CN1557463A - Ganoderma lucidum and gynostemma pentaphylla oral liquid - Google Patents
Ganoderma lucidum and gynostemma pentaphylla oral liquid Download PDFInfo
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- CN1557463A CN1557463A CNA200410021814XA CN200410021814A CN1557463A CN 1557463 A CN1557463 A CN 1557463A CN A200410021814X A CNA200410021814X A CN A200410021814XA CN 200410021814 A CN200410021814 A CN 200410021814A CN 1557463 A CN1557463 A CN 1557463A
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Abstract
The glossy ganoderma-gynostemma pentaphylla oral liquid is prepared with glossy ganoderma, gynostemma pentaphylla, licorice and menthol. Compared with available technology, the present invention has the advantages of simple technological process, easy-to-control product quality, etc. The oral liquid has the functions of benefiting vital energy, invigorating spleen and tranquilizing, and is used in treating diseases with palpitation, short breath, insomnia and other syndromes caused by deficiency in heart energy. The medicine may be also prepared into other forms, including capsule, granule, etc.
Description
Technical field: the present invention is a kind of " glossy ganoderma-gynostemma pentaphyllum " oral liquid and preparation method thereof, belongs to the field of traditional Chinese medicine technology.
Technical background: the applicant applied for once before carrying out the restructuring of enterprise that a name was called " production method of " glossy ganoderma-gynostemma pentaphyllum " oral liquid " application number and is: 931034337 patent of invention; Because the restriction of at that time production technology, thus find that this technology is in fact very backward, product quality have no idea to be effectively controlled and quality itself just poor, do not satisfy the demand of modernized pharmaceutical production; In addition such medical materials such as Ganoderma, Herb Gynostemmae Pentaphylli only just are made into the demand that oral liquid obviously can not satisfy market; Along with the progress of society, the progressively raising of people's living standard, all there is more requirement in market to kind, the dosage form of these class health product.
Summary of the invention: the objective of the invention is to: a kind of " glossy ganoderma-gynostemma pentaphyllum " oral liquid and preparation method thereof is provided; This method technology that we provide is fairly simple, and quality is easy to control especially, and the product quality that obtains has effective assurance, and effect is more definite simultaneously; The present invention also is made into this prescription other dosage form in addition, can fully satisfy demand often like this, for market increases new kind.The present invention constitutes like this: " glossy ganoderma-gynostemma pentaphyllum " oral liquid: calculate according to composition by weight, it is prepared from by Ganoderma 200-400, Herb Gynostemmae Pentaphylli 50-150, Radix Glycyrrhizae 10-30, Mentholum 0.1-0.5.Say accurately: it is made by Ganoderma 300g, Herb Gynostemmae Pentaphylli 100g, Radix Glycyrrhizae 20g, Mentholum 0.3g.This preparation is all oral formulations that medically allow, and comprising: capsule, soft capsule, granule.The preparation method of " glossy ganoderma-gynostemma pentaphyllum " oral liquid is calculated according to composition by weight, with Ganoderma 200-400, Herb Gynostemmae Pentaphylli 50-150, Radix Glycyrrhizae 10-30, Mentholum 0.1-0.5, except that Mentholum, all the other Ganodermas etc. three flavor decocts with water that secondary is above, collecting decoction, filter, filtrate concentrates, and cooling adds ethanol, makes to contain the alcohol amount and reach 50%, fully stir, leave standstill, the leaching supernatant, it is an amount of that residue adds ethanol, stir evenly, leave standstill, filter merging filtrate, reclaim ethanol to 40% of supernatant total amount, add water, regulate stirring evenly with sodium hydroxide solution
