CN112043757B - Health-preserving coffee and traditional Chinese medicine composition - Google Patents
Health-preserving coffee and traditional Chinese medicine composition Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F5/00—Coffee; Coffee substitutes; Preparations thereof
- A23F5/10—Treating roasted coffee; Preparations produced thereby
- A23F5/14—Treating roasted coffee; Preparations produced thereby using additives, e.g. milk, sugar; Coating, e.g. for preserving
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Abstract
The invention relates to health-preserving coffee and a traditional Chinese medicine composition for people with qi-yin deficiency type metabolic syndrome. The health-preserving coffee or the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-7 parts of radix pseudostellariae, 2-4 parts of kudzu root, 0.5-2 parts of mint and 8-10 parts of coffee. Animal experiments show that for a rat model of metabolic syndrome induced by high fat and high salt, the Chinese medicinal health-care coffee can obviously reduce the blood fat and blood sugar levels by matching with conventional blood sugar reducing medicaments, and particularly has obvious advantage on the aspect of regulating blood fat. Clinical experiments show that the traditional Chinese medicine composition can improve the traditional Chinese medicine symptoms of qi-yin deficiency type metabolic syndrome and reduce the levels of triglyceride and cholesterol. The invention is helpful to avoid aggravation of qi and yin deficiency symptoms caused by night-out drinking of coffee, has precise and appropriate medication, has obvious effects of relieving symptoms such as hypodynamia, thirst, irritability and the like and reducing blood fat level, and has the advantages of few raw material compositions and convenient preparation.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine health care, in particular to health-preserving coffee and a traditional Chinese medicine composition.
Background
Metabolic Syndrome (MS) is a pathological state in which various metabolic components including proteins, fats, carbohydrates, etc. are abnormally aggregated, and is a complex group of metabolic disorder syndromes. MS is an important risk factor for diabetes, cardiovascular and cerebrovascular diseases, the specific pathogenesis of MS is not fully understood, and central obesity and insulin resistance are considered to be the main pathogenic factors. Traditional Chinese medicine does not specially discuss MS per se, but according to the characteristics of symptoms related to MS, the traditional Chinese medicine belongs to the disease categories of 'fever', 'splenic fever', 'obesity', 'thirst' and the like. Because the traditional Chinese medicine has the characteristics of multiple targets, small adverse reaction and integral regulation, the traditional Chinese medicine has obvious advantages in treatment for MS with complex components and various manifestations. At present, the etiology and pathogenesis of MS are still explored in traditional Chinese medicine, and a unified judgment standard is lacked. Regarding the syndrome differentiation and typing of MS, the syndrome of accumulation of phlegm-heat, deficiency of both qi and yin, and syndrome of intermingled phlegm and blood stasis are considered as the main types. The syndrome of deficiency of both qi and yin is mainly manifested as shortness of breath, spontaneous sweating, lassitude, dry mouth, watery stool, dry stool, pale red tongue with little coating, deep, thready or rapid pulse, etc.
At present, the incidence rate and the harm of MS are on the rise, and the MS is recognized as a public health problem worldwide. MS is closely related to bad living habits such as greasy diet, sedentary, little exercise, staying up all night and the like, and in MS people, the number of people who have the habit of staying up all night and drinking coffee is large. The coffee has the functions of refreshing and restoring consciousness, but the coffee contains caffeine, so that the nerve excitability is increased, insomnia is easily caused, and then the coffee can consume qi and injure yin after staying up all night, so that the common coffee can aggravate the symptoms of qi and yin deficiency of MS crowds who often stay up all night, such as weakness, thirst, hectic fever, night sweat, irritability and the like. The application aims to provide a traditional Chinese medicine composition and health-preserving coffee which can improve the qi-yin deficiency type MS symptoms and avoid aggravation of symptoms caused by formation of vicious circle.
