CN101879240A - Chinese medicinal compound suppository for treating endometritis of livestock and preparation method thereof - Google Patents
Chinese medicinal compound suppository for treating endometritis of livestock and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine, in particular to a Chinese medicinal compound suppository for treating endometritis of livestock and a preparation method thereof. The Chinese medicinal compound suppository is prepared by mixing 1 to 2 parts of golden thread, 1 part of cortex phellodendri, 1 part of lightyellow sophora root, 1 to 2 parts of leonurus heterophyllus, 1 to 2 parts of safflower, 1 to 2 parts of Chinese angelica, 1 part of astragalus and a suppository matrix. The method for preparing the Chinese medicinal compound suppository for treating the endometritis of the livestock comprises the following steps of: extraction of active ingredients of each traditional Chinese medicine, concentrating, drying, pulverizing and preparation of the suppository. The suppository has the advantages of pure Chinese medicinal preparation, no problem of antibiotic residues, stable medicinal quality and easy carrying and storage. For the acute endometritis and hidden endometritis of dairy cattle, the two Chinese medicinal suppositories are put into uteruses once every other day, and after the Chinese medicinal suppositories are used continuously for three times, the curative rate reaches 83 percent; and for the hidden endometritis of the dairy cattle during oestrum, the two suppositories are dissolved in 50 milliliters of physiological saline to perform the treatment of intrauterine administration, the suppositories are used once every other day and are used continuously for three times, and the curative rate reaches 62.5 percent.
Description
Technical field
The present invention relates to a kind of Chinese medicine, particularly treat Chinese medicine compound suppository of endometritis of livestock and preparation method thereof.
Background technology
Endometritis is a kind of common milch cow reproductive system disease, the endometrial mucus or the purulent inflammation that generally take place in puerperal.Because the inflammation course of disease, inflammatory products and bacteriotoxic influence that are subjected to uterine mucosa make the disorder of domestic animal sexual cycle, directly endanger the vigor and the embryo nidation of sperm again, cause breeding infertile, be the one of the main reasons that causes the domestic animal infertility.The sickness rate of cow endometritis is very high, the foreign statistic cow endometritis sickness rate average out to 30%-40% that grows up, and China's sickness rate is about 20%-50%, milk was discarded during endometritis made calving interval prolongation, milk yield minimizing, mortality increase, medical expense increase and antibiotic therapy, cause very big economic loss, very big to the economic benefit influence of dairy.Bow plain prunus mume (sieb.) sieb.et zucc. etc. (is bent plain prunus mume (sieb.) sieb.et zucc. in the prior art, Ni Yaodi, Guo Hongbin. research [J] the Hubei animal and veterinary of the biochemical bolt of treatment cow endometritis Herba Leonuri, 2006 (7): 19-20) adopt and will prepare suppository behind Chinese powder medicine and the drug matrices mixing, by rectally treatment cow endometritis.Cure 40 after using the biochemical bolt treatment of Herba Leonuri, cure rate is 95.24%.The suppository quality and the volume of this method preparation are bigger, and the targeting of administration is not strong.
Summary of the invention
The present invention is on treatment endometritis of livestock Chinese medicine proved recipe basis, pharmaceutically active ingredient in the extraction, by extracorporeal bacteria inhibitor test Chinese prescription optimization is determined singly to put forward composite compound method, further prepare dry extract then, after the drying it is prepared into powder, then with substrate be mixed with out a kind of, volume less action time persistent efficient, low-residual Chinese medicine intrauterine administration suppository.
For achieving the above object, the solution of the present invention is as follows: 1, a kind of Chinese medicine compound suppository for the treatment of endometritis of livestock is characterized in that this Chinese medicine compound suppository is to make compound suppository after being mixed by 1～2 portion of Rhizoma Coptidis, 1 portion of Cortex Phellodendri, 1 part of Radix Sophorae Flavescentis, 1～2 part of Herba Leonuri, 1～2 part of Flos Carthami, 1～2 part of Radix Angelicae Sinensis, 1 part of Radix Astragali and suppository base.