Leave standstill, filter, filtrate adds Mentholum, sucrose, makes.Specifically: described oral liquid prepares like this: with Ganoderma 300g, Herb Gynostemmae Pentaphylli 100g, Radix Glycyrrhizae 20g, Mentholum 0.3g, more than four the flavor, except that Mentholum, three flavors such as all the other Ganodermas decoct with water three times, add 12 times of amounts of water for the first time, decocted second 2 hours, respectively add 7 times of amounts of water for three times, 6 times of amounts decocted 1.5 hours, collecting decoction filters, and it is 1.20～1.25 (70～80 ℃ clear paste) that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 50%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 50% ethanol, stir evenly, left standstill 12 hours, filter, merging filtrate reclaims ethanol to 40% of supernatant total amount, and it is an amount of to add water, regulate pH value to 6.5 with 40% sodium hydroxide solution, stir evenly, left standstill 12 hours, filter, filtrate adds Mentholum, sucrose 150g and steviosin 1g, stirring makes dissolving, add water and make 1000ml, stir evenly, left standstill 12 hours, filter, fill, sterilization, promptly.Other preparation is produced like this: with Ganoderma 300g, Herb Gynostemmae Pentaphylli 100g, Radix Glycyrrhizae 20g, Mentholum 0.3g, more than four the flavor, except that Mentholum, three flavors such as all the other Ganodermas decoct with water three times, add 12 times of amounts of water for the first time, decocted second 2 hours, respectively add 7 times of amounts of water for three times, 6 times of amounts decocted 1.5 hours, collecting decoction, filter, it is 1.20～1.25 (70～80 ℃ clear paste) that filtrate is concentrated into relative density, slowly adds ethanol when being chilled to 40 ℃, make and contain alcohol amount and reach 50%, fully stir, left standstill the leaching supernatant 12 hours, it is an amount of that residue adds 50% ethanol, stir evenly, left standstill 12 hours, filter, merging filtrate, reclaim ethanol to 40% of supernatant total amount, it is an amount of to add water, regulates pH value to 6.5 with 40% sodium hydroxide solution, stir evenly, left standstill 12 hours, and filtered, filtrate adds Mentholum, can be prepared into granule behind the convection drying then, perhaps incapsulate, in the soft capsule.
We are made up of the four Chinese medicine thing, and Ganoderma property is put down in the side, sweet in the mouth, go into the heart, Liver Channel, are invigorating QI and tranquilization, and the effect of relieving cough and asthma is used for dizzy sleeplessness, shortness of breath and palpitation, and the asthenia cough with asthma is monarch drug.Herb Gynostemmae Pentaphylli is cold in nature, and bitter in the mouth, little sweet is gone into the heart, liver,spleen,kidney warp, supplementing QI and nourishing YIN, and slow down aging is ministerial drug.Radix Glycyrrhizae, property is flat, and sweet in the mouth is gone into the heart, spleen, stomach warp, invigorating the spleen and replenishing QI, coordinating the actions of various ingredients in a prescription is adjuvant.Mentholum is a remedium corrigens.Above-mentioned all medicines share, and play QI invigorating altogether, spleen invigorating, the merit of calming the nerves.
Compared with prior art: technology of the present invention is simpler than original method, and the quality of production is easy to control, the reliable product quality that obtains, and the kind of increase fully satisfies people's demand.The product function that obtains cures mainly: QI invigorating, and spleen invigorating is calmed the nerves, and is used for syndrome of deficiency of heart qi, can improve cardiopalmus, breathes hard symptoms such as insomnia; It is prepared into different dosage forms, can be convenient for people to use, it is fast especially to be prepared into the liquid dosage form absorption,
Capsule, soft capsule dosage form carry and are more convenient, the taking convenience of granular preparation.
Concrete embodiment:
Embodiments of the invention 1: oral liquid prepares like this: with Ganoderma 300g, Herb Gynostemmae Pentaphylli 100g, Radix Glycyrrhizae 20g, Mentholum 0.3g, more than four the flavor, except that Mentholum, three flavors such as all the other Ganodermas decoct with water three times, add 12 times of amounts of water for the first time, decocted second 2 hours, respectively add 7 times of amounts of water for three times, 6 times of amounts decocted 1.5 hours, collecting decoction filters, and it is 1.20～1.25 (70～80 ℃ clear paste) that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 50%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 50% ethanol, stir evenly, left standstill 12 hours, filter, merging filtrate reclaims ethanol to 40% of supernatant total amount, and it is an amount of to add water, regulate pH value to 6.5 with 40% sodium hydroxide solution, stir evenly, left standstill 12 hours, filter, filtrate adds Mentholum, sucrose 150g and steviosin 1g, stirring makes dissolving, add water and make 1000ml, stir evenly, left standstill 12 hours, filter, fill, sterilization, promptly.Usage and dosage: oral, a 10ml, 3 times on the one.
