CN1692117A - 由吗啡制备可待因 - Google Patents

由吗啡制备可待因 Download PDF

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Publication number
CN1692117A
CN1692117A CN200380100724.3A CN200380100724A CN1692117A CN 1692117 A CN1692117 A CN 1692117A CN 200380100724 A CN200380100724 A CN 200380100724A CN 1692117 A CN1692117 A CN 1692117A
Authority
CN
China
Prior art keywords
morphine
hydrocarbon solvent
monomethyl ether
reaction mixture
toluene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200380100724.3A
Other languages
English (en)
Chinese (zh)
Inventor
劳埃德·P·希尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of CN1692117A publication Critical patent/CN1692117A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200380100724.3A 2002-10-21 2003-10-14 由吗啡制备可待因 Pending CN1692117A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/274,702 2002-10-21
US10/274,702 US6579985B1 (en) 2002-10-21 2002-10-21 Preparation of codeine from morphine

Publications (1)

Publication Number Publication Date
CN1692117A true CN1692117A (zh) 2005-11-02

Family

ID=23049276

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200380100724.3A Pending CN1692117A (zh) 2002-10-21 2003-10-14 由吗啡制备可待因

Country Status (11)

Country Link
US (1) US6579985B1 (enExample)
EP (1) EP1560833B1 (enExample)
JP (1) JP2006505588A (enExample)
CN (1) CN1692117A (enExample)
AT (1) ATE356819T1 (enExample)
AU (1) AU2003279287B2 (enExample)
CA (1) CA2502935A1 (enExample)
DE (1) DE60312543T2 (enExample)
ES (1) ES2282689T3 (enExample)
MX (1) MXPA05004162A (enExample)
WO (1) WO2004037826A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110261194A (zh) * 2019-06-06 2019-09-20 深圳砺剑防卫技术有限公司 一种毒品探测设备校验品的制备方法及毒品探测设备校验品

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6949645B1 (en) 2004-05-20 2005-09-27 Acura Pharmaceuticals, Inc. Process for the production of opiates
US6972332B1 (en) * 2004-05-20 2005-12-06 Acura Pharmaceuticals, Inc. Process for the production of opiates
WO2008022285A1 (en) * 2006-08-16 2008-02-21 Auspex Pharmaceuticals, Inc. Preparation and utility of opioid analgesics
CN105247038B (zh) * 2013-03-15 2021-08-27 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)的微生物及其制备和使用方法
CN112410379B (zh) 2013-11-04 2024-12-31 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法
JP7266966B2 (ja) 2015-05-08 2023-05-01 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー エピメラーゼ及びベンジルイソキノリンアルカロイドを産生する方法
CN120399912A (zh) 2019-03-08 2025-08-01 小利兰·斯坦福大学托管委员会 产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法
TR2021022252A2 (tr) * 2021-12-31 2022-01-21 Toprak Mahsulleri Ofisi Genel Mueduerluegue Kodei̇n kamphosulfonat üreti̇mi̇ne dai̇r yeni̇ bi̇r yöntem

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3679327D1 (de) * 1986-11-25 1991-06-20 Council Scient Ind Res Verfahren zur herstellung von codein aus morphin.
CS277517B6 (sk) * 1990-12-12 1993-02-17 Slovakofarma S P Spósob čistenia kodeinu připraveného metylizáciou morfínu
US6204337B1 (en) * 1996-11-19 2001-03-20 The Board Of Regents Of The University And Community College System Of Neveda Solid-phase synthesis of codeine from morphine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110261194A (zh) * 2019-06-06 2019-09-20 深圳砺剑防卫技术有限公司 一种毒品探测设备校验品的制备方法及毒品探测设备校验品

Also Published As

Publication number Publication date
WO2004037826A3 (en) 2004-07-01
WO2004037826A2 (en) 2004-05-06
AU2003279287A1 (en) 2004-05-13
DE60312543T2 (de) 2007-11-15
US6579985B1 (en) 2003-06-17
EP1560833A2 (en) 2005-08-10
AU2003279287B2 (en) 2009-01-29
ES2282689T3 (es) 2007-10-16
CA2502935A1 (en) 2004-05-06
ATE356819T1 (de) 2007-04-15
DE60312543D1 (de) 2007-04-26
JP2006505588A (ja) 2006-02-16
MXPA05004162A (es) 2005-06-22
EP1560833B1 (en) 2007-03-14

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WD01 Invention patent application deemed withdrawn after publication

Open date: 20051102