CN1824081A - External use preparation for treating vulnus slow agglutination and its preparation method - Google Patents
External use preparation for treating vulnus slow agglutination and its preparation method Download PDFInfo
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Abstract
An exterior-applied Chinese medicine for preventing the infection of wound and the generation of residual scar and promoting the healing of wound is prepared from Tokyo violet herb, red sage root, rehmannia root, Chinese angelica root, elephant skin and metronidazole.
Description
Affiliated technical field
The present invention relates to a kind of slow external used medicine of wound healing and preparation method thereof for the treatment of.
Background technology
Cause the slow reason of wound healing a lot, as wound, war wound, burn and scald, mosquito are bitten, operation, diabetes and great saphenous varicose vein cause skin ulcer etc.At present, domesticly use oral or quiet of antibiotic and ethacridine, vaseline gauze are changed dressings more, can cure common wound to acute ulcer treatment, but not good enough to special acute ulcer effect.Chronic ulcer is used vitamins, zinc preparation and various nutrient drug, as insulin, Vitc, Chinese medicine Shengji Yuhong Gao, SHENGJISAN etc., can promote the granulation growth, but be difficult to make epithelial repair than large tracts of land ulcer, the need that have are made skin graft, and form serious cicatrix, cause great misery and heavy financial burden to the patient.Disclosed among the patent documentation CN93110207.3 with Olibanum, Myrrha, Radix Glycyrrhizae, Radix Angelicae Sinensis, the ointment for growing muscle and healing skin of Radix Angelicae Dahuricae compatibility, this ointment has removing the necrotic tissue, detumescence, pain relieving, granulation promoting, the skin function that heals, the treating acute and chronic skin ulcer, trick is chapped, anal fissure etc.However, this Chinese medicine preparation curative effect still can not be satisfactory.
Summary of the invention
The purpose of this invention is to provide a kind ofly both eliminated traumatic infection, the granulation promoting skin rapidly, does not stay obvious cicatrix, the technical scheme of the easy to make again and external Chinese and western medicinal composition that the treatment cost is low.
Another object of the present invention has provided the preparation method of this external Chinese and western medicinal composition.
The present invention is achieved by the following technical solutions, the main medicine of making by the raw material of following weight parts ratio, and each amounts of components is for all to have better curative effect in the following weight parts scope:
3～9 parts of Herba Violaes, 3～9 parts of Radix Salviae Miltiorrhizaes, 2～6 parts in the Radix Rehmanniae, 2～6 parts of Radix Angelicae Sinensis, 3～9 parts of Corium elephatiss, 0.1～1 part of metronidazole.
Optimizing prescription is: 5～7 parts of Herba Violaes, 5～7 parts of Radix Salviae Miltiorrhizaes, 4～5 parts in the Radix Rehmanniae, 4～5 parts of Radix Angelicae Sinensis, 5～8 parts of Corium elephatiss, 0.1～0.5 part of metronidazole.
Be preferably: 6 parts of Herba Violaes, 6 parts of Radix Salviae Miltiorrhizaes, 4.5 parts in the Radix Rehmanniae, 4.5 parts of Radix Angelicae Sinensis, 6 parts of Corium elephatiss, 0.25 part of metronidazole.
During medicine of the present invention can adopt, the conventional method of Western medicine preparation is prepared into any conventional external preparation, for example these crude drug can be made unguentum, also these crude drug can be made powder.
The preparation method of unguentum is
(1) fried material: get Oleum Sesami 25～75 weight portions and put into pot and endure heat, with fried withered and yellow in Radix Salviae Miltiorrhizae, the Radix Rehmanniae, Radix Angelicae Sinensis, the input oil to medical material, treating that temperature drops to added Herba Violae, Corium elephatis, Flos Lonicerae, Herba Taraxaci, Radix Arnebiae (Radix Lithospermi) reheat 3～10 minutes between 110～140 ℃, should stir during heating, in case that medical material is heated is inhomogeneous, with the medicinal residues drop to the greatest extent, stay oil standby when treating the Corium elephatis fusing;
(2) molten cured: as to treat that oil temperature reduces to 70～90 ℃, get Cera Flava 3～9 weight portions and put oily internal heating fusing, stir cooling;
When (3) treating that the ointment temperature is reduced to 50～60 ℃ metronidazole powder added in the ointment and stir evenly, be unguentum of the present invention after the back packing sterilization that cools.
