CN105267951B - A kind of nanometer silver antimicrobial ionized water wound care composition - Google Patents
A kind of nanometer silver antimicrobial ionized water wound care composition Download PDFInfo
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- CN105267951B CN105267951B CN201510760574.3A CN201510760574A CN105267951B CN 105267951 B CN105267951 B CN 105267951B CN 201510760574 A CN201510760574 A CN 201510760574A CN 105267951 B CN105267951 B CN 105267951B
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- ionized water
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Abstract
Disclosed by the invention is a kind of nanometer silver antimicrobial ionized water wound care composition, and it is made up of the composition of following percentage by weight：Nanometer silver antimicrobial ionized water 5~30%, polypropylene ether trihydroxylic alcohol 2~4%, polyethylene glycol oxide 0.05~0.1%, antibacterial peptide 1~2.5%, antioxidant 0.02~0.05%, dispersant 0.03~0.1%, surplus is deionized water；Its preparation method is：Silver oxide and dust technology are mixed, 75~78 DEG C is heated to, obtains silver oxide solution, be passed through chlorine and be electrolysed, obtain the nanometer silver antimicrobial ionized water；The nanometer silver antimicrobial ionized water is mixed with remaining composition again, you can the nanometer silver antimicrobial ionized water wound care composition is made.Said composition can be effective against and kill various bacteriums, prevent wound infection, have no side effect, and prepare easy, and bioavilability is high, has certain practical value in terms of the later stage nursing of clinical wound.
Description
Technical field
The present invention relates to medical nursing medicament technical field, a kind of nanometer silver antimicrobial ionized water wound shield is specifically related to
Manage composition.
Background technology
Skin is the important armour of human body, and it can control body temperature, prevent attacking for various extraneous bacterial viruses
Hit, resist various infection.But, when human body is by wound, scratch, exanthemv and burn, skin can come to harm, skin
Damage easily cause bacterium infection, body fluid is lost in and causes various complication, then, this natural cover for defense does not just have original yet
Should play the role of.
Skin injury, it is more common in clinic, it is typically all after treatment or processing, using the medicine of various anti-inflammations
Thing come prevent infection, more using some antibiotic or antibiotic.Recently as the extensive use of antibiotic, antibody-resistant bacterium is gradually
Increase, not a kind of germ causes traumatic infection sometimes, therefore Trauma infection is difficult to filter out effective antibiotic, is led
The small ideal of curative effect is caused, the course of disease is long.If nursing is improper, it can infect and scar.
In addition, for deeper wound, most wounds can obtain certain healing after operation stitching.But also can
There are some ill symptomses, such as local red, swollen, hot, pain and body fluid ooze out, and what is had has obvious wound sense of discomfort, such as fiber crops
Wood, pain, part are hardened.Because wound is too deep, there is bacterium to invade inner cortex, connective tissue layer, muscle layer, cause interior
Portion's connective tissue recovers bad.And existing antiseptic can not play thoroughly antibacterial action because can not go deep into inside, therefore,
The antibacterial care agent for developing layer tissue in can effectively going deep into has great importance for the nursing of clinical wound.
The content of the invention
Present invention solves the technical problem that it is to provide a kind of nanometer silver antimicrobial ionized water wound care composition, can be deep enough
Skin inner layer, is effective against and kills various bacteriums, is highly suitable for the later stage nursing of skin injury.
The technical scheme is that：A kind of nanometer silver antimicrobial ionized water wound care composition, by following weight percent
The composition of ratio is made：Nanometer silver antimicrobial ionized water 5~30%, polypropylene ether trihydroxylic alcohol 2~4%, polyethylene glycol oxide 0.05~
0.1%th, antibacterial peptide 1~2.5%, antioxidant 0.02~0.05%, dispersant 0.03~0.1%, surplus is deionized water；Institute
The preparation method for stating nanometer silver antimicrobial ionized water is：It is 1 in mass ratio by silver oxide and dust technology:The ratio of (3.2~3.6) is mixed
Close, be heated to 75~78 DEG C, silver to be oxidized is dissolved completely in dust technology, obtain silver oxide solution；In the silver oxide solution
In be passed through chlorine relative to its gross weight 0.2~0.25%, be electrolysed into electrolytic cell, power-on voltage is in electrolytic process
3~5V of direct current, conduction time is 18~24min, and obtained electrolyte is the nanometer silver antimicrobial ionized water, prepared by this method
Nanometer silver antimicrobial ionized water there is excellent penetration and antibacterial activity, the sterilization and treatment of deep layer can be carried out.
