CN101564486A - Medicament for preventing and treating ruminant post-natal diseases and preparation method thereof - Google Patents
Medicament for preventing and treating ruminant post-natal diseases and preparation method thereof Download PDFInfo
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- CN101564486A CN101564486A CNA2008100311240A CN200810031124A CN101564486A CN 101564486 A CN101564486 A CN 101564486A CN A2008100311240 A CNA2008100311240 A CN A2008100311240A CN 200810031124 A CN200810031124 A CN 200810031124A CN 101564486 A CN101564486 A CN 101564486A
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Abstract
The invention discloses a medicament for preventing and curing ruminant post-natal diseases, which mainly uses 43 Chinese medicinal herbs of cowherb seed, safflower, rhizoma ligustici wallichii, herba hyperici sampsonii, catnip, loofah, vervain, Baizaocao, Guiwei, white paeony root seed, salvia miltiorrhiza, flaccid knotweed herb, corydalis tuber, climbing nightshade, fiveleaf akebia, squama manitis, yam, honeysuckle, Buhuang, frankincense, pulvis glycyrrhizae praeparatus, Chinese violet, angelica dahurica, Huangshao seed, liquorice, radix astragali, ramulus euonymi, spina gleditsiae, peach kerne, ginseng, angelica, barbary wolfberry fruit, herba epimedii, baikal skullcap root, red paeonia, sweet potato, momordica dioica, shizandra berry, radix rhapontici seu radix echinopsis, dried immature fruit of citron orange, nothapodytes foetida, gardenia and sedge grass as base materials, uses motherwort, mahonia, philippine flemingia root, radix sophorae falvescentis, radix linderae and artemisia leaf as active ingredients and uses brown sugar as a saccharifying ferment according to certain proportioning by weight. The medicament can be prepared into pulvis for orally taking and has the functions of enriching the blood, invigorating the blood circulation, regulating the menstruation, relieving pains, lubricating the intestines, relaxing the bowels, promoting the eruption, clearing heat, detoxifying, lifting the yang-energy, regulating the vital energy, strengthening the spleen, coordinating the exterior and the interior, promoting the immunity, tonifying Qi, strengthening the exterior, removing sores, promoting the granulation, tonifying middle-Jiao and Qi, clearing damp, promoting diuresis, and the like. The medicament has quick effect for preventing and curing the ruminant post-natal diseases, high cure rate, safety and no toxic side effect.
Description
Technical field
The present invention relates to a kind of medicine of preventing and treating ruminant post-natal diseases and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Ruminant post-natal diseases is a modal disease in the breeding process, incidence rate accounts for 60% of whole disease, many clinically with the anorexia in puerperal, puerperal fever, the puerperal hypogalactia hypogalactia, puerperal mastitis, the uterine prolapse in puerperal, prolonged lochia, placenta retention, diseases such as postpartum paralysis are many, thereby cause the vaginitis of female animal, endometritis, pyometra, the uterus is slow, puerperal deteriorated blood etc., cause female animal not oestrus normally, breeding, young stock can not absorb healthy milk and growth promoter normally, even cause the lifelong parturient paresis of female animal, lose and kind use value, cause great economic loss to the raiser.
Manyly during western medicine replenish the calcium to mend sugar, prevention of inflammation occurs as the rule of treatment.Medicine commonly used has glucose, calcium chloride, normal saline, antibiotic, quinolones etc., and these medicines can play the effect of treatment ruminant post-natal diseases to a certain extent, but can't reach prevention and opsonic action.Some medicine can have a strong impact on the growth promoter of young stock, serious as quinolones to the osteoarthrosis infringement of young stock, can cause the heavy burden cartilage lesion, cause Tong pain and limping, simultaneously antibiotic medicine residual has a strong impact on food safety, and country has prohibited the use antibiotics in antenatal and a period of time in puerperal as milch cow.
Many during treatment by Chinese herbs is the rule of treatment with benefiting qi and nourishing blood, blood circulation promoting and blood stasis dispelling and soothing the channels and quicking the network vessels.Common drug has YIMUSHENGHUA SAN, Radix Angelicae Pubescentis to loose etc., though these medicines have certain curative effect not have special specific aim.Be widely used in ruminant post-natal diseases as YIMUSHENGHUA SAN, said preparation is made up of Herba Leonuri, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Persicae, Rhizoma Zingiberis and Radix Glycyrrhizae.Said preparation has the effect of blood circulation promoting and blood stasis dispelling, antalgic, is used for the treatment of puerperal diseases such as disease that postpartum lochia can't go, abdominal pain due to blood stasis.However, this Chinese medicine preparation still adopts traditional handicraft processing such as traditional pulverizing, mixing and packing, and the preparation curative effect still can not be satisfactory.
Summary of the invention
Therefore, still there is demand in the Chinese medicine preparation that people better prevent and treat ruminant post-natal diseases to curative effect, and especially country advocates under the environment of pollution-free food, green cultivation, and the demand of Chinese medicine preparation is bigger.Up to now, also do not find the report of any relevant pharmaceutical composition of the present invention.The inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, has found the oral medicinal herb medicine that the control of better curative effect ruminant post-natal diseases is arranged finally, thereby has finished the present invention.
Purpose of the present invention just provides a kind of a kind of Chinese medicine composition of more effectively preventing and treating ruminant post-natal diseases.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
Medicament selection Semen Vaccariae of the present invention, Flos Carthami, Rhizoma Chuanxiong, Herba Hyperici Sampsonii, Jing Jie, Retinervus Luffae Fructus, Herba Verbenae, lose algae grass, Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Herba polygoni hydropiperis, Rhizoma Corydalis, Herba Solani Lyrati, Caulis Akebiae, Squama Manis, Rhizoma Dioscoreae Nipponicae; Flos Lonicerae, fore-telling Huang, Olibanum, Preparatum Glycyrrhizae, Herba Violae, the Radix Angelicae Dahuricae, HUANGSHAOZI, Radix Glycyrrhizae, the Radix Astragali, Ramulus Euonymi, Spina Gleditsiae, Semen Persicae, Radix Ginseng, Radix Angelicae Sinensis, Fructus Lycii, Herba Epimedii make up, and according to a certain weight ratio, make each efficacy of drugs produce synergism these pharmaceutical science combinations, having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy, regulating qi-flowing for strengthening spleen, reconciling superficies and interior, immunological enhancement, invigorating QI to consolidate the body surface resistance, holder skin ulcer granulation promoting, invigorating the spleen and replenishing QI, invigorating the spleen and benefiting QI, functions such as promoting diuresis to clear away damp pathogen.
In order to reach better therapeutic, medicine of the present invention also makes up with Radix Scutellariae, Radix Paeoniae Rubra, FANSHU, dioecism momordica root, WUKOUZI, Radix Rhapontici, Fructus Aurantii Immaturus, QINGZHI, Fructus Gardeniae, Rhizoma Cyperi.This is because add the merit that can help the product immunological enhancement that helps the monarch and his subjects, invigorating the spleen and replenishing QI, invigorating the spleen and benefiting QI behind these medicines jointly.
