CN1634361A - Chinese traditional medicine powder medicine for treating milk cow mastitis - Google Patents
Chinese traditional medicine powder medicine for treating milk cow mastitis Download PDFInfo
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Abstract
The invention discloses a Chinese traditional medicine powder medicine for treating milk cow mastitis which is prepared from capsule of weeping forsythia, dandelion, elephantopus, Bupleurum root, baikal skullcap root, white mustard seed, dragon's bone, oyster shell, motherwort, frankincense, and myrrh.
Description
Technical field
The invention belongs to tcm field, relate to a kind of veterinary drug, particularly a kind of Chinese powder medicine mastitis that is used for the treatment of bovine mastitis disappears.
Background technology
Mastitis be in the world milk cattle cultivating industry sickness rate the highest, popular the fastest, one of maximum disease causes damage.Join in a common effort meter according to U.S.'s milk, clinical type bovine mastitis sickness rate is up to 50%, and total incidence can account for 70% of whole cows.Because it is more to cause the paathogenic factor of bovine mastitis, the infective pathogen type is more assorted, therefore how effectively to prevent and treat various types of mastitis to have become world subject.Correlational study both domestic and external in recent years report has highlighted methods such as the antibiotherapy that is used to prevent and treat bovine mastitis, recombinant vaccine, interferon, yolk antibody, and the pluses and minuses between them are compared.
One, bovine mastitis is the very big disease of world's milk product industry hazardness, it is reported that mastitis comprise to the harm that dairy causes: directly cause the minimizing of milk yield; The cattle milk that quilt is outwelled because milk modification and drug residue are used people's anorexia; Some Niu Wufa cure and the loss that is eliminated and caused; The spending of medical care expenses during the treatment mastitis; Nurse the required extra labour force spending of disease cattle etc.The sickness rate of most countries mastitis is about 40% in the world, and every cattle decreased average milk amount is about 15%.Since the nineties, be subjected to this to influence annual economic loss in the U.S. and reach 2,000,000,000 dollars, about 200 dollars of the annual losses of average every cattle.Even more serious is because some mastitis has infectiousness, and the infection of several cattle just often can cause spreading of whole cattle farm mastitis.From pathology, mastitis are mammary gland tissue a kind of inflammatory reaction processes for extraneous bad conditions such as antibacterial, fungus, mycete, chemicals, warm stimulation and mechanical injuries.This process comprises: the leukocytic quantity in the concentration of immune protein and mammary gland tissue and Ruzhong in the elevating blood.Studies show that the mastitis in China pasture are all caused by pathogenic microorganism more than 80%.
Two, the treatment measure of mastitis
1, the antibiotic use of antibiotic is a kind of treatment means that generally adopts both at home and abroad at present.Clinical commonly used drug generally includes following a few class: beta-lactam antibiotic (being penicillin medicine), aminoglycoside medicaments, macrolide antibiotic and lincomycin etc.The main dry milk phase therapy of using promptly after milking for the last time age of sucking, is injected the antibiotic of doses to each breast district of every cattle.Have and report that this method can comparatively effectively control the infection of infectiousness pathogenic bacterium such as staphylococcus aureus, streptococcus etc., and to the microbial mastitis effect of the large intestine in the environment and not obvious.Also have some antibiotic oral formulations also can reach the effect of sterilization, antiinflammatory in addition.Usually effect is comparatively desirable in the early stage to use antibiotherapy, but also there are many unfavorable factors in it: (1) is prone to Drug resistance and drug resistance.(2) the single medicine antimicrobial spectrum is wide inadequately, often needs several antibiotic mixing to use, and spends higher.(3) cause some other side effect,, influence appetite etc. as alteration of intestinal flora.(4) cause the residual and milch cow drug disposition savings of milk Chinese medicine, jeopardize human health indirectly.