Further, the antibacterial peptide is Human β defensin-3 (HBD-3), and Human β defensin-3 (HBD-3) has stronger
Antibacterial activity and wider array of antimicrobial spectrum are low to host cell toxic to salinity relative insensitivity.
Further, the antioxidant includes but is not limited to：Tocopherol, Co-Q10, lipoic acid, ascorbic acid palm fibre
One or more in glycerin monostearate, butylated hydroxy anisole (BHA), antioxidant can prevent and delay the oxidation of active ingredient
It is rotten, free radical can also be effectively antagonized and removed, skin is protected.
Further, the dispersant is made up according to a certain ratio of polyethylene glycol and polyacrylamide, according to this side
The dispersant that method is made, can not only disperse homogeneous by other active ingredients, and can promote drug permeability, strengthen medicine
Effect.
Further, the dispersant is by 1 by polyethylene glycol and polyacrylamide:The mass ratio proportioning of (8~10)
It is made.
Further, the mass concentration of the dust technology is 8~9%, and dust technology is in this concentration range, then coordinates institute
The temperature stated, silver oxide can be dissolved well, and be conducive to cell reaction.
The preparation method of the nanometer silver antimicrobial ionized water wound care composition is as follows：
(1) polyethylene glycol oxide and deionized water are pressed 1 in dispensing canister:The mass ratio mixing of (100~120), disperses equal
It is even；
(2) it is further continued in dispensing canister adding the bar that temperature in polypropylene ether trihydroxylic alcohol, holding dispensing canister is 42~45 DEG C
Under part, stir while adding, the speed of stirring is 60~80r/min, mixing time is 6~10min, make mixed liquor into homogeneous
Solution；
(3) greenhouse cooling, to 38~40 DEG C, adds nanometer silver antimicrobial ionized water, antioxidant, dispersant in dispensing canister,
And remaining deionized water, with homogenizer, with rotating speed 2000~2400r/min, 15~20min of homogeneous,.
As an improvement, in the nanometer silver antimicrobial ionized water wound care composition of above-mentioned preparation, it can also add
0.03~0.1% ultra-violet stabilizer, the ultra-violet stabilizer can be：Septichen phenyl ester, salicylic acid esters, 4-
The cinnamic acids such as the benzophenone such as hydroxyl -3- carboxyl benzophenones series, cinnamic acid monooctyl ester series, ultra-violet absorber can individually make
With that can also be used in combination, add after ultra-violet stabilizer, it is sudden and violent that the care agent being made is applicable to face, hand etc.
It is exposed to the position in the external world.
The beneficial effects of the invention are as follows：The nanometer silver antimicrobial ionized water wound care composition of the present invention, mainly by nanometer
Silver-colored antibacterial ion water is made, the deep enough skin inner layer of energy, and can go directly affected part depths, be effective against and kill various bacteriums, then match somebody with somebody
This antibacterial material with stronger antibacterial activity and wider antimicrobial spectrum of antibacterial peptide is closed, antibacterial, anti-inflammatory can be reached, effectively prevention
Wound infection, the effect of exanthemv；, will not to human body with good physiological compatibility and care agent of the present invention is nontoxic
Produce adverse reaction and pessimal stimulation；In addition, care agent of the present invention prepares easy, effective ingredient is easy to release, absorbs fast,
Bioavilability is high, and being respectively provided with nursing well for the wound such as burn, scald, postoperative wound inflammation, trauma ulcer, worm poison makees
With, and it is without any side effects, there is certain practical value in terms of the later stage nursing of clinical wound.