Above-mentioned Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Leonuri, Flos Carthami, Radix Angelicae Sinensis and the Radix Astragali are after independent extraction, make Chinese medicine extract dry powder, make Chinese medicine compound suppository then with after suppository base mixes.
Above-mentioned suppository base is that Tween 80 and Polyethylene Glycol are formed, and wherein Polyethylene Glycol is made up of Macrogol 600 and polyethylene glycol 6000.
Above-mentioned Chinese medicine compound suppository is made up of 25%～40% Chinese medicine extract dry powder and 3%～10% Tween 80,28%～35% Macrogol 600 (PEG600) and 25%～35% polyethylene glycol 6000 (PEG6000).
The method of the Chinese medicine compound suppository of preparation treatment endometritis of livestock, its preparation process is:
1) each Chinese medicine extracts active ingredients:
1. the extraction of Rhizoma Coptidis: at first Rhizoma Coptidis powder is broken to about 50 orders, it is 80% alcoholic solution that Rhizoma Coptidis after will pulverizing is then put into volumetric concentration, adopt supersound extraction, extract each extraction time 20-40min 2 times, extract about 50 ℃ of temperature, alcoholic solution during extraction and the weight ratio of Rhizoma Coptidis are respectively 1:8-10; After the solution of extracted twice mixed, filters, collect filtrate and be condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
2. the extraction of Cortex Phellodendri: at first with after the Cortex Phellodendri section, put into volumetric concentration and be 55% alcoholic solution, adopt reflux, extract,, extract 2 times, each extraction time 60-120min extracts about 80 ℃ of temperature, and alcoholic solution during extraction and the weight ratio of Cortex Phellodendri are 1:8; After the solution of extracted twice mixed, filters, collect filtrate and be condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
3. the extraction of Radix Sophorae Flavescentis: at first with behind the Cortex Phellodendri shave, put into volumetric concentration and be 60% alcoholic solution, adopt reflux, extract,, extract 3 times, each extraction time 90-150min extracts about 80 ℃ of temperature, and alcoholic solution during extraction and the weight ratio of Cortex Phellodendri are 1:6-8; After the solution that extracts for three times mixed, filters, collect filtrate, be condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
4. the extraction of Herba Leonuri: at first Herba Leonuri is cut into the section of 1-2 ㎝, puts into water, adopt decocting method to extract, extract 2 times, each 2-12 hours extraction times, the water during extraction and the weight ratio of Herba Leonuri are 1:8-12; After the solution of extracted twice mixed, filters, be concentrated into every milliliter of fluid extract that is equivalent to 1 gram crude drug, in fluid extract, add an amount of dehydrated alcohol then, precipitate after 10-12 hours, collect supernatant, again supernatant is condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
5. the extraction of Flos Carthami: Flos Carthami put into the sealed container that volumetric concentration is 70% methanol solution is housed, the employing infusion process is extracted, 10-14 hours extraction times, alcoholic solution during extraction and the weight ratio of Flos Carthami are 1:10-12, and the filtrate after extracting is condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
6. the extraction of Radix Angelicae Sinensis: at first Radix Angelicae Sinensis is thinly sliced, decocting for Chinese herbal medicine method routinely decocts 2 times, after the extraction solution after 2 times are decocted mixes, is condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
7. the extraction of the Radix Astragali: at first the Radix Astragali is thinly sliced, decocting for Chinese herbal medicine method routinely decocts 3 times, after the extraction solution after 3 times are decocted mixes, is condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
2) dry, pulverize: the concentrated medicament of the various medicines of above-mentioned preparation is mixed, centrifugal removal precipitation, supernatant is 60 ℃ a baking oven inner drying in temperature, pulverizes dried extractum standby;
3) preparation of suppository: at first put into Macrogol 600, polyethylene glycol 6000, soil temperature 80 in the water-bath about 60-65 ℃ in proportion respectively, after under stirring, fully dissolving, add above-mentioned concentrate drying, the Chinese medicine extract after pulverizing, behind the mixing, pour in the mould that scribbles paraffin oil, mould is placed in 4 ℃ of refrigerators, take out after 20-30 minutes, pour out suppository and be finished product Chinese medicine compound suppository.
