CN1688543A - 呋喃酮衍生物及其制备方法 - Google Patents

呋喃酮衍生物及其制备方法 Download PDF

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Publication number
CN1688543A
CN1688543A CNA038243997A CN03824399A CN1688543A CN 1688543 A CN1688543 A CN 1688543A CN A038243997 A CNA038243997 A CN A038243997A CN 03824399 A CN03824399 A CN 03824399A CN 1688543 A CN1688543 A CN 1688543A
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CN
China
Prior art keywords
replacement
unsubstituted
compound
halogen
arylalkyl
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Pending
Application number
CNA038243997A
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English (en)
Chinese (zh)
Inventor
纳雷什·库马尔
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Biosignal Australia Pty Ltd
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Biosignal Australia Pty Ltd
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Publication of CN1688543A publication Critical patent/CN1688543A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Cultivation Of Plants (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
CNA038243997A 2002-08-19 2003-08-19 呋喃酮衍生物及其制备方法 Pending CN1688543A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2002950862 2002-08-19
AU2002950862A AU2002950862A0 (en) 2002-08-19 2002-08-19 Furanone derivatives and methods of making same

Publications (1)

Publication Number Publication Date
CN1688543A true CN1688543A (zh) 2005-10-26

Family

ID=27809947

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038243997A Pending CN1688543A (zh) 2002-08-19 2003-08-19 呋喃酮衍生物及其制备方法

Country Status (7)

Country Link
US (1) US20050215772A1 (enExample)
EP (1) EP1539692A4 (enExample)
JP (1) JP2006514610A (enExample)
CN (1) CN1688543A (enExample)
AU (1) AU2002950862A0 (enExample)
CA (1) CA2495784A1 (enExample)
WO (1) WO2004016588A1 (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101503397B (zh) * 2009-03-23 2012-07-18 暨南大学 卤代呋喃酮化合物及其在制备抗感染药物上的应用
CN105050393A (zh) * 2013-02-01 2015-11-11 荷兰联合利华有限公司 包含内酰胺和助水溶剂的抗微生物组合物
CN107920979A (zh) * 2015-08-20 2018-04-17 荷兰联合利华有限公司 改善的内酰胺溶解度
CN108024938A (zh) * 2015-08-20 2018-05-11 荷兰联合利华有限公司 改善的内酰胺溶解度
CN106518818B (zh) * 2016-10-14 2018-07-27 宁波大学 一种呋喃酮类化合物及其制备方法和用途
CN109705068A (zh) * 2019-02-27 2019-05-03 重庆医药高等专科学校 原白头翁素合成方法
CN109922659A (zh) * 2016-11-17 2019-06-21 荷兰联合利华有限公司 内酰胺组合物
US10918107B2 (en) 2015-05-20 2021-02-16 Conopco, Inc. Encapsulated lactams
US10986837B2 (en) 2015-08-20 2021-04-27 Conopco, Inc. Lactam solubility
US11077036B2 (en) 2015-08-20 2021-08-03 Conopco, Inc. Lactam solubility