In order to obtain optimum curative effect, medicine of the present invention has also added Herba Leonuri, Mahonia fortunei (Lindl.) Fedde, Radix Flemingiae Philippinensis, Radix Sophorae Flavescentis, the Radix Linderae, Folium Artemisiae Argyi on the basis of said medicine, and extract active component in the medicine by advanced processing technique, improve that enriching blood of main medicine invigorated blood circulation, effects for removing toxic heat.
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each amounts of components is for all to have better curative effect in the following weight parts scope:
55～65 parts of Semen Vaccariae, 16～23 parts on Flos Carthami, 26～34 parts of Rhizoma Chuanxiongs, 26～34 parts of Herba Hyperici Sampsoniis, 26～34 parts of Jing Jie, 16～23 parts of Retinervus Luffae Fructuss, 26～34 parts of Herba Verbenae, lose 35～45 parts of algae grass, 35～45 parts of Radix Angelicae Sinensis, 26～34 parts of Radix Paeoniae Alba, 8～12 parts of Radix Salviae Miltiorrhizaes, 12～18 parts of Herba polygoni hydropiperiss, 16～23 parts of Rhizoma Corydalis, 26～34 parts of Herba Solani Lyratis, 26～34 parts of Caulis Akebiaes, 8～12 parts of Squama Maniss, 16～23 parts of Rhizoma Dioscoreae Nipponicae; 16～23 parts of Flos Loniceraes, yellow 26～34 parts of fore-telling, 1.5～2.5 parts of Olibanums, 26～34 parts of Preparatum Glycyrrhizaes, 26～34 parts of Herba Violaes, 26～34 parts of the Radixs Angelicae Dahuricae, 26～34 parts of HUANGSHAOZI, 8～12 parts in Radix Glycyrrhizae, 16～23 parts of the Radixs Astragali, 12～18 parts of Ramulus Euonymis, 16～23 parts of Spina Gleditsiaes, 16～23 parts in Semen Persicae, 12～18 parts of Radix Ginsengs, 3～7 parts of Radix Angelicae Sinensis, 26～34 parts of Fructus Lycii, 8～12 parts of Herba Epimedii.
Be preferably: 60 parts of Semen Vaccariae, 20 parts on Flos Carthami, 30 parts of Rhizoma Chuanxiongs, 30 parts of Herba Hyperici Sampsoniis, 30 parts of Jing Jie, 20 parts of Retinervus Luffae Fructuss, 30 parts of Herba Verbenae, lose 40 parts of algae grass, 40 parts of Radix Angelicae Sinensis, 30 parts of Radix Paeoniae Alba, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba polygoni hydropiperiss, 20 parts of Rhizoma Corydalis, 30 parts of Herba Solani Lyratis, 30 parts of Caulis Akebiaes, 10 parts of Squama Maniss, 20 parts of Rhizoma Dioscoreae Nipponicae; 20 parts of Flos Loniceraes, yellow 30 parts of fore-telling, 2 parts of Olibanums, 30 parts of Preparatum Glycyrrhizaes, 30 parts of Herba Violaes, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of HUANGSHAOZI, 10 parts in Radix Glycyrrhizae, 20 parts of the Radixs Astragali, 15 parts of Ramulus Euonymis, 20 parts of Spina Gleditsiaes, 20 parts in Semen Persicae, 15 parts of Radix Ginsengs, 5 parts of Radix Angelicae Sinensis, 30 parts of Fructus Lycii, 10 parts of Herba Epimedii.
Each amounts of components of medicine of the present invention can also be 55～65 parts of Semen Vaccariae, 16～23 parts on Flos Carthami, 26～34 parts of Rhizoma Chuanxiongs, 26～34 parts of Herba Hyperici Sampsoniis, 26～34 parts of Jing Jie, 16～23 parts of Retinervus Luffae Fructuss, 26～34 parts of Herba Verbenae, lose 35～45 parts of algae grass, 35～45 parts of Radix Angelicae Sinensis, 26～34 parts of Radix Paeoniae Alba, 8～12 parts of Radix Salviae Miltiorrhizaes, 12～18 parts of Herba polygoni hydropiperiss, 16～23 parts of Rhizoma Corydalis, 26～34 parts of Herba Solani Lyratis, 26～34 parts of Caulis Akebiaes, 8～12 parts of Squama Maniss, 16～23 parts of Rhizoma Dioscoreae Nipponicae; 16～23 parts of Flos Loniceraes, yellow 26～34 parts of fore-telling, 1.5～2.5 parts of Olibanums, 26～34 parts of Preparatum Glycyrrhizaes, 26～34 parts of Herba Violaes, 26～34 parts of the Radixs Angelicae Dahuricae, 26～34 parts of HUANGSHAOZI, 8～12 parts in Radix Glycyrrhizae, 16～23 parts of the Radixs Astragali, 12～18 parts of Ramulus Euonymis, 16～23 parts of Spina Gleditsiaes, 16～23 parts in Semen Persicae, 12～18 parts of Radix Ginsengs, 3～7 parts of Radix Angelicae Sinensis, 26～34 parts of Fructus Lycii, 8～12 parts of Herba Epimedii; 16～23 parts of Radix Scutellariaes, 16～23 parts of Radix Paeoniae Rubra, 16～23 parts of FANSHU, 26～34 parts of dioecism momordica roots, 26～34 parts of WUKOUZI, 16～23 parts of Radix Rhapontici, 12～18 parts of Fructus Aurantii Immaturuss, 22～28 parts of QINGZHI, 26～34 parts of Fructus Gardeniaees, 16～23 parts of Rhizoma Cyperi.
Be preferably: 60 parts of Semen Vaccariae, 20 parts on Flos Carthami, 30 parts of Rhizoma Chuanxiongs, 30 parts of Herba Hyperici Sampsoniis, 30 parts of Jing Jie, 20 parts of Retinervus Luffae Fructuss, 30 parts of Herba Verbenae, lose 40 parts of algae grass, 40 parts of Radix Angelicae Sinensis, 30 parts of Radix Paeoniae Alba, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba polygoni hydropiperiss, 20 parts of Rhizoma Corydalis, 30 parts of Herba Solani Lyratis, 30 parts of Caulis Akebiaes, 10 parts of Squama Maniss, 20 parts of Rhizoma Dioscoreae Nipponicae; 20 parts of Flos Loniceraes, yellow 30 parts of fore-telling, 2 parts of Olibanums, 30 parts of Preparatum Glycyrrhizaes, 30 parts of Herba Violaes, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of HUANGSHAOZI, 10 parts in Radix Glycyrrhizae, 20 parts of the Radixs Astragali, 15 parts of Ramulus Euonymis, 20 parts of Spina Gleditsiaes, 20 parts in Semen Persicae, 15 parts of Radix Ginsengs, 5 parts of Radix Angelicae Sinensis, 30 parts of Fructus Lycii, 10 parts of Herba Epimedii; 20 parts of Radix Scutellariaes, 20 parts of Radix Paeoniae Rubra, 20 parts of FANSHU, 30 parts of dioecism momordica roots, 30 parts of WUKOUZI, 20 parts of Radix Rhapontici, 15 parts of Fructus Aurantii Immaturuss, 25 parts of QINGZHI, 30 parts of Fructus Gardeniaees, 20 parts of Rhizoma Cyperi.
