CN1676520A - 一种苦参总黄酮提取物及其制备方法和用途 - Google Patents
一种苦参总黄酮提取物及其制备方法和用途 Download PDFInfo
- Publication number
- CN1676520A CN1676520A CNA200410030937XA CN200410030937A CN1676520A CN 1676520 A CN1676520 A CN 1676520A CN A200410030937X A CNA200410030937X A CN A200410030937XA CN 200410030937 A CN200410030937 A CN 200410030937A CN 1676520 A CN1676520 A CN 1676520A
- Authority
- CN
- China
- Prior art keywords
- kuh
- kurarinone
- seng
- total flavone
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
药物浓度(μg/ml) | TNFa(pg/ml) | TNFa表达抑制率(%) | IL-1β(pg/ml) | IL-1β表达抑制率(%) | |
苦参总黄酮提取物 | 10 | 129.1±10.6 | 34.4±10.1 | 184.9±12.4 | 47.7±10.1 |
30 | 50.9±9.8 | 72.9±2.1 | 76.9±10.2 | 76.8±2.1 | |
100 | 10.4±0.4 | 94.3±2.4 | 19.6±0.4 | 93.9±2.4 | |
苦参酮 | 10 | 92.2±2.7 | 52.5±4.2 | 129.8±8.4 | 62.4±4.2 |
30 | 39.5±1.5 | 78.5±4.1 | 80.5±3.7 | 75.0±4.1 | |
100 | 2.1±0.3 | 98.8±2.1 | 3.1±0.3 | 99.0±0.5 | |
外周血单核细胞 | 11.0±1.1 | / | 5.8±1.0 | / | |
LPS | 215.7±36.4 | / | 460.8±16.4 | / | |
10uM DEX | 120.9±3.4 | 61.3±1.9 | 275.6±5.3 | 72.9±1.6 |
Claims (12)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNA200410030937XA CN1676520A (zh) | 2004-04-01 | 2004-04-01 | 一种苦参总黄酮提取物及其制备方法和用途 |
PCT/CN2005/000436 WO2005095375A1 (en) | 2004-04-01 | 2005-04-01 | Extract of sophora flavescens flavonoids and uses thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNA200410030937XA CN1676520A (zh) | 2004-04-01 | 2004-04-01 | 一种苦参总黄酮提取物及其制备方法和用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1676520A true CN1676520A (zh) | 2005-10-05 |
Family
ID=35049283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA200410030937XA Pending CN1676520A (zh) | 2004-04-01 | 2004-04-01 | 一种苦参总黄酮提取物及其制备方法和用途 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN1676520A (zh) |
WO (1) | WO2005095375A1 (zh) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100528855C (zh) * | 2005-12-27 | 2009-08-19 | 中国科学院山西煤炭化学研究所 | 由苦参生产苦参总黄酮或黄酮盐的方法 |
CN100528856C (zh) * | 2005-12-27 | 2009-08-19 | 中国科学院山西煤炭化学研究所 | 一种生产苦参总黄酮及黄酮盐类的方法 |
CN102423312A (zh) * | 2007-02-21 | 2012-04-25 | 生物光谱公司 | 含有苦参碱或其氧化衍生物的用于改善皮肤状况的组合物 |
CN103598386A (zh) * | 2013-11-19 | 2014-02-26 | 界首市赫赫发食品有限公司 | 儿童补硒巧克力 |
CN105832718A (zh) * | 2016-04-26 | 2016-08-10 | 宁夏医科大学 | 黄酮Sophoraflavanone G在制备防治糖尿病药物中的应用 |
CN106309427A (zh) * | 2016-09-30 | 2017-01-11 | 宁夏医科大学 | 黄酮Sophoraflavanone G作为制备抗抑郁药物的应用及药物组合物 |
CN106727495A (zh) * | 2016-12-29 | 2017-05-31 | 云南中医学院 | 一类二氢黄酮化合物在制备心肌保护药物中的应用 |
CN110840928A (zh) * | 2019-11-29 | 2020-02-28 | 广东药科大学 | 苦参总黄酮在制备治疗溃疡性结肠炎药物中的应用 |
CN115010689A (zh) * | 2022-07-14 | 2022-09-06 | 贵州医科大学 | 一种化合物kurarinol A及其制备方法与应用 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9326968B2 (en) | 2010-09-27 | 2016-05-03 | Korea Research Institute Of Bioscience And Biotechnology | Composition for enhancing immunity containing compounds represented by chemical formulas 1-8 or sophora flavescens extract as active ingredient |
US11147835B1 (en) | 2020-08-20 | 2021-10-19 | Frank Kelly Reilly, III | Nutritional supplement |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010084363A (ko) * | 2000-02-25 | 2001-09-06 | 이병훈 | 라반둘릴플라보노이드를 포함하는 세포자멸사 유도용약학적 조성물 |
-
2004
- 2004-04-01 CN CNA200410030937XA patent/CN1676520A/zh active Pending
-
2005
- 2005-04-01 WO PCT/CN2005/000436 patent/WO2005095375A1/en active Application Filing