Embodiment
Embodiment 1：
A kind of nanometer silver antimicrobial ionized water wound care composition, is made up of the composition of following percentage by weight：Nano Silver
Antibacterial ion water 5%, polypropylene ether trihydroxylic alcohol 2%, polyethylene glycol oxide 0.05%, antibacterial peptide 1%, antioxidant 0.02%, point
Powder 0.03%, surplus is deionized water；The preparation method of the nanometer silver antimicrobial ionized water is：Silver oxide and dust technology are pressed
Mass ratio is 1:3.2 ratio mixing, the mass concentration of the dust technology is 8%, is heated to 75 DEG C, silver to be oxidized is completely dissolved
In dust technology, silver oxide solution is obtained；The chlorine relative to its gross weight 0.2% is passed through in the silver oxide solution, is entered
Enter electrolytic cell to be electrolysed, power-on voltage is direct current 3V in electrolytic process, and conduction time is 18min, and obtained electrolyte is
The nanometer silver antimicrobial ionized water, nanometer silver antimicrobial ionized water prepared by this method has excellent penetration and antibacterial activity,
The sterilization and treatment of deep layer can be carried out.
Wherein, the antibacterial peptide is Human β defensin-3 (HBD-3), and Human β defensin-3 (HBD-3) has stronger antibacterial
Active and wider array of antimicrobial spectrum is low to host cell toxic to salinity relative insensitivity.The antioxidant is tocopherol,
The oxidation deterioration of active ingredient can be prevented and delayed, free radical can also be effectively antagonized and remove, skin is protected.It is described scattered
Agent is by 1 by polyethylene glycol and polyacrylamide:8 mass ratio is made, the dispersant being made according to the method, can not only
Other active ingredients are disperseed homogeneous, and drug permeability can be promoted, strengthen drug effect.
The preparation method of the nanometer silver antimicrobial ionized water wound care composition is as follows：
(1) polyethylene glycol oxide and deionized water are pressed 1 in dispensing canister:100 mass ratio mixing, is uniformly dispersed；
(2) be further continued in dispensing canister add polypropylene ether trihydroxylic alcohol, keep dispensing canister in temperature be 42 DEG C under conditions of,
Stir while adding, the speed of stirring is 60r/min, and mixing time is 6min, makes mixed liquor into homogeneous solution；
(3) greenhouse cooling, to 38 DEG C, adds nanometer silver antimicrobial ionized water, antioxidant, dispersant in dispensing canister, and
Remaining deionized water, with homogenizer, with rotating speed 2000r/min homogeneous 15min,.
Embodiment 2：
A kind of nanometer silver antimicrobial ionized water wound care composition, is made up of the composition of following percentage by weight：Nano Silver
Antibacterial ion water 17.5%, polypropylene ether trihydroxylic alcohol 3%, polyethylene glycol oxide 0.075%, antibacterial peptide 1.75%, antioxidant
0.035%th, dispersant 0.065%, surplus is deionized water；The preparation method of the nanometer silver antimicrobial ionized water is：Will oxidation
Silver and dust technology are 1 in mass ratio:3.4 ratio mixing, the mass concentration of the dust technology is 8.5%, is heated to 76.5 DEG C,
Silver to be oxidized is dissolved completely in dust technology, obtains silver oxide solution；It is passed through in the silver oxide solution relative to its gross weight
The chlorine of amount 0.225%, is electrolysed into electrolytic cell, and power-on voltage is direct current 4V in electrolytic process, and conduction time is
21min, obtained electrolyte is the nanometer silver antimicrobial ionized water, and nanometer silver antimicrobial ionized water prepared by this method has excellent
Good penetration and antibacterial activity, can carry out the sterilization and treatment of deep layer.
Wherein, the antibacterial peptide is Human β defensin-3 (HBD-3), and Human β defensin-3 (HBD-3) has stronger antibacterial
Active and wider array of antimicrobial spectrum is low to host cell toxic to salinity relative insensitivity.The antioxidant is Co-Q10,
The oxidation deterioration of active ingredient can be prevented and delayed, free radical can also be effectively antagonized and remove, skin is protected.It is described scattered
Agent is by 1 by polyethylene glycol and polyacrylamide:9 mass ratio is made, the dispersant being made according to the method, can not only
Other active ingredients are disperseed homogeneous, and drug permeability can be promoted, strengthen drug effect.
