CN113398190A

CN113398190A - Medicine for treating diabetes accompanied with depression and preparation method thereof

Info

Publication number: CN113398190A
Application number: CN202110916485.9A
Authority: CN
Inventors: 蔡萧君; 陆振华; 王磊; 王涛; 颉彦鹏
Original assignee: Heilongjiang College Of Traditional Chinese Medicine Heilongjiang Hospital Of Traditional Chinese Medicine
Current assignee: Heilongjiang College Of Traditional Chinese Medicine Heilongjiang Hospital Of Traditional Chinese Medicine
Priority date: 2021-08-11
Filing date: 2021-08-11
Publication date: 2021-09-17

Abstract

A medicine for treating diabetes accompanied with depression and a preparation method thereof, relating to a medicine for treating diabetes accompanied with depression and a preparation method thereof. The invention is used for treating diabetes with depression, the medicine can control blood sugar, eliminate the symptom of depression and improve sleep quality. The medicine for treating diabetes accompanied with depression is prepared from red ginseng, pilose antler, astragalus root, fleece-flower root, schisandra fruit, morinda root, curculigo rhizome, immature bitter orange and licorice root according to the parts by weight. The medicine adopts brand new compatibility, controls blood sugar by utilizing the interaction between the traditional Chinese medicine decoction pieces, relieves the symptom of depression and improves the sleep quality of patients. For patients with type 2 diabetes accompanied with diabetes and depression, the treatment period of the medicament is generally 60 days, and the treatment effect is obvious and effective.

Description

Medicine for treating diabetes accompanied with depression and preparation method thereof

Technical Field

The invention relates to a medicine for treating diabetes accompanied with depression and a preparation method thereof.

Background

Psychosomatic diseases refer to body diseases in which emotional factors are the main or important factors, and pathological changes mainly affect organs and tissues governed by the autonomic nervous system, resulting in structural changes or dysfunction of these organs and tissues. Diabetes is consistent with the basic concept of psychosomatic diseases because life events, social support and coping styles, personality factors, and the like are closely related to the onset of diabetes.

Psychosomatic studies have shown that stress causes negative mood in humans, while depression and anxiety can lead to various somatic diseases through abnormal changes in the endocrine, immune and autonomic nervous systems. Researches show that the diabetic patients generally have the personality characteristics of passivity, dependence, child qi, pain avoidance, lack of autonomy and the like.

It has been found in 2006 that 29% of the patients with moderate or severe depressed mood or simultaneous depression syndrome in diabetes mellitus and 31% of the patients with overt anxiety mood or anxiety syndrome. Glucose metabolism indexes (fasting blood glucose, postprandial blood glucose of 2 hours, glycosylated hemoglobin index) have a correlation with depression score and anxiety score.

Sleep is a very important physiological process of human body, and sleep disorder not only can independently affect human health, but also has close relationship with some chronic diseases such as cardiovascular and cerebrovascular diseases, diabetes, depression, dementia and the like. The general Ji Fang records that the patients with diabetes have bad sleep and lassitude of limbs, and it is known that the people in modern medicine and ancient Chinese physicians have a certain understanding of the sleep problems of diabetes.

Patients with diabetes and depression are treated by psychiatric drugs at present, and are taken with diabetes drugs to control blood sugar. Although the effect of the concurrent treatment of the psychiatric drugs and the diabetes drugs is ideal, most psychiatric drugs are western drugs, and the burden of patients is increased by taking 2 different drugs simultaneously.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine for treating diabetes with depression, which can control blood sugar, eliminate symptoms of depression and improve sleep quality.

The medicine for treating diabetes accompanied with depression is prepared from 18-22 parts of red ginseng, 13-17 parts of pilose antler, 45-55 parts of astragalus root, 27-33 parts of fleece-flower root, 8-12 parts of schisandra fruit, 22-27 parts of morinda officinalis, 13-17 parts of curculigo orchioides, 13-17 parts of immature bitter orange and 13-17 parts of liquorice in parts by weight.

The preparation method of the medicine for treating diabetes accompanied with depression comprises the following steps: weighing 18-22 parts of red ginseng, 13-17 parts of pilose antler, 45-55 parts of astragalus root, 27-33 parts of tuber fleeceflower root, 8-12 parts of Chinese magnoliavine fruit, 22-27 parts of medicinal indianmulberry root, 13-17 parts of common curculigo rhizome, 13-17 parts of immature bitter orange and 13-17 parts of liquoric root according to the parts by weight, then grinding and mixing to prepare the capsule.

The other preparation method of the medicine for treating diabetes with depression comprises the following steps: weighing 18-22 parts of red ginseng, 13-17 parts of pilose antler, 45-55 parts of astragalus root, 27-33 parts of tuber fleeceflower root, 8-12 parts of Chinese magnoliavine fruit, 22-27 parts of medicinal indianmulberry root, 13-17 parts of common curculigo rhizome, 13-17 parts of immature bitter orange and 13-17 parts of liquoric root according to the parts by weight, then soaking, decocting, concentrating, collecting paste, and preparing dry paste powder into capsules.

Red ginseng: has effects in invigorating qi, nourishing yin, tonifying blood, promoting salivation, tonifying heart, invigorating stomach, and tranquilizing mind.

Pilose antler: sweet and salty in nature and warm in nature. It enters kidney and liver meridians. Has the effects of tonifying kidney yang, benefiting essence and blood, strengthening tendons and bones, regulating thoroughfare and conception vessels and supporting sore toxin.

Astragalus root: sweet in nature and taste, slightly warm. Meridian tropism: it enters lung and spleen meridians. The efficacy is as follows: invigorating spleen, strengthening middle energizer, invigorating yang, lifting body, consolidating superficial resistance, promoting urination, removing toxic materials, and promoting granulation.

Polygonum multiflorum: it is sweet in nature, enters heart and liver meridian. Has the functions of nourishing blood, tranquilizing, dispelling wind and dredging meridian.

Schisandra chinensis: sour, sweet and warm in nature. It enters lung, heart and kidney meridians. Has effects of astringing, arresting discharge, invigorating qi, promoting fluid production, invigorating kidney, and calming heart.

Morinda officinalis: pungent and sweet in property, slightly warm. It enters kidney and liver meridians. Has effects of invigorating kidney, tonifying yang, dispelling pathogenic wind, and removing dampness.

Rhizoma curculiginis: being pungent and hot in property, it enters kidney and liver meridians. Has the functions of warming kidney, strengthening Yang, dispelling cold and eliminating dampness.

Immature bitter orange: bitter in property, octanoic acid, warm. It enters spleen, stomach and large intestine meridians. Has the effects of breaking qi, relieving distension, eliminating phlegm and removing food retention.

Licorice root: it is sweet and neutral in nature and enters heart, lung and spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, eliminating phlegm and relieving cough, relieving spasm and pain, clearing away heat and toxic materials, and harmonizing the effects of the other medicines.

The medicine adopts brand new compatibility, controls blood sugar by utilizing the interaction between the traditional Chinese medicine decoction pieces, relieves the symptom of depression and improves the sleep quality of patients. For patients with type 2 diabetes accompanied with diabetes and depression, the treatment period of the medicament is generally 60 days, and the treatment effect is obvious and effective.

The medicine is prepared by adding and subtracting pulse-activating decoction, and the red ginseng, the astragalus and the schisandra chinensis are monarch medicines for tonifying qi, nourishing yin and promoting the production of body fluid, and simultaneously can improve immunity and improve microcirculation; cornu Cervi Pantotrichum, rhizoma Curculiginis, and radix Morindae officinalis as ministerial drugs for invigorating kidney, supporting yang, and dispelling dampness and heat; the pilose antler has obvious effects of resisting lipid peroxidation and stress; radix Polygoni Multiflori and fructus Aurantii Immaturus as adjuvant drugs for tranquilizing mind and resolving food stagnation; licorice root, radix Glycyrrhizae coordinates the other drugs and directs them to the disease focus. The medicine is derived from pulse-activating decoction, but is mainly used for treating diabetes and diabetes accompanied with depression, and has obvious treatment effect. The medicine is forbidden for patients with diabetic ketoacidosis.

Detailed Description

The technical solution of the present invention is not limited to the following specific embodiments, but includes any combination of the specific embodiments.

The first embodiment is as follows: the medicine for treating diabetes accompanied with depression is prepared from 18-22 parts of red ginseng, 13-17 parts of pilose antler, 45-55 parts of astragalus root, 27-33 parts of fleece-flower root, 8-12 parts of schisandra fruit, 22-27 parts of morinda officinalis, 13-17 parts of curculigo orchioides, 13-17 parts of immature bitter orange and 13-17 parts of liquorice in parts by weight.

The second embodiment is as follows: the medicine for treating diabetes accompanied with depression is prepared from 20 parts of red ginseng, 15 parts of pilose antler, 50 parts of astragalus root, 30 parts of fleece-flower root, 10 parts of schisandra fruit, 25 parts of morinda officinalis, 15 parts of curculigo rhizome, 15 parts of immature bitter orange and 15 parts of liquorice in parts by weight.

The third concrete implementation mode: the first preparation method of the medicine for treating diabetes with depression comprises the following steps: weighing 18-22 parts of red ginseng, 13-17 parts of pilose antler, 45-55 parts of astragalus root, 27-33 parts of tuber fleeceflower root, 8-12 parts of Chinese magnoliavine fruit, 22-27 parts of medicinal indianmulberry root, 13-17 parts of common curculigo rhizome, 13-17 parts of immature bitter orange and 13-17 parts of liquoric root according to the parts by weight, then grinding and mixing to prepare the capsule.