There are many reports on the prior art of the traditional Chinese medicine formula for treating MS, such as:
the literature (a cymbidium faberi mirror, a clinical curative effect observation [ D ] of 'channel dredging and viscera regulating' for treating metabolic syndrome (qi-yin deficiency syndrome) reports that a clinical random contrast study of comprehensively treating the qi-yin deficiency syndrome by combining low-frequency pulse stimulation acupuncture points with traditional Chinese medicines (channel dredging and viscera regulating) is developed by taking the theory of 'channel dredging and channel regulating' as a core, and the clinical curative effect and the safety are observed by comparing the clinical random contrast study with a western medicine of metformin. The method comprises the following steps: by adopting a random contrast research method, after an elution period of one month, 60 patients meeting the diagnosis standard of the qi-yin deficiency syndrome of the metabolic syndrome are divided into 30 patients in a channel-dredging and viscera-regulating treatment group and 30 western medicine contrast groups. The modified radix codonopsis, astragalus membranaceus and rehmanniae radix decoction (the modified radix codonopsis, astragalus membranaceus and rehmanniae radix decoction comprises 15g of radix codonopsis, 30g of radix astragali, 30g of prepared rehmannia root, 20g of dogwood, 20g of Chinese yam, 15g of poria cocos, 15g of rhizoma alismatis, 15g of cortex moutan, 15g of ligusticum wallichii, 15g of salvia miltiorrhiza and 15g of coptis chinensis) is administered to the channel-dredging and viscera-regulating treatment group for oral administration and low-frequency pulse stimulation acupoint combination treatment, metformin is administered to the western medicine control group for oral administration, and clinical observation lasts for 12 weeks. Before and after treatment, the two groups respectively evaluate the weight, BMI, waistline, fasting blood sugar, 2h blood sugar after meal, glycosylated hemoglobin, triglyceride, fasting insulin, total integration of traditional Chinese medicine symptoms, traditional Chinese medicine syndrome curative effect and the like, and safety indexes such as blood and urine routine, liver and kidney functions, electrocardiogram and the like. As a result: evaluation of traditional Chinese medicine symptoms: after the treatment of the channel-dredging and viscera-regulating treatment group, the traditional Chinese medicine symptoms are obviously improved, the total effective rate is 93.33 percent, and the total effective rate of a western medicine control group is 73.33 percent. After treatment, the main traditional Chinese medicine symptoms of the meridian-dredging and viscera-regulating treatment group are improved (P is less than 0.05), and the secondary traditional Chinese medicine symptoms are improved (P is less than 0.05); the main traditional Chinese medicine symptoms of the western medicine control group are all improved (thirst, desire for drink, mental fatigue and hypodynamia, frequent micturition P is less than 0.05), the secondary traditional Chinese medicine symptoms are partially improved (dizziness, dreaminess, feverish palms and soles, soreness and weakness of waist and knees P is less than 0.05), and constipation, spontaneous perspiration and night sweat are not obviously improved (P is more than 0.05); the curative effect of the group for treating the diseases for restoring menstrual flow and regulating viscera is better than that of the control group (P is less than 0.05) in the aspect of improving the symptoms of the traditional Chinese medicine. The improvement of the traditional Chinese medicine symptom total score of the meridian-dredging and viscera-regulating treatment group is significantly different from that of a western medicine control group (P is less than 0.05). Objective index evaluation: compared with the western medicine control group, the group treated by dredging channels and regulating viscera has differences in body weight, BMI, fasting blood glucose and HbA1C (P < 0.05). Compared with western medicine control groups, the group for treating the diseases of dredging channels and regulating viscera has significant difference (P <0.01) in terms of waistline, 2h blood sugar after meal, triglyceride and fasting insulin. And (4) conclusion: the curative effect of treating metabolic syndrome (qi-yin deficiency syndrome) by dredging channels and regulating viscera (oral administration of the modified Shenqi Dihuang decoction is combined with low-frequency pulse stimulation on acupuncture points) is obviously superior to that of simple metformin therapy, and the traditional Chinese medicine composition can obviously improve clinical symptoms of traditional Chinese medicine and improve multiple objective indexes.
Literature (yellow shufang, beam monument. traditional chinese medical treatment of metabolic syndrome [ J ]. chinese clinician journal, 2010,38(6):17-19.) discloses the use of eight-treasure decoction plus minus for the treatment of qi-yin deficiency type metabolic syndrome, prescription example: 20g of raw astragalus membranaceus, 10g of angelica sinensis, 15g of ligusticum wallichii, 15g of radix rehmanniae, 15g of radix pseudostellariae, 12g of radix ophiopogonis, 9g of schisandra chinensis, 15g of rhizoma polygonati, 15g of radix scrophulariae, 15g of salvia miltiorrhiza, 10g of peach kernels, 15g of radix puerariae and 15g of radix trichosanthis.