The preparation method of the nanometer silver antimicrobial ionized water wound care composition is as follows：
(1) polyethylene glycol oxide and deionized water are pressed 1 in dispensing canister:110 mass ratio mixing, is uniformly dispersed；
(2) it is further continued in dispensing canister adding the condition that temperature in polypropylene ether trihydroxylic alcohol, holding dispensing canister is 43.5 DEG C
Under, stir while adding, the speed of stirring is 70r/min, and mixing time is 8min, makes mixed liquor into homogeneous solution；
(3) greenhouse cooling, to 39 DEG C, adds nanometer silver antimicrobial ionized water, antioxidant, dispersant in dispensing canister, and
Remaining deionized water, with homogenizer, with rotating speed 2200r/min homogeneous 17.5min,.
Embodiment 3：
A kind of nanometer silver antimicrobial ionized water wound care composition, is made up of the composition of following percentage by weight：Nano Silver
Antibacterial ion water 30%, polypropylene ether trihydroxylic alcohol 4%, polyethylene glycol oxide 0.1%, antibacterial peptide 2.5%, antioxidant 0.05%,
Dispersant 0.1%, surplus is deionized water；The preparation method of the nanometer silver antimicrobial ionized water is：By silver oxide and dust technology
It is 1 in mass ratio:3.6 ratio mixing, the mass concentration of the dust technology is 9%, is heated to 78 DEG C, silver to be oxidized is completely molten
Solution obtains silver oxide solution in dust technology；The chlorine relative to its gross weight 0.25% is passed through in the silver oxide solution,
It is electrolysed into electrolytic cell, power-on voltage is direct current 5V in electrolytic process, and conduction time is 24min, and obtained electrolyte is i.e.
For the nanometer silver antimicrobial ionized water, there is nanometer silver antimicrobial ionized water prepared by this method excellent penetration and antibacterial to live
Property, the sterilization and treatment of deep layer can be carried out.
Wherein, the antibacterial peptide is Human β defensin-3 (HBD-3), and Human β defensin-3 (HBD-3) has stronger antibacterial
Active and wider array of antimicrobial spectrum is low to host cell toxic to salinity relative insensitivity.The antioxidant is lipoic acid,
The oxidation deterioration of active ingredient can be prevented and delayed, free radical can also be effectively antagonized and remove, skin is protected.It is described scattered
Agent is by 1 by polyethylene glycol and polyacrylamide:The mass ratio of (8~10) is made, the dispersant being made according to the method, no
Only other active ingredients can be disperseed homogeneous, and drug permeability can be promoted, strengthen drug effect.
The preparation method of the nanometer silver antimicrobial ionized water wound care composition is as follows：
(1) polyethylene glycol oxide and deionized water are pressed 1 in dispensing canister:120 mass ratio mixing, is uniformly dispersed；
(2) be further continued in dispensing canister add polypropylene ether trihydroxylic alcohol, keep dispensing canister in temperature be 45 DEG C under conditions of,
Stir while adding, the speed of stirring is 80r/min, and mixing time is 10min, makes mixed liquor into homogeneous solution；
(3) greenhouse cooling, to 40 DEG C, adds nanometer silver antimicrobial ionized water, antioxidant, dispersant in dispensing canister, and
Remaining deionized water, with homogenizer, with rotating speed 2400r/min homogeneous 20min,.
Embodiment 4：
A kind of nanometer silver antimicrobial ionized water wound care composition, is made up of the composition of following percentage by weight：Nano Silver
Antibacterial ion water 5%, polypropylene ether trihydroxylic alcohol 2%, polyethylene glycol oxide 0.05%, antibacterial peptide 1%, antioxidant 0.02%, point
Powder 0.03%, ultra-violet stabilizer 0.03%, surplus is deionized water；The preparation method of the nanometer silver antimicrobial ionized water
For：It is 1 in mass ratio by silver oxide and dust technology:3.2 ratio mixing, the mass concentration of the dust technology is 8%, is heated to
75 DEG C, silver to be oxidized is dissolved completely in dust technology, obtains silver oxide solution；It is passed through in the silver oxide solution relative to it
The chlorine of gross weight 0.2%, is electrolysed into electrolytic cell, and power-on voltage is direct current 3V in electrolytic process, and conduction time is
18min, obtained electrolyte is the nanometer silver antimicrobial ionized water, and nanometer silver antimicrobial ionized water prepared by this method has excellent
Good penetration and antibacterial activity, can carry out the sterilization and treatment of deep layer.