Embodiments of the invention 2: with Ganoderma 200g, Herb Gynostemmae Pentaphylli 50g, Radix Glycyrrhizae 10g, Mentholum 0.1g, more than four the flavor, except that Mentholum, three flavors such as all the other Ganodermas decoct with water three times, add 12 times of amounts of water for the first time, decocted second 2 hours, respectively add 7 times of amounts of water for three times, 6 times of amounts decocted 1.5 hours, collecting decoction filters, and it is 1.20～1.25 (70～80 ℃ clear paste) that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 50%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 50% ethanol, stir evenly, left standstill 12 hours, and filtered merging filtrate, reclaim ethanol to 40% of supernatant total amount, it is an amount of to add water, regulates pH value to 6.5 with 40% sodium hydroxide solution, stirs evenly, left standstill 12 hours, filter, filtrate adds Mentholum, is prepared into soft capsule preparation then.
Embodiments of the invention 3: with Ganoderma 400g, Herb Gynostemmae Pentaphylli 150g, Radix Glycyrrhizae 30g, Mentholum 0.5g, more than four the flavor, except that Mentholum, three flavors such as all the other Ganodermas decoct with water three times, add 12 times of amounts of water for the first time, decocted second 2 hours, respectively add 7 times of amounts of water for three times, 6 times of amounts decocted 1.5 hours, collecting decoction filters, and it is 1.20～1.25 (70～80 ℃ clear paste) that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 50%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 50% ethanol, stir evenly, left standstill 12 hours, and filtered merging filtrate, reclaim ethanol to 40% of supernatant total amount, it is an amount of to add water, regulates pH value to 6.5 with 40% sodium hydroxide solution, stirs evenly, left standstill 12 hours, filter, filtrate adds Mentholum, is prepared into granule after the drying then.
Embodiments of the invention 4: with Ganoderma 250g, Herb Gynostemmae Pentaphylli 100g, Radix Glycyrrhizae 15g, Mentholum 0.2g, more than four the flavor, except that Mentholum, three flavors such as all the other Ganodermas decoct with water secondary, add 8 times of amounts of water for the first time, decocted 3 hours, and added 6 times of amounts of water for the second time, decocted 2 hours, collecting decoction filters, and it is 1.20～1.25 (70～80 ℃ clear paste) that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 50%, fully stir
Left standstill 12 hours, it is an amount of that leaching supernatant, residue add 50% ethanol, stir evenly, left standstill 12 hours, filter, merging filtrate reclaims ethanol to 40% of supernatant total amount, and it is an amount of to add water, regulate pH value to 6.5 with 40% sodium hydroxide solution, stir evenly, left standstill 12 hours, filter, filtrate adds Mentholum, incapsulates then.
Embodiments of the invention 5: with Ganoderma 300g, Herb Gynostemmae Pentaphylli 100g, Radix Glycyrrhizae 20g, Mentholum 0.3g, more than four the flavor, except that Mentholum, three flavors such as all the other Ganodermas decoct with water three times, add 6 times of amounts of water for the first time, decocted second 1 hour, respectively add 5 times of amounts of water for three times, 4 times of amounts decocted 1 hour, collecting decoction filters, and it is 1.20～1.25 (70～80 ℃ clear paste) that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 50%, fully stir, left standstill 12 hours, it is an amount of that leaching supernatant, residue add 50% ethanol, stir evenly, left standstill 12 hours, and filtered merging filtrate, reclaim ethanol to 40% of supernatant total amount, it is an amount of to add water, regulates pH value to 6.5 with sodium hydroxide solution, stirs evenly, left standstill 12 hours, filter, filtrate adds Mentholum, is prepared into soft capsule then.
