CN115554373A - Traditional Chinese medicine paste prescription suitable for middle-aged and elderly people to nourish liver and kidney, calm nerves and help sleep and preparation method thereof - Google Patents

Traditional Chinese medicine paste prescription suitable for middle-aged and elderly people to nourish liver and kidney, calm nerves and help sleep and preparation method thereof Download PDF

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Publication number
CN115554373A
CN115554373A CN202211245753.XA CN202211245753A CN115554373A CN 115554373 A CN115554373 A CN 115554373A CN 202211245753 A CN202211245753 A CN 202211245753A CN 115554373 A CN115554373 A CN 115554373A
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China
Prior art keywords
parts
radix
traditional chinese
chinese medicine
fructus
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CN202211245753.XA
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Chinese (zh)
Inventor
朱文宗
宋成城
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Wenzhou Chinese Medicine Hospital
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Wenzhou Chinese Medicine Hospital
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Priority to CN202211245753.XA priority Critical patent/CN115554373A/en
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Abstract

The invention relates to the technical field of traditional Chinese medicine paste formulas, and discloses a traditional Chinese medicine paste formula for nourishing liver and kidney, calming nerves and aiding sleep suitable for middle-aged and elderly people. The traditional Chinese medicine paste formula is guided by the principle of three-factor treatment according to basic pathology of middle-aged and elderly people, regional characteristics of the east south coastal region and physical characteristics of people, adopts a treatment principle of both attack and invigoration, is suitable for health maintenance and invigoration in middle-aged and after middle-aged, and has the effects of nourishing liver and kidney, tonifying spleen and clearing away heart-fire, tonifying qi and activating blood, and soothing nerves and helping sleep.

Description

Traditional Chinese medicine ointment formula suitable for middle-aged and elderly people to nourish liver and kidney, calm nerves and promote sleep and preparation method
Technical Field
The invention relates to the technical field of traditional Chinese medicine paste formulas, in particular to a traditional Chinese medicine paste formula for nourishing liver and kidney, calming nerves and helping sleep and a preparation method thereof, wherein the traditional Chinese medicine paste formula is suitable for middle-aged and elderly people.
Background
The traditional Chinese medicine ointment formula is a traditional health preserving preparation with traditional Chinese medicine characteristics. The prevention and cure of the ointment is extended from the basic idea of ' treating the disease ' in Huangdi ' Nei Jing, is applicable to various weak diseases and is used for palace sense-of-merit nobody in ancient times. The principle of the ointment formula is explored in clinical application of the later generations, namely the winter is the best period for taking the ointment formula. The reason is that the theory of traditional Chinese medicine considers that spring growth in summer, autumn harvest in winter and winter are the season of sealing in winter, which is suitable for storing essence, replenishing water, nourishing vital qi, filling yin and marrow, and winter is used for nourishing, and the ointment formula is the best. The ointment is developed and popular in Jiangzhe and Zhejiang, one important factor is regions, coastal areas in the south east, the body is thin and weak, the body is hot, the yang is redundant, the yin is insufficient, and the cold is severe in winter, so the disease (or plague) is warm in spring, the ointment can nourish yin in winter, prevent the spring temperature, is popular due to obvious effect, and is fixed in seasons.
In modern society, middle-aged and elderly people grow with age, the body shape and function change, qi, blood and essence are gradually consumed, the functions of all internal organs of the body are gradually reduced, and symptoms such as dizziness, waist soreness, leg weakness, tinnitus, deafness, listlessness, palpitation, insomnia, hypomnesis, dry mouth and throat and the like easily appear. Ancient palace medical records leave many life prolonging paste formulas suitable for middle-aged and elderly people with weak constitution, such as Changchun life prolonging Dan formula recorded in Cixi Guangshou medical prescription, which emphasizes tonifying. The traditional Chinese medicine composition is combined with each other, greatly supplements deficiency of heart, kidney, spleen and stomach, strengthens bones and muscles, supplements yin and yang, supplements and relaxes, is suitable for long-term regulation and nourishing, has the effects of enriching blood and replenishing vital essence, tonifying qi and nourishing yin, and resisting senility and prolongs the life, and is used for people with age, weakness, insufficient essence and blood, deficiency of both qi and yin, mental failure and fatigue, soreness and weakness of waist and knees, weakness of feet and feet, lusterless complexion and early graying of hair. However, with the improvement of living standard and medical conditions, the disease characteristics of people nowadays are no longer simple consumptive disease and damage, but complex deficiency and excess mingle, so that the efficacy of prolonging life and eliminating pathogens by danfang is insufficient.