The present invention has following characteristics: 1
,Pure Chinese medicinal preparation, the antibiotic-free residue problem.Because endometritis occurs in puerperal mostly, traditional antibiotic therapy causes a large amount of milk of abandoning, and development brings about great losses to dairy industry.Adopt the Chinese herbal treatment cow endometritis can effectively avoid this class loss.
2, the Chinese medicine filling agent easily precipitated in preserving because volume is bigger, and owing to be plant extract, preserved improper meeting and corruption occurs, and the holding time is not long.This Chinese medicine suppository drug quality is stable, carries easily and preserves, and has overcome the above shortcoming of filling agent.
3, therapeutic effect, the acute endometritis milch cow of before test uterus in 15 days puerperal is non-latching, taking place, throw in two pieces of this Chinese medicine suppository by intrauterine, every other day once, cure rate reaches 83% after the logotype three times, stealthy endometritis in oestrus, is dissolved in intrauterine drug treatment in 50 ml physiological salines with two pieces of suppositorys, and three cure rates of a logotype reach 62.5% every other day.
The specific embodiment
Embodiment 1:
1, Chinese medicine extracts active ingredients
(1) active ingredient extracts in the Rhizoma Coptidis: Rhizoma Coptidis was pulverized 50 mesh sieves, and getting Golden Thread 2 grams after the pulverizing, to add volumetric concentrations be about 20 milliliters of 80% ethanol, puts into the ultrasonic extraction device, extracts 30min at 50 ℃, and filtered through gauze is collected filtrate; Add 16 ml volumes concentration again and be 80% alcohol in medicinal residues, supersound extraction 40min merges collected filtrate twice once more, and filtrate is condensed into fluid extract about 2 milliliters with Rotary Evaporators.
(2) extracts active ingredients in the Cortex Phellodendri: take by weighing Cortex Phellodendri medical material 1 gram of thinly slicing and drop in the round-bottomed flask, adding volumetric concentration to flask again is about 8 milliliters of 55% ethanol, puts into the water-bath reflux, extract, 90min about 80 ℃, and filtered through gauze is collected filtrate.Medicinal residues are extracted once according to repeating for the first time again, and extraction time 120min merges filtrate twice, and filtrate is condensed into fluid extract about 1 milliliter with Rotary Evaporators.
(3) Radix Sophorae Flavescentis extracts active ingredients: take by weighing Radix Sophorae Flavescentis medical material 1 gram of thinly slicing and drop in the round-bottomed flask, adding volumetric concentration to flask again is about 8 milliliters of 60% ethanol, puts into the water-bath reflux, extract, 120min about 80 ℃, and filtered through gauze is collected filtrate.According to for the first time repeating to extract twice again, the time of back extracted twice is respectively 90 and 150min with medicinal residues.Merge three times filtrate, be condensed into fluid extract about 1 milliliter with Rotary Evaporators collecting filtrate.
(4) Herba Leonuri extracts active ingredients: take by weighing Herba Leonuri 2 grams that are cut into about 2cm, put into marmite and add 24 milliliters in water, decoct 12h, filtered through gauze is collected filtrate.Adding entry 18 ml waters in medicinal residues again decocted after two hours, filter the back and merge twice filtrate, be concentrated into every milliliter of fluid extract that is equivalent to 1 gram crude drug, and then in fluid extract, add about 6 milliliters of dehydrated alcohol, precipitate and get supernatant after 12 hours, supernatant is condensed into fluid extract about 2 milliliters with Rotary Evaporators.