The literature (clinical research on metabolic syndrome treatment by using Zhoujiacheng, Jiangdan, Wanghuo Sanqi Dan granules [ J ]. Yunnan traditional Chinese medicine journal 2016 (12)) discloses the clinical efficacy of the Sanqi Dan granules (consisting of astragalus, mulberry, pseudo-ginseng and salvia miltiorrhiza) on the treatment of the metabolic syndrome of qi-yin deficiency and blood vessel stasis. The method comprises the following steps: the patients with the metabolic syndrome of 60 cases are randomly divided into 2 groups, 30 control groups adopt western medicine conventional drug treatment and basic treatment, 30 treatment groups are treated by adding nosocomial preparation Sanqidan particles on the basis of the control groups, and the treatment observation lasts for 8 weeks. The patients were observed for changes in clinical symptom scores, blood pressure, blood lipid, blood glucose, and insulin resistance index before and after treatment. As a result: the total effective rate of the treatment group is 93.3 percent, the total effective rate of the control group is 86.7 percent, and the comparison of the two groups has no statistical significance (P is more than 0.05); the two groups are compared in the aspects of controlling blood sugar and improving insulin resistance, and the curative effect of the treatment group is better than that of the control group (P is less than 0.05); the two groups are compared on the clinical symptom score, and the curative effect of the treatment group is better than that of the control group (P is less than 0.01). And (4) conclusion: the Sanqidan granules can effectively treat metabolic syndrome of deficiency of both qi and yin and blood stasis, and have obvious clinical curative effect.
Patent document CN108066650A discloses a traditional Chinese medicine compound composition with a function of treating metabolic syndrome, which is prepared from the following raw material medicines in parts by weight: 15-45 parts of radix pseudostellariae, 15-45 parts of radix ophiopogonis, 10-30 parts of salvia miltiorrhiza, 10-30 parts of sophora flower bud, 10-30 parts of chrysanthemum, 10-30 parts of honeysuckle, 10-30 parts of cogongrass rhizome and 10-30 parts of radish seed. For MS with syndrome of both qi and yin deficiency and heat stagnation (yin deficiency with blood stasis), the treatment method is to supplement qi and nourish yin, and remove blood stasis and relieve heat. In the formula, the radix pseudostellariae is sweet in taste, slightly bitter and neutral in nature, and has the effects of tonifying qi and spleen, promoting the production of body fluid and moistening the lung. Radix ophiopogonis is sweet and cold in flavor, and has the effects of nourishing yin, promoting the secretion of saliva or body fluid, moistening lung and clearing away heart-fire. The pseudostellaria root and the ophiopogon root are used as monarch drugs together, so that qi and yin are supplemented. Salvia miltiorrhiza, bitter in taste and slightly pungent in flavor, slightly cold in nature, activates blood and removes stasis, nourishes blood and tranquilizes mind, cools blood and reduces swelling. Flos Sophorae Immaturus is cold in nature, sweet and mild in taste, and has effects of clearing liver-fire, cooling blood and stopping bleeding. Chrysanthemum, sweet and bland in taste, cold in nature, clear heat, calm liver and improve eyesight. Honeysuckle flower, flos Lonicerae, sweet and cold in nature, has the effects of clearing away heat and toxic material, and dredging the channels and collaterals. Lalang grass rhizome, sweet and cold, cools blood to stop bleeding, clears heat and induces diuresis. The salvia miltiorrhiza, the sophora flower bud, the chrysanthemum, the honeysuckle and the lalang grass rhizome are combined as ministerial drugs for removing blood stasis and clearing heat. Radish seed, pungent, sweet and mild, has the functions of promoting digestion, relieving flatulence, descending qi, reducing phlegm, improving abdominal fullness symptoms of patients and promoting drug absorption, and is an adjuvant drug. The Chinese medicinal compound composition has good effects of lowering blood pressure, blood sugar and blood lipid.
However, the traditional Chinese medicines have the defects of more medicinal ingredients, or inconvenient batch production due to dialectical addition and subtraction, or the effect of single use needs to be improved. At present, no traditional Chinese medicine composition and health-preserving coffee are available, wherein the traditional Chinese medicine composition has few medicine flavors, does not need to add or subtract medicine flavors aiming at MS populations with deficiency of both qi and yin, and has a remarkable effect of improving the MS with deficiency of both qi and yin.
Disclosure of Invention
The invention aims to provide health-preserving coffee aiming at the defects in the prior art.
The invention further aims to provide the traditional Chinese medicine composition for treating the qi-yin deficiency type metabolic syndrome.
Another object of the present invention is to provide the use of the Chinese medicinal composition.
In order to achieve the first purpose, the invention adopts the technical scheme that:
the health-preserving coffee is prepared from the following raw materials in parts by weight: 5-7 parts of radix pseudostellariae, 2-4 parts of kudzu root, 0.5-2 parts of mint and 8-10 parts of coffee.
As a preferred example of the invention, the health-preserving coffee is prepared from the following raw materials in parts by weight: 6 parts of radix pseudostellariae, 3 parts of radix puerariae, 1 part of mint and 9 parts of coffee.
As another preferred example of the present invention, the preparation method of the health-preserving coffee comprises: pulverizing radix Pseudostellariae, radix Puerariae, herba Menthae, and coffee, mixing, sieving to obtain health coffee powder, and adding hot water for brewing.
More preferably, the screen is not less than 50 mesh.
As another preferred example of the present invention, the health coffee further comprises an additive for improving the appearance, taste, mouthfeel, physical state or storage time of the coffee.
In order to achieve the second object, the invention adopts the technical scheme that:
a traditional Chinese medicine composition for treating qi-yin deficiency type metabolic syndrome is composed of the following raw materials in parts by weight: 5-7 parts of radix pseudostellariae, 2-4 parts of kudzu root, 0.5-2 parts of mint and 8-10 parts of coffee.
As a preferred example of the invention, the traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 6 parts of radix pseudostellariae, 3 parts of radix puerariae, 1 part of mint and 9 parts of coffee.
As another preferred example of the present invention, the Chinese medicine composition further comprises a pharmaceutically acceptable carrier.
In order to achieve the third object, the invention adopts the technical scheme that:
the application of the traditional Chinese medicine composition in preparing the medicine for treating qi-yin deficiency type metabolic syndrome.
As a preferred example of the invention, the treatment of the qi-yin deficiency type metabolic syndrome refers to the improvement of the individual qi-yin deficiency traditional Chinese medicine symptoms and the reduction of the content of triglyceride, cholesterol and low-density lipoprotein.
The invention has the advantages that:
1. the invention provides a traditional Chinese medicine, which is prepared by mixing radix pseudostellariae, radix puerariae and mint with coffee, and using the coffee as a monarch drug to refresh the mind and induce diuresis; radix pseudostellariae is used as a minister, and is capable of supplementing qi and nourishing yin; the kudzu root is used as an adjuvant to strengthen the spleen and promote the production of body fluid; mint is used for soothing liver and relieving depression. The formula is compatible to play the roles of strengthening spleen and inducing resuscitation, and tonifying qi and yin. Animal experiments prove that for a rat model of metabolic syndrome induced by high fat and high salt, the traditional Chinese medicine disclosed by the invention can obviously reduce the blood fat and blood sugar level by matching with a hypoglycemic agent, and particularly has obvious advantages in the aspect of regulating blood fat. Clinical experiments prove that triglyceride and cholesterol of people who are only given to the intervention group (traditional Chinese medicine) of the traditional Chinese medicine are improved compared with those of a control group (common coffee group), the questionnaire score for evaluating traditional Chinese medicine symptoms is reduced, and the symptoms of deficiency of both qi and yin are obviously improved. Therefore, the traditional Chinese medicine can refresh and restore consciousness, can supplement qi and nourish yin for the MS population with qi and yin deficiency syndrome in the habit of staying up and drinking coffee, can greatly reduce symptoms such as hypodynamia, thirst, irritability and the like after staying up, is beneficial to improving the blood lipid level, and can comprehensively improve abnormal glycolipid metabolism by being matched with the conventional medicine.
2. The traditional Chinese medicine composition can be used for treating the MS population with the syndrome of deficiency of both qi and yin, improving the symptoms and reducing the blood fat level.
3. The composition has few raw material varieties and is convenient to prepare.
4. The composition of the invention can obtain good effect for the MS population with qi-yin deficiency syndrome without further adding or reducing the medicinal flavor, and is suitable for batch production into health care products or medicines.
Detailed Description
The following provides a detailed description of specific embodiments of the present invention.
EXAMPLE 1 composition (I) of the invention
The following raw materials in parts by weight: 7 parts of radix pseudostellariae, 2 parts of radix puerariae, 2 parts of mint and 8 parts of coffee are put into a grinder to be ground and ground, and the mixture is sieved by a 60-mesh sieve to obtain the radix pseudostellariae coffee.
Example 2 composition (II) of the invention
The following raw materials in parts by weight: 5 parts of radix pseudostellariae, 4 parts of radix puerariae, 0.5 part of mint and 10 parts of coffee are put into a grinder to be ground and ground, and the mixture is sieved by a 60-mesh sieve to obtain the radix pseudostellariae coffee.
Example 3 inventive composition (III)
The following raw materials in parts by weight: 5-7 parts of radix pseudostellariae, 2-4 parts of radix puerariae, 0.5-2 parts of mint and 8-10 parts of coffee are put into a grinder to be ground and ground, and the mixture is sieved by a 60-mesh sieve to obtain the health-care coffee.
Example 4 inventive composition (IV)
The following raw materials in parts by weight: 5 parts of radix pseudostellariae, 2 parts of radix puerariae, 2 parts of mint and 10 parts of coffee are put into a grinder to be ground and ground, and the mixture is sieved by a 50-mesh sieve to obtain the radix pseudostellariae coffee.
EXAMPLE 5 inventive composition (V)
The following raw materials in parts by weight: 7 parts of radix pseudostellariae, 4 parts of radix puerariae, 0.5 part of mint and 8 parts of coffee are put into a grinder to be ground and ground, and the mixture is sieved by a 80-mesh sieve to obtain the radix pseudostellariae coffee.
Example 6 inventive composition (VI)
The following raw materials in parts by weight: 7 parts of radix pseudostellariae, 2 parts of radix puerariae, 0.5 part of mint and 8 parts of coffee are put into a grinder to be ground and ground, and the mixture is sieved by a 50-mesh sieve to obtain the radix pseudostellariae coffee.
Example 7 composition (seven) of the invention
The following raw materials in parts by weight: 5 parts of radix pseudostellariae, 4 parts of radix puerariae, 2 parts of mint and 10 parts of coffee are put into a grinder to be ground and ground, and the mixture is sieved by a 60-mesh sieve to obtain the radix pseudostellariae coffee.
EXAMPLE 8 inventive composition (eight)
The following raw materials in parts by weight: 6 parts of radix pseudostellariae, 3 parts of radix puerariae, 1 part of mint and 9 parts of coffee are put into a grinder to be ground and ground, and the mixture is sieved by a 60-mesh sieve to obtain the radix pseudostellariae coffee.
Example 9 health coffee of the invention
Infusing the composition of any of examples 1-8 with hot water.
Example 10 health coffee of the invention
Soaking the composition of any one of embodiments 1-8 in hot water, filtering and removing the residue.
Example 11 Experimental study of the present invention on improving metabolism syndrome rat model glycolipid metabolism
1 materials and methods
1.1 animals
Wistar rats, male, lactating (3 weeks old), were purchased from shanghai slaike laboratory animals, ltd.
1.2 Molding
A rat model of the high-fat high-salt induced metabolic syndrome was established according to literature methods. Specifically, feeding is carried out by using a high-fat high-salt feed, and the feed formula is as follows: 10% lard, 10% egg yolk powder, 1.5% cholesterol, 0.2% sodium cholate, 78.3% base material, 4% NaCl. After 18 weeks, carotid blood was drawn and serum insulin content and blood glucose levels were measured along with plasma TC, TG, LDL levels. Compared with the normally bred rats (feed formula: 96% basic material, 4% NaCl), the difference of insulin, blood sugar, TC, TG and LDL reaches the level P <0.05, and the model building is considered to be successful.
1.3 grouping and administration
30 model mice are randomly divided into 3 groups, including a model group, a traditional Chinese medicine coffee group and a traditional Chinese medicine coffee control group, each group comprises 10 mice, and the difference of insulin, blood sugar, TC, TG and LDL among the groups has no statistical significance. Metformin (70 mg-kg) was administered to the coffee group of the present invention as a Chinese medicine-1·d-1) And the traditional Chinese medicine of the invention is used for intragastric administration, and comprises the following components: pulverizing, sieving with 60 mesh sieve to obtain radix Pseudostellariae powder 6g, radix Puerariae powder 3g, herba Menthae powder 1g, and Arabica coffee bean powder 9g, soaking in boiling water, stirring for 5 min, filtering to remove residue, and making into capsule with dosage of 4g crude drug/kg-1·d-11 time daily. Metformin (70 mg-kg) was administered to the traditional Chinese medicine coffee control group-1·d-1) And the eight-treasure soup in the literature is filled with coffee for intragastric administration, and consists of: pulverizing, sieving with 60 mesh sieve, radix astragali powder 2g, radix Angelicae sinensis powder 1g, rhizoma Ligustici Chuanxiong powder 1.5g, radix rehmanniae powder 1.5g, radix Pseudostellariae powder 1.5g, radix Ophiopogonis powder 1.2g, fructus Schisandrae chinensis powder 0.9g, rhizoma Polygonati powder 1.5g, radix scrophulariae powder 1.5g, Saviae Miltiorrhizae radix powder 1.5g, semen Persicae powder 1g, radix Puerariae powder 1.5g, Trichosanthis radix 1.5g, and Arabica coffee bean powder 16.3g, soaking in boiling water, stirring for 5 min, filtering to remove residue, with dosage of 4g crude drug/kg-1·d-11 time daily. The model group is used for infusing common coffee, and the preparation method comprises the following steps: soaking Arabica coffee bean powder in boiling water, stirring for 5 min, filtering to remove residue, and making into powder with dosage of 1.89g crude drug/kg-1·d-11 time daily. A total of 6 normal control groups were also included, and the stomach was perfused with physiological saline. Feeding the basic materials of all groups, and administrating the medicine between 10-11 am every day for 14 days.
1.4 index detection
After the administration is finished, fasting is carried out for 24h, and rat carotid blood is taken to detect blood lipid indexes TC, TG, LDL, serum insulin and blood glucose value.
1.5 statistical treatment
Statistical analysis SPSS 25.0 statistical software was used. Average + -SD for data measurement
And (4) showing. The measurement data conforming to normal distribution is tested by t, the classified ordered data in the counting data is tested by rank sum, and the classified unordered data is tested by chi2And (6) checking. P<0.05 is statistically significant.
2 results
As can be seen from Table 1, compared with the normal group, each index of the model group was significantly increased, and the difference was statistically significant, indicating that the molding was successful. Compared with the model group before and after coffee gavage, the TC and TG levels of the model group are slightly reduced, LDL, fasting insulin and fasting blood glucose are averagely increased, but the difference is not statistically significant. The indexes of the traditional Chinese medicine coffee group and the traditional Chinese medicine coffee control group before and after treatment are obviously reduced compared with those before intervention, and the difference has statistical significance. Compared with a model group, the indexes of the traditional Chinese medicine coffee group are lower, the difference is of statistical significance, the indexes of the traditional Chinese medicine coffee group are lower, and the difference is of statistical significance. Compared with the traditional Chinese medicine coffee control group, the blood fat indexes TC, TG and LDL of the traditional Chinese medicine coffee group are obviously lower than those of the traditional Chinese medicine coffee control group, the difference has statistical significance, and fasting insulin and fasting blood sugar values are slightly lower than those of the traditional Chinese medicine coffee control group, but the difference has no statistical significance.
TABLE 1 comparison of sugar and lipid metabolism related indexes before and after intervention
Note: in comparison with the normal group,*，P<0.01; compared with the pre-intervention treatment period,#，P<0.05，##，P<0.01; in comparison with the set of models,△，P<0.05，△△，P<0.01; compared with the control group of the traditional Chinese medicine coffee,▲，P<0.05，▲▲，P<0.01。
example 12 evaluation study of clinical efficacy of the present invention in improving symptoms of qi and yin deficiency
1 source of cases
All cases were from the group of metabolic syndrome from 3 months in 2019 to 12 months in 2019, checked-up by the subsidiary eosin hospital physical examination center of medical university in Shanghai and often left up to night. The traditional Chinese medicine intervention is carried out on the medicines, and 50 cases of the medicines are included in an intervention group and 50 cases of a control group.
