CN1642924A - 减少了镇静与共济失调效果的抗焦虑剂 - Google Patents
减少了镇静与共济失调效果的抗焦虑剂 Download PDFInfo
- Publication number
- CN1642924A CN1642924A CNA038073439A CN03807343A CN1642924A CN 1642924 A CN1642924 A CN 1642924A CN A038073439 A CNA038073439 A CN A038073439A CN 03807343 A CN03807343 A CN 03807343A CN 1642924 A CN1642924 A CN 1642924A
- Authority
- CN
- China
- Prior art keywords
- substituted
- thienyl
- phenyl
- cyclopropyl
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36840802P | 2002-03-28 | 2002-03-28 | |
| US60/368,408 | 2002-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1642924A true CN1642924A (zh) | 2005-07-20 |
Family
ID=28675480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA038073439A Pending CN1642924A (zh) | 2002-03-28 | 2003-03-28 | 减少了镇静与共济失调效果的抗焦虑剂 |
Country Status (16)
| Country | Link |
|---|---|
| US (6) | US7119196B2 (enExample) |
| EP (1) | EP1490344B1 (enExample) |
| JP (1) | JP2005525392A (enExample) |
| KR (2) | KR100865410B1 (enExample) |
| CN (1) | CN1642924A (enExample) |
| AT (1) | ATE389640T1 (enExample) |
| AU (1) | AU2003230754B2 (enExample) |
| BR (1) | BR0308918A (enExample) |
| CA (1) | CA2480869A1 (enExample) |
| DE (1) | DE60319812T2 (enExample) |
| DK (1) | DK1490344T3 (enExample) |
| ES (1) | ES2300576T3 (enExample) |
| IL (1) | IL163958A0 (enExample) |
| MX (1) | MXPA04009332A (enExample) |
| NZ (1) | NZ535517A (enExample) |
| WO (1) | WO2003082832A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107056760A (zh) * | 2017-01-22 | 2017-08-18 | 苏州楚凯药业有限公司 | 5,7位取代的1H‑苯并[e][1,4]二氮杂‑2(3H)‑酮衍生物的制备方法 |
| CN107216332A (zh) * | 2017-06-29 | 2017-09-29 | 上海药明康德新药开发有限公司 | 叔丁基‑7‑羟甲基‑7,8‑二氢4h吡唑并二氮杂卓5(6h)甲酸基酯的合成方法 |
| CN107325101A (zh) * | 2017-06-29 | 2017-11-07 | 上海合全药物研发有限公司 | 6‑羟甲基‑6,7‑二氢‑5h,9h‑咪唑并二氮杂卓‑8‑羧酸叔丁酯的合成方法 |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE47475E1 (en) * | 2002-03-28 | 2019-07-02 | Wisys Technology Foundation, Inc. | Selective agents for pain suppression |
| AU2005260650A1 (en) | 2004-06-30 | 2006-01-12 | Wisys Technology Foundation, Inc. | Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects |
| US8119629B2 (en) * | 2007-10-03 | 2012-02-21 | Bristol-Meyers Squibb Company | Carboxamide GABAA α2 modulators |
| NZ586225A (en) * | 2008-01-22 | 2012-05-25 | Lilly Co Eli | Kappa selective opioid receptor antagonist |
| US20100261711A1 (en) * | 2009-03-20 | 2010-10-14 | Wisys Technology Foundation | Selective anticonvulsant agents and their uses |
| JP2013209292A (ja) * | 2010-07-23 | 2013-10-10 | Nippon Chemiphar Co Ltd | Ｐ２ｘ４受容体拮抗剤 |
| US9006233B2 (en) | 2011-04-28 | 2015-04-14 | Uwm Research Foundation, Inc. | Gabaergic receptor subtype selective ligands and their uses |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| WO2014047413A1 (en) | 2012-09-21 | 2014-03-27 | Uwm Research Foundation, Inc. | Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma |
| FR3010785B1 (fr) * | 2013-09-18 | 2015-08-21 | Snecma | Procede de controle de la densite d'energie d'un faisceau laser par analyse d'image et dispositif correspondant |
| EP3407886A1 (en) | 2016-01-27 | 2018-12-05 | Universität Zürich | Use of gabaa receptor modulators for treatment of itch |