Clinical verification is summed up: the Guizhou Province People ' s Hospital department of Chinese medicine, the attached institute of the Guiyang Medical College department of Chinese medicine show by the result who " glossy ganoderma-gynostemma pentaphyllum " oral liquid is treated 100 routine syndrome of deficiency of QI patients:
(1) " glossy ganoderma-gynostemma pentaphyllum " oral liquid treatment syndrome of deficiency of QI, disease are seen; Physical fatigue and lassitude of spirit, deficiency of QI with disinclination to talk, cardiopalmus is uncomfortable in chest, insomnia forgetfulness, the food poor appetite moves back or abdominal distention after meal, and chronic cough expectorant is white, big loose stool row, spontaneous perspiration, symptoms such as soreness of the waist and knees, test case 80 examples, total effective rate is 97.5%.Ginseng stilbene syrup matched group 20 examples, total effective rate 95%.Two groups of total effective rates compare there was no significant difference (p＞0.05).Illustrate that " glossy ganoderma-gynostemma pentaphyllum " oral liquid is similar to ginseng stilbene syrup effective percentage.Ginseng stilbene syrup is the essential drugs of the treatment syndrome of deficiency of QI of country's identification.Thereby just affirmed that also " glossy ganoderma-gynostemma pentaphyllum " oral liquid treatment syndrome of deficiency of QI is the medicine that truly has curative effect.
(2) according to the comparisons of treatment group and matched group two groups of ages, sex ratio severe extents and before two groups of treatments, no significant difference, this just proves absolutely that two kinds of medicines treat the syndrome of deficiency of QI persons, has comparability between group.
(3) data shows, treatment group and matched group there is no any untoward reaction and toxic and side effects in treatment.This also proves absolutely the safety of " glossy ganoderma-gynostemma pentaphyllum " oral liquid in clinical practice.
In sum, " glossy ganoderma-gynostemma pentaphyllum " oral liquid really has the QI invigorating tonify deficiency, the calm the nerves effect of spleen invigorating, be applicable to because of the function decline, diseases such as physical fatigue and lassitude of spirit, deficiency of QI with disinclination to talk, the cardiopalmus due to depletion of QI loses is uncomfortable in chest, insomnia forgetfulness, chronic cough expectorant are white, spontaneous perspiration, loss of appetite or abdominal distention after meal have definite curative effect.
Claims (6)
1, a kind of " glossy ganoderma-gynostemma pentaphyllum " oral liquid is characterized in that: calculate according to composition by weight, it is prepared from by Ganoderma 200-400, Herb Gynostemmae Pentaphylli 50-150, Radix Glycyrrhizae 10-30, Mentholum 0.1-0.5.
2, according to the described this " glossy ganoderma-gynostemma pentaphyllum " oral liquid of claim 1, it is characterized in that: it is made by Ganoderma 300g, Herb Gynostemmae Pentaphylli 100g, Radix Glycyrrhizae 20g, Mentholum 0.3g.
3, according to claim 1 or 2 described this " glossy ganoderma-gynostemma pentaphyllum " oral liquids, it is characterized in that: this " glossy ganoderma-gynostemma pentaphyllum " oral liquid can also be: capsule, soft capsule, granule.
4, a kind of preparation method of " glossy ganoderma-gynostemma pentaphyllum " oral liquid is characterized in that: calculate according to composition by weight, with Ganoderma 200-400, Herb Gynostemmae Pentaphylli 50-150, Radix Glycyrrhizae 10-30, Mentholum 0.1-0.5, except that Mentholum, three flavors such as all the other Ganodermas decoct with water more than the secondary, collecting decoction, filter, filtrate concentrates, and cooling adds ethanol, make to contain alcohol amount and reach 50%, fully stir, leave standstill, the leaching supernatant, it is an amount of that residue adds ethanol, stirs evenly, and leaves standstill, filter, merging filtrate reclaims ethanol to 40% of supernatant total amount, adds water, stir evenly with the sodium hydroxide solution adjusting, leave standstill, filter, filtrate adds Mentholum, sucrose is made.