2 diagnostic criteria
2.1 Western diagnostic standards
The standard established in the guidelines for prevention and treatment of type 2 diabetes mellitus (2017 edition) of Chinese medical society, published by diabetes mellitus subdivision 2017, is adopted. (1) Abdominal obesity (i.e. central obesity): the waist circumference of the male is more than or equal to 90cm, and the waist circumference of the female is more than or equal to 85 cm; (2) hyperglycemia: the fasting blood sugar is more than or equal to 6.1mmol/L or the blood sugar is more than or equal to 7.8mmol/L after 2h of sugar load and/or the patient is diagnosed with diabetes and treated; (3) hypertension: blood pressure of 130/85mmHg or more and/or those confirmed to be high blood pressure and treated; (4) the fasting TG is more than or equal to 1.70 mmol/L; (5) three or more HDL-C fasting levels of <1.04mmol/L can be diagnosed.
2.2 Chinese medicine diagnostic Standard
The diagnosis standards of chest stuffiness and palpitation due to deficiency of both qi and yin are drawn up according to the guidance principles of clinical research on new Chinese medicines in 2002 edition and the diagnosis and treatment effect standards of traditional Chinese medicine syndrome in 1994 edition of the people's republic of China.
Deficiency of both qi and yin: the main symptoms are: palpitation, shortness of breath, fatigue, sweating on exertion, spontaneous sweating or night sweat.
The secondary symptoms are as follows: dizziness, restlessness, dry mouth, dark red cheeks on the face.
Tongue pulse: a red tongue with little coating and a thready, rapid and weak pulse or intermittent pulse.
Wherein: satisfying one primary symptom and two secondary symptoms or satisfying both primary symptoms and secondary symptoms simultaneously.
2.3 inclusion criteria
(1) Age 20-75 years;
(2) the diagnostic standard of Western medicine diagnosis is met;
(3) the diagnosis standard of traditional Chinese medicine is met;
(4) willing to sign an informed consent.
2.4 exclusion criteria
(1) Pregnant or lactating women;
(2) there are serious complications such as serious complications of gravity, liver, kidney, etc., or other serious primary diseases, psychosis patient;
(3) metabolic syndrome due to other causes;
(4) is allergic to related medicines in the traditional Chinese medicines and is not suitable for patients who accept the treatment scheme.
2.5 reject and shed criteria
(1) Pregnancy;
(2) apparent study intervention non-compliance;
(3) if clinical side effects or other clinical conditions occur, continued participation in the study is no longer in line with the best interests of the subject;
(4) intervention study subjects met exclusion criteria (emerging or confirmed);
(5) the subjects were unable to receive study intervention for a period of time.
3 grouping and administration
The study mode of random control is adopted. All cases were randomized into two groups at a 1:1 ratio. Coffee is administered simultaneously to the two groups, health coffee containing Chinese medicinal materials (including radix Pseudostellariae 6g, radix Puerariae 3g, herba Menthae 1g, and Arabica coffee bean powder 9g) is administered to the intervention group, and common coffee (Arabica coffee bean powder 9g) is administered to the control group. The use method comprises the following steps: soaking in 250ml boiling water, filtering to remove residue, and taking as required. The taking frequency is as follows: the preparation is administered 3 times a day at most, and 1 time 3 days at least. Two groups of people were observed for 8 weeks. After weeks 4 and 8, fasting blood glucose, postprandial blood glucose of 2 hours, triglyceride, cholesterol, low density lipoprotein, high density lipoprotein were measured and were investigated by a questionnaire (see appendix) of traditional Chinese medicine.
4 results
4.1 comparison of Chinese medicine syndrome scores
As can be seen from Table 2, the total score of the Chinese medicine syndrome before the intervention of the two groups has no significant difference, and each single integral has no significant difference. Has comparability between groups.