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100528856C (zh) * | 2005-12-27 | 2009-08-19 | 中国科学院山西煤炭化学研究所 | 一种生产苦参总黄酮及黄酮盐类的方法 |
CN100528855C (zh) * | 2005-12-27 | 2009-08-19 | 中国科学院山西煤炭化学研究所 | 由苦参生产苦参总黄酮或黄酮盐的方法 |
CN102423312A (zh) * | 2007-02-21 | 2012-04-25 | 生物光谱公司 | 含有苦参碱或其氧化衍生物的用于改善皮肤状况的组合物 |
CN103598386A (zh) * | 2013-11-19 | 2014-02-26 | 界首市赫赫发食品有限公司 | 儿童补硒巧克力 |
CN103598386B (zh) * | 2013-11-19 | 2015-01-07 | 界首市赫赫发食品有限公司 | 儿童补硒巧克力 |
CN105832718B (zh) * | 2016-04-26 | 2018-08-21 | 宁夏医科大学 | 黄酮Sophoraflavanone G在制备防治糖尿病药物中的应用 |
CN105832718A (zh) * | 2016-04-26 | 2016-08-10 | 宁夏医科大学 | 黄酮Sophoraflavanone G在制备防治糖尿病药物中的应用 |
CN106309427A (zh) * | 2016-09-30 | 2017-01-11 | 宁夏医科大学 | 黄酮Sophoraflavanone G作为制备抗抑郁药物的应用及药物组合物 |
CN106727495A (zh) * | 2016-12-29 | 2017-05-31 | 云南中医学院 | 一类二氢黄酮化合物在制备心肌保护药物中的应用 |
CN106727495B (zh) * | 2016-12-29 | 2019-08-06 | 云南中医学院 | 一类二氢黄酮化合物在制备心肌保护药物中的应用 |
CN110840928A (zh) * | 2019-11-29 | 2020-02-28 | 广东药科大学 | 苦参总黄酮在制备治疗溃疡性结肠炎药物中的应用 |
CN115010689A (zh) * | 2022-07-14 | 2022-09-06 | 贵州医科大学 | 一种化合物kurarinol A及其制备方法与应用 |
CN115010689B (zh) * | 2022-07-14 | 2023-10-03 | 贵州医科大学 | 一种化合物kurarinol A及其制备方法与应用 |
Also Published As
Publication number | Publication date |
---|---|
WO2005095375A1 (en) | 2005-10-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1676520A (zh) | 一种苦参总黄酮提取物及其制备方法和用途 | |
CN1197567C (zh) | 山奈酚衍生物用于制备防治脑血管疾病药物的用途 | |
US20050226943A1 (en) | Extract of sophora flavescens flavonoids and uses thereof | |
WO2018082568A1 (en) | Extracts of andrographis paniculata, methods for preparation and use thereof | |
CN1919856A (zh) | 络石藤总木脂素提取物,提取方法及该提取物和其中有效成分的医药用途 | |
CN1566124A (zh) | 山茱萸提取物及其用途 | |
CN1666985A (zh) | 穿心莲内酯及其衍生物、类似物的医药用途 | |
Yang et al. | The Taishan Robinia pseudoacacia polysaccharides enhance immune effects of rabbit haemorrhagic disease virus inactivated vaccines | |
WO2017092230A1 (zh) | 双黄酮化合物及其治疗癌症和制备药物的用途 | |
CN1348813A (zh) | 抗流感病毒的药物有效部位及活性成分的分离制备方法 | |
CN1689628B (zh) | 穿心莲提取物的医药用途 | |
CN109419787B (zh) | 一种松香烷型二萜类化合物的用途 | |
CN1235581C (zh) | 一种龙血竭总黄酮制剂的制备方法及其质量控制方法 | |
CN101036646A (zh) | 苦木总生物碱及其单体生物碱的医药用途 | |
CN115998754A (zh) | 皂苷衍生物在制备用于治疗和预防溃疡性结肠炎药物中的用途、制备方法及应用 | |
TWI435727B (zh) | 調節細胞激素分泌之用途 | |
CN102106884B (zh) | 具有免疫调节功能的医药组合物 | |
CN1416881A (zh) | 一种抗抑郁的药物组合物及其制备方法 | |
CN1261143C (zh) | 抗流感病毒的药物有效部位及活性成分的分离制备方法 | |
Oladejo et al. | Acute and chronic anti-inflammatory effect of Bryophyllum pinnatum leaf extract on wistar rats | |
CN108888628B (zh) | 一种人参皂苷GRh2在制备抗弓形虫复方制剂中的应用及其药物 | |
CN100339353C (zh) | 一枝蒿酮酸的制备方法及用途 | |
CN100441186C (zh) | 伪石蒜碱的医药用途 | |
JP6688585B2 (ja) | バリア機能改善剤 | |
CN100528152C (zh) | 5-羟甲基-2-糠醛及其衍生物、类似物的医药用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
CI01 | Correction of invention patent gazette |
Correction item: Inventor Correct: Zhang Weihan False: Zhang Weiquan Number: 40 Volume: 21 |
|
CI02 | Correction of invention patent application |
Correction item: Inventor Correct: Zhang Weihan False: Zhang Weiquan Number: 40 Page: The title page Volume: 21 |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG WEIQUAN TO: ZHANG WEIHAN |
|
ERR | Gazette correction |
Free format text: CORRECT: INVENTOR; FROM: ZHANG WEIQUAN TO: ZHANG WEIHAN |
|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication |