CN1623400A - Skin disinfectant and its preparation method - Google Patents
Skin disinfectant and its preparation method Download PDFInfo
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- CN1623400A CN1623400A CN 200310117029 CN200310117029A CN1623400A CN 1623400 A CN1623400 A CN 1623400A CN 200310117029 CN200310117029 CN 200310117029 CN 200310117029 A CN200310117029 A CN 200310117029A CN 1623400 A CN1623400 A CN 1623400A
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- coptis
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Abstract
A skin disinfectant is prepared from iodine, non-ionic surfactant, and 6 Chinese-medicinal materials including prickly ash peel, baked alum, rhubard, coptis root, etc through immersing said 6 Chinese-medicinal materials in alcohol, chelating iodine by non-ionic surfactant to become oily chelate, and mixing it with said immersed liquid. Its advantages are high bactericiding activity and effect, high stability, and less irritation to skin.
Description
Technical field
The present invention relates to the disinfectant field, especially medical disinfectant.
Technical background
In medical procedure, especially when surgical intervention, must be to the affected part sterilization that carries out disinfection, disinfectant commonly used at present is to contain Operand, and as Iodophor, the specified standard content of iodine is 5000 mg/litre, promptly 0.5%, can be used for the sterilization that carries out disinfection of affected parts such as the skin of human body and mucous membrane.But iodide ion is extremely active, and oxidability is strong, and other material is met in very fast distillation behind the chance light, also very easily generates precipitation, thereby has reduced effective content, reduces the virus killing effect.Iodide ion has very strong excitant in addition, and wound and tenderer skin can not must take off iodine after promptly using, otherwise can cause cusalgia and skin ambustion directly with the iodine sterilization.
Summary of the invention
The purpose of this invention is to provide and a kind ofly can improve the disinfectant quality, Disinfection Effect is reliable, and little to human body harm, and is safe in utilization and skin antiseptic of treatment wound effect and preparation method thereof arranged.
The present invention adopts emulsification strong, and permeability high nonionic surfactant becomes the oily complex compound with the iodine envelope, adds that medicine with heat-clearing, detoxifcation, hemostasis, convergence effect is refining to form again.Technical scheme is:
The medicinal material prescription of making skin antiseptic is as follows: iodine 0.3～1.0 gram, pericarpium zanthoxyli 2～15 grams, alumen 0.5～5 gram, the root bark of shaggy-fruited dittany 1～10 gram.Emulsifier 2～50 grams, phosphatase 11～10 grams, 50～100 milliliters in water.
In above-mentioned medicinal material prescription, can also add the coptis 2～10 grams, rheum officinale 2～10 grams.
Preparation method of the present invention is as follows:
(1) with pericarpium zanthoxyli, alumen, the coptis, rheum officinale, root bark of shaggy-fruited dittany abrasive dust, be crushed to 30～70% ethanol of 6～7 times of 20～40 orders addings, said medicine is soaked, soaked diafiltration in percolation filter then 24～72 hours, filtrate is concentrated, being concentrated into solid-to-liquid ratio is 1: 1, adds P101 resin 50～200 grams then, absorption fine particle and other impurity, isolate soup, standby.
(2) with iodine and emulsifier, become paste through the emulsification complexing, standby.
(3) above-mentioned parting liquid and paste are mixed, stir, add entry again and be diluted to 100 milliliters, stir again.Survey the content of iodine, less than 0.5% o'clock, directly add iodine, be adjusted to iodine 〉=0.5%, survey PH again, when PH＞1.3～3.0, regulate so far in the scope, then filling and sealing with phosphoric acid as content of iodine.
When the present invention contacted skin, the oily complex compound discharged the high activity iodide ion under suitable concentration, produced quick killing action behind the contact microorganism.Because the affinity interaction of emulsifier, strengthened the active of iodide ion again and to the suction-operated of microorganism, given play to and continued the long-acting bactericidal sterilizing effect.Because emulsified dose of envelope of iodide ion is closed state, guaranteed the stability of iodine in addition,, still had sterilization even store more than 2 years.Medicine is penetrated in the focus at short notice, kills infection pathogen immediately, removes rotten flesh, repairs focus, generates new organization.Wherein contained effective components of Chinese medicinal can quick-acting haemostatic powder, pain relieving, convergence, clearing damp, reduction ooze out, and reduces cicatrization, shortens treatment time in the treatment focus of infection, to normal skin and organize without any side effects.After the sterilization, dry and comfortable naturally, do not need the water flushing, can skin care.
Prove that through a large amount of clinical practices medicine of the present invention is applied to skin can produce bactericidal effect after 18 seconds, still keeps bactericidal action after 6 hours, the present invention is applicable to following situation:
Medical personnel decontamination; Operative site and wound disinfection; Burn, scald mouthful sterilization; Dept. of dermatology, department of obstetrics and gynecology, STD Dept. sterilization and treatment; The counting personnel of bank, the sterilization of traffic driver and conductor hand; Easy infection position disinfection in the daily life, preventing from scar does not stay pigmentation, and antipruritic analgesic hemostatic effect is obvious.
Medicine of the present invention has following characteristics:
(1) activity is high, bactericidal effect is strong; (2) stable performance is difficult for losing efficacy; (3) excitant to skin is little; (4) high infiltration is high softening, has the double action that sterilizing and treatment are infected; (5) scope of application is wide, no taboo crowd.