The medicine of the present invention further consumption of each component is 55～65 parts of Semen Vaccariae, 16～23 parts on Flos Carthami, 26～34 parts of Rhizoma Chuanxiongs, 26～34 parts of Herba Hyperici Sampsoniis, 26～34 parts of Jing Jie, 16～23 parts of Retinervus Luffae Fructuss, 26～34 parts of Herba Verbenae, loses 35～45 parts of algae grass, 35～45 parts of Radix Angelicae Sinensis, 26～34 parts of Radix Paeoniae Alba, 8～12 parts of Radix Salviae Miltiorrhizaes, 12～18 parts of Herba polygoni hydropiperiss, 16～23 parts of Rhizoma Corydalis, 26～34 parts of Herba Solani Lyratis, 26～34 parts of Caulis Akebiaes, 8～12 parts of Squama Maniss, 16～23 parts of Rhizoma Dioscoreae Nipponicae; 16～23 parts of Flos Loniceraes, yellow 26～34 parts of fore-telling, 1.5～2.5 parts of Olibanums, 26～34 parts of Preparatum Glycyrrhizaes, 26～34 parts of Herba Violaes, 26～34 parts of the Radixs Angelicae Dahuricae, 26～34 parts of HUANGSHAOZI, 8～12 parts in Radix Glycyrrhizae, 16～23 parts of the Radixs Astragali, 12～18 parts of Ramulus Euonymis, 16～23 parts of Spina Gleditsiaes, 16～23 parts in Semen Persicae, 12～18 parts of Radix Ginsengs, 3～7 parts of Radix Angelicae Sinensis, 26～34 parts of Fructus Lycii, 8～12 parts of Herba Epimedii; 16～23 parts of Radix Scutellariaes, 16～23 parts of Radix Paeoniae Rubra, 16～23 parts of FANSHU, 26～34 parts of dioecism momordica roots, 26～34 parts of WUKOUZI, 16～23 parts of Radix Rhapontici, 12～18 parts of Fructus Aurantii Immaturuss, 22～28 parts of QINGZHI, 26～34 parts of Fructus Gardeniaees, 16～23 parts of Rhizoma Cyperi; 55～65 parts of Herba Leonuris, 26～34 parts of Mahonia fortunei (Lindl.) Fedde, 45～55 parts of Radix Sophorae Flavescentiss, 22～28 parts of the Radixs Linderae, 8～12 parts of Radix Flemingiae Philippinensiss, 26～34 parts of Folium Artemisiae Argyis.
Be preferably: 60 parts of Semen Vaccariae, 20 parts on Flos Carthami, 30 parts of Rhizoma Chuanxiongs, 30 parts of Herba Hyperici Sampsoniis, 30 parts of Jing Jie, 20 parts of Retinervus Luffae Fructuss, 30 parts of Herba Verbenae, lose 40 parts of algae grass, 40 parts of Radix Angelicae Sinensis, 30 parts of Radix Paeoniae Alba, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba polygoni hydropiperiss, 20 parts of Rhizoma Corydalis, 30 parts of Herba Solani Lyratis, 30 parts of Caulis Akebiaes, 10 parts of Squama Maniss, 20 parts of Rhizoma Dioscoreae Nipponicae; 20 parts of Flos Loniceraes, yellow 30 parts of fore-telling, 2 parts of Olibanums, 30 parts of Preparatum Glycyrrhizaes, 30 parts of Herba Violaes, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of HUANGSHAOZI, 10 parts in Radix Glycyrrhizae, 20 parts of the Radixs Astragali, 15 parts of Ramulus Euonymis, 20 parts of Spina Gleditsiaes, 20 parts in Semen Persicae, 15 parts of Radix Ginsengs, 5 parts of Radix Angelicae Sinensis, 30 parts of Fructus Lycii, 10 parts of Herba Epimedii; 20 parts of Radix Scutellariaes, 20 parts of Radix Paeoniae Rubra, 20 parts of FANSHU, 30 parts of dioecism momordica roots, 30 parts of WUKOUZI, 20 parts of Radix Rhapontici, 15 parts of Fructus Aurantii Immaturuss, 25 parts of QINGZHI, 30 parts of Fructus Gardeniaees, 20 parts of Rhizoma Cyperi; 60 parts of Herba Leonuris, 30 parts of Mahonia fortunei (Lindl.) Fedde, 50 parts of Radix Sophorae Flavescentiss, 25 parts of the Radixs Linderae, 10 parts of Radix Flemingiae Philippinensiss, 30 parts of Folium Artemisiae Argyis.
What medicine of the present invention adopted is to change traditional in the past fabrication and processing technology, on the basis of pulverizing, advanced Chinese medicine preparation process technologies such as a lot of medicines have adopted sugared stir-fry, vinegar stir-fry, steaming and decocting, fermentation, concentrate, extraction, thereby the effective active composition in the extraction Chinese medicine, can directly act on the target organ of body, curative effect is provided, and can regulates the physiological function of animal body, play conditioning, health care, prophylactic effect.
Preferably, the preparation method of medicine activity component of the present invention is as follows:
A) with Semen Vaccariae, Flos Carthami, Rhizoma Chuanxiong, Herba Hyperici Sampsonii, Jing Jie, Retinervus Luffae Fructus, the Herba Verbenae of described weight proportion, lose algae grass, Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Herba polygoni hydropiperis, Rhizoma Corydalis, Herba Solani Lyrati, Caulis Akebiae, Squama Manis, Rhizoma Dioscoreae Nipponicae the pure Chinese medicine of totally 17 flavors 70～80 ℃ of oven dry down, moisture Control is below 8%, to cross No. 3 sieve behind these Chinese medicine pulverize separately, get mixture 1;
B) with the pure Chinese medicine of the totally 16 flavors oven dry under 80～90 ℃ of Flos Lonicerae, fore-telling Huang, Olibanum, Preparatum Glycyrrhizae, Herba Violae, the Radix Angelicae Dahuricae, HUANGSHAOZI, Radix Glycyrrhizae, the Radix Astragali, Ramulus Euonymi, Spina Gleditsiae, Semen Persicae, Radix Ginseng, Radix Angelicae Sinensis, Fructus Lycii, Herba Epimedii, moisture Control is below 5%, to cross No. 6 sieve behind these Chinese medicine pulverize separately, get mixture 2;
C) combined mixture 1 and mixture 2 are ground into powder with it, just have been prepared into the active component of medicine of the present invention.
If also with Radix Scutellariae, Radix Paeoniae Rubra, FANSHU, dioecism momordica root, WUKOUZI, Radix Rhapontici, Fructus Aurantii Immaturus, QINGZHI, Fructus Gardeniae, Rhizoma Cyperi combination, its preparation method is:
A) with Semen Vaccariae, Flos Carthami, Rhizoma Chuanxiong, Herba Hyperici Sampsonii, Jing Jie, Retinervus Luffae Fructus, the Herba Verbenae of described weight proportion, lose algae grass, Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Herba polygoni hydropiperis, Rhizoma Corydalis, Herba Solani Lyrati, Caulis Akebiae, Squama Manis, Rhizoma Dioscoreae Nipponicae the pure Chinese medicine of totally 17 flavors 70～80 ℃ of oven dry down, moisture Control is below 8%, to cross No. 3 sieve behind these Chinese medicine pulverize separately, get mixture 1;
B) with the pure Chinese medicine of the totally 16 flavors oven dry under 80～90 ℃ of Flos Lonicerae, fore-telling Huang, Olibanum, Preparatum Glycyrrhizae, Herba Violae, the Radix Angelicae Dahuricae, HUANGSHAOZI, Radix Glycyrrhizae, the Radix Astragali, Ramulus Euonymi, Spina Gleditsiae, Semen Persicae, Radix Ginseng, Radix Angelicae Sinensis, Fructus Lycii, Herba Epimedii, moisture Control is below 5%, to cross No. 6 sieve behind these Chinese medicine pulverize separately, get mixture 2;
C) under slow fire, use the vinegar parch after the pure Chinese medicine of totally 10 flavors mixes with Radix Scutellariae, Radix Paeoniae Rubra, FANSHU, dioecism momordica root, WUKOUZI, Radix Rhapontici, Fructus Aurantii Immaturus, QINGZHI, Fructus Gardeniae, Rhizoma Cyperi, get mixture 3;
D) mixture 1, mixture 2, mixture 3 are merged, stirring and evenly mixing after fermentation 2 days is dried naturally, pulverizes No. 3 sieves of the whole mistakes in back, just has been prepared into the active component of medicine of the present invention.
If also add Herba Leonuri, Mahonia fortunei (Lindl.) Fedde, Radix Flemingiae Philippinensis, Radix Sophorae Flavescentis, the Radix Linderae, Folium Artemisiae Argyi, the preparation method of medicine of the present invention is:
A) with Semen Vaccariae, Flos Carthami, Rhizoma Chuanxiong, Herba Hyperici Sampsonii, Jing Jie, Retinervus Luffae Fructus, the Herba Verbenae of described weight proportion, lose algae grass, Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Herba polygoni hydropiperis, Rhizoma Corydalis, Herba Solani Lyrati, Caulis Akebiae, Squama Manis, Rhizoma Dioscoreae Nipponicae the pure Chinese medicine of totally 17 flavors 70～80 ℃ of oven dry down, moisture Control is below 8%, to cross No. 3 sieve behind these Chinese medicine pulverize separately, get mixture 1;
B) with the pure Chinese medicine of the totally 16 flavors oven dry under 80～90 ℃ of Flos Lonicerae, fore-telling Huang, Olibanum, Preparatum Glycyrrhizae, Herba Violae, the Radix Angelicae Dahuricae, HUANGSHAOZI, Radix Glycyrrhizae, the Radix Astragali, Ramulus Euonymi, Spina Gleditsiae, Semen Persicae, Radix Ginseng, Radix Angelicae Sinensis, Fructus Lycii, Herba Epimedii, moisture Control is below 5%, to cross No. 6 sieve behind these Chinese medicine pulverize separately, get mixture 2;
C) under slow fire, use the vinegar parch after the pure Chinese medicine of totally 10 flavors mixes with Radix Scutellariae, Radix Paeoniae Rubra, FANSHU, dioecism momordica root, WUKOUZI, Radix Rhapontici, Fructus Aurantii Immaturus, QINGZHI, Fructus Gardeniae, Rhizoma Cyperi, get mixture 3;
D) under slow fire, use the brown sugar parch after the pure Chinese medicine of totally 6 flavors mixes with Herba Leonuri, Mahonia fortunei (Lindl.) Fedde, Radix Flemingiae Philippinensis, Radix Sophorae Flavescentis, the Radix Linderae, Folium Artemisiae Argyi, add the water steaming and decocting, for the first time add 8 times of amounts of water, steaming and decocting 1.5 hours adds 6 times of amounts of water for the second time, steaming and decocting 1 hour, add 4 times of amounts of water for the third time, steaming and decocting 0.5 hour is filtered respectively, after merging three filtrate, mixture 4;
E) mixture 1, mixture 2, mixture 3 are merged, add mixture 4 again, stirring and evenly mixing after fermentation 2 days is dried naturally, pulverizes No. 3 sieves of the whole mistakes in back, just has been prepared into the active component of medicine of the present invention.
Medicine of the present invention has to enrich blood invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, delivers rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy, regulating qi-flowing for strengthening spleen, reconciling superficies and interior, immunological enhancement, invigorating QI to consolidate the body surface resistance, holder skin ulcer granulation promoting, invigorating the spleen and replenishing QI, invigorating the spleen and benefiting QI, functions such as promoting diuresis to clear away damp pathogen, be used to prevent and treat ruminant post-natal diseases, can extrude milk up to standard in 4-8 hour after medication, female animal can normally oestrus, breed in the conventional time limit after wean.
The specific embodiment
Below further set forth the beneficial effect of medicine of the present invention by testing example, these are tested examples and have comprised that the safety testing (acute toxicity test and subchronic toxicity test) of medicine of the present invention (to call poultry health in puerperal in the following text) and clinical observation on the therapeutic effect test.
[test example 1] medicine of the present invention is to the acute toxicity test of white mice
1. test material
1.1 for the reagent thing
Poultry health in puerperal, the inferior animal husbandry of Hunan prestige Science and Technology Ltd. produces lot number: 20071005.
1.2 for the examination animal
50 of healthy mices, male and female half and half, body weight are 18～22g, available from laboratory animal portion of Central South University.
2. test method
50 white mice are divided into 5 groups at random, and 10 every group, male and female half and half are pressed the dose of 1g/kg body weight, 20g/kg body weight, 50g/kg body weight, 80g/kg body weight, five dosage groups of 120g/kg body weight respectively poultry health in puerperal one natural gift are irritated the stomach mice 5 times.After the administration, observe and write down the toxic reaction that animal is occurred in the 7d, add up the dead animal number and, then carry out histology's microscopy if any pathological tissues to the timely postmortem of dead animal.Calculate LD with the improvement karber's method
50And 95% average fiducial limit.
3. result and analysis
The The acute toxicity tests of table 1 poultry health in puerperal
| Group | Dosage g/kg body weight | Number of animals/only | Death toll/only | Mortality rate/% | Survival rate/% |
| 1 | 1 | 10 | 0 | 0 | 100 |
| 2 | 20 | 10 | 0 | 0 | 100 |
| 3 | 50 | 10 | 2 | 20 | 80 |
| 4 | 80 | 10 | 5 | 50 | 50 |
| 5 | 120 | 10 | 8 | 80 | 20 |
The acute toxicity tests sees Table 1.The result shows: behind the mice lavage medicine, first group and second group all survives, and clinical manifestation is normal; The 3rd group dead in 24h 2; The 4th group dead in 12h 5; The 5th group dead 8 at 4h.Poisoning white mice cardinal symptom is depressed, the dyspnea of spirit, based on ventral breathing, dead white mice is cutd open inspection, and finding has flatulence and bulge phenomenon, and remaining tissue there is no unusually.
Calculate poultry health in puerperal median lethal dose(LD 50) (LD for oral administration by the improvement karber's method
50) be the 72g/kg body weight, 95% average credible 68.4～80g/kg body weight that is limited to is judged the basic toxic formulation that is by the toxicity criterion.
4. conclusion
Poultry health in puerperal is given the median lethal dose(LD 50) (LD of mice lavage
50) be the 72g/kg body weight, be basic toxic formulation by safety of medicine toxicological evaluation standard, (1～20g/kg body weight) is safe in the medical treatment scope.