What 2, recombinant vaccine adopted the vaccine control mastitis is safer, effective method.It excites the intravital specific antibody of disease cattle to reach the purpose of bactericidal antiphlogistic by injecting inactivated bacteria or weak malicious Seedling.Utilizing the modal problem of vaccine control bovine mastitis is the variation of bacterial antigens, and the structure that antibacterial constantly changes virulence factor makes immune system always lag behind antibacterial when producing new antibody.Cause vaccine fine 1 year effect, 1 year ineffective.Research worker finds that the gram negative bacteria cell wall contains a kind of " general cAg " and will be exposed to immune system at the fastest this position of exponential phase of bacterial growth afterwards.At this moment antibody is with it in conjunction with reaching preventive and therapeutic effect.For example the J5 bacillus coli vaccine utilizes this principle development.Also have a class vaccine also to utilize the general cAg of gram negative bacteria to design.It is reported that this vaccine makes gram negative bacteria commit suiside by to containing the conversion of sucrose-6 fructose-transferring enzyme substrate plasmid, collects these negative bacterium and prepares vaccine under sucrose induction.It is said that it does not damage the immunogenicity of vaccine, can not damage the significant points of correct stimulation animal immune system, can not produce alternate, non-natural vaccine antigen.Used chemical inducer is edible sucrose, thereby needn't remove.Can reduce simultaneously endotoxin content in the body greatly, stimulating immune system is resisted the caused bovine mastitises of gram negative bacteria such as escherichia coli.But because the paathogenic factor complexity, present vaccine is difficult to various mastitis are all played excellent curative.
3. the immunocyte and the non-immunocyte of reorganization cattle gamma interferon (rboIFN-γ) body can synthesize and secrete the micromolecular polypeptide class factor, and they can regulate the various kinds of cell physiological function, are called cytokine.Present known interleukin, interferon (Interferon, IFN), colony stimulating factor, tumor necrosis factor, transforming growth factor etc. all are cytokines that immunocyte produces, they play very important regulating and controlling effect in immune system, also can cause pathological reaction under abnormal conditions.IFN is the cytokine of finding at first, as far back as nineteen fifty-seven, people such as Issacs find that the cell of viral infection produces a kind of factor, can resist the infection of virus, duplicating of viral interference, thereby called after interferon are according to its source and structure, IFN can be divided into IFN-α, IFN-β and IFN-γ, they are produced by leukocyte, fibrocyte and activating T cell respectively.IFN also has antitumor except that antivirus action is arranged, immunomodulating, control cell proliferation and cause effect such as heating.After cloning IFN-γ first in 1986, the method for relevant in the last few years IFN-γ treatment mastitis is subjected to people's attention gradually.IFN-γ is one section and contains 143 amino acid whose glycoproteins that molecular weight is between 14-18kDa.It is to be produced by NK cell that is activated and T emiocytosis.Sordillo etc. have carried out the experiment of heifer immunity, prevent coliform property mastitis with rboIFN-γ.It is 42% that the result uses the matched group mortality rate of placebo, and treatment group milch cow all survives.Show that interferon-can suppress the growth of coliform, strengthen the immunity of nascent heifer coliform.The rboIFN-γ dosage of again newborn pond being injected has carried out testing (Snider etc., 1992) after this.Studies show that: the suitable dose of rboIFN-γ is about 105U/ breast district, and SCC value and constituent content all do not have obvious variation in the sample of suckling this moment.The SCC value can significantly raise when the injected dose in the every newborn pond of rboIFN-γ surpasses 107U, and lactose content and the pH value in the milk component all can descend simultaneously, and milk quality is reduced.RboIFN-γ experiment in vitro finds that a certain amount of rboIFN-γ can strengthen the phagocytic activity of neutrophil and macrophage, but does not influence its sterilizing ability.The mechanism of the bovine mastitis of rboIFN-γ method treatment at present still imperfectly understands, it must with the receptors bind competence exertion biological activity of its high-affinity.Along with the enhancing of present consumer health's consciousness, carry out " relieved milk " in China also imperative comprehensively.