In the present embodiment, each capsule contains 1.0 g of drug powder.

The fourth concrete implementation mode: the second preparation method of the medicine for treating diabetes with depression comprises the following steps: weighing 18-22 parts of red ginseng, 13-17 parts of pilose antler, 45-55 parts of astragalus root, 27-33 parts of tuber fleeceflower root, 8-12 parts of Chinese magnoliavine fruit, 22-27 parts of medicinal indianmulberry root, 13-17 parts of common curculigo rhizome, 13-17 parts of immature bitter orange and 13-17 parts of liquoric root according to the parts by weight, then soaking, decocting, concentrating, collecting paste, and preparing dry paste powder into capsules.

In the embodiment, each capsule contains 1.0 g of medicinal powder.

Example 1

Weighing 20 parts of red ginseng, 15 parts of pilose antler, 50 parts of astragalus, 30 parts of polygonum multiflorum, 10 parts of schisandra chinensis, 25 parts of morinda officinalis, 15 parts of curculigo orchioides, 15 parts of immature bitter orange and 15 parts of liquorice according to the weight parts, then grinding and mixing the materials, and preparing the capsules. In the embodiment, each capsule contains 1.0 g of medicine powder, and the application and dosage are as follows: the oral preparation is taken by adults 2-4 granules at a time, 3 times a day, after meals.

The anxiety and depression conditions of the type 2 diabetes mellitus are evaluated by selecting an anxiety self-rating scale (SAS) and a depression self-rating scale (SDS), wherein the evaluation time range is the actual feeling of the subject in the past 1 week.

The main statistical index of the depression self-rating scale (SDS) is total rough score, namely the sum of scores of each item of 20 items, the total rough score is multiplied by 1.25 to obtain an integer part to obtain a standard score, the upper limit of the total rough score is 80 scores, and the upper limit of the standard score is 100 scores. Total SDS scores (standard score) 53-62 were mild depression, 63-72 were moderate depression, and >72 were major depression.

Anxiety self rating scale (SAS): the organization and detailed assessment method of Zung, compiled in 1971, was similar to SDS and was used to assess the subjective perception of anxiety by subjects. The main statistical index of the SAS scale is the total rough score, namely the sum of the scores of all items of 20 items, the total rough score is multiplied by 1.25 to obtain an integer part to obtain a standard score, the upper limit of the total rough score is 80 scores, and the upper limit of the standard score is 100 scores. Anxiety is located according to standard value > 50, mild anxiety is classified at 50-59, moderate anxiety is classified at 60-69, and severe anxiety is classified at > 70. Patient anxiety was determined from SAS and SDS values.

The first patient: chen is certain, male, 52 years old. Patients with diabetes mellitus for more than 10 years have been treated in local hospitals, and blood sugar control is poor. Pre-treatment symptoms: dry mouth, palpitation, chest distress, hypodynamia, easy dysphoria, easy sleep and easy wakefulness. SAS score of 61 points and SDS score of 63 points are used for outpatient traditional Chinese medicine treatment. Is diagnosed as type 2 diabetes, which is accompanied by depressive state. After the medicine capsule is taken 3 capsules at a time 3 times a day after meals, after 60 days, the patients have palpitation, chest distress, easy sleep awakening and dysphoria, the fasting blood sugar is well controlled, and the mouth is occasionally dry.

The second patient: yaoyao, female, age 40, history of diabetes 5 years, pre-treatment symptoms: numbness of limbs, dry mouth, bitter taste, dysphoria, insomnia, and poor control of blood sugar. SAS score of 63 and SDS score of 60 are used for outpatient traditional Chinese medicine treatment. Is diagnosed as type 2 diabetes, which is accompanied by depressive state. After the capsule of the embodiment is taken 4 capsules at a time and 3 times a day, the capsule is taken after meals, and after 60 days, the capsule has good blood sugar control and no uncomfortable symptoms (the symptoms of numbness of limbs, dry mouth, bitter taste, dysphoria and insomnia disappear).

The third patient: jia in, woman, age 50, diabetes for more than 1 year. Pre-treatment symptoms: chest distress, marked after sweating, dysphoria, dreaminess, dry mouth, no fever, poor appetite. SAS score of 63 and SDS score of 60 are used for outpatient traditional Chinese medicine treatment. Is diagnosed as type 2 diabetes, which is accompanied by depressive state. After taking the capsule of the embodiment 4 capsules at a time and 3 times a day, the symptoms disappear and the patient occasionally sweats after taking the capsule for 60 days.

The medicine for treating diabetes accompanied with depression has obvious treatment effect on patients with diabetes and diabetes accompanied with depression, the blood sugar of the patients is well controlled, the depression symptoms basically disappear, and the sleep quality is obviously improved.