[test example 2] medicine of the present invention is to the subchronic toxicity test of rat
1. test material
1.1 for the reagent thing
Poultry health in puerperal, the inferior animal husbandry of Hunan prestige Science and Technology Ltd. produces lot number: 20071005.
1.2 for the examination animal
50 of healthy white rats, male and female half and half, body weight are 120～128g, available from laboratory animal portion of Central South University.
2. test method
Irritate stomach poultry health in puerperal 5g/kgd, 20g/kgd (be equivalent to clinical administration dosage 5 times, 20 times) respectively to rat, continuous four months, observe and the record toxic reaction that animal occurred, to physical signs inspections such as the blood routine examination of rat, liver function test, Electrocardioscopy, and anatomic observation is respectively organized the pathological change of internal organs during off-test.
3. result and analysis
3.1 the general activity after the two dosage group rat administrations, the mental status, hair, feces etc. there is no notable difference.
3.2 peripheral hemogram before and after the administration comprises that erythrocyte, leukocyte, erythrocyte, packed cell volume all fluctuate in normal range.
3.3 three livers (SGPT, SGOT), kidney (blood urea nitrogen, creatinine) functional parameter be there is no obvious influence.
3.4 during off-test, the content of total protein, albumin, alkali phosphatase is compared no significant difference with matched group in the animal serum.
3.5 Electrocardioscopy is all no abnormal.
3.6 each main organs macroscopy is not seen morphological changes of various tissue components such as obvious enlargement, hyperemia, necrosis.
3.7 the weight coefficient of the heart, liver, spleen, lung, kidney, thymus, adrenal gland, uterus, testis is compared with matched group, no significant difference.
3.8 histopathologic examination there is no unusual.
3.9 this medicine of above presentation of results is safer, in institute's amount of reagent scope.
4. conclusion
The subchronic toxicity test result of study shows: irritate stomach poultry health in puerperal 5g/kgd, 20g/kgd (be equivalent to clinical administration dosage 5 times, 20 times) respectively to rat, continuous four months, general activity after the administration of two dosage group rat, physical signs inspections such as blood routine examination, liver function test, Electrocardioscopy respectively organize the pathological change of internal organs to there is no unusually.Judge the basic toxic formulation that is by the toxicity criterion, (1～20g/kg body weight) is safe in the medical treatment scope.
The clinical efficacy test of [test example 3] medical treatment postpartum cow constitutional debility of the present invention and placenta retention
1. test material
1.1 for the reagent thing
Poultry health in puerperal, the inferior animal husbandry of Hunan prestige Science and Technology Ltd. produces lot number: 20071005.
1.2 for the examination animal
Cattle farm, step county, provincial capital, Hunan, puerperal, milch cow was 60, wherein had a delicate constitution 52 puerperal, 8 of placenta retention.
2. disease symptoms
Performance is uneasy, lassitude, and appetite is ruminated minimizing, and haunch is exerted duty, shows the posture of urinating, from the vaginal orifice banded afterbirth that hangs down, discharge kermesinus stench liquid from vagina when exerting duty, slight stomachache sometimes, body temperature is little high, milch cow hypogalactia in puerperal, mammary swelling is hard, and milk ejection is not smooth, and amount is few, the Tong pain of touching.Divide the puerperium to surpass 12 hours afterbirths and do not discharge, lassitude, loss of appetite, body temperature is more than 39 ℃, and haunch is exerted duty frequently.Or afterbirth normally comes off, but still the lochia amount is many a few days in puerperal, is dirty red, brown, and is stench, and slight stomachache is arranged.During examination per rectum, cornua uteri is asymmetric, and Uterus wall thickens, pressure fluctuation arranged.
3. test method
3.1 test grouping
Ill milch cow is divided into two groups at random, and 30 of treatment groups have a delicate constitution 26,4 of placenta retention, year mean age (3.5 ± 0.5), the course of disease (4 ± 3) sky; 30 of matched groups have a delicate constitution 26,4 of placenta retention, year mean age (3.5 ± 0.3), the course of disease (4 ± 2.5) sky; Two groups of ill milch cow ages, course of disease aspect differences do not have significance (P＞0.05), have comparability.
3.2 test method
The treatment group gives poultry health in puerperal, and matched group gives YIMUSHENGHUA SAN.For having a delicate constitution puerperal and the milch cow of placenta retention, two groups respectively every day Chinese medicines for oral administration 1 bag (500g), logotype 3～5 days.For the prolonged lochia symptom, two groups of difference Chinese medicine for oral administration every day 1 bags (500g), logotype 2～3 days.
3.3 the standard of efficacy determination
Cure: symptom and sign disappears; Produce effects: symptom and sign obviously improves;
Effectively: the more preceding improvement of symptom and sign; Invalid: symptom and sign no change and increasing the weight of.
4. result and analysis
4.1 clinical efficacy
Have a delicate constitution puerperal and the milch cow administration of placenta retention after 3～5 days, prolonged lochia symptom administration is after 2～3 days, treatment group total effective rate 100%, and matched group total effective rate 79.8% is analyzed through Ridit, and difference has significance (P＜0.05), sees Table 2.Prompting poultry health in puerperal treatment postpartum cow constitutional debility and placenta retention curative effect are better than YIMUSHENGHUA SAN.
The curative effect of table 2 poultry health in puerperal treatment postpartum cow constitutional debility and placenta retention
4.2 untoward reaction: treatment group and matched group incidence rate of adverse reaction are respectively 0% and 3.3%.Facts have proved that it is little that poultry health in puerperal is used for clinical toxic and side effects, no any untoward reaction after the medication, drug safety.
5. conclusion
The clinical efficacy result of study shows: poultry health in puerperal control postpartum cow constitutional debility and placenta retention safety, effective, its clinical cure rate 80%, obvious effective rate 16.7%, effective percentage 3.3%, total effective rate 100%; Matched group clinical cure rate 33.3%, obvious effective rate 36.7%, effective percentage 13.3%, inefficiency is 16.7%, total effective rate 79.8%.Two groups of total effective rates compare, P＜0.05, and difference has significance.Prompting poultry health in puerperal treatment postpartum cow constitutional debility and placenta retention curative effect are better than YIMUSHENGHUA SAN.
The untoward reaction observed result is shown: poultry Kang Wei in puerperal finds obvious toxic-side effects, and it is little that this product is used for clinical toxic and side effects, no any untoward reaction after the medication, drug safety.
This result of the test shows: poultry health in puerperal is the ideal medicament of control postpartum cow constitutional debility and placenta retention, its determined curative effect, and compatibility and processing technology are reasonable, no obvious toxic-side effects.
Come further to set forth the preparation method of medicine of the present invention by the following examples.
