CN112546190B - Traditional Chinese medicine composition for treating myelodysplastic syndrome, preparation method and application thereof, and honeyed pills - Google Patents

Traditional Chinese medicine composition for treating myelodysplastic syndrome, preparation method and application thereof, and honeyed pills Download PDF

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CN112546190B
CN112546190B CN202011605671.2A CN202011605671A CN112546190B CN 112546190 B CN112546190 B CN 112546190B CN 202011605671 A CN202011605671 A CN 202011605671A CN 112546190 B CN112546190 B CN 112546190B
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decoction
radix
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chinese medicine
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仕丽
胡少丹
罗威
徐丽伟
许馨月
迟翔
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Changchun University of Chinese Medicine
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Abstract

The invention belongs to the technical field of extraction of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating myelodysplastic syndrome, a preparation method and application thereof, and honeyed pills. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 12-20 parts of radix rehmanniae recen, 12-15 parts of honey-fried licorice root, 12-15 parts of cassia twig, 20-24 parts of radix ophiopogonis, 5-8 parts of ginseng, 10-12 parts of donkey-hide gelatin, 10-12 parts of ginger, 30-60 parts of Chinese date, 10-15 parts of poria cocos, 30-50 parts of astragalus mongholicus, 6-10 parts of angelica sinensis, 10-15 parts of scutellaria baicalensis, 10-15 parts of gypsum and 10-15 parts of polygala tenuifolia. The invention combines the medicines according to the proportion, combines the medicines and exerts the effect of treating myelodysplastic syndrome together.

Description

Traditional Chinese medicine composition for treating myelodysplastic syndrome, preparation method and application thereof, and honeyed pills
Technical Field
The invention relates to the technical field of extraction of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating myelodysplastic syndrome, a preparation method and application thereof, and honeyed pills.
Background
Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal diseases of the myeloid lineage that originate from hematopoietic stem cells and is characterized by abnormal development of myeloid cells, manifested by ineffective hematopoiesis, refractory cytopenia, and high risk of transformation into acute myeloid leukemia. According to the pathogenesis characteristics and clinical manifestations, the traditional Chinese medicine is defined as marrow toxicity strain, wherein the marrow represents the disease position, the toxicity represents the disease property, and the strain represents the disease state. The pathogenesis of the marrow toxicity is the deficiency of vital qi, repeated affection of pathogenic toxin, internal retention of the pathogenic toxin, lying in bone marrow, blocking the biochemistry of qi and blood, blood stasis caused by the toxin, toxic stasis mutual resistance, inability to generate essence and blood, resulting in essence deficiency and blood deficiency, shortness of breath and weakness, and presenting the symptoms of deficient and impaired symptoms. The pathogenesis is characterized in that the disease belongs to the syndrome of excess pathogenic factors and deficiency-excess mixed disease, toxin and stasis are excess pathogenic factors, deficiency of qi and blood and yin and yang is deficiency vital qi, the relationship of mutual elimination and growth exists between the vital qi and the pathogenic factors, the deficiency of the vital qi is aggravated by the injury of the vital qi caused by excess pathogenic factors, and the excess pathogenic factors are more predominant by the failure of the vital qi to resist the pathogenic factors.
At present, modern medicine is mainly used for treating myelodysplastic syndrome, and although some traditional medical treatment formulas are available in recent years, the treatment effect is not ideal.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a traditional Chinese medicine composition for treating myelodysplastic syndrome, a preparation method and application thereof, and honeyed pills. The traditional Chinese medicine composition and the honeyed pills provided by the invention can effectively improve myelodysplastic syndrome and various clinical symptoms caused by myelodysplastic syndrome, and have remarkable effects.
In order to achieve the purpose, the invention provides the following technical scheme:
the invention provides a traditional Chinese medicine composition for treating myelodysplastic syndrome, which comprises the following raw materials in parts by weight: 12-20 parts of radix rehmanniae recen, 12-15 parts of honey-fried licorice root, 12-15 parts of cassia twig, 20-24 parts of radix ophiopogonis, 5-8 parts of ginseng, 10-12 parts of donkey-hide gelatin, 10-12 parts of ginger, 30-60 parts of Chinese date, 10-15 parts of poria cocos, 30-50 parts of astragalus mongholicus, 6-10 parts of angelica sinensis, 10-15 parts of scutellaria baicalensis, 10-15 parts of gypsum and 10-15 parts of polygala tenuifolia.
Preferably, the angelica is whole angelica, and the whole angelica comprises an angelica head, an angelica body and an angelica tail.
The invention also provides a preparation method of the traditional Chinese medicine composition in the scheme, which comprises the following steps:
decocting radix rehmanniae, radix Glycyrrhizae Preparata, ramulus Cinnamomi, radix Ophiopogonis, Ginseng radix, rhizoma Zingiberis recens, fructus Jujubae, Poria, radix astragali, radix Angelicae sinensis, Scutellariae radix, Gypsum Fibrosum and cortex et radix Polygalae with water to obtain decoction;
melting colla Corii Asini to obtain colla Corii Asini solution;
mixing the decoction and colla Corii Asini solution to obtain the Chinese medicinal composition.