Be to replace said method, develop that the pharmaceutical treatment bovine mastitis is imperative in a kind of treatment, relate to the key technology brainstorm project of " original new drug and the modernization of Chinese medicine ", " the milk industry develops " and " food safety " these three Ministry of Science and Technology's propositions.
Summary of the invention
The object of the invention is to provide a kind of Chinese powder medicine that is used for the treatment of bovine mastitis, and this medicine all adopts Chinese medicine to form, and can effectively treat bovine mastitis.
The objective of the invention is to be achieved through the following technical solutions:
A kind of Chinese medicine that is used for the treatment of bovine mastitis looses, and it is characterized in that this Chinese patent medicine is made up of the Chinese medicine ingredients of following weight parts: ERJIHUA 35～45g, Fructus Forsythiae 35～45g, Herba Taraxaci 35～45g, Herba Violae 15～25g, Radix Bupleuri 25～35g, Radix Scutellariae 25～35g, Semen Sinapis Albae 15～25g, Os Draconis 25～35g, Concha Ostreae 25～35g, Herba Leonuri 55～65g, Olibanum 10～20g, Myrrha 10～20g.
Its preparation method is, above-mentioned Chinese medicine is dried, chooses clean impurity, pulverizing, crosses 80 mesh sieves, tightly seals with the double-layer plastic bag by every bag 400g to get final product.
Chinese medicine of the present invention looses, and facts have proved that through clinic diagnosis mastitis disappears evident in efficacy, and it has heat-clearing and toxic substances removing, the blood circulation promoting and blood stasis dispelling eliminating stagnation, and effects such as detumescence stimulating milk secretion, and also milk yield returns to normal level very soon after curing, and keeps stable, is difficult for recurrence.
The specific embodiment
The pharmacodynamics test of this Chinese patent medicine that provides below in conjunction with the inventor and acute and long term toxicity test and specific embodiment are described in further detail the present invention.
Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Herba Violae, Radix Scutellariae heat-clearing and toxic substances removing, sterilizing and anti-virus in the prescription of the present invention; Inside and outside Radix Scutellariae, Radix Glycyrrhizae, dried summer regulating cold and heat, the reconciliation; Olibanum, Myrrha, Herba Leonuri blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic; Herba Leonuri, the Radix Angelicae Dahuricae, Semen Sinapis Albae, Os Draconis, Concha Ostreae, the soft eliminating stagnation of Bulbus Fritillariae Thunbergii, inducing diuresis to remove edema; Radix Glycyrrhizae, Fructus Aurantii, antiallergic, protect taste, harmonizing the functional activities of vital QI, full side plays disease-resistant former altogether, blood stasis dispelling blood, the pain that relieves the pain, clear swelling soft or hard knot, the merit in lactogenesis road is the potion good medicine of treatment milch cow acute and chronic mastitis on the present veterinary clinic.
1. pharmacodynamics test
The Chinese medicine of this treatment bovine mastitis looses with matched group, group, middle amount group, a large amount of group experimentize in a small amount, and proving that Chinese medicine of the present invention is diffusing has significant effect (seeing table) to sick cattle cure rate
| Group | Dosage (g/ days) | Sick cattle number (head) | Cure rate (%) | Remarks |
| Matched group | 0 | ?10 | ?0 | |
| Organize in a small amount | 300 | ?10 | ?90 | Administration time is longer, and total dosage is big |
| Middle amount group | 400 | ?10 | ?100 | The medication phase is short, and total dosage is little |
| A large amount of groups | 500 | ?10 | ?60 |
2. animal acute toxicity test
Once irritate each 20 of stomach mices with the dose of the tolerant Cmax of animal (3g/ml), 0.8ml, male and female half and half were observed 7 days continuously, did not take place dead.Dosage is the 120g/kg body weight, is equivalent to 179.1 times of clinical consumption.At viewing duration, do not find that animal has obvious poisoning symptom.