The powder preparation of [test example] medicine of the present invention
A) with Semen Vaccariae 60g, Flos Carthami 20g, Rhizoma Chuanxiong 30g, Herba Hyperici Sampsonii 30g, Jing Jie 30g, Retinervus Luffae Fructus 20g, Herba Verbenae 30g, lose algae grass 40g, Radix Angelicae Sinensis 40g, the sub-30g of the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae 10g, Herba polygoni hydropiperis 15g, Rhizoma Corydalis 20g, Herba Solani Lyrati 30g, Caulis Akebiae 30g, Squama Manis 10g, Rhizoma Dioscoreae Nipponicae 20g the pure Chinese medicine of totally 17 flavors 70～80 ℃ of oven dry down, moisture Control is below 8%, to cross No. 3 sieve behind these Chinese medicine pulverize separately, get mixture 1;
B) with Flos Lonicerae 20g, foretell yellow 30g, Olibanum 2g, Preparatum Glycyrrhizae 30g, Herba Violae 30g, Radix Angelicae Dahuricae 30g, HUANGSHAOZI 30g, Radix Glycyrrhizae 10g, Radix Astragali 20g, Ramulus Euonymi 15g, Spina Gleditsiae 20g, Semen Persicae 20g, Radix Ginseng 15g, Radix Angelicae Sinensis 5g, Fructus Lycii 30g, Herba Epimedii 10g the pure Chinese medicine of totally 16 flavors 80～90 ℃ of down oven dry, moisture Control is below 5%, to cross No. 6 sieve behind these Chinese medicine pulverize separately, get mixture 2;
C) under slow fire, use the vinegar parch after the pure Chinese medicine of totally 10 flavors mixes with Radix Scutellariae 20g, Radix Paeoniae Rubra 20g, FANSHU 20g, dioecism momordica root 30g, WUKOUZI 30g, Radix Rhapontici 20g, Fructus Aurantii Immaturus 15g, QINGZHI 25g, Fructus Gardeniae 30g, Rhizoma Cyperi 20g, get mixture 3;
D) under slow fire, use the brown sugar parch after the pure Chinese medicine of totally 6 flavors mixes with Herba Leonuri 60g, Mahonia fortunei (Lindl.) Fedde 30g, Radix Sophorae Flavescentis 50g, Radix Linderae 25g, Radix Flemingiae Philippinensis 10g, Folium Artemisiae Argyi 30g, add the water steaming and decocting, for the first time add 8 times of amounts of water, steaming and decocting 1.5 hours adds 6 times of amounts of water for the second time, steaming and decocting 1 hour, add 4 times of amounts of water for the third time, steaming and decocting 0.5 hour is filtered respectively, after merging three filtrate, mixture 4;
E) mixture 1, mixture 2, mixture 3 are merged, add mixture 4 again, stirring and evenly mixing after fermentation 2 days is dried naturally, pulverizes No. 3 sieves of the whole mistakes in back, in the aluminium plastic bag of packing into, goes into warehouse for finished product after the assay was approved.
Claims (11)
1, a kind of medicine of preventing and treating ruminant post-natal diseases is characterized in that it mainly is to be made by following bulk drugs: 55～65 parts of Semen Vaccariae, 16～23 parts on Flos Carthami, 26～34 parts of Rhizoma Chuanxiongs, 26～34 parts of Herba Hyperici Sampsoniis, 26～34 parts of Jing Jie, 16～23 parts of Retinervus Luffae Fructuss, 26～34 parts of Herba Verbenae, lose 35～45 parts of algae grass, 35～45 parts of Radix Angelicae Sinensis, 26～34 parts of Radix Paeoniae Alba, 8～12 parts of Radix Salviae Miltiorrhizaes, 12～18 parts of Herba polygoni hydropiperiss, 16～23 parts of Rhizoma Corydalis, 26～34 parts of Herba Solani Lyratis, 26～34 parts of Caulis Akebiaes, 8～12 parts of Squama Maniss, 16～23 parts of Rhizoma Dioscoreae Nipponicae; 16～23 parts of Flos Loniceraes, yellow 26～34 parts of fore-telling, 1.5～2.5 parts of Olibanums, 26～34 parts of Preparatum Glycyrrhizaes, 26～34 parts of Herba Violaes, 26～34 parts of the Radixs Angelicae Dahuricae, 26～34 parts of HUANGSHAOZI, 8～12 parts in Radix Glycyrrhizae, 16～23 parts of the Radixs Astragali, 12～18 parts of Ramulus Euonymis, 16～23 parts of Spina Gleditsiaes, 16～23 parts in Semen Persicae, 12～18 parts of Radix Ginsengs, 3～7 parts of Radix Angelicae Sinensis, 26～34 parts of Fructus Lycii, 8～12 parts of Herba Epimedii.
2, according to the medicine of claim 1, wherein the consumption of a crude drug is: 60 parts of Semen Vaccariae, 20 parts on Flos Carthami, 30 parts of Rhizoma Chuanxiongs, 30 parts of Herba Hyperici Sampsoniis, 30 parts of Jing Jie, 20 parts of Retinervus Luffae Fructuss, 30 parts of Herba Verbenae, lose 40 parts of algae grass, 40 parts of Radix Angelicae Sinensis, 30 parts of Radix Paeoniae Alba, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba polygoni hydropiperiss, 20 parts of Rhizoma Corydalis, 30 parts of Herba Solani Lyratis, 30 parts of Caulis Akebiaes, 10 parts of Squama Maniss, 20 parts of Rhizoma Dioscoreae Nipponicae; 20 parts of Flos Loniceraes, yellow 30 parts of fore-telling, 2 parts of Olibanums, 30 parts of Preparatum Glycyrrhizaes, 30 parts of Herba Violaes, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of HUANGSHAOZI, 10 parts in Radix Glycyrrhizae, 20 parts of the Radixs Astragali, 15 parts of Ramulus Euonymis, 20 parts of Spina Gleditsiaes, 20 parts in Semen Persicae, 15 parts of Radix Ginsengs, 5 parts of Radix Angelicae Sinensis, 30 parts of Fructus Lycii, 10 parts of Herba Epimedii.
3, according to the preparation method of claim 1 or 2 described medicines, it comprises the following steps:
A) take by weighing each crude drug Semen Vaccariae, Flos Carthami, Rhizoma Chuanxiong, Herba Hyperici Sampsonii, Jing Jie, Retinervus Luffae Fructus, Herba Verbenae, lose algae grass, Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Herba polygoni hydropiperis, Rhizoma Corydalis, Herba Solani Lyrati, Caulis Akebiae, Squama Manis, Rhizoma Dioscoreae Nipponicae; Flos Lonicerae, fore-telling Huang, Olibanum, Preparatum Glycyrrhizae, Herba Violae, the Radix Angelicae Dahuricae, HUANGSHAOZI, Radix Glycyrrhizae, the Radix Astragali, Ramulus Euonymi, Spina Gleditsiae, Semen Persicae, Radix Ginseng, Radix Angelicae Sinensis, Fructus Lycii, Herba Epimedii, standby.
B) with Semen Vaccariae, Flos Carthami, Rhizoma Chuanxiong, Herba Hyperici Sampsonii, Jing Jie, Retinervus Luffae Fructus, Herba Verbenae, lose the pure Chinese medicine of the totally 17 flavors oven dry of algae grass, Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Herba polygoni hydropiperis, Rhizoma Corydalis, Herba Solani Lyrati, Caulis Akebiae, Squama Manis, Rhizoma Dioscoreae Nipponicae, control moisture, to sieve behind these Chinese medicine pulverize separately, get mixture 1;
C) with the pure Chinese medicine oven dry of totally 16 flavors of Flos Lonicerae, fore-telling Huang, Olibanum, Preparatum Glycyrrhizae, Herba Violae, the Radix Angelicae Dahuricae, HUANGSHAOZI, Radix Glycyrrhizae, the Radix Astragali, Ramulus Euonymi, Spina Gleditsiae, Semen Persicae, Radix Ginseng, Radix Angelicae Sinensis, Fructus Lycii, Herba Epimedii, control moisture, to sieve behind these Chinese medicine pulverize separately, get mixture 2;
D) combined mixture 1 and mixture 2 are ground into powder with it, just have been prepared into the active component of medicine of the present invention.