For further enhancing detumescence, granulation promoting, the skin function heals, more effectively infection, improve local microcirculation and histotrophic nutrition, each amounts of components of medicine of the present invention can also be: 3～9 parts of Herba Violaes, 3～9 parts of Radix Salviae Miltiorrhizaes, 2～6 parts in the Radix Rehmanniae, 2～6 parts of Radix Angelicae Sinensis, 3～9 parts of Corium elephatiss, 0.1～1 part of metronidazole, 3～9 parts of Flos Loniceraes, 3～9 parts of Herba Taraxacis, 2～6 parts of Radix Arnebiae (Radix Lithospermi)s.
Be preferably: 6 parts of Herba Violaes, 6 parts of Radix Salviae Miltiorrhizaes, 4.5 parts in the Radix Rehmanniae, 4.5 parts of Radix Angelicae Sinensis, 6 parts of Corium elephatiss, 0.25 part of metronidazole, 6 parts of Flos Loniceraes, 6 parts of Herba Taraxacis, 4.5 parts of Radix Arnebiae (Radix Lithospermi)s.
Medicine unguentum preparation method of the present invention is as follows:
(1) fried material: get Oleum Sesami 25～75 weight portions and put into pot and endure heat, with Radix Salviae Miltiorrhizae, the Radix Rehmanniae, Radix Angelicae Sinensis, input, fried withered and yellow to medical material, treat that temperature drops to and added Herba Violae, Corium elephatis, Flos Lonicerae, Herba Taraxaci, Radix Arnebiae (Radix Lithospermi) reheat between 110～140 ℃ 3～10 minutes.Should stir during heating,, with the medicinal residues drop to the greatest extent, stay oil standby when treating the Corium elephatis fusing in case that medical material is heated is inhomogeneous;
(2) molten cured: as to treat that the wet goods temperature reduces to 70～90 ℃, get Cera Flava 3～9 weight portions and put oily internal heating fusing, stir cooling;
When (3) treating that the ointment temperature is reduced to 40～60 ℃ metronidazole powder added in the ointment and stir evenly, be unguentum of the present invention after the back packing sterilization that cools.
The preparation method of drug powder of the present invention is:
(1) it is standby to take by weighing each crude drug by described weight;
(2) Chinese medicine that takes by weighing is detected, screening, cleans by national standard, 80 ℃ of freeze-day with constant temperature behind the pulverize separately, with metronidazole powder uniform mixing in proportion again, get final product after packing, the sterilization.
The using method of medicine of the present invention: at first clean wound surface, by the ulcer area, be coated with last layer thickness and be generally 2 millimeters ointment on gauze then, be affixed on the affected part, changed dressings once in per 1～3 day (wound surface is big, secretions was changed dressings once in 1～2 day for a long time, and wound surface is little, secretions was changed dressings once in 3 days after a little while).To specificity ulcer need do antibacterial cultivate add the medicine sensitization test after, select rational antibiotic partner treatment.
The traditional Chinese medical science is thought: wound healing is slow is lose by temper empty, due to the insufficiency of vital energy and blood, damp-heat accumulation, stagnation of blood stasis.Doctor trained in Western medicine is thought: wound infection, local blood supply deficiency, wound surface is dealt with improperly is the slow main cause of wound healing.This tcm clinical practice is adopted more the method for replenishing QI to invigorate the spleen, nourishing blood and promoting granulation, blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis.