Embodiment
Below by preferred specific embodiment, the invention will be further described.
Prescription: iodine 0.5 gram, the coptis 5 grams, pericarpium zanthoxyli 5 grams, alumen 2.5 grams, kuh-seng 5 grams, rheum officinale 3 grams, the root bark of shaggy-fruited dittany 4 grams, alkyl alcohol ether 10 grams, phosphoric acid 5 grams, P101 epoxy resin 50 grams, 70% ethanol is an amount of.
Preparation technology is as follows:
(1) with pericarpium zanthoxyli, alumen, the coptis, rheum officinale, root bark of shaggy-fruited dittany abrasive dust, cross 40 mesh sieves, in above-mentioned mixing fine powders, add 70% ethanol of 6 times of volumes then, fine powder is flooded, soaked 48 hours, in percolation filter, carry out diafiltration, gained filtrate is concentrated again, and being concentrated into solid-to-liquid ratio is 1: 1, adds the P101 epoxy resin absorption dregs of a decoction, isolate soup, parting liquid stays standby.
(2) iodine is mixed with the emulsifier alkyl alcohol ether, become paste standby through the emulsification complexing.
(3) parting liquid and paste are mixed, stir, thin up to 100 milliliter stirs again again, surveys content of iodine, regulates content of iodine to 〉=0.5%, surveys pH value again, with phosphoric acid regulating ph value to 2.0, and filling and sealing then.
Claims (3)
1, a kind of skin antiseptic is characterized by by following medicinal materials and makes, iodine 0.3～1.0 gram, pericarpium zanthoxyli 2～15 grams, alumen 0.5～5 gram, the root bark of shaggy-fruited dittany 1～10 gram, emulsifier 2～50 grams, phosphatase 11～10 grams, 50～100 milliliters in water.
2, skin antiseptic according to claim 1 is characterized by and also contains the coptis 2～10 grams in prescription, rheum officinale 2～10 grams.
3, the preparation method of skin antiseptic is characterized by:
(1) with pericarpium zanthoxyli, alumen, the coptis, rheum officinale, root bark of shaggy-fruited dittany abrasive dust, being crushed to 20～40 orders sieves, add 30～70% ethanol of 6～7 times of volumes, soaked diafiltration in percolation filter then 24～72 hours, again filtrate is concentrated, being concentrated into solid-to-liquid ratio is 1: 1, adds P101 resin 50～200 grams again, absorption fine particle and other impurity, isolate soup, standby.
(2) with iodine and emulsifier, become paste through the emulsification complexing, standby.
(3) above-mentioned separation soup and paste are mixed, stir, again thin up to 100 milliliter, stir again, survey the content of iodine, with the method that directly adds iodine content of iodine is adjusted to 〉=0.5%, survey PH again, PH is adjusted to 1.3～3.0, then filling and sealing with phosphoric acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310117029 CN1245082C (en) | 2003-12-04 | 2003-12-04 | Skin disinfectant and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310117029 CN1245082C (en) | 2003-12-04 | 2003-12-04 | Skin disinfectant and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1623400A true CN1623400A (en) | 2005-06-08 |
| CN1245082C CN1245082C (en) | 2006-03-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310117029 Expired - Fee Related CN1245082C (en) | 2003-12-04 | 2003-12-04 | Skin disinfectant and its preparation method |
Country Status (1)
| Country | Link |
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| CN (1) | CN1245082C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102357147A (en) * | 2011-10-26 | 2012-02-22 | 山东轻工业学院 | Chinese medicine composite tincture capable of diminishing inflammation, relieving pain and preventing viruses and preparation method thereof |
| CN102988564A (en) * | 2012-11-22 | 2013-03-27 | 王雪娟 | Traditional Chinese medicine composition for treating solar dermatitis |
| WO2013040944A1 (en) * | 2011-09-20 | 2013-03-28 | 天津博克尼科技发展有限公司 | Polyoxyethylene sorbitan monolaurate iodine complex |
| CN103006446A (en) * | 2011-09-20 | 2013-04-03 | 天津博克尼科技发展有限公司 | Iodine-containing toilet water |
| CN103006451A (en) * | 2011-09-20 | 2013-04-03 | 天津博克尼科技发展有限公司 | Iodine-containing sterilization type denture cleaning agent |
-
2003
- 2003-12-04 CN CN 200310117029 patent/CN1245082C/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013040944A1 (en) * | 2011-09-20 | 2013-03-28 | 天津博克尼科技发展有限公司 | Polyoxyethylene sorbitan monolaurate iodine complex |
| CN103006446A (en) * | 2011-09-20 | 2013-04-03 | 天津博克尼科技发展有限公司 | Iodine-containing toilet water |
| CN103006451A (en) * | 2011-09-20 | 2013-04-03 | 天津博克尼科技发展有限公司 | Iodine-containing sterilization type denture cleaning agent |
| CN102357147A (en) * | 2011-10-26 | 2012-02-22 | 山东轻工业学院 | Chinese medicine composite tincture capable of diminishing inflammation, relieving pain and preventing viruses and preparation method thereof |
| CN102988564A (en) * | 2012-11-22 | 2013-03-27 | 王雪娟 | Traditional Chinese medicine composition for treating solar dermatitis |
| CN102988564B (en) * | 2012-11-22 | 2014-08-20 | 王雪娟 | Traditional Chinese medicine composition for treating solar dermatitis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1245082C (en) | 2006-03-15 |
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