4, according to the described medicine of claim 1, wherein crude drug also has: 16～23 parts of Radix Scutellariaes, 16～23 parts of Radix Paeoniae Rubra, 16～23 parts of FANSHU, 26～34 parts of dioecism momordica roots, 26～34 parts of WUKOUZI, 16～23 parts of Radix Rhapontici, 12～18 parts of Fructus Aurantii Immaturuss, 22～28 parts of QINGZHI, 26～34 parts of Fructus Gardeniaees, 16～23 parts of Rhizoma Cyperi.
5, medicine according to claim 4, wherein the consumption of each component is: 60 parts of Semen Vaccariae, 20 parts on Flos Carthami, 30 parts of Rhizoma Chuanxiongs, 30 parts of Herba Hyperici Sampsoniis, 30 parts of Jing Jie, 20 parts of Retinervus Luffae Fructuss, 30 parts of Herba Verbenae, lose 40 parts of algae grass, 40 parts of Radix Angelicae Sinensis, 30 parts of Radix Paeoniae Alba, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba polygoni hydropiperiss, 20 parts of Rhizoma Corydalis, 30 parts of Herba Solani Lyratis, 30 parts of Caulis Akebiaes, 10 parts of Squama Maniss, 20 parts of Rhizoma Dioscoreae Nipponicae; 20 parts of Flos Loniceraes, yellow 30 parts of fore-telling, 2 parts of Olibanums, 30 parts of Preparatum Glycyrrhizaes, 30 parts of Herba Violaes, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of HUANGSHAOZI, 10 parts in Radix Glycyrrhizae, 20 parts of the Radixs Astragali, 15 parts of Ramulus Euonymis, 20 parts of Spina Gleditsiaes, 20 parts in Semen Persicae, 15 parts of Radix Ginsengs, 5 parts of Radix Angelicae Sinensis, 30 parts of Fructus Lycii, 10 parts of Herba Epimedii; 20 parts of Radix Scutellariaes, 20 parts of Radix Paeoniae Rubra, 20 parts of FANSHU, 30 parts of dioecism momordica roots, 30 parts of WUKOUZI, 20 parts of Radix Rhapontici, 15 parts of Fructus Aurantii Immaturuss, 25 parts of QINGZHI, 30 parts of Fructus Gardeniaees, 20 parts of Rhizoma Cyperi.
6, the preparation method of claim 4 or 5 described medicines, it comprises the following steps:
A) take by weighing each crude drug Semen Vaccariae, Flos Carthami, Rhizoma Chuanxiong, Herba Hyperici Sampsonii, Jing Jie, Retinervus Luffae Fructus, Herba Verbenae, lose algae grass, Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Herba polygoni hydropiperis, Rhizoma Corydalis, Herba Solani Lyrati, Caulis Akebiae, Squama Manis, Rhizoma Dioscoreae Nipponicae; Flos Lonicerae, fore-telling Huang, Olibanum, Preparatum Glycyrrhizae, Herba Violae, the Radix Angelicae Dahuricae, HUANGSHAOZI, Radix Glycyrrhizae, the Radix Astragali, Ramulus Euonymi, Spina Gleditsiae, Semen Persicae, Radix Ginseng, Radix Angelicae Sinensis, Fructus Lycii, Herba Epimedii, Radix Scutellariae, Radix Paeoniae Rubra, FANSHU, dioecism momordica root, WUKOUZI, Radix Rhapontici, Fructus Aurantii Immaturus, QINGZHI, Fructus Gardeniae, Rhizoma Cyperi, standby.
B) with Semen Vaccariae, Flos Carthami, Rhizoma Chuanxiong, Herba Hyperici Sampsonii, Jing Jie, Retinervus Luffae Fructus, Herba Verbenae, lose the pure Chinese medicine of the totally 17 flavors oven dry of algae grass, Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Herba polygoni hydropiperis, Rhizoma Corydalis, Herba Solani Lyrati, Caulis Akebiae, Squama Manis, Rhizoma Dioscoreae Nipponicae, control moisture, to sieve behind these Chinese medicine pulverize separately, get mixture 1;
C) with the pure Chinese medicine oven dry of totally 16 flavors of Flos Lonicerae, fore-telling Huang, Olibanum, Preparatum Glycyrrhizae, Herba Violae, the Radix Angelicae Dahuricae, HUANGSHAOZI, Radix Glycyrrhizae, the Radix Astragali, Ramulus Euonymi, Spina Gleditsiae, Semen Persicae, Radix Ginseng, Radix Angelicae Sinensis, Fructus Lycii, Herba Epimedii, control moisture, to sieve behind these Chinese medicine pulverize separately, get mixture 2;
D) with the pure Chinese medicine mixing parch of totally 10 flavors of Radix Scutellariae, Radix Paeoniae Rubra, FANSHU, dioecism momordica root, WUKOUZI, Radix Rhapontici, Fructus Aurantii Immaturus, QINGZHI, Fructus Gardeniae, Rhizoma Cyperi, get mixture 3;
E) mixture 1, mixture 2, mixture 3 are merged, the stirring and evenly mixing after fermentation is dried, and pulverizes, and just has been prepared into the active component of medicine of the present invention.
7, according to the medicine of claim 4, wherein also have in the crude drug: 55～65 parts of Herba Leonuris, 26～34 parts of Mahonia fortunei (Lindl.) Fedde, 45～55 parts of Radix Sophorae Flavescentiss, 22～28 parts of the Radixs Linderae, 8～12 parts of Radix Flemingiae Philippinensiss, 26～34 parts of Folium Artemisiae Argyis.
8, medicine according to claim 7, wherein the consumption of each component is: 60 parts of Semen Vaccariae, 20 parts on Flos Carthami, 30 parts of Rhizoma Chuanxiongs, 30 parts of Herba Hyperici Sampsoniis, 30 parts of Jing Jie, 20 parts of Retinervus Luffae Fructuss, 30 parts of Herba Verbenae, lose 40 parts of algae grass, 40 parts of Radix Angelicae Sinensis, 30 parts of Radix Paeoniae Alba, 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba polygoni hydropiperiss, 20 parts of Rhizoma Corydalis, 30 parts of Herba Solani Lyratis, 30 parts of Caulis Akebiaes, 10 parts of Squama Maniss, 20 parts of Rhizoma Dioscoreae Nipponicae; 20 parts of Flos Loniceraes, yellow 30 parts of fore-telling, 2 parts of Olibanums, 30 parts of Preparatum Glycyrrhizaes, 30 parts of Herba Violaes, 30 parts of the Radixs Angelicae Dahuricae, 30 parts of HUANGSHAOZI, 10 parts in Radix Glycyrrhizae, 20 parts of the Radixs Astragali, 15 parts of Ramulus Euonymis, 20 parts of Spina Gleditsiaes, 20 parts in Semen Persicae, 15 parts of Radix Ginsengs, 5 parts of Radix Angelicae Sinensis, 30 parts of Fructus Lycii, 10 parts of Herba Epimedii; 20 parts of Radix Scutellariaes, 20 parts of Radix Paeoniae Rubra, 20 parts of FANSHU, 30 parts of dioecism momordica roots, 30 parts of WUKOUZI, 20 parts of Radix Rhapontici, 15 parts of Fructus Aurantii Immaturuss, 25 parts of QINGZHI, 30 parts of Fructus Gardeniaees, 20 parts of Rhizoma Cyperi; 60 parts of Herba Leonuris, 30 parts of Mahonia fortunei (Lindl.) Fedde, 50 parts of Radix Sophorae Flavescentiss, 25 parts of the Radixs Linderae, 10 parts of Radix Flemingiae Philippinensiss, 30 parts of Folium Artemisiae Argyis.