Herba Violae among the present invention has the merit of heat-clearing and toxic substances removing, removing heat from blood detumescence.Be used for cards such as carbuncle furuncle furuncle, erysipelas, acute mastitis, acute appendicitis more.Herba Taraxaci has the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dampness removing jaundice eliminating.Experiment in vitro: staphylococcus aureus is had remarkable inhibitory action.Escherichia coli, dysentery bacterium and various skin tinea bacterium there is inhibitory action.The Flos Lonicerae heat-clearing and toxic substances removing restores menstrual flow and invigorates blood circulation, the cool breeze heat radiation.Have stronger antipyretic and antidote functions, be usually used in the pyretic toxicity abscess, carbuncle furuncle furuncle etc.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, analgesic, regulate effect such as immunity.Flos Lonicerae all has certain inhibitory action to various pathogens, comprise staphylococcus aureus, Hemolytic streptococcus, escherichia coli, dysentery bacterium, vibrio cholera, Bacillus typhi, Salmonella paratyphi, also effective to streptococcus pneumoniae, meningococcus, bacillus pyocyaneus, tubercule bacillus, morbific Streptococcus mutans, unwrapping wire Bacillus adhaerens have also been shown stronger antibacterial activity.Flos Lonicerae also has the leukocytic phagocytic function of promotion.Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Herba Violae is joined Herba Taraxaci, heat-clearing and toxic substances removing, and mass dissipating and swelling eliminating strength strengthens; Join Flos Lonicerae, the detoxifcation removing heat from blood, the merit of detumescence heat radiation strengthens; Join Radix Angelicae Sinensis, heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis increased functionality.The Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.With the Flos Lonicerae compatibility, be used for carbuncle sore tumefacting virus.To staphylococcus, the random vibrio of the leaves of pulse plants, tubercule bacillus, escherichia coli, bacillus pyocyaneus, Bacillus typhi, will Hayes and shigella flexneri and some dermatophytes etc., inhibitory action is arranged all.Radix Salviae Miltiorrhizae promotes that wound repair is relevant with following factor: (1) blood circulation promoting and blood stasis dispelling, and microcirculation improvement increases wound surface blood fortune and nutrition; (2) the stable and reinforcement effect of direct cell membrane reduces inflammation and edema; (3) antibacterial and anti-inflammation functions; (4) increase wound surface angiogenesis factor and fibroblast growth factor content or directly promote new capillary vessel and fibroblast, epithelial growth metabolism etc.Skin ulcer is held back in the Corium elephatis hemostasis.Control all wounds, ulcer does not close up for a long time.The Radix Rehmanniae has the clearing away heat and cooling blood effect.Radix Arnebiae (Radix Lithospermi) has removing heat from blood, invigorates blood circulation, detoxifcation rash effect.Metronidazole has another name called metronidazole, by to clinical observation, except that being used for infusorian, amebic dysentery, all morbific anaerobe is all had tangible antibacterial action recently.It has antibiotic wide, sterilizing power is strong, toxic and side effects is few, advantage such as have no drug resistance.Clinical research in recent years proves, its mechanism of action be for should disturb growth, the breeding of antibacterial by its reduzate and bacterial cell dna antisense, last kill bacteria.
All medicines share, and following advantage is arranged: (1) infection, bacteria growing inhibiting; (2) improve local microcirculation and histotrophic nutrition, impel granulation tissue, the ramp of edge of wound epithelium, shorten wound healing time; (3) reduce cicatrization.
Observation of curative effect: to open fracture, decubital ulcer, vasculitis, the refractory wound surface of formation such as diabetes and anus all has significant effect.
With the anus is example, observes as follows:
1 data and method
1.1 physical data 50 examples are the patient after the simple property anal fistula of row of being in hospital [according to Chinese Hengshui meeting unified standard classification bill (1975 the)] excision, are divided into treatment group and matched group at random, wherein 25 examples are organized in treatment, male 20 examples, women 5 examples; 18～65 years old age, average 35.27 ± 9.86 years old, wound surface area 7.92 ± 1.02cm
2, matched group 25 examples, male 21 examples, women 4 examples; 20～63 years old age, average 37.31 ± 8.92 years old, wound surface area 8.14 ± 1.21cm
2Differences such as two groups age, sex, wound surface area do not have significance (P＞0.05), and two to form facial position close or symmetrical, all the tool comparability.Patients such as diabetes, tuberculosis, malnutrition and endocrine regulation do not include observation in.
After 1.2 the conventional debridement of face is formed in the Therapeutic Method treatment, external application unguentum of the present invention, 6 layers of dressing cover, fix, and every day 1 time is till healing; Matched group external application MAYINGLONGZHICHUANGGAO, other handles with the treatment group identical, and stopping using during the treatment, all influence the medicine of this treatment.
1.3 observation item (1) wound surface is in postoperative healing rate in the time of the 3rd, 7,14 days, with (the existing wound surface area of 1-/former wound surface area) * 100% expression; (2) healing natural law.
1.4 the statistical method measurement data represents that with X ± s homogenizing relatively with the t check, uses the SPSS10.0 statistical package.
2 results
2.1 the 3rd day two groups of differences of postoperative do not have significance, the 7th, 14 days treatment group granulation tissuies of postoperative are significantly higher than matched group.
