evaluation of a cancer
CA2728762A1 (en) * 2008-07-02 2010-01-07 Enzon Pharmaceuticals, Inc. Rna antagonists targeting hsp27
CN102099041B (zh) * 2008-07-18 2013-07-31 Ogx科技公司 反义制剂
WO2011054811A1 (en) 2009-11-03 2011-05-12 Santaris Pharma A/S Rna antagonists targeting hsp27 combination therapy
KR101217866B1 (ko) * 2010-08-18 2013-01-03 한국원자력의학원 혈관신생 억제용 약학 조성물 및 혈관신생 억제용 활성물질을 스크리닝하는 방법
DE102010056610A1 (de) * 2010-12-31 2012-07-05 Volker A. Erdmann Pharmazeutische Zusammensetzung enthaltend L-DNA
JP5658696B2 (ja) * 2011-02-25 2015-01-28 株式会社ファンケル 皮膚のストレス蓄積度の評価方法
CA2747509C (en) 2011-05-12 2017-07-18 Oncogenex Technologies Inc. Treatment of pulmonary and pleural fibrosis using hsp27 inhibitors
US9717792B2 (en) 2012-02-02 2017-08-01 The University Of British Columbia Combination therapy for cancer using HSP27 inhibitor and EGFR tyrosine kinase inhibitors or anti-folates
GB201204785D0 (en) 2012-03-19 2012-05-02 Queen Mary & Westfield College Method for determining prognosis of prostate cancer in a subject
KR101374585B1 (ko) * 2012-05-02 2014-03-17 연세대학교 산학협력단 ＨＳＰ２７ 발현을 억제하는 ｓｈＲＮＡ
JP2015529073A (ja) 2012-08-20 2015-10-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 生物可逆性基を有するポリヌクレオチド
US20170216297A1 (en) 2014-07-28 2017-08-03 Technische Universitaet Dresden Efficient inhibition of hsp27
WO2017091885A1 (en) 2015-11-30 2017-06-08 The University Of British Columbia Monocarboxylate transporter 4 (mct4) antisense oligonucleotide (aso) inhibitors for use as therapeutics in the treatment of cancer
WO2019050948A1 (en) 2017-09-05 2019-03-14 Regeneron Pharmaceuticals, Inc. ADMINISTRATION OF A GENE EDITION SYSTEM HAVING ONLY ONE RETROVIRAL PARTICLE AND METHODS OF GENERATING AND USING

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08504766A (ja) * 1992-12-14 1996-05-21 スタート テクノロジー パートナーシップ ドーパミン作動性神経系の病態の診断および治療に関するドーパミン受容体ｍＲＮＡに対してアンチセンスのオリゴヌクレオチドの投与
IL108367A0 (en) * 1993-01-27 1994-04-12 Hektoen Inst For Medical Resea Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
US5417978A (en) 1993-07-29 1995-05-23 Board Of Regents, The University Of Texas System Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use
US5801154A (en) * 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US5855911A (en) 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
JPH09176011A (ja) * 1995-12-27 1997-07-08 Kureha Chem Ind Co Ltd Ｈｓｐ２７ファミリーに属するタンパク質のフラボノイド含有合成抑制剤
US20060008448A1 (en) * 1996-06-11 2006-01-12 Minzhen Xu Inhibition of li expression in mammalian cells
JPH107559A (ja) 1996-06-18 1998-01-13 Kureha Chem Ind Co Ltd Ｈｓｐ２７ファミリーに属するタンパク質のベルベリン誘導体含有合成抑制剤
US5962262A (en) * 1997-07-25 1999-10-05 Incyte Pharmaceuticals, Inc. Human heat shock 27 like protein
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
US5998148A (en) * 1999-04-08 1999-12-07 Isis Pharmaceuticals Inc. Antisense modulation of microtubule-associated protein 4 expression
ATE393220T1 (de) 1999-07-19 2008-05-15 Univ British Columbia Antisense-therapie für hormonregulierte tumoren
WO2001070976A2 (en) * 2000-03-21 2001-09-27 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian and endometrial cancer
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
WO2003018758A2 (en) * 2001-08-23 2003-03-06 Arizona Board Of Regents Reagents and methods for smooth muscle therapies
NZ538841A (en) 2002-10-02 2006-10-27 Univ British Columbia Compositions for reducing hsp27 for the treatment of prostate and other cancers
US7250496B2 (en) * 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
WO2007025229A2 (en) * 2005-08-25 2007-03-01 Isis Pharmaceuticals, Inc. Compositions and their uses directed to hsp27
US9381209B2 (en) 2007-03-05 2016-07-05 The University Of British Columbia Treatment of squamous cell carcinoma with HSP27 antisense oligonucleotides and radiotherapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Sandrine Horman et al.anti-sense inhibition ofsmall-heat-shock-protein(HSP27)expression in MCF-7mammary-carcinoma cells induces theirspontaneousacquisition of a secretory phenotype.Int.J.Cancer82 4.1999,82(4),574-582.
Sandrine Horman et al.anti-sense inhibition ofsmall-heat-shock-protein(HSP27)expression in MCF-7mammary-carcinoma cells induces theirspontaneousacquisition of a secretory phenotype.Int.J.Cancer82 4.1999,82(4),574-582. *

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US7847091B2 (en) 2010-12-07
US8772470B1 (en) 2014-07-08
US20160326527A1 (en) 2016-11-10
NZ538841A (en) 2006-10-27
EP1545561A2 (en) 2005-06-29
DK1545561T3 (da) 2010-08-02
US20040127441A1 (en) 2004-07-01
IL167621A (en) 2011-11-30
DE60332363D1 (de) 2010-06-10
WO2004030660A3 (en) 2004-06-10
US20060040886A1 (en) 2006-02-23
JP2006503904A (ja) 2006-02-02
NO338310B1 (no) 2016-08-08
US20150232843A1 (en) 2015-08-20
US20090221678A1 (en) 2009-09-03
US7723312B2 (en) 2010-05-25
ATE465743T1 (de) 2010-05-15
WO2004030660A2 (en) 2004-04-15
JP2010215669A (ja) 2010-09-30
US7550580B2 (en) 2009-06-23
AU2003278028A1 (en) 2004-04-23
JP5127138B2 (ja) 2013-01-23
JP5237996B2 (ja) 2013-07-17
KR101142080B1 (ko) 2012-05-03
EP2216029A3 (en) 2010-12-22
MXPA05003551A (es) 2005-10-19
ZA200502603B (en) 2006-06-28
US20060276424A1 (en) 2006-12-07
ES2345330T3 (es) 2010-09-21
US7101991B2 (en) 2006-09-05
EP2216029A2 (en) 2010-08-11
EP1545561B1 (en) 2010-04-28
US9580712B2 (en) 2017-02-28
AU2003278028B2 (en) 2008-12-18
US20140315978A1 (en) 2014-10-23
NO20160655A1 (no) 2016-04-20
US9085769B2 (en) 2015-07-21
CN1703229A (zh) 2005-11-30
CA2498026C (en) 2015-06-30
NO20052055L (no) 2005-06-23
KR20050050111A (ko) 2005-05-27
CA2498026A1 (en) 2004-04-15
US9404109B2 (en) 2016-08-02

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