Preferably, the preparation of the decoction comprises the following steps:
(1) soaking radix rehmanniae, radix Glycyrrhizae Preparata, ramulus Cinnamomi, radix Ophiopogonis, Ginseng radix, rhizoma Zingiberis recens, fructus Jujubae, Poria, radix astragali, radix Angelicae sinensis, Scutellariae radix, Gypsum Fibrosum and cortex et radix Polygalae in water;
(2) carrying out first decoction on the traditional Chinese medicine soaked in the step (1) to obtain a first decoction liquid and first decoction dregs;
(3) mixing the first decoction dregs obtained in the step (2) with water, and then carrying out second decoction to obtain a second decoction liquid and second decoction dregs;
(4) mixing the second decoction dregs obtained in the step (3) with water, and then carrying out third decoction to obtain a third decoction liquid;
(5) and mixing the first decoction, the second decoction and the third decoction to obtain a decoction.
Preferably, the soaking time in the step (1) is 15-25 min.
Preferably, the water dosage in the steps (1), (3) and (4) is respectively and independently 2-3 cm higher than the corresponding medicine surface.
Preferably, the first decoction, the second decoction and the third decoction are respectively and independently carried out by boiling the liquid medicine with strong fire and then decocting with slow fire.
Preferably, the time of slow fire decoction in the first decoction and the time of slow fire decoction in the second decoction are respectively and independently 20-40 min; and in the third decoction, the time of decoction with slow fire is 15-25 min.
The invention also provides application of the traditional Chinese medicine composition in the scheme in preparation of a medicine for treating myelodysplastic syndrome.
The invention also provides a honeyed pill for treating myelodysplastic syndrome, which comprises the raw materials of the traditional Chinese medicine composition and honey.
Has the advantages that:
the invention provides a traditional Chinese medicine composition for treating myelodysplastic syndrome, which comprises the following raw materials in parts by weight: 12-20 parts of radix rehmanniae recen, 12-15 parts of honey-fried licorice root, 12-15 parts of cassia twig, 20-24 parts of radix ophiopogonis, 5-8 parts of ginseng, 10-12 parts of donkey-hide gelatin, 10-12 parts of ginger, 30-60 parts of Chinese date, 10-15 parts of poria cocos, 30-50 parts of astragalus mongholicus, 6-10 parts of angelica sinensis, 10-15 parts of scutellaria baicalensis, 10-15 parts of gypsum and 10-15 parts of polygala tenuifolia. In the invention, the radix rehmanniae is used for nourishing yin and heart, the honey-fried licorice root is sweet and warm and can tonify qi, and the two medicines are used for treating acute and chronic diseases, and can tonify qi and nourish blood to recover pulse, and are used as monarch medicines together; colla Corii Asini, radix Ophiopogonis nourish heart yin, nourish heart blood, congestion, ginseng tonify qi of spleen and lung, ramulus Cinnamomi warms and dredge channels, radix Angelicae sinensis invigorates blood and harmonizes blood, radix astragali invigorates qi, Poria invigorates spleen and promotes diuresis, as ministerial drugs together; ginger is pungent and warm and has the effect of freeing, scutellaria root clears heat and dampness, gypsum is good at clearing heat, jujube tonifies heart and spleen, and polygala root calms heart, soothes nerves and benefits intelligence as adjuvant drugs. The invention combines the medicines according to the proportion, combines the medicines and exerts the effect of treating myelodysplastic syndrome together. The results of the examples show that: the traditional Chinese medicine composition prepared by the invention has a total effective rate of 54.3% on myelodysplastic syndrome, and can be effectively used for treating myelodysplastic syndrome. Meanwhile, the traditional Chinese medicine composition is adopted, so that the medicine is small in toxic and side effects and safer to use.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating myelodysplastic syndrome, which comprises the following raw materials in parts by weight: 12-20 parts of radix rehmanniae recen, 12-15 parts of honey-fried licorice root, 12-15 parts of cassia twig, 20-24 parts of radix ophiopogonis, 5-8 parts of ginseng, 10-12 parts of donkey-hide gelatin, 10-12 parts of ginger, 30-60 parts of Chinese date, 10-15 parts of poria cocos, 30-50 parts of astragalus mongholicus, 6-10 parts of angelica sinensis, 10-15 parts of scutellaria baicalensis, 10-15 parts of gypsum and 10-15 parts of polygala tenuifolia.
If not specifically stated, the sources of the components of the Chinese medicinal composition are not particularly required, and commercially available products well known to those skilled in the art can be adopted.
The traditional Chinese medicine composition comprises, by weight, 12-20 parts of radix rehmanniae recen, preferably 16-20 parts of radix rehmanniae recen, and more preferably 20 parts of radix rehmanniae recen. In the invention, the dried rehmannia root has the effects of nourishing yin and blood.
Based on the weight of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 12-15 parts of radix glycyrrhizae preparata, preferably 13-15 parts, and more preferably 15 parts. In the invention, the honey-fried licorice root has the effects of warming and tonifying qi, and relieving urgency and nourishing heart.
Based on the weight parts of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 12-15 parts of cassia twig, preferably 14-15 parts, and more preferably 15 parts. In the present invention, the cassia twig has the function of warming and dredging channels and collaterals.
Based on the weight parts of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 20-24 parts of radix ophiopogonis, preferably 20-22 parts, and more preferably 20 parts. In the present invention, the ophiopogon root has the function of nourishing heart yin.
Based on the weight parts of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 5-8 parts of ginseng, preferably 5-7 parts, and more preferably 6 parts. In the present invention, the ginseng has the effect of invigorating qi of the spleen and lung.
Based on the weight parts of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 10-12 parts of donkey-hide gelatin, preferably 10-11 parts, and more preferably 10 parts. In the invention, the donkey-hide gelatin has the effects of nourishing yin and nourishing blood.
Based on the weight parts of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 6-10 parts of ginger, preferably 9-11 parts, and more preferably 10 parts. In the invention, the ginger has the effect of dredging.
Based on the weight parts of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 30-60 parts of Chinese dates, preferably 30-40 parts, and more preferably 30 parts. In the invention, the Chinese dates have the effect of tonifying heart and spleen.
Based on the weight parts of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 10-15 parts of poria cocos, preferably 12-15 parts, and more preferably 15 parts. In the invention, the poria cocos has the effects of tonifying spleen and promoting diuresis.
Based on the weight parts of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 30-50 parts of astragalus, preferably 40-50 parts, and more preferably 50 parts. In the invention, the astragalus has the effects of tonifying qi and strengthening exterior.
Based on the weight parts of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 6-10 parts of angelica sinensis, preferably 8-10 parts, and more preferably 10 parts. In the present invention, the angelica is preferably whole angelica, which preferably includes angelica head, angelica body and angelica tail. The angelica sinensis disclosed by the invention has the effects of tonifying blood and regulating blood.
Based on the weight part of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 10-15 parts of scutellaria baicalensis, preferably 12-15 parts, and more preferably 15 parts. In the invention, the scutellaria has the efficacy of clearing heat and drying dampness.
Based on the weight part of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 10-15 parts of gypsum, preferably 12-15 parts, and more preferably 15 parts. In the invention, the gypsum has the effects of clearing heat and purging fire.
Based on the weight parts of the radix rehmanniae recen, the traditional Chinese medicine composition provided by the invention comprises 10-15 parts of polygala tenuifolia, preferably 12-15 parts, and more preferably 15 parts. In the invention, the polygala root has the effects of soothing nerves and promoting intelligence.
In the invention, the raw rehmannia root, the liquorice, the slow and urgent medicines and the other medicines are used together to play the roles of nourishing yin and heart, nourishing yin and blood, tonifying qi and benefiting qi, and nourishing heart, and the two medicines are used together as monarch medicines; colla Corii Asini, radix Ophiopogonis nourish heart yin, nourish heart blood, congestion, ginseng tonify qi of spleen and lung, ramulus Cinnamomi warms and dredge channels, radix Angelicae sinensis invigorates blood and harmonizes blood, radix astragali invigorates qi, Poria invigorates spleen and promotes diuresis, as ministerial drugs together; the ginger is pungent and warm and has the effect of freeing, the scutellaria baicalensis clears heat and dampness, the gypsum is good at clearing heat, the jujube tonifies heart and spleen, the polygala tenuifolia calms heart, soothes nerves and benefits intelligence to be used as an adjuvant drug, and the monarch, minister, assistant and common effects play a role in treating myelodysplastic syndrome.
The invention also provides a preparation method of the traditional Chinese medicine composition in the scheme, which comprises the following steps:
decocting radix rehmanniae, radix Glycyrrhizae Preparata, ramulus Cinnamomi, radix Ophiopogonis, Ginseng radix, rhizoma Zingiberis recens, fructus Jujubae, Poria, radix astragali, radix Angelicae sinensis, Scutellariae radix, Gypsum Fibrosum and cortex et radix Polygalae with water to obtain decoction;
melting colla Corii Asini to obtain colla Corii Asini solution;
mixing the decoction and colla Corii Asini solution to obtain the Chinese medicinal composition.
The invention is prepared by decocting radix rehmanniae, radix glycyrrhizae preparata, cassia twig, radix ophiopogonis, ginseng, ginger, Chinese date, tuckahoe, astragalus, angelica, scutellaria, gypsum and polygala tenuifolia with water to obtain a decoction. In the present invention, the preparation of the decoction preferably further comprises the steps of:
(1) soaking radix rehmanniae, radix Glycyrrhizae Preparata, ramulus Cinnamomi, radix Ophiopogonis, Ginseng radix, rhizoma Zingiberis recens, fructus Jujubae, Poria, radix astragali, radix Angelicae sinensis, Scutellariae radix, Gypsum Fibrosum and cortex et radix Polygalae in water;
(2) carrying out first decoction on the traditional Chinese medicine soaked in the step (1) to obtain a first decoction liquid and first decoction dregs;
(3) mixing the first decoction dregs obtained in the step (2) with water, and then carrying out second decoction to obtain a second decoction liquid and second decoction dregs;
(4) mixing the second decoction dregs obtained in the step (3) with water, and then carrying out third decoction to obtain a third decoction liquid;
(5) and mixing the first decoction, the second decoction and the third decoction to obtain decoction.