TABLE 2 comparison of the Prior Art Chinese medicine syndrome scores
As can be seen from Table 3, the scores of the symptoms of weakness, dizziness and vexation after the intervention in the two groups were reduced compared with the scores of the control group, and the difference was statistically significant.
TABLE 3 comparison of the Chinese medicine symptom scores after prognosis
Note: compare! represents P <0.05 compared with control group.
As can be seen from table 4, the scores of the traditional Chinese medicine symptoms of the intervening population gradually decreased, which indicates that the qi-yin deficiency symptoms of the intervention group are obviously improved after the intervention group takes the traditional Chinese medicine, and the difference is statistically significant compared with the difference of the control group.
TABLE 4 two observation comparisons of Chinese medicine syndrome questionnaire indexes at different periods
Note: compare! represents P <0.05 compared with control group.
4.2 sugar metabolism-related index comparison
As can be seen from Table 5, there was no difference in blood glucose index between the intervention groups after the administration of the Chinese herbs and the control group.
TABLE 5 Observation and comparison of sugar metabolism related indexes before and after two groups of intervention
4.3 lipid metabolism-related index comparison
As can be seen from Table 6, after the Chinese herbal medicines are taken, the cholesterol and triglyceride of the intervention group are obviously reduced, and the difference has statistical significance, which shows that the Chinese herbal medicine health coffee has good performance in reducing cholesterol and triglyceride.
TABLE 6 comparison of lipid metabolism-related indicators before and after intervention
Note: compare! represents P <0.05 compared with control group.
Appendix:
chinese medicine symptom questionnaire
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.
Claims (10)
1. The health-preserving coffee is characterized by being prepared from the following raw materials in parts by weight: 5-7 parts of radix pseudostellariae, 2-4 parts of kudzu root, 0.5-2 parts of mint and 8-10 parts of coffee.
2. The health-preserving coffee as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 6 parts of radix pseudostellariae, 3 parts of radix puerariae, 1 part of mint and 9 parts of coffee.
3. Health coffee according to claim 1 or 2, characterized in that it is prepared by a method comprising: pulverizing radix Pseudostellariae, radix Puerariae, herba Menthae, and coffee, mixing, sieving to obtain health coffee powder, and adding hot water for brewing.
4. Health preserving coffee as claimed in claim 3, characterized in that the screen is not lower than 50 mesh.
5. Health coffee according to claim 1 or 2, further comprising an additive for improving the appearance, taste, mouthfeel, physical state or shelf life of the coffee.
6. The traditional Chinese medicine composition for treating qi-yin deficiency type metabolic syndrome is characterized by comprising the following raw materials in parts by weight: 5-7 parts of radix pseudostellariae, 2-4 parts of kudzu root, 0.5-2 parts of mint and 8-10 parts of coffee.
7. The traditional Chinese medicine composition according to claim 6, which is prepared from the following raw materials in parts by weight: 6 parts of radix pseudostellariae, 3 parts of radix puerariae, 1 part of mint and 9 parts of coffee.
8. The Chinese medicinal composition of claim 6, further comprising a pharmaceutically acceptable carrier.
9. Use of the Chinese medicinal composition of any one of claims 6-8 in the preparation of a medicament for treating qi-yin deficiency type metabolic syndrome.
10. The use of claim 9, wherein the treatment of qi-yin deficiency type metabolic syndrome is improvement of qi-yin deficiency syndrome in an individual and reduction of triglyceride, cholesterol, low density lipoprotein levels.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879696A (en) * | 2006-05-01 | 2006-12-20 | 吴开敏 | Preparation for promoting secretion of saliva, its preparation method and application |
| CN102224846A (en) * | 2011-06-02 | 2011-10-26 | 食品行业生产力促进中心 | Instant healthcare coffee and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879696A (en) * | 2006-05-01 | 2006-12-20 | 吴开敏 | Preparation for promoting secretion of saliva, its preparation method and application |
| CN102224846A (en) * | 2011-06-02 | 2011-10-26 | 食品行业生产力促进中心 | Instant healthcare coffee and preparation method thereof |
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| 咖啡对胰岛素抵抗大鼠胰岛素受体底物及其酪氨酸、丝氨酸磷酸化的影响;陈琳;《山东医药》;20141231;第54卷(第20期);第20-23和27页 * |
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