2.2 postoperative was formed the face healing rate in the 7th day two, the treatment group is (77.9 ± 6.6) %, and matched group is after 33.9 ± 7.4%, two groups of data are learned processing by statistics, and difference has significance (t=22.158, P＜0.01).The correlation test result shows that the face granulation tissue is formed in postoperative treatment in the 7th day and the wound healing rate is significance positive correlation (r=0.909, r 0.01 (23)=0.505, P＜0.01).
2.3 two form face healing natural law, treatment group healing time is 13.56 ± 3.77 days, and matched group is 18.52 ± 3.88 days, two groups of comparing differences have significance (t=4.584, P＜0.01), correlation coefficient r=-0.916, P＜0.01, it is short that the face healing time is formed in the prompting treatment.
Model case:
1, poplar * *, man, 27 years old, because of traffic accident causes the right lower extremity fracture of tibia, during the plaster fixation treatment that the inboard large stretch of soft tissue extruding of right thigh is downright bad, area 16cm * 14cm, dark be 0.5cm～1.5cm, does not feel any better with quiet antibiotic and the routine 3 wheat harvesting period wounds of changing dressings in hospital.Repair no scar contracture fully through 15 wound surface of changing dressings with unguentum of the present invention.
2, the king *, the man, 5 years old, because of by the two buttocks of dilute sulfuric acid burn, be diagnosed as deep ii degree burn, it is inferior every day 2 to adopt external used medicine to be coated with, to inject penicillin sodium outward, treats all wound surface and does not feel any better; Adopt unguentum external curing of the present invention, apply and cover aseptic dressing, change dressings every day once, its wound healing of changing dressings continuously 7 times altogether, new skin generates no cicatrix and obvious color change.
Medicine of the present invention has: 1, applied widely, and skin ulcer that can be used for that wound, war wound, burn and scald, mosquito are bitten, operation, diabetes and great saphenous varicose vein causes etc.2, easy to use, safe, cheap.3, curative effect is reliable.4, production technology is simple, is easy to deposit, carry.
The specific embodiment
Below narration realizes the specific embodiment of the present invention, certainly the not only following several examples of embodiment, numerous embodiments in addition:
The unguentum preparation of [embodiment 1] medicine of the present invention
1. take by weighing each crude drug by following weight: Herba Violae 600g, Radix Salviae Miltiorrhizae 600g, Radix Rehmanniae 450g, Radix Angelicae Sinensis 450g, Corium elephatis 600g, metronidazole 25g, standby.
2. manufacture method:
(1) fried material: get Oleum Sesami 5000g and put into pot and endure heat, Radix Salviae Miltiorrhizae, the Radix Rehmanniae, Radix Angelicae Sinensis, input is fried withered and yellow to medical material, treat that temperature drops to and add Herba Violae, Corium elephatis heating 3～10 minutes between 110～140 ℃ again.Should stir during heating,, with the medicinal residues drop to the greatest extent, stay oil standby when treating the Corium elephatis fusing in case that medical material is heated is inhomogeneous;
(2) molten cured: as to treat that oil temperature reduces to about 70～90 ℃, get Cera Flava 600g and put oily internal heating fusing, stir cooling;
When (3) treating that the ointment temperature is reduced to 40～60 ℃ metronidazole powder added in the wax liquid and stir evenly, be unguentum of the present invention after the packing that the cools sterilization.
[embodiment 2] take by weighing each crude drug by following weight: Herba Violae 600g, Radix Salviae Miltiorrhizae 600g, Radix Rehmanniae 400g, Radix Angelicae Sinensis 400g, Corium elephatis 600g, metronidazole 20g, and standby.Preparation method is with embodiment 1.
[embodiment 3] take by weighing each crude drug by following weight: Herba Violae 800g, Radix Salviae Miltiorrhizae 800g, Radix Rehmanniae 400g, Radix Angelicae Sinensis 400g, Corium elephatis 800g, metronidazole 25g, and standby.Preparation method is with embodiment 1.
The unguentum preparation of [embodiment 4] medicine of the present invention
1. take by weighing each crude drug by following weight: Herba Violae 600g, Radix Salviae Miltiorrhizae 600g, Radix Rehmanniae 450g, Radix Angelicae Sinensis 450g, Corium elephatis 600g, metronidazole 25g, Flos Lonicerae 600g, Herba Taraxaci 600g, Radix Arnebiae (Radix Lithospermi) 450g, standby.