The method is characterized in that the Chinese medicine has the advantages that the family history, the prescription, the old and the mr analyze basic pathology of the middle-aged and the elderly diseases, and the middle-aged and the elderly diseases have deficiency-excess mixed disease characteristics of phlegm-damp turbidity and blood stasis blocking, wherein firstly, the vital essence of viscera is weakened, and deficiency of spleen and kidney is taken as the key point; secondly, phlegm-damp turbidity and blood stasis are caused by qi and blood circulation disorder and viscera hypofunction, and the proved ointment of the historical and the extraordinary experience is formed on the basis. The formula has the advantages of tonifying liver and kidney, removing blood stasis, eliminating phlegm, clearing fire and calming the heart. The formula is suitable for patients with deficiency of both spleen and kidney, deficiency of both qi and blood, dizziness, tinnitus, palpitation, hypomnesis, anorexia, dyspepsia, abdominal distention, and constipation, and is suitable for preventing and treating middle-aged and elderly diseases such as coronary heart disease, hyperlipidemia, hypertension, etc.
However, different regions have different constitutions and different pathogenesis characteristics. For example, the constitution of people in southeast coastal areas is different from that of people in inland due to the influence of climate, diet and the like. Although proved by the proved recipe of the Shifangqijing, the disease characteristics of deficiency-excess mixed disease caused by turbid phlegm-dampness and blood stasis are provided based on the basic pathology of the senile diseases, the knowledge of the disease symptoms of people in the southeast coastal region cannot be met. The traditional Chinese medicine is used for treating diseases on the basis of ' holistic view ', takes ' treatment based on syndrome differentiation ' as a guideline, combines the three-cause treatment preference ' and ' Tianren correspondence ' and the like, and is used according to the method and the selected formula. Therefore, it is necessary to develop a formula suitable for middle-aged and elderly people in the southeast coastal areas such as Wenzhou.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine paste formula for nourishing liver and kidney, soothing nerves and aiding sleep, which is suitable for middle-aged and elderly people according to basic pathology of the middle-aged and elderly people, regional characteristics of the southeast coastal region and physical characteristics of people, is suitable for middle-aged and elderly people with impairment of food and spleen deficiency and damp stagnation and yang pathogenesis in the southeast coastal region, and plays a good role in nourishing liver and kidney, soothing nerves and aiding sleep.
The invention provides the following technical scheme:
the technical scheme provided by the invention is as follows:
a traditional Chinese medicine ointment formula for nourishing liver and kidney, soothing nerves and aiding sleep comprises the following components: radix asparagi, radix Ophiopogonis, radix rehmanniae, achyranthis radix, rhizoma Dioscoreae, eucommiae cortex, corni fructus, poria, radix Ginseng, radix Codonopsis, radix Glehniae, fructus Schisandrae, radix Morindae officinalis, radix Angelicae sinensis, semen Ziziphi Spinosae, saviae Miltiorrhizae radix, radix astragali, cortex Lycii, pericarpium Citri Tangerinae, semen Cuscutae, cistanchis herba, fructus Lycii, flos Chrysanthemi, rubi fructus, rhizoma Curculiginis, herba Epimedii, cortex Phellodendri, parched Atractylodis rhizoma, fructus Hordei Germinatus preparata, fructus Hordei Germinatus, fructus oryzae, endothelium corneum Gigeriae Galli, fructus Amomi rotundus, fructus Amomi, semen Juglandis, colla Corii Asini, colla Plastri Testudinis, and gelatinum oxhide.
At present, it is generally believed that middle-aged and elderly people are mostly accompanied by stagnation of pathological products such as phlegm and fluid retention, damp turbidity, blood stasis and the like due to qi and blood circulation disorder on the basis of qi deficiency of viscera. The traditional Chinese medicine famous family Zhuwenzong and the like in traditional Chinese medicine of Wenzhou city are found in running medicine, the disease characteristics of middle-aged and old people in southeast coastal areas, particularly in Wenzhou areas, show certain particularity on the pathology, and the disease characteristics are found through empirical analysis because Wenzhou is in the southeast coastal areas, summer is long, winter is warm, climate is hot and humid, people mostly eat seafood, and mostly eat fat, sweet, thick and greasy food, so that the regional people mainly have the pathogenesis characteristics of overeating spleen deficiency and dampness stagnation and yang deficiency, and the medicine characteristics that a paste prescription is nourishing and is easy to obstruct the spleen and stomach and generate dampness are combined.
The inventor takes three reasons system suitable in the basic theory of traditional Chinese medicine as guidance according to the basic pathology of middle-aged and old people, regional characteristics of the east China coastal region, especially the Wenzhou region and constitutional characteristics of people, adopts the treatment principle of attacking and tonifying and applying simultaneously, treats the deficiency of heart, kidney, spleen and stomach, strengthens bones and yin and yang, and simultaneously has the effects of clearing heat, eliminating phlegm, removing blood stasis, promoting digestion, warming yang and eliminating dampness, forms the winter season nourishing paste formula for nourishing liver and kidney, soothing nerves and aiding sleep after the formula is repeatedly tested, and more accords with the qualitative characteristics of the middle-aged and old people in the east China coastal region, especially the Wenzhou region.
In the technical solution of the present application,
radix rehmanniae, radix asparagi, radix Ophiopogonis, radix Adenophorae are all yin essence nourishing products, and are combined with Ginseng radix and radix Codonopsis to tonify qi and five internal organs, and to supplement primordial qi, nourish essence and blood, benefit heart and kidney. The miraculous analysis formula of Ming Dynasty Li Zhongzi is called "Tianyishenshui", so the kidney is the origin of all things and is the human body. When the Nei fell its yuan, the root should not be so strong that it is too hot, so the heat is so strong that the patient is liable to be attacked by fire and cough. Taking the two herbs to tonify the kidney as the monarch and supplement essence with the flavor; selecting Erdong as a ministerial drug for lung protection, and supplementing a mother drug for deficiency; fire attacking gold but lung qi failing, except ren Shen and Mo can rescue, and Dong Yuan-so-called yang deficiency can lead to yin failing to grow. The cornus and the dodder are used for treating dizziness, tinnitus, waist soreness and backache caused by liver and kidney deficiency; colla Corii Asini, colla Plastri Testudinis, and oxhide gelatin can nourish yin of liver and kidney; the medlar can nourish essence of five internal organs, promote hair growth, tranquilize mind and improve eyesight; the eucommia bark and the raspberry can nourish liver and kidney, strengthen bones and muscles and treat soreness of lower limbs; cistanche deserticola has the effects of tonifying kidney yang and nourishing kidney yin. The innate essence can not be separated from the acquired essence, so the astragalus, the yam and the white atractylodes rhizome are used for tonifying qi and strengthening spleen and nourishing acquired essence; the poria with hostwood has the effects of tonifying spleen, eliminating dampness, regulating spleen and stomach functions and soothing nerves; the spina date seed can nourish heart and benefit liver to treat insomnia; the schisandra chinensis is good in taste, and has the effects of nourishing five internal organs, strengthening body and improving memory. The above medicines are all monarch medicines.
Strengthening the body resistance and eliminating pathogenic factors, and regulating qi-flowing for promoting appetite, invigorating spleen and eliminating dampness by using pericarpium Citri Tangerinae, fructus Amomi rotundus and fructus Amomi; when dampness exceeds the original value, yang is slight, and Xian Mao, xian Ling Pi, ba Ji Tian and Ju ren are used to tonify yang of the whole body and help to resolve water dampness; parching fructus Hordei Germinatus, fructus oryzae, and endothelium corneum Gigeriae Galli to promote digestion and invigorate stomach; cortex Lycii is administered to nourish kidney-qi and remove liver fire; for phellodendron bark and Hangzhou white chrysanthemum, it can clear heat and purge fire, and is good at treating stagnated heat in liver channel; the angelica and the salvia can promote blood circulation to remove blood stasis, and the achyranthes can promote blood circulation to remove blood stasis while tonifying the liver and kidney. All the medicines are ministerial medicines.