(5) safflower effective ingredients extracts: with Flos Carthami 2 grams that take by weighing, put into that 24 ml volumes concentration are housed is the sealed container of 70% methanol, behind normal temperature dipping 12h, filter and collect filtrate, with filtrate at the fluid extract that is condensed on the Rotary Evaporators about 2 milliliters.
(6) Radix Angelicae Sinensis extracts active ingredients: take by weighing and thinly slice Radix Angelicae Sinensis medical material 1 gram, decocting for Chinese herbal medicine method routinely decocts 2 times, after the extraction solution after 2 times are decocted mixes, with filtrate at the fluid extract that is condensed on the Rotary Evaporators about 1 milliliter.
(7) Radix Astragali extracts active ingredients: take by weighing Milkvetch Root 1 gram of thinly slicing, decocting for Chinese herbal medicine method routinely decocts 3 times, after the extraction solution mixing with 3 decoctions, at the fluid extract that is condensed on the Rotary Evaporators about 1 milliliter.
2, Chinese medicine compound compatibility and extract dry powder preparation;
The fluid extract of each flavor Chinese medicine is mixed, behind static 2 hours of the room temperature, it is centrifugal to put into centrifuge, collect supernatant, with supernatant place be concentrated into slightly thickness on the Rotary Evaporators after, move into white disk and place drying baker, be dried to dry extract, dry extract is ground make Chinese medical concrete dry powder then at 60 ℃.
3, suppository preparation;
With 12.5g Macrogol 600,12.5g polyethylene glycol 6000,2.5g Tween 80, place 65 ℃ of water-bath heating and melting to mix, slowly adding the above-mentioned grinding that is mixed in proportion makes the medicine 10g of Chinese medical concrete dry powder and stirs, pour in the suppository mould, the suppository mould was put into 4 ℃ of refrigerators after 30 minutes, taking-up demoulding finishing is finished product Chinese medicine compound suppository.This Chinese medicine compound suppository smooth surface, drug distribution evenly is sepia, and aromatic odor is arranged, and certain degree of hardness is arranged.
4, clinical effectiveness is observed.
Be chosen at 20 of the acute endometritis milch cows that uterus in 15 days puerperal takes place before non-latching, throw in two pieces of this Chinese medicine compound suppositorys by intrauterine, every other day once, cure rate reaches 80% after the logotype three times.Stealthy endometritis is chosen 20 the milch cow in oestrus, two pieces of suppositorys are dissolved in 50 ml physiological salines, the intrauterine drug treatment, three cure rates of a logotype reach 65% every other day.
| The cow endometritis type | A treatment number (head) | Cure a number (head) | Cure rate (%) |
| Acute endometritis | 20 | 16 | 80 |
| Recessive endometritis | 20 | 13 | 65 |
Embodiment 2:
On the basic basis of invariable of Chinese medicine extracts active ingredients of embodiment 1, it is as follows to change the suppository prescription:
Place 65 ℃ of water-bath heating and melting to stir 10g Macrogol 600,8g polyethylene glycol 6000,1g Tween 80, mixing, slowly add medicine 12g and stir, pour into 5 gram suppository moulds, put into 4 ℃ of refrigerators and took out demoulding rest and reorganization in 30 minutes.Prepare Chinese medicine suppository.The suppository smooth surface of system, drug distribution evenly is sepia, and aromatic odor is arranged, and certain degree of hardness is arranged.
4, clinical effectiveness is observed.
Be chosen at 20 of the acute endometritis milch cows that uterus in 15 days puerperal takes place before non-latching, throw in two pieces of this Chinese medicine suppository by intrauterine, every other day once, cure rate reaches 90% after the logotype three times.Stealthy endometritis is chosen 20 the milch cow in oestrus, two pieces of suppositorys are dissolved in intrauterine drug treatment in 50 ml physiological salines, three cure rates of a logotype reach 65% every other day.
| The cow endometritis type | A treatment number (head) | Cure a number (head) | Cure rate (%) |
| Acute endometritis | 20 | 18 | 90 |
| Recessive endometritis | 20 | 13 | 65 |
In the foregoing description 1,2, the preparation of fluid extract prepares according to the pharmacopeia regulation.Pharmacopeia regulation: fluid extract, extractum mean that medical material extracts with The suitable solvent, boil off all or part of solvent, are adjusted to normal concentration and the preparation made.Each milliliter of fluid extract is equivalent to raw material one gram.
