CN1700920B - 羟基甾族化合物的预防和治疗应用 - Google Patents

羟基甾族化合物的预防和治疗应用 Download PDF

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Publication number
CN1700920B
CN1700920B CN028202627A CN02820262A CN1700920B CN 1700920 B CN1700920 B CN 1700920B CN 028202627 A CN028202627 A CN 028202627A CN 02820262 A CN02820262 A CN 02820262A CN 1700920 B CN1700920 B CN 1700920B
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carbon atom
carbonyl
group
atom
alkyl
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Expired - Fee Related
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CN028202627A
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English (en)
Chinese (zh)
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CN1700920A (zh
Inventor
恩斯特·武尔费特
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Hunter Fleming Ltd
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Hunter Fleming Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN028202627A 2001-08-14 2002-08-13 羟基甾族化合物的预防和治疗应用 Expired - Fee Related CN1700920B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0119810A GB2378898A (en) 2001-08-14 2001-08-14 Prophylactic and therapeutic use of hydroxysteroids
GB0119810.0 2001-08-14
PCT/GB2002/003770 WO2003015791A1 (en) 2001-08-14 2002-08-13 Phophylactic and therapeutic use of hydroxysteroids

Publications (2)

Publication Number Publication Date
CN1700920A CN1700920A (zh) 2005-11-23
CN1700920B true CN1700920B (zh) 2012-05-30

Family

ID=9920376

Family Applications (1)

Application Number Title Priority Date Filing Date
CN028202627A Expired - Fee Related CN1700920B (zh) 2001-08-14 2002-08-13 羟基甾族化合物的预防和治疗应用

Country Status (19)

Country Link
US (1) US8148355B2 (enExample)
EP (1) EP1416937B1 (enExample)
JP (1) JP4541698B2 (enExample)
KR (1) KR100895281B1 (enExample)
CN (1) CN1700920B (enExample)
AT (1) ATE429919T1 (enExample)
AU (1) AU2002321472B2 (enExample)
CA (1) CA2457050C (enExample)
CY (1) CY1109233T1 (enExample)
DE (1) DE60232154D1 (enExample)
DK (1) DK1416937T3 (enExample)
ES (1) ES2324859T3 (enExample)
GB (1) GB2378898A (enExample)
IL (2) IL160362A0 (enExample)
NO (1) NO334819B1 (enExample)
NZ (1) NZ531100A (enExample)
PT (1) PT1416937E (enExample)
RU (1) RU2329049C2 (enExample)
WO (1) WO2003015791A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0409498D0 (en) * 2004-04-28 2004-06-02 Hunter Fleming Ltd Transdermal steroid formulation
US7910755B2 (en) 2004-09-29 2011-03-22 Harbor Biosciences, Inc. Stem cell expansion and uses
GB0623971D0 (en) * 2006-11-30 2007-01-10 Hunter Fleming Ltd Modulation of prostaglandin/cyclooxygenase metabolic pathways
KR20090086272A (ko) * 2006-11-30 2009-08-11 헌터-플레밍 리미티드 프로스타글란딘／시클로옥시게나제 대사 경로의 조절
EP2653163A1 (en) * 2012-04-19 2013-10-23 Université de Liège Estrogenic components for use in the treatment of neurological disorders
CN105078954A (zh) * 2015-08-20 2015-11-25 南京华宽信息咨询中心 一种治疗急性肾衰药物及其应用
CN105168197A (zh) * 2015-08-22 2015-12-23 南京华宽信息咨询中心 一种治疗肾功能不全药物及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686438A (en) * 1993-03-09 1997-11-11 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
ATE283052T1 (de) * 1993-03-09 2004-12-15 Univ Utah Res Found Verwendung von dhea oder dessen derivate zur herstellung eines medikaments zur vorbeugung von progressiver gewebe-nekrose, reperfusionsschädigung, bakterieller translokation und vom atemnotsyndrom bei erwachsenen
US5846963A (en) * 1995-06-07 1998-12-08 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5753640A (en) * 1995-06-07 1998-05-19 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5977095A (en) * 1993-03-09 1999-11-02 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and respiratory distress syndrome
IT1282289B1 (it) * 1995-06-23 1998-03-16 Sigma Tau Ind Farmaceuti 17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare,
WO1999011271A1 (en) * 1997-08-29 1999-03-11 Dalhousie University Use of polycyclic steroid compounds for the manufacture of a medicament for the treatment of cystic kidney diseases, vascular infarction, uremia and related conditions
AU3467699A (en) * 1998-04-14 1999-11-01 Pharmadigm, Inc. Method for reducing central nervous system impairment
GB0003524D0 (en) * 2000-02-15 2000-04-05 Btg Int Ltd Cytoprotective steroids (II)
GB2363984A (en) * 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 3-hydroxy-7 -hydroxy steroids and 3-oxo-7 -hydroxy steroids
GB2363983A (en) * 2000-06-29 2002-01-16 Hunter Fleming Ltd Protection against neuronal damage using 7-hydroxyepiandrosterone

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ROSE KEN ET AL.Neurosteroid hydroxylase CYP7B.Vivid reporter activity indentate gyrus of gene-targeted mice and abolition of awidedspread pathway of steroid and oxysterol hydroxylation.JOURNAL OF BIOLOGICAL CHEMISTRY276 26.2001,第23937-23944页.
ROSE KEN ET AL.Neurosteroid hydroxylase CYP7B.Vivid reporter activity indentate gyrus of gene-targeted mice and abolition of awidedspread pathway of steroid and oxysterol hydroxylation.JOURNAL OF BIOLOGICAL CHEMISTRY276 26.2001,第23937-23944页. *

Also Published As

Publication number Publication date
KR20040041577A (ko) 2004-05-17
RU2329049C2 (ru) 2008-07-20
CA2457050A1 (en) 2003-02-27
JP2005506321A (ja) 2005-03-03
CN1700920A (zh) 2005-11-23
EP1416937B1 (en) 2009-04-29
AU2002321472B2 (en) 2007-11-08
EP1416937A1 (en) 2004-05-12
US8148355B2 (en) 2012-04-03
KR100895281B1 (ko) 2009-04-29
ES2324859T3 (es) 2009-08-18
IL160362A0 (en) 2004-07-25
DK1416937T3 (da) 2009-08-24
NO20041057L (no) 2004-03-12
HK1065703A1 (en) 2005-03-04
DE60232154D1 (de) 2009-06-10
RU2004104362A (ru) 2005-05-10
GB2378898A (en) 2003-02-26
WO2003015791A1 (en) 2003-02-27
JP4541698B2 (ja) 2010-09-08
US20040248868A1 (en) 2004-12-09
CA2457050C (en) 2010-10-12
PT1416937E (pt) 2009-07-24
CY1109233T1 (el) 2014-07-02
NZ531100A (en) 2006-02-24
IL160362A (en) 2011-10-31
ATE429919T1 (de) 2009-05-15
GB0119810D0 (en) 2001-10-10
NO334819B1 (no) 2014-06-10

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120530

Termination date: 20160813

CF01 Termination of patent right due to non-payment of annual fee