As the optimization of the invention, the traditional Chinese medicine ointment formula comprises the following components in parts by weight:
50-150 parts of radix asparagi, 50-150 parts of radix ophiopogonis, 100-200 parts of radix rehmanniae, 50-150 parts of radix achyranthis bidentatae, 150-250 parts of Chinese yam, 50-150 parts of eucommia ulmoides, 50-150 parts of cornus officinalis, 100-200 parts of poria with hostwood, 50-100 parts of sun-dried ginseng, 50-100 parts of codonopsis pilosula, 50-100 parts of radix glehniae, 50-120 parts of schisandra chinensis, 100-150 parts of morinda officinalis, 60-120 parts of angelica sinensis, 50-150 parts of spina date seed, 50-150 parts of salvia miltiorrhiza, 50-150 parts of raw astragalus membranaceus, 60-120 parts of cortex lycii radicis, 60-120 parts of pericarpium citri reticulatae, 100-150 parts of semen cuscutae, and 100-200 parts of cistanche, 50-150 parts of wolfberry fruit, 40-80 parts of Hangzhou white chrysanthemum, 50-150 parts of raspberry, 50-150 parts of curculigo orchioides, 100-200 parts of epimedium, 40-80 parts of golden cypress, 100-150 parts of fried bighead atractylodes rhizome, 50-150 parts of fried malt, 50-150 parts of raw malt, 50-150 parts of rice sprout, 40-80 parts of chicken's gizzard-membrane, 10-50 parts of amomum cardamomum, 40-80 parts of fructus amomi, 100-200 parts of walnut meat, 100-200 parts of donkey-hide gelatin, 100-200 parts of tortoise-shell glue and 100-200 parts of yellow gelatin.
As the optimization of the invention, the traditional Chinese medicine ointment formula comprises the following components in parts by weight:
100 parts of asparagus cochinchinensis, 100 parts of radix ophiopogonis, 150 parts of radix rehmanniae, 100 parts of radix achyranthis bidentatae, 200 parts of Chinese yam, 100 parts of eucommia ulmoides, 100 parts of cornus officinalis, 150 parts of poria with hostwood, 50 parts of sun-dried ginseng, 50 parts of codonopsis pilosula, 50 parts of radix glehniae, 90 parts of schisandra chinensis, 120 parts of morinda officinalis, 90 parts of angelica sinensis, 100 parts of spina date seeds, 100 parts of salvia miltiorrhiza, 100 parts of raw astragalus membranaceus, 120 parts of cortex lycii radicis, 90 parts of pericarpium citri reticulatae, 120 parts of semen cuscutae, 150 parts of cistanche, 100 parts of wolfberry fruits, 60 parts of Hangzhou white chrysanthemum, 100 parts of raspberry, 100 parts of curculigo orchioides, 150 parts of epimedium chinensis, 60 parts of golden cypress, 120 parts of fried bighead atractylodes rhizome, 100 parts of fried malt, 100 parts of raw malt, 100 parts of rice sprout, 60 parts of endothelium corneum gigeriae galli, 30 parts of amomum cardamomum, 50 parts of walnut meat, 100 parts of donkey-hide gelatin, 100 parts of tortoise-shell glue and 100 parts of yellow gelatin.
As the optimization of the invention, the traditional Chinese medicine paste formula also contains one or more of yellow wine, honey and sweetener. The above components exist as adjuvants, wherein yellow wine can dissolve out effective components of the medicine, and can be easily absorbed by human body, and has effects of promoting blood circulation, guiding the medicine efficacy to the part to be treated, and entering liver and kidney channels, and moistening dryness with Mel.
Preferably, the sweetener is xylitol. Xylitol not only can keep the taste of the cream formula, but also can regulate and protect the medicinal flavor.
The preparation method of the traditional Chinese medicine ointment formula comprises the following steps:
(1) Soaking the above materials in water, decocting, and separating medicinal liquid;
(2) Concentrating the medicinal liquid to obtain extract, adding the sun-dried ginseng decoction when the medicinal liquid is clear, adding colla Corii Asini, colla Plastri Testudinis and oxhide gelatin, and stirring;
(3) Decocting with slow fire to obtain paste, adding semen Juglandis, decocting, adding the concentrated solution of fructus Amomi and fructus Amomi rotundus, and mixing.
As a preference of the process of the present invention, in step (1): the dosage ratio of the medicines to the water is 1.
Preferably, the method of the invention comprises the steps of firstly decocting for 1.5-2.5 h, separating the liquid medicine, adding warm water with the mass of 60-70% of the first water into the dregs of a decoction, decocting for 1-1.5 h, separating the liquid medicine, and combining the liquid medicine obtained in two times.
Preferably, the gelatin powder of the donkey-hide gelatin, the tortoise-shell gelatin and the oxhide gelatin in the step (2) is soaked in yellow wine for 2 to 3 days for use. Enhancing qi and blood invigorating effect, and removing fishy smell of various gels.