Milk that milch cow produces in the therapeutic process is carried out antibiotic measure, all antibiotic-free is residual in the milk.
Claims (5)
1. Chinese medicine compound suppository for the treatment of endometritis of livestock is characterized in that this Chinese medicine compound suppository is to make compound suppository after being mixed by 1～2 portion of Rhizoma Coptidis, 1 portion of Cortex Phellodendri, 1 part of Radix Sophorae Flavescentis, 1～2 part of Herba Leonuri, 1～2 part of Flos Carthami, 1～2 part of Radix Angelicae Sinensis, 1 part of Radix Astragali and suppository base.
2. the Chinese medicine compound suppository of treatment endometritis of livestock according to claim 1, it is characterized in that above-mentioned Rhizoma Coptidis, Cortex Phellodendri, Radix Sophorae Flavescentis, Herba Leonuri, Flos Carthami, Radix Angelicae Sinensis and the Radix Astragali are after independent extraction, make Chinese medicine extract dry powder, make Chinese medicine compound suppository then with after suppository base mixes.
3. the Chinese medicine compound suppository of treatment endometritis of livestock according to claim 1 and 2 is characterized in that above-mentioned suppository base is that Tween 80 and Polyethylene Glycol are formed, and wherein Polyethylene Glycol is made up of Macrogol 600 and polyethylene glycol 6000.
4. the Chinese medicine compound suppository of treatment endometritis of livestock according to claim 3 is characterized in that above-mentioned Chinese medicine compound suppository is made up of 25%～40% Chinese medicine extract dry powder and 3%～10% Tween 80,28%～35% Macrogol 600 (PEG600) and 25%～35% polyethylene glycol 6000 (PEG6000).
5. prepare the method for the Chinese medicine compound suppository of above-mentioned any described treatment endometritis of livestock of claim, its preparation process is:
1) each Chinese medicine extracts active ingredients:
1. the extraction of Rhizoma Coptidis: at first Rhizoma Coptidis powder is broken to about 50 orders, it is 80% alcoholic solution that Rhizoma Coptidis after will pulverizing is then put into volumetric concentration, adopt supersound extraction, extract each extraction time 20-40min 2 times, extract about 50 ℃ of temperature, alcoholic solution during extraction and the weight ratio of Rhizoma Coptidis are respectively 1:8-10; After the solution of extracted twice mixed, filters, collect filtrate and be condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
2. the extraction of Cortex Phellodendri: at first with after the Cortex Phellodendri section, put into volumetric concentration and be 55% alcoholic solution, adopt reflux, extract,, extract 2 times, each extraction time 60-120min extracts about 80 ℃ of temperature, and alcoholic solution during extraction and the weight ratio of Cortex Phellodendri are 1:8; After the solution of extracted twice mixed, filters, collect filtrate and be condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
3. the extraction of Radix Sophorae Flavescentis: at first with behind the Cortex Phellodendri shave, put into volumetric concentration and be 60% alcoholic solution, adopt reflux, extract,, extract 3 times, each extraction time 90-150min extracts about 80 ℃ of temperature, and alcoholic solution during extraction and the weight ratio of Cortex Phellodendri are 1:6-8; After the solution that extracts for three times mixed, filters, collect filtrate, be condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
4. the extraction of Herba Leonuri: at first Herba Leonuri is cut into the section of 1-2 ㎝, puts into water, adopt decocting method to extract, extract 2 times, each 2-12 hours extraction times, the water during extraction and the weight ratio of Herba Leonuri are 1:8-12; After the solution of extracted twice mixed, filters, be concentrated into every milliliter of fluid extract that is equivalent to 1 gram crude drug, in fluid extract, add an amount of dehydrated alcohol then, precipitate after 10-12 hours, collect supernatant, again supernatant is condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
5. the extraction of Flos Carthami: Flos Carthami put into the sealed container that volumetric concentration is 70% methanol solution is housed, the employing infusion process is extracted, 10-14 hours extraction times, alcoholic solution during extraction and the weight ratio of Flos Carthami are 1:10-12, and the filtrate after extracting is condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
6. the extraction of Radix Angelicae Sinensis: at first Radix Angelicae Sinensis is thinly sliced, decocting for Chinese herbal medicine method routinely decocts 2 times, after the extraction solution after 2 times are decocted mixes, is condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
7. the extraction of the Radix Astragali: at first the Radix Astragali is thinly sliced, decocting for Chinese herbal medicine method routinely decocts 3 times, after the extraction solution after 3 times are decocted mixes, is condensed into every milliliter of fluid extract that is equivalent to 1 gram crude drug;
2) concentrate drying, pulverizing: the medicinal liquid that the various medicines of above-mentioned preparation are condensed into mixes, and supernatant is collected in centrifugal back, with standby after supernatant concentration, drying, the pulverizing;
3) preparation of suppository: at first put into Macrogol 600, polyethylene glycol 6000, soil temperature 80 in the water-bath about 60-65 ℃ in proportion respectively, after under stirring, fully dissolving, add above-mentionedly concentrate, dry, the Chinese medicine extract after pulverizing, behind the mixing, pour in the mould that scribbles paraffin oil, mould is placed in 4 ℃ of refrigerators, take out after 20-30 minutes, pour out suppository and be finished product Chinese medicine compound suppository.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000145A (en) * | 2010-12-16 | 2011-04-06 | 南京日升昌生物技术有限公司 | Traditional Chinese medicine and western medicine compound infusion liquid for preventing and treating endometritis of dam and preparing method thereof |
| CN102743503A (en) * | 2012-07-13 | 2012-10-24 | 宁夏大学 | Method for preparing Chinese medicinal compound effervescent tablets for treating endometritis of cows |
| CN104173630A (en) * | 2014-08-19 | 2014-12-03 | 河南华牧生物科技有限公司 | Chinese traditional medicine perfusate for treating endometritis of cows and preparation process of Chinese traditional medicine perfusate |
| CN106983831A (en) * | 2017-05-22 | 2017-07-28 | 南宁学院 | A kind of composition of prevention bovine endometritis |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086724A (en) * | 1993-08-04 | 1994-05-18 | 李社伦 | Atomized pudendal cleaning liquid |
| CN1401374A (en) * | 2002-07-18 | 2003-03-12 | 李洪国 | Semifluid motherwort extract and producing process thereof |
| CN1559470A (en) * | 2004-03-01 | 2005-01-05 | 王原成 | Chinese patent drug for livestock |