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007520588A (ja) * 2003-12-05 2007-07-26 バイオシグナル リミテッド 抗微生物性化合物と表面およびポリマーとの結合
US7642285B2 (en) * 2005-02-04 2010-01-05 Wisconsin Alumni Research Foundation Compounds and methods for modulating communication and virulence in quorum sensing bacteria
JP4969065B2 (ja) * 2005-07-13 2012-07-04 株式会社 メドレックス 常温性イオン性液体を含有する医薬組成物
RU2008134473A (ru) 2006-01-24 2010-02-27 Байосигнал Лимитед (Au) Новые лактамы
AU2015200142B2 (en) * 2006-01-24 2016-07-07 Unilever Plc Novel lactams
US8071691B2 (en) 2006-05-15 2011-12-06 Tyco Healthcare Group Lp Furanone endcapped polymers
WO2007133781A2 (en) * 2006-05-15 2007-11-22 Tyco Healthcare Group Lp Furanone-initiated polymers
AU2007304839A1 (en) * 2006-10-06 2008-04-10 Unilever Plc Furanone compounds and lactam analogues thereof
CA2670899C (en) * 2006-12-01 2016-11-22 Laclede, Inc. Use of hydrolytic and oxidative enzymes to dissolve biofilm in ears
WO2008116029A1 (en) 2007-03-19 2008-09-25 Wisconsin Alumni Research Foundation Modulation of bacterial quorum sensing with synthetic ligands
US8624063B2 (en) * 2009-06-30 2014-01-07 Wisconsin Alumni Research Foundation Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing
EP2425862B1 (de) * 2010-09-07 2012-08-29 Miele & Cie. KG Verfahren zur Reinigung und thermischen Desinfektion von Spülgut
CN102002024B (zh) * 2010-11-19 2012-10-10 吉首大学 3-芳基-4-芳氨基-2（5h）-呋喃酮型化合物及其制法和用途
AU2013317791B2 (en) 2012-09-21 2018-05-10 Midwestern University Inhibitors of beta-hydrolase for treatment of cancer
WO2014183164A1 (en) * 2013-05-17 2014-11-20 Naresh Kumar Dihydropyrrolones and their use as antimicrobial agents
WO2016176146A1 (en) * 2015-04-26 2016-11-03 The Trustees Of Princeton University Surfaces comprising attached quorum sensing modulators
CN107920977A (zh) * 2015-08-20 2018-04-17 荷兰联合利华有限公司 内酰胺组合物
WO2018015280A1 (en) 2016-07-21 2018-01-25 Unilever Plc 4-(4-chlorophenyl)-5-methylene-pyrrol-2-one and 5-methylene-4-(p-tolyl)pyrrol-2-one for use in the treatment of gram negative bacterial infections
EP3487494A1 (en) 2016-07-21 2019-05-29 Unilever PLC Lactams for the treatment of respiratory tract infections
CN109475527A (zh) 2016-07-21 2019-03-15 荷兰联合利华有限公司 用于治疗皮肤损伤的内酰胺
BR112019010124A2 (pt) 2016-11-17 2019-08-20 Unilever Nv composições de lactama e usos da composição farmacêutica
US10526278B2 (en) 2017-10-19 2020-01-07 Wisconsin Alumni Research Foundation Inhibitors of quorum sensing receptor LasR
RU2691634C2 (ru) * 2017-11-27 2019-06-17 Федеральное Государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт мясного скотоводства СПОСОБ ПРИМЕНЕНИЯ ГАММА-ОКТАЛАКТОНА В КАЧЕСТВЕ ИНГИБИТОРА СИСТЕМЫ "КВОРУМ СЕНСИНГА" LuxI/LuxR ТИПА У БАКТЕРИЙ
WO2021214041A1 (en) * 2020-04-21 2021-10-28 Unilever Ip Holdings B.V. Varnish
EP4168460A1 (en) * 2020-06-23 2023-04-26 Akzo Nobel Coatings International B.V. Radiation-curable coating composition, method of coating a substrate and coated substrate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3755356A (en) * 1969-11-06 1973-08-28 Zoecon Corp Substituted crotonic amide ypsilon-lactams
AUPM666694A0 (en) * 1994-07-06 1994-07-28 Unisearch Limited Natural antifouling compositions
AUPQ841900A0 (en) * 2000-06-28 2000-07-20 Unisearch Limited Synthesis of cyclic compounds

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101503397B (zh) * 2009-03-23 2012-07-18 暨南大学 卤代呋喃酮化合物及其在制备抗感染药物上的应用
CN105050393B (zh) * 2013-02-01 2018-07-03 荷兰联合利华有限公司 包含内酰胺和助水溶剂的抗微生物组合物
CN105050393A (zh) * 2013-02-01 2015-11-11 荷兰联合利华有限公司 包含内酰胺和助水溶剂的抗微生物组合物
US9930888B2 (en) 2013-02-01 2018-04-03 Conopco, Inc. Composition
US10918107B2 (en) 2015-05-20 2021-02-16 Conopco, Inc. Encapsulated lactams
US10888087B2 (en) 2015-08-20 2021-01-12 Conopco, Inc. Lactam solubility
CN108024938A (zh) * 2015-08-20 2018-05-11 荷兰联合利华有限公司 改善的内酰胺溶解度
CN107920979A (zh) * 2015-08-20 2018-04-17 荷兰联合利华有限公司 改善的内酰胺溶解度
US10986837B2 (en) 2015-08-20 2021-04-27 Conopco, Inc. Lactam solubility
US11077036B2 (en) 2015-08-20 2021-08-03 Conopco, Inc. Lactam solubility
CN116983220A (zh) * 2015-08-20 2023-11-03 联合利华知识产权控股有限公司 改善的内酰胺溶解度
CN106518818B (zh) * 2016-10-14 2018-07-27 宁波大学 一种呋喃酮类化合物及其制备方法和用途
CN109922659A (zh) * 2016-11-17 2019-06-21 荷兰联合利华有限公司 内酰胺组合物
CN109705068A (zh) * 2019-02-27 2019-05-03 重庆医药高等专科学校 原白头翁素合成方法

Also Published As

Publication number Publication date
US20050215772A1 (en) 2005-09-29
AU2002950862A0 (en) 2002-09-12
EP1539692A1 (en) 2005-06-15
EP1539692A4 (en) 2005-08-24
CA2495784A1 (en) 2004-02-26
WO2004016588A1 (en) 2004-02-26
JP2006514610A (ja) 2006-05-11

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Open date: 20051026