In the invention, the soaking preferably comprises the step of compacting the traditional Chinese medicine and then soaking, the dosage of water in the soaking is preferably 2-3 cm higher than the medicine surface, and the soaking time is preferably 15-25 min, and more preferably 20 min.
In the invention, the decoction method is preferably that the liquid medicine is boiled by strong fire and then decocted by slow fire; the first decoction preferably comprises the step of directly decocting the soaked traditional Chinese medicines and water, wherein the slow fire decoction time in the first decoction is preferably 20-40 min, and more preferably 30 min;
the dosage of the water in the second decoction is preferably 2-3 cm higher than the medicine surface of the first decoction dregs, and the time of the slow fire decoction in the second decoction is preferably 20-40 min, and more preferably 30 min;
the dosage of the water in the third decoction is preferably 2-3 cm higher than the medicine surface of the second medicine residue; the time of decocting with slow fire in the third decoction is preferably 15-25 min, and more preferably 20 min.
The invention melts the donkey-hide gelatin to obtain the donkey-hide gelatin solution. In the present invention, the melting of the E-gelatin preferably further comprises crushing the E-gelatin and melting the crushed E-gelatin with hot water. The melting operation of the donkey-hide gelatin is not limited in the present invention, and can be performed by a method known to those skilled in the art.
The invention mixes the decoction and the donkey-hide gelatin liquid to obtain the traditional Chinese medicine composition. In the present invention, the mixing method is not particularly limited, and a mixing method known to those skilled in the art may be used.
In the invention, the dosage form of the traditional Chinese medicine composition preferably comprises tablets, granules, capsules and oral liquid preparations. The invention has no special limitation on the auxiliary materials of the preparation formulation, and the auxiliary materials for preparing tablets, granules, capsules and oral liquid preparations which are well known by the technical personnel in the field can be adopted.
The invention also provides application of the traditional Chinese medicine composition in the scheme in preparation of a medicine for treating myelodysplastic syndrome.
The invention also provides a honeyed pill for treating myelodysplastic syndrome, which comprises the traditional Chinese medicine composition and honey according to the technical scheme; the mass ratio of the total mass of the traditional Chinese medicine composition to the honey is preferably 1: 1.2-1.5, and more preferably 1: 1.2. In the present invention, the source of the honey is not particularly limited, and commercially available products known to those skilled in the art may be used.
In the present invention, the preparation method of the honeyed pill preferably comprises: pulverizing, mixing with Mel, refining Mel, mixing, and making pill.
In the present invention, the powdering preferably comprises drying radix rehmanniae, radix Glycyrrhizae Preparata, ramulus Cinnamomi, radix Ophiopogonis, radix Ginseng, colla Corii Asini, rhizoma Zingiberis recens, fructus Jujubae, Poria, radix astragali, radix Angelicae sinensis, radix Scutellariae, Gypsum Fibrosum and radix Polygalae, and making into fine powder; the drying preferably comprises fine fire baking or exposure to sunlight; the preparation of the fine powder preferably comprises making into fine powder by a powder mill. The source of the powder mill of the present invention is not particularly limited, and commercially available products known to those skilled in the art may be used.
In the invention, the refined honey is preferably boiled with strong fire firstly and then slowly boiled with slow fire. The honey refining preferably comprises the steps that when honey is in a yellow foam state, one bamboo chopstick is used for dipping one drop in the honey, then the bamboo chopstick is moved to the position above a cold water bowl, the honey is dropped into the water, and if the honey does not disperse in the water and sinks to the bottom (namely the honey drops into beads), the honey is refined.
In the invention, the medicine mixing preferably comprises pouring the boiled honey into a disinfection vessel filled with the medicinal powder under the condition of stirring; the step of adding honey preferably comprises pouring honey into the medicinal powder contained in the disinfection basin by using a spoon; the stirring preferably comprises stirring with thick bamboo chopsticks.
In the present invention, the rolling preferably comprises rolling after dropping a small amount of glycerin, sesame oil or peanut oil on the palm of the palm; the mass of the honeyed pill is preferably 9-11 g per pill.
After the pills are rolled, the invention preferably also comprises packaging and storage; the packaging and storing preferably comprises sweating the honeyed pills with round and smooth appearance, compact and moist surface and no visible fiber or other abnormal color points, wrapping the honeyed pills with wax paper, glass paper, plastic bags or wax shells and the like after the appearance of the honeyed pills becomes hard, and storing the honeyed pills in a cool and dry place; the sweating time of the pill is preferably 2-5 d, and more preferably 3 d.
In the invention, the traditional Chinese medicine composition is preferably taken orally, and the taking method of the traditional Chinese medicine composition is preferably 100-200 mL/time, more preferably 100 mL/time and 2 times/day.
In the invention, the honeyed pill is preferably taken orally, and the administration method of the honeyed pill is preferably 1 pill/time and 2 times/day.
In the present invention, the Chinese medicinal composition and the honeyed pill are preferably administered 1 time each before and half an hour after a meal.
The traditional Chinese medicine composition and the honeyed pills provided by the invention can effectively improve myelodysplastic syndrome and various clinical symptoms caused by myelodysplastic syndrome, and have remarkable effects.
For further illustration of the present invention, the following examples are provided to describe the Chinese medicinal composition for treating myelodysplastic syndrome, its preparation method and application, and honeyed pills in detail, but they should not be construed as limiting the scope of the present invention.
Example 1
A traditional Chinese medicine composition for treating myelodysplastic syndrome is prepared from the following raw materials in parts by weight: 20 parts of radix rehmanniae recen, 15 parts of honey-fried licorice root, 15 parts of cassia twig, 20 parts of dwarf lilyturf tuber, 6 parts of ginseng, 10 parts of ginger, 30 parts of Chinese date, 15 parts of tuckahoe, 50 parts of astragalus root, 10 parts of angelica, 10 parts of donkey-hide gelatin, 15 parts of scutellaria root, 15 parts of gypsum and 15 parts of polygala root.
The preparation of the traditional Chinese medicine composition comprises the following steps:
(1) compacting 20g of radix rehmanniae, 15g of radix glycyrrhizae preparata, 15g of cassia twig, 20g of radix ophiopogonis, 6g of ginseng, 10g of donkey-hide gelatin, 10g of ginger, 30g of Chinese date, 15g of poria cocos, 50g of astragalus membranaceus, 10g of Chinese angelica, 15g of scutellaria baicalensis, 15g of gypsum and 15g of polygala tenuifolia, adding water to immerse the medicinal powder for 2cm, and soaking for 20 min;
(2) boiling the soaked Chinese medicinal materials with strong fire, and decocting with slow fire for 30min to obtain first decoction and first residue;
(3) mixing the obtained first decoction dregs with water to submerge the surface of the medicine for 2cm, boiling the liquid medicine with strong fire, and slowly decocting with slow fire for 30min to obtain a second decoction and second decoction dregs;
(4) mixing the obtained second decoction dregs with water until the second decoction dregs submerge 2cm above the medicine surface, boiling the liquid medicine with strong fire, and then slowly decocting with slow fire for 20min to obtain a third decoction and third decoction dregs;
(5) melting 10g of colla Corii Asini to obtain colla Corii Asini solution;
(6) mixing the decoctions obtained in the steps (2), (3) and (4), and mixing with the colla corii asini liquid obtained in the step (5) to obtain the traditional Chinese medicine composition.
Example 2
The honeyed pill for treating myelodysplastic syndrome is prepared from the following raw materials in parts by weight: 20 parts of radix rehmanniae recen, 15 parts of honey-fried licorice root, 15 parts of cassia twig, 20 parts of dwarf lilyturf tuber, 8 parts of ginseng, 10 parts of donkey-hide gelatin, 10 parts of ginger, 30 parts of Chinese date, 15 parts of tuckahoe, 50 parts of astragalus root, 10 parts of angelica, 15 parts of scutellaria root, 12 parts of gypsum and 15 parts of polygala root.
The preparation of the honeyed pill comprises the following steps:
(1) drying radix rehmanniae 20g, radix Glycyrrhizae Preparata 15g, ramulus Cinnamomi 15g, radix Ophiopogonis 20g, Ginseng radix 8g, colla Corii Asini 10g, rhizoma Zingiberis recens 10g, fructus Jujubae 30g, Poria 15g, radix astragali 50g, radix Angelicae sinensis 10g, Scutellariae radix 15g, Gypsum Fibrosum 12g, and cortex et radix Polygalae 15g in the sun, pulverizing into fine powder with a pulverizer;
(2) 269g of the medicinal powder is prepared into 323g of honey according to the mass ratio of 1: 1.2;
(3) boiling honey, boiling the honey by strong fire, then slowly boiling by slow fire, when the honey turns yellow and foams, dipping a drop of the honey by a bamboo chopstick, then moving the bamboo chopstick above a cold water bowl, and dropping the honey into water, wherein if the honey does not disperse in the water and sinks to the bottom (namely, the honey drops to form beads), the refined honey is obtained;
(4) pouring the boiled honey into the medicinal powder contained in the disinfection basin by using a spoon, stirring the medicinal powder by using thick bamboo chopsticks, pouring the honey while adjusting the medicinal powder, and stopping adding the honey when dry medicinal powder is basically not seen;
(5) the pill can be rubbed with a small amount of glycerin on the palm, 9g for each pill;
(6) the prepared honeyed pill has round and smooth appearance, compact and moist surface, no visible fiber or other abnormal color points, and when the pill sweats for 3 days and becomes hard in appearance, the honeyed pill is wrapped by wax paper, cellophane, plastic bags or wax shells and the like and stored in a cool and dry place.