3. long-term toxicity test for animals
Rat is irritated stomach mastitis disappear continuous four months of 5g/kg/d, 15g/kg/d (be equivalent to clinical administration dosage 7.4,22.2 times) respectively, the general activity behind the two dosage group rat medicines, and the mental status, hair, feces etc. show no obvious abnormalities.Peripheral hemogram before and after the administration comprises that erythrocyte, leukocyte and classification, hemoglobin, packed cell volume all fluctuate in normal range.Three livers (SGPT, SGOT), kidney (blood urea nitrogen, creatinine) functional parameter be there is no obvious influence.During off-test, the content of total protein, albumin, alkali phosphatase is compared no significant difference with matched group in the animal serum.Electrocardioscopy is all no abnormal.Each main organs macroscopy is not seen morphological changes of various tissue components such as obvious enlargement, hyperemia, necrosis.The weight coefficient of the heart, liver, spleen, lung, kidney, thymus, adrenal gland, uterus, testis is compared with matched group, no significant difference.Histopathologic examination there is no unusual.The above presentation of results mastitis comparison safety that disappears there is no obvious toxic-side effects in institute's amount of reagent scope.(raw data is kept at animal and veterinary institute of Xibei Univ. of Agricultural ﹠ Forest Science ﹠ Technology).
4. the mastitis clinical practice report of (loosing) that disappears
Contrast test: with the milk cattle is example, is divided into three groups, and I group is with " mastitis disappears " treatment, and the II group is with the quiet notes treatment of penicillin, every day every consumption 600 million international units, the III group is treated with streptomycin, every day, every consumption 8g the results are shown in Table 1.
Table 1 " mastitis dissipation ", penicillin, the scorching effect table of streptomycin treatment dairy cow breast
| Group | Treatment cattle number (head) | Cure number (head) | Cure rate (%) |
| Mastitis dissipation (I group) | 30 | ?29 | ?96.7 |
| Penicillin (II group) | 30 | ?22 | ?73.3 |
| Streptomycin (III group) | 30 | ?21 | ?70.0 |
As can be seen from Table 1, the scorching effect of " mastitis dissipation " treatment dairy cow breast is obvious.
In the past, the clinical treatment mammitis of cow mainly used antibiotic, hormone and chemical synthetic drug, so brought a series of problems.Increase as Resistant strain, endocrine dysfunction, antibiotic and residue of veterinary drug exceed standard etc., badly influence human health.Along with China joined WTO, consumers in general require more and more higher to milk quality, propose the requirement of antibiotic-free milk, noresidue milk.At this situation, from JIUYUE, 1998 to 2004 year April, the applicant uses this Chinese medicine preparation mastitis treatment bovine mastitis 1283 examples that disappear, and total effective rate reaches more than 96%.
5. specific embodiment
Embodiment 1:
According to technical scheme of the present invention, the best preparation that this Chinese medicine that is used for the treatment of bovine mastitis looses is made up of the Chinese medicine ingredients of following weight parts: ERJIHUA 40g, Fructus Forsythiae 40g, Herba Taraxaci 40g, Herba Violae 20g, Bulbus Fritillariae Thunbergii 15g, Radix Angelicae Dahuricae 25g, Fructus Aurantii 40g, Radix Glycyrrhizae 20g, Radix Bupleuri 30g, Radix Scutellariae 30g, Semen Sinapis Albae 20g, Os Draconis 30g, Concha Ostreae 30g, Herba Leonuri 60g, Olibanum 15g, Myrrha 15g.
Its preparation method is that above-mentioned Chinese medicine is dried, chooses clean impurity, pulverizing, crosses 80 mesh sieves, tightly seals with the double-layer plastic bag by every bag 400g to get final product.