Example 2

Weighing 20 parts of red ginseng, 15 parts of pilose antler, 50 parts of astragalus, 30 parts of polygonum multiflorum, 10 parts of schisandra chinensis, 25 parts of morinda officinalis, 15 parts of curculigo orchioides, 15 parts of immature bitter orange and 15 parts of liquorice according to the weight part ratio, then soaking, decocting, concentrating, collecting paste, and preparing dry paste powder into capsules.

In the embodiment, each capsule contains 1.0 g of medicinal powder, and the dosage by using method is as follows: the oral preparation is taken by adults 2-4 granules at a time, 3 times a day, after meals.

The first patient: lie, woman, 62 years old. The patients with diabetes mellitus for more than 8 years are treated in local hospitals, and the blood sugar control is poor. Pre-treatment symptoms: dry mouth, palpitation, chest oppression, poor sleep and irritability. SAS score of 65 and SDS score of 67 are used for outpatient traditional Chinese medicine treatment. Is diagnosed as type 2 diabetes, which is accompanied by depressive state. After the capsule of the embodiment is taken 4 capsules at a time and 3 times a day, the capsule is taken after meals, after 60 days, the mood of the patient such as palpitation, chest distress, easy sleep awakening and dysphoria disappears, the fasting blood sugar is controlled to be about 6.5mmol/L, and the mouth is occasionally dry.

The second patient: xiaoji, woman, 42 years old, history of diabetes 3 years, pre-treatment symptoms: dry mouth, bitter mouth, dysphoria, intolerance of cold, poor blood sugar control, fasting blood sugar of about 8. The SAS score of 64 and the SDS score of 62 are used for outpatient traditional Chinese medicine treatment. Is diagnosed as type 2 diabetes, which is accompanied by depressive state. After taking the medicine capsule of the embodiment 3 capsules at a time and 3 times a day, the medicine capsule is taken after meals, and after taking the medicine capsule for 60 days, the blood sugar is well controlled, and discomfort symptoms (dry mouth, bitter taste, dysphoria and chill-intolerance symptoms disappear) are avoided.

The third patient: xuan, male, age 55, diabetes mellitus for more than 1 year. Pre-treatment symptoms: frequent micturition, marked sweating after activity, restlessness, dreaminess, dry mouth, no fever, and asthenia. SAS score of 61 points and SDS score of 65 points are used for outpatient traditional Chinese medicine treatment. Is diagnosed as type 2 diabetes, which is accompanied by depressive state. After taking the capsule of the embodiment 4 capsules at a time and 3 times a day, the symptoms disappear and the fatigue occasionally occurs after 60 days of taking.

Claims

1. The medicine for treating diabetes accompanied with depression is characterized by being prepared from 18-22 parts of red ginseng, 13-17 parts of pilose antler, 45-55 parts of astragalus root, 27-33 parts of fleece-flower root, 8-12 parts of Chinese magnoliavine fruit, 22-27 parts of morinda officinalis, 13-17 parts of curculigo orchioides, 13-17 parts of immature bitter orange and 13-17 parts of liquorice in parts by weight.

2. The medicament for treating diabetes with depression according to claim 1, which is prepared from 20 parts by weight of red ginseng, 15 parts by weight of pilose antler, 50 parts by weight of astragalus root, 30 parts by weight of fleece-flower root, 10 parts by weight of schisandra fruit, 25 parts by weight of morinda officinalis, 15 parts by weight of curculigo orchioides, 15 parts by weight of immature bitter orange and 15 parts by weight of licorice root.

3. The preparation method of the medicine for treating diabetes with depression as claimed in claim 1, is characterized by comprising the following steps:

weighing 18-22 parts of red ginseng, 13-17 parts of pilose antler, 45-55 parts of astragalus root, 27-33 parts of tuber fleeceflower root, 8-12 parts of Chinese magnoliavine fruit, 22-27 parts of medicinal indianmulberry root, 13-17 parts of common curculigo rhizome, 13-17 parts of immature bitter orange and 13-17 parts of liquoric root according to the parts by weight, then grinding and mixing to prepare the capsule.

4. The preparation method of the medicine for treating diabetes with depression as claimed in claim 1, is characterized by comprising the following steps:

weighing 18-22 parts of red ginseng, 13-17 parts of pilose antler, 45-55 parts of astragalus root, 27-33 parts of tuber fleeceflower root, 8-12 parts of Chinese magnoliavine fruit, 22-27 parts of medicinal indianmulberry root, 13-17 parts of common curculigo rhizome, 13-17 parts of immature bitter orange and 13-17 parts of liquoric root according to the parts by weight, then soaking, decocting, concentrating, collecting paste, and preparing dry paste powder into capsules.