Example 3
A traditional Chinese medicine composition for treating myelodysplastic syndrome similar to that in example 1, the only difference is that the raw materials are prepared according to the following parts by weight: 12 parts of radix rehmanniae recen, 12 parts of honey-fried licorice root, 12 parts of cassia twig, 22 parts of dwarf lilyturf tuber, 5 parts of ginseng, 11 parts of donkey-hide gelatin, 11 parts of ginger, 40 parts of Chinese date, 10 parts of tuckahoe, 30 parts of astragalus root, 6 parts of angelica, 10 parts of scutellaria root, 10 parts of gypsum and 10 parts of polygala root.
Example 4
A traditional Chinese medicine composition for treating myelodysplastic syndrome similar to example 1, with the only difference that the raw materials are prepared according to the following parts by weight: 17 parts of radix rehmanniae recen, 14 parts of honey-fried licorice root, 14 parts of cassia twig, 24 parts of dwarf lilyturf tuber, 7 parts of ginseng, 12 parts of donkey-hide gelatin, 12 parts of ginger, 60 parts of Chinese date, 13 parts of tuckahoe, 40 parts of astragalus root, 8 parts of angelica, 13 parts of scutellaria root, 15 parts of gypsum and 13 parts of polygala root.
Comparative example 1
A traditional Chinese medicine composition for treating myelodysplastic syndrome similar to that in example 1, the only difference is that the raw materials are prepared according to the following parts by weight: 20 parts of radix rehmanniae recen, 15 parts of honey-fried licorice root, 15 parts of cassia twig, 20 parts of dwarf lilyturf tuber, 6 parts of ginseng, 10 parts of ginger, 30 parts of Chinese date, 50 parts of astragalus root and 10 parts of fructus cannabis.
Application example 1
Patient, female, first visit 2018, 5 month 24, chief complaint: "MDS" was diagnosed for 7 months and was exacerbated for 3 days. The current medical history: the patient suffers from debilitation and continuous aggravation 7 months ago, and is subjected to examinations such as routine blood, bone marrow puncture and biopsy, bone puncture biopsy: hematopoietic area: 20% (31-49). Fat area 50% (20-36%). Trabecular bone: 30% (21-31%). Megakaryocytes: 1 per square millimeter (7-15). HE and PAS staining showed that the examined small amount of bone marrow nucleated cells were less hyperplastic, the two lines of granulocytes were few, scattered and focal distributed. Megakaryocytes are sporadic. Dyeing of reticular fibers (MF-0). The diagnostic opinion: the part has low marrow nucleated cell hyperplasia, is diagnosed as MDS, and has relieved symptoms after chemotherapy, blood transfusion and symptomatic treatment. No cause of debilitation is further aggravated 3 days ago, and the traditional Chinese and western medicine combined treatment is sought, so that the traditional Chinese medicine and western medicine combined treatment is used in the outpatient service of the inventor. The current symptoms are as follows: weakness, palpitation, spontaneous perspiration and night sweat, dry throat, dyspnea after activity, good sleep, normal urine and constipation, and 1 row in 3-4 days. Tongue pulse: red tongue with scanty coating and intermittent pulse. Blood routine: neutrophil count: 0.47X 109L, red blood cells: 1.57X 1012L, hemoglobin: 53g/L, platelets: 27X 109And L. The diagnostic opinion: in this area, the bone marrow has low proliferation of nucleated cells, and should be considered clinically.
Traditional Chinese medicine diagnosis: marrow toxin Lao (deficiency of both qi and yin)
And (3) Western diagnosis: myelodysplastic syndrome
The traditional Chinese medicine composition prepared in the example 1 is taken 15 times, each dose is 300ml, 150ml is taken once, twice a day and orally.
The doctor consults for 6 months and 9 days in 2019; symptoms are: the debilitation is relieved, the dry mouth is relieved, the dry eyes disappear, the dyspnea is improved earlier, the sleep is improved, and the stool is normal. Tongue pulse: a red tongue with a thin and white coating and a wiry pulse. Blood routine review: neutrophil count: 1.91X 109L, red blood cells: 1.72X 1012L, hemoglobin: 56g/L, platelet: 54 x 109/L。
Application example 2
Patient, male, first visit 2019, 3 months and 5 days, chief complaint: "MDS" was diagnosed for 1 year and exacerbated for 2 months. The current medical history is as follows: the patients have weakness after being infected with cold 1 year ago, the routine examination of blood indicates thrombocytopenia, the examination of hospital treatment and bone puncture is carried out without MDS, the patients are treated by oral treatment (the specific medication is unknown) of compound ferrous sulfate and the like, the condition of the patients is not obviously improved after the patients are taken, and the platelets are low. 2 months before, the fatigue aggravates, and the bone puncture is performed again: the proportion of granulocytes and megakaryocytes is reduced, the proportion of erythrocytes is increased, and each line of cells can be changed in pathological state, and is diagnosed as 'MDS'. Intermittent oral taking of medicine for treating hematopathy. The current symptoms are as follows: debilitation, aggravation after activity, intermittent fever at night, dry mouth, restlessness, insomnia, short breath, poor diet, general sleep, frequent urination, dry stool. A red tongue with yellow coating and a deficient and rapid pulse. Bone marrow biopsy report: myeloproliferation is approximately normal, and granulocytic, erythrocytic and megakaryocytic hyperplasia with abnormal morphology. Blood routine: neutrophil count: 0.62X 109L, red blood cells: 2.04X 1012L, hemoglobin: 63g/L, platelets: 39X 109/L。
Traditional Chinese medicine diagnosis: marrow toxin Lao (deficiency of both qi and yin)
And (3) Western diagnosis: myelodysplastic syndrome
The traditional Chinese medicine composition prepared in the example 1 is taken 15 times, each dose is 300ml, 150ml is taken once, twice a day and orally.
The doctor makes a double-diagnosis for 3 months and 20 days in 2019; symptoms are: the fatigue is relieved, and no fever is seen. Sleep can be improved, and the stool and urine are normal. Pale with white coating and thready pulse. Blood review routine: neutrophil count: 1.3X 109L, red blood cells: 2.2X 1012L, hemoglobin: 68g/L, 56X 10 platelets9/L。
Application example 3
Clinical experiment and result observation for treating myelodysplastic syndrome
1 data and method
1.1 study object
The study subjects were selected from 60 myelodysplastic syndrome patients collected in subsidiary hospitals of vinpocetine traditional Chinese medicine university from 10 months in 2017 to 10 months in 2019, wherein 30 cases are male and 30 cases are female; the age is 40-75 years, the average age is 57.5 years, 40 cases of mild symptoms, 10 cases of moderate symptoms, 9 cases of severe symptoms and 1 case of critically ill symptoms.
1.2 diagnostic criteria for myelodysplastic syndrome
1.2.1 Western diagnosis:
the diagnosis of myelodysplastic syndrome requires 2 requirements and 1 determination criterion.
The requirements are as follows:
(1) continuous (more than or equal to 6 months) primary or multi-blood cell reduction; hemoglobin (HGB) <110g/L, neutrophil absolute count (ANC) < 1.5X 109/L, Platelets (PLT) < 100X 109/L;
(2) other hematopoietic and non-hematopoietic disorders that can lead to cytopenia and dysplasia are excluded.
Determination of the standard:
(1) dysplasia: the proportion of dysplastic cells in the erythroid, granulocytic and megakaryocytic cell lines in the bone marrow smear was > 10%.
(2) The proportion of the annular sideroblasts to the nucleated erythrocytes is 15 percent; or 5% of the proportion of nuclear erythrocytes occupied by the circular sideroblasts accompanied by the SF3B1 mutation.
(3) Primary cells: the content of the smear in the bone marrow reaches 5 to 19 percent.
(4) MDS is a common chromosomal abnormality.
1.3 treatment regimens
The study subjects were randomly divided into four groups according to sex, mild disease and moderate disease, and four groups according to severe disease and critical illness (1 patient in critical illness was divided into group 1), wherein group 1 took 15 doses of the Chinese medicinal composition prepared in example 1, 300ml per dose, 150ml once, twice a day, and orally; group 2 took 30 pills of the honeyed pill prepared in example 2, 1 pill/time and 2 times/day, and was orally taken; group 3 takes 15 doses of the traditional Chinese medicine composition prepared in the example 3, each dose is 300ml, 150ml is taken once, and the traditional Chinese medicine composition is taken twice a day; group 4 takes 15 doses of the Chinese medicinal composition prepared in example 4, each dose is 300ml, 150ml is taken once, twice a day and orally; group 5 took 15 doses of the Chinese medicinal composition prepared in comparative example 1, each dose was 300ml, 150ml was once, twice a day, and taken orally.
1.4 therapeutic criteria
Firstly, symptom observation: observing the improvement condition of the traditional Chinese medicine treatment on the clinical symptoms of the patients, such as shortness of breath, hypodynamia, lusterless complexion, dry mouth and throat, bleeding position and the like.
Evaluation indexes are as follows: the symptoms of traditional Chinese medicine are divided into four grades according to clinical observation:
(1) mild case of slight card
(2) Medium and high grade
(3) Serious syndrome
(4) Critical syndrome/pattern
Treatment was recorded as the appearance of symptoms.
The evaluation method comprises the following steps: comparison of Total integral of symptoms before and after treatment (before/after treatment)
The effect is shown: the clinical symptoms and physical signs of the traditional Chinese medicine are obviously improved, and the syndrome integral is reduced by 70 to 94 percent.
The method has the following advantages: the clinical symptoms and physical signs of the traditional Chinese medicine are improved, and the syndrome integral is reduced by 30-69%.
And (4) invalidation: the clinical symptoms and physical signs of the traditional Chinese medicine are not obviously improved or even aggravated, and the syndrome integral is reduced by less than 30 percent.