Embodiment 2:
The preparation that this Chinese medicine that is used for the treatment of bovine mastitis looses is made up of the Chinese medicine ingredients of following weight parts: ERJIHUA 35g, Fructus Forsythiae 35g, Herba Taraxaci 35g, Herba Violae 15g, Radix Bupleuri 25g, Radix Scutellariae 25g, Semen Sinapis Albae 15g, Os Draconis 25g, Concha Ostreae 25g, Herba Leonuri 55g, Olibanum 10g, Myrrha 10g.
Its preparation method is with embodiment 1.
Embodiment 3:
The preparation that this Chinese medicine that is used for the treatment of bovine mastitis looses is made up of the Chinese medicine ingredients of following weight parts: ERJIHUA 45g, Fructus Forsythiae 45g, Herba Taraxaci 45g, Herba Violae 25g, Radix Bupleuri 35g, Radix Scutellariae 35g, Semen Sinapis Albae 25g, Os Draconis 35g, Concha Ostreae 35g, Herba Leonuri 65g, Olibanum 20g, Myrrha 20g.
Its preparation method is with embodiment 1.
If be used for producing in batches, can be by the proportional amplification of above-mentioned prescription.
Prescription of the present invention is used in combination with the Western medicine XIAOZHONGLING, and then curative effect is better, and its prescription is as follows:
10% glucose injection 1000.0
5% calcirm chloride injization 250.0
10% caffeine and sodium benzoate injection 30.0
10% sodium salicylate injection 150.0
Once a day, quiet notes, for three days on end.
6. adaptation symptom
The early stage milk character of clinical type mastitis is unusual, thin, includes ziega or floccule, and what have is mixed with blood or pus, and the milk that has is discharged not smooth, and lactation amount reduces or stops.The middle and late stage breast is red, swollen, hot, bitterly, the lymphonodi mammarici enlargement.Most of milch cow is except that above-mentioned symptom, also with General Symptomies such as lassitude, appetite minimizing, fervescence.
The general clinical symptoms of latent mammitis is not obvious, and sense organ checks that milk does not have ANOMALOUS VARIATIONS, only shows the milk amount usually and reduces gradually, and most alcohol testings are positive.
7. using method
Mastitis (loosing) the each 400g that disappears, boiled water reconstitutes, and waits temperature and gavages every day 1-2 time.The person that has the General Symptoms is used in combination antibiotic, after General Symptoms disappears, takes mastitis again and disappears to keep in 1-3 days and consolidate curative effect, in case recurrence.
8. concrete case
Case on June 28th, 1,1999, light a certain the 6 years old Fresian in Yangling District Li Tai township, main suit: find both sides breast redness when milking before 3 days, please local veterinary use penicillin, streptomycin, kanamycin etc. still ineffective, and lassitude occur, loss of appetite.Check: bilateral breast is red, swollen, hot, bitterly, the lymphonodi supramammarici enlargement.Treatment disappears with mastitis and sooner or later respectively obeys 400g, and that the swelling has gone down is more than half for breast during the next day further consultation, and the reuse mastitis disappears 400g/ day, logotype 4 days, recovery from illness.
Case 2, on April 5 calendar year 2001,5 years old milch cow of Xingping City Sang Zhen Cao is examined the main suit: the milk amount descends to some extent recently, the milk sense organ is normal, but milk shed rejects after with alcohol testing, further check, and milk acidity is 20 ° of T, belong to alcohol positive milk, high acidity should be latent mammitis.Mastitis for oral administration 3 bags that disappear, the next day after, the milk acceptance(check), the milk amount is also gone up to some extent.
Claims (2)
1. Chinese powder medicine that is used for the treatment of bovine mastitis is characterized in that this Chinese powder medicine is made up of the Chinese medicine ingredients of following weight parts: ERJIHUA 35～45g, Fructus Forsythiae 35～45g, Herba Taraxaci 35～45g, Herba Violae 15～25g, Radix Bupleuri 25～35g, Radix Scutellariae 25～35g, Semen Sinapis Albae 15～25g, Os Draconis 25～35g, Concha Ostreae 25～35g, Herba Leonuri 55～65g, Olibanum 10～20g, Myrrha 10～20g.