| WO2017161370A1 (en) | 2016-03-18 | 2017-09-21 | Uwm Reseach Foundation, Inc. | Treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders with alpha5-containing gabaa receptor agonists |
| CN109790170B (zh) | 2016-08-16 | 2022-08-02 | Uwm研究基金会有限公司 | Gaba(a)受体调节剂和控制哮喘中气道高反应性和炎症的方法 |
| CN109906220A (zh) * | 2016-11-01 | 2019-06-18 | 豪夫迈·罗氏有限公司 | 用于治疗cns相关疾病的1,3-二氢-1,4-苯并二氮杂*-2-硫酮化合物 |
| WO2019070910A1 (en) | 2017-10-03 | 2019-04-11 | Uwm Research Foundation, Inc. | NEW POLYTHERAPY FOR ANXIETY, EPILEPSY AND PAIN DISORDERS |
| CA3167543A1 (en) | 2020-03-31 | 2021-10-07 | F. Hoffmann-La Roche Ag | Benzodiazepine derivatives as gaba a gamma1 pams |
| US12161622B2 (en) | 2021-05-04 | 2024-12-10 | Janssen Pharmaceuticals, Inc. | Compositions and methods for the treatment of depression |
| AR127127A1 (es) * | 2021-09-24 | 2023-12-20 | Hoffmann La Roche | NUEVOS DERIVADOS DE PIRIDODIAZEPINAS COMO PAM DE GABAA g1 |
| CN118019742A (zh) | 2021-09-29 | 2024-05-10 | 豪夫迈·罗氏有限公司 | 作为GABA A γ1 PAM的新颖苯并二氮杂䓬衍生物 |
| KR20240073892A (ko) | 2021-10-06 | 2024-05-27 | 에프. 호프만-라 로슈 아게 | Gaba a gamma1 수용체의 양성 알로스테릭 조절인자로서의 벤조디아제핀 유도체 |
| IL315415A (en) | 2022-03-07 | 2024-11-01 | Janssen Pharmaceuticals Inc | The compositions containing eticarpant |
| CA3254365A1 (en) | 2022-03-07 | 2023-09-14 | Janssen Pharmaceuticals, Inc. | POLYMORPHIC FORMS OF ATICAPRANT INTENDED FOR USE IN THE TREATMENT OF MAJOR DEPRESSION |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2893992A (en) | 1959-07-07 | I ii i i | ||
| US3886141A (en) * | 1971-10-07 | 1975-05-27 | Hoffmann La Roche | Preparation of 5-pyridyl benzodiazepine utilizing hexamethylenetetramine |
| US4440685A (en) * | 1974-09-11 | 1984-04-03 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
| US4280957A (en) | 1974-09-11 | 1981-07-28 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
| US4401597A (en) | 1978-05-15 | 1983-08-30 | Hoffmann-La Roche Inc. | Imidazodiazepines and processes therefor |
| DE3435973A1 (de) * | 1984-10-01 | 1986-04-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung |
| EP0230942B1 (de) * | 1986-01-21 | 1992-04-29 | Boehringer Ingelheim Kg | Thieno-1,4-diazepine |
| MC1999A1 (fr) | 1987-12-18 | 1990-01-26 | Hoffmann La Roche | Composes tricycliques |
| US4959361A (en) * | 1987-12-18 | 1990-09-25 | Hoffmann-La Roche Inc. | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists |
| US5968176A (en) * | 1997-05-29 | 1999-10-19 | 3Com Corporation | Multilayer firewall system |
| IL157873A0 (en) | 2001-04-12 | 2004-03-28 | Hoffmann La Roche | DIHYDRO-BENZO [b] [1,4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II |
| US7161904B2 (en) * | 2002-06-04 | 2007-01-09 | Fortinet, Inc. | System and method for hierarchical metering in a virtual router based network switch |
| US7415723B2 (en) * | 2002-06-11 | 2008-08-19 | Pandya Ashish A | Distributed network security system and a hardware processor therefor |
-
2003
- 2003-03-28 US US10/402,538 patent/US7119196B2/en not_active Expired - Lifetime
- 2003-03-28 DE DE60319812T patent/DE60319812T2/de not_active Expired - Lifetime
- 2003-03-28 CA CA002480869A patent/CA2480869A1/en not_active Abandoned