1.5 analysis of results
Chinese medicine symptom integration result (unit: case)
Figure GDA0003549715610000121
Figure GDA0003549715610000131
It can be seen from the results of groups 1 and 5 that the total effective rate of treatment of myelodysplastic syndrome is significantly improved by replacing fructus cannabis with poria cocos, angelica sinensis, scutellaria baicalensis, gypsum and polygala tenuifolia. Mainly because the body fluid of the myelodysplastic syndrome is slightly consumed, the fructus cannabis is removed; in addition, because the syndrome is the symptoms of essence deficiency and blood deficiency, qi deficiency and deficiency, and deficiency and damage in one group, the angelica is added to enhance the effect of enriching the blood; in addition, the syndrome is also a syndrome of deficiency of both qi and yin, and consumes qi and damages yin, the treatment principle of the gypsum and the scutellaria baicalensis in combination with the ginseng and the ophiopogon root in tonifying qi, nourishing yin and clearing heat is to nourish heart yin, clear heart and calm nerves, and the polygala tenuifolia in combination of calming heart and calming nerves, so that the medicines are cooperatively combined to play a role in treating myelodysplastic syndrome.
In summary, the application examples 1 to 3 show that the traditional Chinese medicine composition and the honeyed pills prepared by the invention can effectively improve the symptoms of myelodysplastic syndrome, have the total effective rate of more than 40 percent, and can relieve the progress of the myelodysplastic syndrome.
In addition, the Chinese medicinal composition prepared in example 1 has the best effect by comprehensively considering the treatment effect.
Although the present invention has been described in detail with reference to the above embodiments, it is only a part of the embodiments of the present invention, not all of the embodiments, and other embodiments can be obtained without inventive step according to the embodiments, and the embodiments are within the scope of the present invention.

Claims (10)

1. A traditional Chinese medicine composition for treating myelodysplastic syndrome is characterized by being prepared from the following raw materials in parts by weight: 17 parts of radix rehmanniae recen, 14 parts of honey-fried licorice root, 14 parts of cassia twig, 24 parts of dwarf lilyturf tuber, 7 parts of ginseng, 12 parts of donkey-hide gelatin, 12 parts of ginger, 60 parts of Chinese date, 13 parts of tuckahoe, 40 parts of astragalus root, 8 parts of angelica, 13 parts of scutellaria root, 15 parts of gypsum and 13 parts of polygala root.
2. The traditional Chinese medicine composition of claim 1, wherein the angelica is whole angelica, and the whole angelica comprises angelica head, angelica body and angelica tail.
3. A method for preparing the Chinese medicinal composition of claim 1 or 2, comprising the steps of:
decocting radix rehmanniae, radix Glycyrrhizae Preparata, ramulus Cinnamomi, radix Ophiopogonis, Ginseng radix, rhizoma Zingiberis recens, fructus Jujubae, Poria, radix astragali, radix Angelicae sinensis, Scutellariae radix, Gypsum Fibrosum and cortex et radix Polygalae with water to obtain decoction;
melting colla Corii Asini to obtain colla Corii Asini solution;
mixing the decoction and colla Corii Asini solution to obtain the Chinese medicinal composition.
4. The method for preparing a decoction according to claim 3, wherein the preparation of the decoction comprises the steps of:
(1) soaking radix rehmanniae, radix Glycyrrhizae Preparata, ramulus Cinnamomi, radix Ophiopogonis, Ginseng radix, rhizoma Zingiberis recens, fructus Jujubae, Poria, radix astragali, radix Angelicae sinensis, Scutellariae radix, Gypsum Fibrosum and cortex et radix Polygalae in water;
(2) carrying out first decoction on the traditional Chinese medicine soaked in the step (1) to obtain a first decoction liquid and first decoction dregs;
(3) mixing the first decoction dregs obtained in the step (2) with water, and then carrying out second decoction to obtain a second decoction liquid and second decoction dregs;
(4) mixing the second decoction dregs obtained in the step (3) with water, and then carrying out third decoction to obtain a third decoction liquid;
(5) and mixing the first decoction, the second decoction and the third decoction to obtain decoction.
5. The preparation method according to claim 4, wherein the soaking time in the step (1) is 15-25 min.
6. The preparation method according to claim 4, wherein the amount of water used in the steps (1), (3) and (4) is 2-3 cm higher than the corresponding drug surface.
7. The preparation method of claim 4, wherein the first decoction, the second decoction and the third decoction are carried out by boiling the decoction with strong fire and then decocting with slow fire.
8. The preparation method according to claim 7, wherein the time of the slow fire decoction in the first decoction and the second decoction is 20-40 min; and in the third decoction, the time of decoction with slow fire is 15-25 min.
9. Use of the Chinese medicinal composition of claim 1 or 2 or the Chinese medicinal composition obtained by the preparation method of claims 3-8 in preparing a medicament for treating myelodysplastic syndrome.
10. Honeyed pill for the treatment of myelodysplastic syndrome, comprising the raw materials of the Chinese medicinal composition of claim 1 or 2 and honey.
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