As a preferred method of the present invention, the concentrate of fructus Amomi and fructus Amomi rotundus in step (3) is prepared by the following steps: crushing the raw materials, putting the crushed raw materials into a sealed container, adding water, boiling for 2-3 h, and then separating liquid medicine to obtain concentrated solution;
and/or the step (3) also comprises adding the walnut meat and then adding the sweetening agent or honey.
The invention has the following beneficial effects:
the traditional Chinese medicine paste formula is guided by the principle of 'three reasons suitable' in the basic theory of traditional Chinese medicine, adopts the treatment principle formula of attacking and tonifying, is suitable for middle-aged and middle-aged people to nourish the health and tonify, has the effects of nourishing liver and kidney, tonifying spleen and clearing heart, tonifying qi and activating blood, soothing nerves and aiding sleep, is suitable for patients with symptoms of palpitation and insomnia, dizziness and weakness, waist soreness and tinnitus, soreness and weakness of lower limbs, hectic fever and night sweat, hypomnesis, inappetence, dyspepsia and abdominal distension and constipation, and is more suitable for people with constitution and pathogenesis characteristics in the southeast coast, especially in the Wenzhou region compared with other paste formulas, the theoretical basis is invar and more practical, and the clinical curative effect is remarkable.
Detailed Description
The following further describes the embodiments of the present invention.
The starting materials used in the present invention are commercially available or commonly used in the art, unless otherwise specified, and the methods in the following examples are conventional in the art, unless otherwise specified.
The invention provides a traditional Chinese medicine paste formula for nourishing liver and kidney, calming nerves and aiding sleep, which is suitable for middle-aged and elderly people in southeast coastal areas, particularly Wenzhou areas, and comprises the following components: radix asparagi, radix Ophiopogonis, radix rehmanniae, achyranthis radix, rhizoma Dioscoreae, eucommiae cortex, corni fructus, poria, radix Ginseng, radix Codonopsis, radix Glehniae, fructus Schisandrae, radix Morindae officinalis, radix Angelicae sinensis, semen Ziziphi Spinosae, saviae Miltiorrhizae radix, radix astragali, cortex Lycii, pericarpium Citri Tangerinae, semen Cuscutae, cistanchis herba, fructus Lycii, flos Chrysanthemi, rubi fructus, rhizoma Curculiginis, herba Epimedii, cortex Phellodendri, parched Atractylodis rhizoma, fructus Hordei Germinatus preparata, fructus Hordei Germinatus, fructus oryzae, endothelium corneum Gigeriae Galli, fructus Amomi rotundus, fructus Amomi, semen Juglandis, colla Corii Asini, colla Plastri Testudinis, and gelatinum oxhide.
In some embodiments provided by the invention, the traditional Chinese medicine ointment formula comprises the following components in parts by weight:
50-150 parts of radix asparagi, 50-150 parts of radix ophiopogonis, 100-200 parts of radix rehmanniae, 50-150 parts of radix achyranthis bidentatae, 150-250 parts of Chinese yam, 50-150 parts of eucommia ulmoides, 50-150 parts of cornus officinalis, 100-200 parts of poria with hostwood, 50-100 parts of sun-dried ginseng, 50-100 parts of codonopsis pilosula, 50-100 parts of radix glehniae, 50-120 parts of schisandra chinensis, 100-150 parts of morinda officinalis, 60-120 parts of angelica sinensis, 50-150 parts of spina date seed, 50-150 parts of salvia miltiorrhiza, 50-150 parts of raw astragalus membranaceus, 60-120 parts of cortex lycii radicis, 60-120 parts of pericarpium citri reticulatae, 100-150 parts of semen cuscutae, and 100-200 parts of cistanche, 50-150 parts of wolfberry fruit, 40-80 parts of chrysanthemum morifolium, 50-150 parts of raspberry, 50-150 parts of curculigo orchioides, 100-200 parts of epimedium, 40-80 parts of golden cypress, 100-150 parts of fried bighead atractylodes rhizome, 50-150 parts of fried malt, 50-150 parts of raw malt, 50-150 parts of rice sprout, 40-80 parts of chicken's gizzard-membrane, 10-50 parts of amomum cardamomum, 40-80 parts of fructus amomi, 100-200 parts of walnut meat, 100-200 parts of donkey-hide gelatin, 100-200 parts of tortoise-shell glue and 100-200 parts of yellow gelatin.