| CN101564486A (en) * | 2008-04-22 | 2009-10-28 | 赵松柏 | Medicament for preventing and treating ruminant post-natal diseases and preparation method thereof |
| CN101612282A (en) * | 2008-06-23 | 2009-12-30 | 孙爱东 | Method for treating chronic endometritis of cattle by using traditional Chinese medicine |
| CN101618134A (en) * | 2008-07-06 | 2010-01-06 | 王丽平 | Method for treating chronic uterine inflammation of pigs by using traditional Chinese medicine |
| CN101623056A (en) * | 2009-07-31 | 2010-01-13 | 山西天沐合生农牧科技开发有限公司 | Chinese herbal medicine feed additive for ewes |
-
2010
- 2010-07-20 CN CN2010102307177A patent/CN101879240B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086724A (en) * | 1993-08-04 | 1994-05-18 | 李社伦 | Atomized pudendal cleaning liquid |
| CN1401374A (en) * | 2002-07-18 | 2003-03-12 | 李洪国 | Semifluid motherwort extract and producing process thereof |
| CN1559470A (en) * | 2004-03-01 | 2005-01-05 | 王原成 | Chinese patent drug for livestock |
| CN101564486A (en) * | 2008-04-22 | 2009-10-28 | 赵松柏 | Medicament for preventing and treating ruminant post-natal diseases and preparation method thereof |
| CN101612282A (en) * | 2008-06-23 | 2009-12-30 | 孙爱东 | Method for treating chronic endometritis of cattle by using traditional Chinese medicine |
| CN101618134A (en) * | 2008-07-06 | 2010-01-06 | 王丽平 | Method for treating chronic uterine inflammation of pigs by using traditional Chinese medicine |
| CN101623056A (en) * | 2009-07-31 | 2010-01-13 | 山西天沐合生农牧科技开发有限公司 | Chinese herbal medicine feed additive for ewes |
Non-Patent Citations (8)
| Title |
|---|
| 《中国畜牧兽医》 20090720 万玛吉 中草药防治奶牛子宫内膜炎 212-213 1-5 第36卷, 第7期 2 * |
| 《中国畜牧兽医学会家畜内科学分会2009年学术研讨会论文集》 20090801 祁燕蓉等 中药复方治疗奶牛子宫内膜炎的疗效观察 85-87 1-5 , 2 * |
| 《今日畜牧兽医》 20071208 张振涛等 奶牛子宫内膜炎的研究现状及防治措施 48-49 1-5 , 第12期 2 * |
| 《兽医导刊》 20081115 严作廷等 中草药在奶牛子宫内膜炎防治中的应用 35-37 1-5 , 2 * |
| 《安徽农业科学》 20080901 王东升等 防治奶牛子宫内膜炎中药制剂的研究进展 10881-10883 1-5 第36卷, 第25期 2 * |
| 《甘肃畜牧兽医》 20090515 祁燕蓉等 中草药复方防治奶牛子宫内膜炎的药理性研究 12-13 1-5 , 2 * |
| 《畜牧兽医杂志》 20080710 李星艳等 中草药治疗奶牛子宫内膜炎的研究进展 38-40 1-5 第27卷, 第4期 2 * |
| 《畜禽业》 20080815 李玉鸿 浅谈奶牛子宫内膜炎的中西药治疗 79-80 1-5 , 第232期 2 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000145A (en) * | 2010-12-16 | 2011-04-06 | 南京日升昌生物技术有限公司 | Traditional Chinese medicine and western medicine compound infusion liquid for preventing and treating endometritis of dam and preparing method thereof |
| CN102000145B (en) * | 2010-12-16 | 2011-11-23 | 南京日升昌生物技术有限公司 | Traditional Chinese medicine and western medicine compound infusion liquid for preventing and treating endometritis of dam and preparing method thereof |
| CN102743503A (en) * | 2012-07-13 | 2012-10-24 | 宁夏大学 | Method for preparing Chinese medicinal compound effervescent tablets for treating endometritis of cows |
| CN102743503B (en) * | 2012-07-13 | 2013-09-25 | 宁夏大学 | Method for preparing Chinese medicinal compound effervescent tablets for treating endometritis of cows |
| CN104173630A (en) * | 2014-08-19 | 2014-12-03 | 河南华牧生物科技有限公司 | Chinese traditional medicine perfusate for treating endometritis of cows and preparation process of Chinese traditional medicine perfusate |
| CN104173630B (en) * | 2014-08-19 | 2017-08-25 | 河南华牧生物科技有限公司 | Treat the Chinese medicinal perfusion liquid and its preparation technology of cow endometritis |
| CN106983831A (en) * | 2017-05-22 | 2017-07-28 | 南宁学院 | A kind of composition of prevention bovine endometritis |
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| CN101879240B (en) | 2011-08-17 |
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