Wherein, the antibacterial peptide is Human β defensin-3 (HBD-3), and Human β defensin-3 (HBD-3) has stronger antibacterial
Active and wider array of antimicrobial spectrum is low to host cell toxic to salinity relative insensitivity.The antioxidant is ascorbic acid
Palmitate, can prevent and delay the oxidation deterioration of active ingredient, can also effectively antagonize and remove free radical, protect skin
Skin.The dispersant is by 1 by polyethylene glycol and polyacrylamide:8 mass ratio is made, and what is be made according to the method is scattered
Agent, can not only disperse homogeneous by other active ingredients, and can promote drug permeability, strengthen drug effect.The ultraviolet
Stabilizer is septichen phenyl ester, is added after ultra-violet stabilizer, and it is sudden and violent that the care agent being made is applicable to face, hand etc.
It is exposed to the position in the external world.
The preparation method of the nanometer silver antimicrobial ionized water wound care composition is as follows：
(1) polyethylene glycol oxide and deionized water are pressed 1 in dispensing canister:100 mass ratio mixing, is uniformly dispersed；
(2) be further continued in dispensing canister add polypropylene ether trihydroxylic alcohol, keep dispensing canister in temperature be 42 DEG C under conditions of,
Stir while adding, the speed of stirring is 60r/min, and mixing time is 6min, makes mixed liquor into homogeneous solution；
(3) greenhouse cooling, to 38 DEG C, adds nanometer silver antimicrobial ionized water, antioxidant, dispersant, ultraviolet in dispensing canister
Line stabilization agent, and remaining deionized water, with homogenizer, with rotating speed 2000r/min homogeneous 15min,.
Embodiment 5：
A kind of nanometer silver antimicrobial ionized water wound care composition, is made up of the composition of following percentage by weight：Nano Silver
Antibacterial ion water 17.5%, polypropylene ether trihydroxylic alcohol 3%, polyethylene glycol oxide 0.075%, antibacterial peptide 1.75%, antioxidant
0.035%th, dispersant 0.065%, ultra-violet stabilizer 0.065%, surplus is deionized water；The nanometer silver antimicrobial ionized water
Preparation method be：It is 1 in mass ratio by silver oxide and dust technology:3.4 ratio is mixed, and the mass concentration of the dust technology is
8.5%, 76.5 DEG C are heated to, silver to be oxidized is dissolved completely in dust technology, obtain silver oxide solution；In the silver oxide solution
In be passed through chlorine relative to its gross weight 0.225%, be electrolysed into electrolytic cell, power-on voltage is direct current in electrolytic process
4V, conduction time is 21min, and obtained electrolyte is the nanometer silver antimicrobial ionized water, and Nano Silver prepared by this method resists
Bacterium ionized water has excellent penetration and antibacterial activity, can carry out the sterilization and treatment of deep layer.
Wherein, the antibacterial peptide is Human β defensin-3 (HBD-3), and Human β defensin-3 (HBD-3) has stronger antibacterial
Active and wider array of antimicrobial spectrum is low to host cell toxic to salinity relative insensitivity.The antioxidant is butylhydroxy
Anisole (BHA), can prevent and delay the oxidation deterioration of active ingredient, can also effectively antagonize and remove free radical, protection
Skin.The dispersant is by 1 by polyethylene glycol and polyacrylamide:9 mass ratio is made, point being made according to the method
Powder, can not only disperse homogeneous by other active ingredients, and can promote drug permeability, strengthen drug effect.It is described ultraviolet
Line stabilization agent is salicylic acid esters, is added after ultra-violet stabilizer, the care agent being made is applicable to face, hand etc. and is exposed to
Extraneous position.