2. manufacture method:
(1) fried material: get Oleum Sesami 5000g and put into pot and endure heat, Radix Salviae Miltiorrhizae, the Radix Rehmanniae, Radix Angelicae Sinensis, input is fried withered and yellow to medical material, treat that temperature drops to and added Herba Violae, Corium elephatis, Flos Lonicerae, Herba Taraxaci, Radix Arnebiae (Radix Lithospermi) heating between 110～140 ℃ again 3～10 minutes.Should stir during heating,, with the medicinal residues drop to the greatest extent, stay oil standby when treating the Corium elephatis fusing in case that medical material is heated is inhomogeneous;
(2) molten cured: as to treat that oil temperature reduces to about 70～90 ℃, get Cera Flava 600g and put oily internal heating fusing, stir cooling;
When (3) treating that the ointment temperature is reduced to 40～60 ℃ metronidazole powder added in the wax liquid and stir evenly, be unguentum of the present invention after the packing that cools, the sterilization.
[embodiment 5] take by weighing each crude drug by following weight: Herba Violae 800g, Radix Salviae Miltiorrhizae 800g, Radix Rehmanniae 400g, Radix Angelicae Sinensis 400g, Corium elephatis 800g, metronidazole 25g, Flos Lonicerae 400g, Herba Taraxaci 400g, Radix Arnebiae (Radix Lithospermi) 400g, and standby; Preparation method is with embodiment 4.
The powder preparation of [embodiment 6] medicine of the present invention
1. take by weighing each crude drug by following weight: Herba Violae 600g, Radix Salviae Miltiorrhizae 600g, Radix Rehmanniae 450g, Radix Angelicae Sinensis 450g, Corium elephatis 600g, metronidazole 25g, standby.
2. will go up medicine by national standard detect, screening cleans Herba Violae, Radix Salviae Miltiorrhizae, the Radix Rehmanniae, Radix Angelicae Sinensis, Corium elephatis, 80 ℃ of freeze-day with constant temperature behind the pulverize separately, with metronidazole powder uniform mixing in proportion again, get final product after packing, the sterilization.
The powder preparation of [embodiment 7] medicine of the present invention
1. take by weighing each crude drug by following weight: Herba Violae 600g, Radix Salviae Miltiorrhizae 600g, Radix Rehmanniae 300g, Radix Angelicae Sinensis 300g, Corium elephatis 600g, Flos Lonicerae 300g, Herba Taraxaci 300g, Radix Arnebiae (Radix Lithospermi) 600g, metronidazole 25g, standby.
2. will go up medicine detects, screens Herba Violae, Radix Salviae Miltiorrhizae, the Radix Rehmanniae, Radix Angelicae Sinensis, Corium elephatis, Flos Lonicerae, Herba Taraxaci, Radix Arnebiae (Radix Lithospermi) are cleaned by national standard, 80 ℃ of freeze-day with constant temperature, behind the pulverize separately,, get final product after packing, the sterilization with metronidazole powder uniform mixing in proportion again.
Claims (10)
1. treat the slow external preparation of wound healing for one kind, it is characterized in that: the main medicine of making by the raw material of following weight parts ratio,
3～9 parts of Herba Violaes, 3～9 parts of Radix Salviae Miltiorrhizaes, 2～6 parts in the Radix Rehmanniae, 2～6 parts of Radix Angelicae Sinensis, 3～9 parts of Corium elephatiss, 0.1～1 part of metronidazole.
2. a kind of slow external preparation of wound healing for the treatment of according to claim 1, it is characterized in that: wherein each crude drug consumption is,
5～7 parts of Herba Violaes, 5～7 parts of Radix Salviae Miltiorrhizaes, 4～5 parts in the Radix Rehmanniae, 4～5 parts of Radix Angelicae Sinensis, 5～8 parts of Corium elephatiss, 0.1～0.5 part of metronidazole.
3. a kind of slow external preparation of wound healing for the treatment of according to claim 1 and 2, it is characterized in that: wherein each crude drug consumption is, 6 parts of Herba Violaes, 6 parts of Radix Salviae Miltiorrhizaes, 4.5 parts in the Radix Rehmanniae, 4.5 parts of Radix Angelicae Sinensis, 6 parts of Corium elephatiss, 0.25 part of metronidazole.