- 2003-03-28 AU AU2003230754A patent/AU2003230754B2/en not_active Ceased
- 2003-03-28 NZ NZ535517A patent/NZ535517A/en not_active IP Right Cessation
- 2003-03-28 MX MXPA04009332A patent/MXPA04009332A/es active IP Right Grant
- 2003-03-28 WO PCT/US2003/009587 patent/WO2003082832A2/en not_active Ceased
- 2003-03-28 JP JP2003580300A patent/JP2005525392A/ja active Pending
- 2003-03-28 DK DK03723846T patent/DK1490344T3/da active
- 2003-03-28 AT AT03723846T patent/ATE389640T1/de not_active IP Right Cessation
- 2003-03-28 BR BR0308918-5A patent/BR0308918A/pt not_active IP Right Cessation
- 2003-03-28 ES ES03723846T patent/ES2300576T3/es not_active Expired - Lifetime
- 2003-03-28 KR KR1020047015305A patent/KR100865410B1/ko not_active Expired - Fee Related
- 2003-03-28 KR KR1020087012062A patent/KR20080060286A/ko not_active Ceased
- 2003-03-28 CN CNA038073439A patent/CN1642924A/zh active Pending
- 2003-03-28 IL IL16395803A patent/IL163958A0/xx unknown
- 2003-03-28 EP EP03723846A patent/EP1490344B1/en not_active Expired - Lifetime
-
2006
- 2006-07-20 US US11/458,855 patent/US20070049580A1/en not_active Abandoned
- 2006-07-20 US US11/458,739 patent/US7235656B2/en not_active Expired - Fee Related
-
2007
- 2007-06-24 US US11/767,515 patent/US20070299058A1/en not_active Abandoned
- 2007-10-30 US US11/929,860 patent/US20080108605A1/en not_active Abandoned
-
2010
- 2010-01-08 US US12/684,845 patent/US20100130481A1/en not_active Abandoned
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107056760A (zh) * | 2017-01-22 | 2017-08-18 | 苏州楚凯药业有限公司 | 5,7位取代的1H‑苯并[e][1,4]二氮杂‑2(3H)‑酮衍生物的制备方法 |
| CN107216332A (zh) * | 2017-06-29 | 2017-09-29 | 上海药明康德新药开发有限公司 | 叔丁基‑7‑羟甲基‑7,8‑二氢4h吡唑并二氮杂卓5(6h)甲酸基酯的合成方法 |
| CN107325101A (zh) * | 2017-06-29 | 2017-11-07 | 上海合全药物研发有限公司 | 6‑羟甲基‑6,7‑二氢‑5h,9h‑咪唑并二氮杂卓‑8‑羧酸叔丁酯的合成方法 |
| CN107325101B (zh) * | 2017-06-29 | 2019-03-26 | 上海合全药物研发有限公司 | 6-羟甲基-6,7-二氢-5h,9h-咪唑并二氮杂卓-8-羧酸叔丁酯的合成方法 |
| CN107216332B (zh) * | 2017-06-29 | 2019-04-30 | 上海药明康德新药开发有限公司 | 叔丁基-7-羟甲基-7,8-二氢4h吡唑并二氮杂卓5(6h)甲酸基酯的合成方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20070049580A1 (en) | 2007-03-01 |
| US20070299058A1 (en) | 2007-12-27 |
| US20070054881A1 (en) | 2007-03-08 |
| EP1490344A2 (en) | 2004-12-29 |
| WO2003082832A3 (en) | 2004-04-08 |
| CA2480869A1 (en) | 2003-10-09 |
| KR20080060286A (ko) | 2008-07-01 |
| US20080108605A1 (en) | 2008-05-08 |
| AU2003230754B2 (en) | 2007-10-25 |
| KR100865410B1 (ko) | 2008-10-24 |
| DK1490344T3 (da) | 2008-06-16 |
| DE60319812T2 (de) | 2009-04-23 |
| NZ535517A (en) | 2007-02-23 |
| DE60319812D1 (de) | 2008-04-30 |
| EP1490344B1 (en) | 2008-03-19 |
| US7235656B2 (en) | 2007-06-26 |
| US20100130481A1 (en) | 2010-05-27 |
| JP2005525392A (ja) | 2005-08-25 |
| BR0308918A (pt) | 2005-01-04 |
| US20040082573A1 (en) | 2004-04-29 |
| AU2003230754A1 (en) | 2003-10-13 |
| ATE389640T1 (de) | 2008-04-15 |
| WO2003082832A2 (en) | 2003-10-09 |
| KR20040098029A (ko) | 2004-11-18 |
| IL163958A0 (en) | 2005-12-18 |
| US7119196B2 (en) | 2006-10-10 |
| ES2300576T3 (es) | 2008-06-16 |
| MXPA04009332A (es) | 2005-12-12 |
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