The preparation method of the nanometer silver antimicrobial ionized water wound care composition is as follows：
(1) polyethylene glycol oxide and deionized water are pressed 1 in dispensing canister:110 mass ratio mixing, is uniformly dispersed；
(2) it is further continued in dispensing canister adding the condition that temperature in polypropylene ether trihydroxylic alcohol, holding dispensing canister is 43.5 DEG C
Under, stir while adding, the speed of stirring is 70r/min, and mixing time is 8min, makes mixed liquor into homogeneous solution；
(3) greenhouse cooling, to 39 DEG C, adds nanometer silver antimicrobial ionized water, antioxidant, dispersant, ultraviolet in dispensing canister
Line stabilization agent, and remaining deionized water, with homogenizer, with rotating speed 2200r/min homogeneous 17.5min,.
Embodiment 6：
A kind of nanometer silver antimicrobial ionized water wound care composition, is made up of the composition of following percentage by weight：Nano Silver
Antibacterial ion water 30%, polypropylene ether trihydroxylic alcohol 4%, polyethylene glycol oxide 0.1%, antibacterial peptide 2.5%, antioxidant 0.05%,
Dispersant 0.1%, ultra-violet stabilizer 0.1%, surplus is deionized water；The preparation method of the nanometer silver antimicrobial ionized water
For：It is 1 in mass ratio by silver oxide and dust technology:3.6 ratio mixing, the mass concentration of the dust technology is 9%, is heated to
78 DEG C, silver to be oxidized is dissolved completely in dust technology, obtains silver oxide solution；It is passed through in the silver oxide solution relative to it
The chlorine of gross weight 0.25%, is electrolysed into electrolytic cell, and power-on voltage is direct current 5V in electrolytic process, and conduction time is
24min, obtained electrolyte is the nanometer silver antimicrobial ionized water, and nanometer silver antimicrobial ionized water prepared by this method has excellent
Good penetration and antibacterial activity, can carry out the sterilization and treatment of deep layer.
Wherein, the antibacterial peptide is Human β defensin-3 (HBD-3), and Human β defensin-3 (HBD-3) has stronger antibacterial
Active and wider array of antimicrobial spectrum is low to host cell toxic to salinity relative insensitivity.The antioxidant is ascorbic acid
Palmitate, can prevent and delay the oxidation deterioration of active ingredient, can also effectively antagonize and remove free radical, protect skin
Skin.The dispersant is by 1 by polyethylene glycol and polyacrylamide:The mass ratio of (8~10) is made, and is made according to the method
Dispersant, other active ingredients can not only be disperseed homogeneous, and can promote drug permeability, strengthen drug effect.It is described
Ultra-violet stabilizer is septichen phenyl ester and cinnamic acid monooctyl ester by 1:1 mass ratio is combined, and adds ultraviolet steady
Determine after agent, the care agent being made is applicable to face, hand etc. exposed to extraneous position.
The preparation method of the nanometer silver antimicrobial ionized water wound care composition is as follows：
(1) polyethylene glycol oxide and deionized water are pressed 1 in dispensing canister:120 mass ratio mixing, is uniformly dispersed；
(2) be further continued in dispensing canister add polypropylene ether trihydroxylic alcohol, keep dispensing canister in temperature be 45 DEG C under conditions of,
Stir while adding, the speed of stirring is 80r/min, and mixing time is 10min, makes mixed liquor into homogeneous solution；
(3) greenhouse cooling, to 40 DEG C, adds nanometer silver antimicrobial ionized water, antioxidant, dispersant, ultraviolet in dispensing canister
Line stabilization agent, and remaining deionized water, with homogenizer, with rotating speed 2400r/min homogeneous 20min,.
Antibacterial experiment：
1. experimental subjects：The healthy mice for taking 80 body weight to be more or less the same, is divided into 4 groups, i.e. experimental group 1, experimental group
2nd, control group 1 and control group 2, every group each 20.
2. test method：One piece of 2cm*2cm region is shaved out in every mouse buttocks same position, is cut out with blade
Wound deep 1.5cm, the nanometer silver antimicrobial ionized water wound care composition that experimental group 1 is prepared using the embodiment of the present invention 2 enters
Row processing, control group 1 is carried out after surgical wound suture, made using the embodiment of the present invention 2 without any processing, experimental group 2
Standby nanometer silver antimicrobial ionized water wound care composition is handled, and control group 2 is carried out after surgical wound suture, without
Other are handled, other aspect all sames such as diet of 4 groups of mouse, and wound healing or infection conditions are observed after 10 days.
3. the wound healing of mouse buttocks and infection conditions standard：
Healing completely：Wound healing, without other infection symptoms, such as rotten to the corn, red and swollen, ulcer；Not completely healed：Wound does not have
There is complete healing, but taken a turn for the better, while occurring in that some infection symptoms；Have no healing：Wound has no healing, but occurs
It is not too serious infection symptoms；Deteriorate：Wound does not have any healing, and severe infections symptom occurs.
4. experimental data is counted：
| Group | Heal completely/only | Not completely healed/only | Have no healing/only | Deteriorate/only |
| Experimental group 1 | 10 | 7 | 2 | 1 |
| Control group 1 | 1 | 2 | 9 | 8 |
| Experimental group 2 | 19 | 1 | 0 | 0 |
| Control group 2 | 3 | 12 | 4 | 1 |
5. conclusion：As can be seen from the above experimental data, injury is carried out after suture operation outside mouse, then with the use of this
The nanometer silver antimicrobial ionized water wound care composition of invention, the wound of mouse substantially completely heals, and without any sense of appearance
Symptom is contaminated, and only carries out the control group 2 of the unused nanometer silver antimicrobial ionized water wound care composition of the invention of suture operation
Mouse wound healing situation it is then substantially poor, and most of all occur in that different degrees of infection；In addition, for mouse wound
In the case of without operation stitching, the simple nanometer silver antimicrobial ionized water wound care composition using the present invention is hindered
The mouse of mouthfeel dye is few more many than without the mouse for carrying out any processing.Also nanometer silver antimicrobial ionized water wound of the present invention is just illustrated
Care composition antibacterial effect is good, can prevent wound infection, effectively facilitate wound healing.
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
The present invention is described in detail with reference to the foregoing embodiments, it will be understood by those within the art that：It still may be used
To be modified to the technical scheme described in previous embodiment, or equivalent substitution is carried out to which part technical characteristic；And
These modifications are replaced, and the essence of appropriate technical solution is departed from the spirit and model of technical scheme of the embodiment of the present invention
Enclose.
Claims (1)
1. a kind of nanometer silver antimicrobial ionized water wound care composition, it is characterised in that by the composition system of following percentage by weight
Into：Nanometer silver antimicrobial ionized water 5~30%, polypropylene ether trihydroxylic alcohol 2~4%, polyethylene glycol oxide 0.05~0.1%, antibacterial peptide 1
~2.5%, antioxidant 0.02~0.05%, dispersant 0.03~0.1%, surplus is deionized water；The nanometer silver antimicrobial
The preparation method of ionized water is：It is 1 in mass ratio by silver oxide and dust technology:The ratio mixing of (3.2~3.6), is heated to 75
~78 DEG C, silver to be oxidized is dissolved completely in dust technology, obtains silver oxide solution；Be passed through in the silver oxide solution relative to
The chlorine of its gross weight 0.2~0.25%, is electrolysed into electrolytic cell, obtained electrolyte be the nanometer silver antimicrobial from
Sub- water；
The antibacterial peptide is Human β defensin-3；
The antioxidant is in tocopherol, Co-Q10, lipoic acid, ascorbyl palmitate, butylated hydroxy anisole
It is one or more；
The dispersant is by 1 by polyethylene glycol and polyacrylamide:The mass ratio proportioning of (8~10) is made；
The mass concentration of the dust technology is 8~9%；
A kind of described nanometer silver antimicrobial ionized water wound care composition, preparation method is as follows：
(1) polyethylene glycol oxide and deionized water are pressed 1:The mass ratio mixing of (100~120), is uniformly dispersed；
(2) polypropylene ether trihydroxylic alcohol is added, keeping temperature is under conditions of 42~45 DEG C, to stir while adding, the speed of stirring
Degree is 60~80r/min, and mixing time is 6~10min, makes mixed liquor into homogeneous solution；
(3) 38~40 DEG C are cooled to, nanometer silver antimicrobial ionized water, antibacterial peptide, antioxidant, dispersant is added, and it is remaining
Deionized water, with homogenizer, with rotating speed 2000~2400r/min, 15~20min of homogeneous,.
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