5, preparation method according to the described this " glossy ganoderma-gynostemma pentaphyllum " oral liquid of claim 4, it is characterized in that: described oral liquid prepares like this: with Ganoderma 300g, Herb Gynostemmae Pentaphylli 100g, Radix Glycyrrhizae 20g, Mentholum 0.3g, more than four flavors, except that Mentholum, all the other Ganodermas etc. three flavor, decoct with water three times, for the first time add 12 times of amounts of water, decocted second 2 hours, respectively add 7 times of amounts of water for three times, 6 times of amounts, decocted 1.5 hours, collecting decoction filters, and it is 1.20～1.25 clear paste for survey in the time of 70～80 ℃ that filtrate is concentrated into relative density, slowly add ethanol when being chilled to 40 ℃, make to contain alcohol amount and reach 50%, fully stir, left standstill 12 hours, the leaching supernatant, it is an amount of that residue adds 50% ethanol, stirs evenly, and left standstill 12 hours, filter, merging filtrate reclaims ethanol to 40% of supernatant total amount, and it is an amount of to add water, regulate pH value to 6.5 with 40% sodium hydroxide solution, stir evenly, left standstill 12 hours, filter, filtrate adds Mentholum, sucrose 150g and steviosin 1g stir and make dissolving, add water and make 1000ml, stir evenly, left standstill 12 hours, and filtered fill, sterilization, promptly.
6, preparation method according to claim 4 or 5 described this " glossy ganoderma-gynostemma pentaphyllum " oral liquids is characterized in that: other preparation is produced like this: with Ganoderma, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae, Mentholum four flavors are except that Mentholum, three flavors such as all the other Ganodermas decoct with water three times, add 12 times of amounts of water for the first time, decocted second 2 hours, respectively add 7 times of amounts of water for three times, 6 times of amounts decocted 1.5 hours, collecting decoction, filter, it is 1.20～1.25 (70～80 ℃ clear paste) that filtrate is concentrated into relative density, slowly adds ethanol when being chilled to 40 ℃, make and contain alcohol amount and reach 50%, fully stir, left standstill the leaching supernatant 12 hours, it is an amount of that residue adds 50% ethanol, stir evenly, left standstill 12 hours, filter, merging filtrate, reclaim ethanol to 40% of supernatant total amount, it is an amount of to add water, regulates pH value to 6.5 with 40% sodium hydroxide solution, stir evenly, left standstill 12 hours, and filtered, filtrate adds Mentholum, can directly be prepared into granule then, perhaps incapsulate, in the soft capsule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225416A (en) * | 2014-06-29 | 2014-12-24 | 潍坊诺达药业有限公司 | Chinese veterinary drug for accelerating after-disease feed intake recovery of poultry and preparation method of Chinese veterinary drug |
| CN108452122A (en) * | 2018-07-08 | 2018-08-28 | 高戈 | A kind of compound Chinese medicinal preparation and preparation method thereof of tranquilizing the mind, brain tonic of having one's ideas straightened out |
-
2004
- 2004-02-11 CN CNA200410021814XA patent/CN1557463A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104225416A (en) * | 2014-06-29 | 2014-12-24 | 潍坊诺达药业有限公司 | Chinese veterinary drug for accelerating after-disease feed intake recovery of poultry and preparation method of Chinese veterinary drug |
| CN104225416B (en) * | 2014-06-29 | 2017-05-03 | 潍坊诺达药业有限公司 | Chinese veterinary drug for accelerating after-disease feed intake recovery of poultry and preparation method of Chinese veterinary drug |
| CN108452122A (en) * | 2018-07-08 | 2018-08-28 | 高戈 | A kind of compound Chinese medicinal preparation and preparation method thereof of tranquilizing the mind, brain tonic of having one's ideas straightened out |
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