9, according to the preparation method of claim 7 or 8 described medicines, it comprises the following steps:
A) take by weighing each crude drug Semen Vaccariae, Flos Carthami, Rhizoma Chuanxiong, Herba Hyperici Sampsonii, Jing Jie, Retinervus Luffae Fructus, Herba Verbenae, lose algae grass, Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Herba polygoni hydropiperis, Rhizoma Corydalis, Herba Solani Lyrati, Caulis Akebiae, Squama Manis, Rhizoma Dioscoreae Nipponicae; Flos Lonicerae, fore-telling Huang, Olibanum, Preparatum Glycyrrhizae, Herba Violae, the Radix Angelicae Dahuricae, HUANGSHAOZI, Radix Glycyrrhizae, the Radix Astragali, Ramulus Euonymi, Spina Gleditsiae, Semen Persicae, Radix Ginseng, Radix Angelicae Sinensis, Fructus Lycii, Herba Epimedii, Radix Scutellariae, Radix Paeoniae Rubra, FANSHU, dioecism momordica root, WUKOUZI, Radix Rhapontici, Fructus Aurantii Immaturus, QINGZHI, Fructus Gardeniae, Rhizoma Cyperi, Herba Leonuri, Mahonia fortunei (Lindl.) Fedde, Radix Flemingiae Philippinensis, Radix Sophorae Flavescentis, the Radix Linderae, Folium Artemisiae Argyi, standby.
B) with Semen Vaccariae, Flos Carthami, Rhizoma Chuanxiong, Herba Hyperici Sampsonii, Jing Jie, Retinervus Luffae Fructus, Herba Verbenae, lose the pure Chinese medicine of the totally 17 flavors oven dry of algae grass, Radix Angelicae Sinensis, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Herba polygoni hydropiperis, Rhizoma Corydalis, Herba Solani Lyrati, Caulis Akebiae, Squama Manis, Rhizoma Dioscoreae Nipponicae, control moisture, to sieve behind these Chinese medicine pulverize separately, get mixture 1;
C) with the pure Chinese medicine oven dry of totally 16 flavors of Flos Lonicerae, fore-telling Huang, Olibanum, Preparatum Glycyrrhizae, Herba Violae, the Radix Angelicae Dahuricae, HUANGSHAOZI, Radix Glycyrrhizae, the Radix Astragali, Ramulus Euonymi, Spina Gleditsiae, Semen Persicae, Radix Ginseng, Radix Angelicae Sinensis, Fructus Lycii, Herba Epimedii, control moisture, to sieve behind these Chinese medicine pulverize separately, get mixture 2;
D) with the pure Chinese medicine mixing parch of totally 10 flavors of Radix Scutellariae, Radix Paeoniae Rubra, FANSHU, dioecism momordica root, WUKOUZI, Radix Rhapontici, Fructus Aurantii Immaturus, QINGZHI, Fructus Gardeniae, Rhizoma Cyperi, get mixture 3;
E) with Herba Leonuri, Mahonia fortunei (Lindl.) Fedde, Radix Flemingiae Philippinensis, Radix Sophorae Flavescentis, the Radix Linderae, Folium Artemisiae Argyi the pure Chinese medicine of totally 6 flavors mix the back parch, steaming and decocting is filtered, merges three filtrate after, get mixture 4;
F) mixture 1, mixture 2, mixture 3 are merged, add mixture 4 again, fermentation is dried, and just has been prepared into the active component of medicine of the present invention.
10, the preparation method of the described medicine of claim 9, the active component that wherein step f) is made is pulverized, and in the aluminium plastic bag of packing into, can go into warehouse for finished product after the assay was approved.
11, according to the method for claim 3,6 or 9 described medicines, wherein bake out temperature is 70～80 ℃ in the process of preparation mixture 1, and moisture Control is pulverized the back and crossed sieve No. 3 below 8%; Bake out temperature is 80～90 ℃ in the process of preparation mixture 2, and moisture Control is pulverized the back and crossed sieve No. 6 below 5%; The duration and degree of heating of vinegar parch is a slow fire in the process of preparation mixture 3; The duration and degree of heating of brown sugar parch is a slow fire in the process of preparation mixture 4, when medicine is added water steaming and decocting extraction, adds 8 times of amounts of water for the first time, and steaming and decocting 1.5 hours adds 6 times of amounts of water for the second time, and steaming and decocting 1 hour adds 4 times of amounts of water, steaming and decocting 0.5 hour for the third time; The stirring and evenly mixing after fermentation is 2 days in step f), dries naturally, pulverizes No. 3 sieves of the whole mistakes in back.
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| CN101879240A (en) * | 2010-07-20 | 2010-11-10 | 宁夏大学 | Chinese medicinal compound suppository for treating endometritis of livestock and preparation method thereof |
| CN101879240B (en) * | 2010-07-20 | 2011-08-17 | 宁夏大学 | Chinese medicinal compound suppository for treating endometritis of livestock and preparation method thereof |
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| CN102988788B (en) * | 2011-11-15 | 2014-06-04 | 王延飒 | Traditional Chinese medicine for treating chronic pelvic inflammatory disease and clysis nursing method |
| CN103340312A (en) * | 2013-07-11 | 2013-10-09 | 曾勇 | Feed additive for preventing dairy cow mastitis |
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| CN103349771B (en) * | 2013-07-25 | 2015-09-02 | 恒盛高科（天津）生物技术有限公司 | A kind of Chinese medicine composition for the treatment of dog puerperal hypogalactia |
| CN104304809A (en) * | 2014-11-09 | 2015-01-28 | 蒋法成 | Feed additive for cow during lactation period and application of feed additive |
| CN104304809B (en) * | 2014-11-09 | 2016-08-17 | 蒋法成 | Milk cow in lactation period feed additive and application thereof |
| CN107753636A (en) * | 2016-08-22 | 2018-03-06 | 北京大伟嘉生物技术股份有限公司 | A kind of compound Chinese herb powder for sows in perinatal period health care |
| CN109971543A (en) * | 2019-03-18 | 2019-07-05 | 湖北中烟工业有限责任公司 | The method for preparing cigarette Luo Han Guo Paste In Foods with arhat fruit tincture residue using cigarette |
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