2. the Chinese powder medicine that is used for the treatment of bovine mastitis as claimed in claim 1 is characterized in that this Chinese patent medicine is made up of the Chinese medicine ingredients of following weight parts: ERJIHUA 40g, Fructus Forsythiae 40g, Herba Taraxaci 40g, Herba Violae 20g, Bulbus Fritillariae Thunbergii 15g, Radix Angelicae Dahuricae 25g, Fructus Aurantii 40g, Radix Glycyrrhizae 20g, Radix Bupleuri 30g, Radix Scutellariae 30g, Semen Sinapis Albae 20g, Os Draconis 30g, Concha Ostreae 30g, Herba Leonuri 60g, Olibanum 15g, Myrrha 15g.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101780205A (en) * | 2010-03-24 | 2010-07-21 | 安徽农业大学 | Traditional Chinese medicine compound transdermal patch for treating mastitis of dairy cattle and preparation method thereof |
| CN101301389B (en) * | 2008-07-07 | 2010-10-13 | 赵守财 | Chinese medicinal composition for treating mammilla and lacteal cistern neoplasm disease of milk cattle and preparation and use thereof |
| CN101947258A (en) * | 2010-04-12 | 2011-01-19 | 湖南圣雅凯生物科技有限公司 | Film-spraying agent for treating bovine mastitis |
| CN103720930A (en) * | 2013-11-15 | 2014-04-16 | 北安市飞龙动物药厂 | Traditional Chinese medicine composition for treating dairy cow mastitis |
| CN105168770A (en) * | 2015-09-06 | 2015-12-23 | 王璐 | Veterinary drug for treating mastopathy of dairy cows |
| CN106176955A (en) * | 2016-07-22 | 2016-12-07 | 太仓市爱农奶牛专业合作社 | A kind of antiinflammatory treating mammitis of cow and preparation method thereof |
Families Citing this family (1)
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| CN101411757B (en) * | 2008-12-12 | 2011-04-20 | 河北农业大学 | Injection for treating milk cattle mastitis and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1217686C (en) * | 2003-04-01 | 2005-09-07 | 赵林 | Preparation method of dairy cattle mammitis anhinflammation powder |
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- 2004-11-18 CN CNB2004100732896A patent/CN1315513C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101301389B (en) * | 2008-07-07 | 2010-10-13 | 赵守财 | Chinese medicinal composition for treating mammilla and lacteal cistern neoplasm disease of milk cattle and preparation and use thereof |
| CN101780205A (en) * | 2010-03-24 | 2010-07-21 | 安徽农业大学 | Traditional Chinese medicine compound transdermal patch for treating mastitis of dairy cattle and preparation method thereof |
| CN101947258A (en) * | 2010-04-12 | 2011-01-19 | 湖南圣雅凯生物科技有限公司 | Film-spraying agent for treating bovine mastitis |
| CN101947258B (en) * | 2010-04-12 | 2011-07-20 | 湖南圣雅凯生物科技有限公司 | Film-spraying agent for treating bovine mastitis |
| CN103720930A (en) * | 2013-11-15 | 2014-04-16 | 北安市飞龙动物药厂 | Traditional Chinese medicine composition for treating dairy cow mastitis |
| CN103720930B (en) * | 2013-11-15 | 2016-07-06 | 北安市飞龙动物药厂 | A kind of Chinese medicine composition treating bovine mastitis |
| CN105168770A (en) * | 2015-09-06 | 2015-12-23 | 王璐 | Veterinary drug for treating mastopathy of dairy cows |
| CN106176955A (en) * | 2016-07-22 | 2016-12-07 | 太仓市爱农奶牛专业合作社 | A kind of antiinflammatory treating mammitis of cow and preparation method thereof |
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