4. according to claim 1 or 2 or 3 described a kind of slow external preparation of wound healing for the treatment of, it is characterized in that: this medicine is a kind of unguentum.
5. the described a kind of preparation method for the treatment of the slow external preparation of wound healing of claim 4 is characterized in that: mainly comprises the steps,
(1) fried material: get Oleum Sesami 25～75 weight portions and put into pot and endure heat, with fried withered and yellow in Radix Salviae Miltiorrhizae, the Radix Rehmanniae, Radix Angelicae Sinensis, the input oil to medical material, treating that temperature drops to adds Herba Violae, Corium elephatis heating 3～10 minutes again between 110～140 ℃, should in time stir during heating, in case that medical material is heated is inhomogeneous, with the medicinal residues drop to the greatest extent, stay oil standby when treating the Corium elephatis fusing;
(2) molten cured: as to treat that oil temperature reduces to 70～90 ℃, get Cera Flava 3～9 weight portions and put oily internal heating fusing, stir cooling;
When (3) treating that the ointment temperature is reduced to 50～60 ℃ metronidazole powder added in the ointment and stir evenly, the back packing sterilization that cools is unguentum of the present invention.
6. a kind of slow external preparation of wound healing for the treatment of according to claim 1 is characterized in that: wherein also have following raw medicaments in portion by weight,
3～9 parts of Flos Loniceraes, 3～9 parts of Herba Taraxacis, 2～6 parts of Radix Arnebiae (Radix Lithospermi)s.
7. a kind of slow external preparation of wound healing for the treatment of according to claim 6, it is characterized in that: this medicine is a kind of unguentum.
8. a kind of preparation method for the treatment of the slow external preparation of wound healing according to claim 7 is characterized in that: mainly comprises the steps,
(1) fried material: get Oleum Sesami 25～75 weight portions and put into pot and endure heat, with fried withered and yellow in Radix Salviae Miltiorrhizae, the Radix Rehmanniae, Radix Angelicae Sinensis, the input oil to medical material, treating that temperature drops to added Herba Violae, Corium elephatis, Flos Lonicerae, Herba Taraxaci, Radix Arnebiae (Radix Lithospermi) reheat 3～10 minutes between 110～140 ℃, should stir during heating, in case that medical material is heated is inhomogeneous, with the medicinal residues drop to the greatest extent, stay oil standby when treating the Corium elephatis fusing;
(2) molten cured: as to treat that oil temperature reduces to 70～90 ℃, get Cera Flava 3～9 weight portions and put oily internal heating fusing, stir cooling;
When (3) treating that the ointment temperature is reduced to 50～60 ℃ metronidazole powder added in the ointment and stir evenly, be unguentum of the present invention after the back packing sterilization that cools.
9. according to claim 1 or 2 or 3 or 6 described a kind of slow external preparation of wound healing for the treatment of, it is characterized in that: this medicine is a kind of powder.
10. a kind of preparation method for the treatment of the slow external preparation of wound healing according to claim 9 is characterized in that: mainly comprises the steps,
(1) it is standby to take by weighing each crude drug by described weight;
(2) Chinese medicine that takes by weighing is detected, screening, cleans by national standard, 80 ℃ of freeze-day with constant temperature behind the pulverize separately, with metronidazole powder uniform mixing in proportion again, get final product after packing, the sterilization.
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| CNB2005101311920A CN100471514C (en) | 2005-12-30 | 2005-12-30 | External use preparation for treating vulnus slow agglutination and its preparation method |
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| CNB2005101311920A CN100471514C (en) | 2005-12-30 | 2005-12-30 | External use preparation for treating vulnus slow agglutination and its preparation method |
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| CN101658610B (en) * | 2009-09-21 | 2010-09-08 | 石景洋 | Chinese materia medica preparation for treating bedsore and preparation method thereof |
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| CN109453314A (en) * | 2018-12-24 | 2019-03-12 | 南京中医药大学 | A kind of Chinese medicine composition fumigated for gynaecology's postoperative rehabilitation |
| CN109453314B (en) * | 2018-12-24 | 2021-07-02 | 南京中医药大学 | Traditional Chinese medicine composition for treating poor perineal wound healing |
| CN112386534A (en) * | 2019-08-14 | 2021-02-23 | 百岳特生物科技（上海）有限公司 | Viola yedoensis makino extract, extraction method and application thereof |
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