In some embodiments provided herein, the traditional Chinese medicine ointment formula comprises the following components in parts by weight:
100 parts of asparagus cochinchinensis, 100 parts of radix ophiopogonis, 150 parts of radix rehmanniae, 100 parts of radix achyranthis bidentatae, 200 parts of Chinese yam, 100 parts of eucommia ulmoides, 100 parts of cornus officinalis, 150 parts of poria with hostwood, 50 parts of sun-dried ginseng, 50 parts of codonopsis pilosula, 50 parts of radix glehniae, 90 parts of schisandra chinensis, 120 parts of morinda officinalis, 90 parts of angelica sinensis, 100 parts of spina date seeds, 100 parts of salvia miltiorrhiza, 100 parts of raw astragalus membranaceus, 120 parts of cortex lycii radicis, 90 parts of pericarpium citri reticulatae, 120 parts of semen cuscutae, 150 parts of cistanche, 100 parts of wolfberry fruits, 60 parts of Hangzhou white chrysanthemum, 100 parts of raspberry, 100 parts of curculigo orchioides, 150 parts of epimedium chinensis, 60 parts of golden cypress, 120 parts of fried bighead atractylodes rhizome, 100 parts of fried malt, 100 parts of raw malt, 100 parts of rice sprout, 60 parts of endothelium corneum gigeriae galli, 30 parts of amomum cardamomum, 50 parts of walnut meat, 100 parts of donkey-hide gelatin, 100 parts of tortoise-shell glue and 100 parts of yellow gelatin. Statistics show that nearly 280 people eat the existing cream formula, the fatigue is improved by 85 percent, the insomnia is improved by 80 percent, the waist soreness is improved by 82 percent, and the abdominal distension and constipation are improved by 60 percent.
In some embodiments provided by the invention, the traditional Chinese medicine ointment formula further comprises auxiliary materials, and the auxiliary materials can be selected from yellow wine, honey and a sweetening agent.
In some embodiments provided herein, the sweetener is xylitol.
The invention also provides an implementation method of the preparation method of the traditional Chinese medicine ointment formula, which comprises the following steps:
(1) Soaking the above materials in water, decocting, and separating medicinal liquid;
(2) Concentrating the medicinal liquid to obtain extract, adding radix Ginseng decoction, colla Corii Asini, colla Plastri Testudinis and oxhide gelatin, and stirring;
(3) Decocting with slow fire to obtain paste, adding semen Juglandis, decocting to obtain suspension, adding the concentrated solution of fructus Amomi and fructus Amomi rotundus, and mixing.
In some embodiments provided herein, in step (1): the dosage ratio of the medicines to the water is 1.5-7, and/or the soaking time is 6-8 h.
In some embodiments provided by the invention, the decoction is carried out in a high-pressure decoction machine, such as a ten-function self-help decoction machine, the ten-function automatic decoction machine enables effective components in the traditional Chinese medicinal materials to be easier to decoct due to the existence of pressure, the protein of animal medicines is easier to hydrolyze, and the decoction rate of the effective components is improved by pressurization and high temperature.
In some embodiments provided by the invention, the decoction is carried out by two times, the decoction is firstly decocted for 1.5 to 2.5 hours, the liquid medicine is separated, then warm water with the mass of 60 to 70 percent of the first water is added into the dregs of a decoction for 1 to 1.5 hours, the liquid medicine is separated, and the liquid medicines at the two times are combined.
In some embodiments provided by the invention, the liquid medicine is concentrated in a sandwich pressure steam concentration pot to obtain paste, and the paste is concentrated to obtain clear paste by stirring continuously.
In some embodiments provided by the present invention, the gelatin powder of the donkey-hide gelatin, the tortoise-shell gelatin and the oxhide gelatin in the step (2) is used after being soaked in yellow wine for 2 to 3 days. The yellow wine is preferably 5-year-old Huadiao wine.
In some embodiments of the present invention, the concentrate of fructus Amomi and fructus Amomi rotundus in step (3) is prepared by the following method: crushing the raw materials, putting the crushed raw materials into a sealed container, adding water, boiling for 2-3 h, and then separating liquid medicine to obtain concentrated solution;
and/or the step (3) also comprises adding the walnut meat and then adding the sweetening agent or honey.
The following is further illustrated by the more detailed examples
Example 1
A traditional Chinese medicine ointment formula for nourishing liver and kidney, soothing nerves and aiding sleep is prepared from the following medicines:
100g of asparagus, 100g of dwarf lilyturf tuber, 150g of rehmannia root, 100g of twotooth achyranthes root, 200g of common yam rhizome, 100g of eucommia bark, 100g of cornus fruit, 150g of Indian bread with pine, 50g of sun-dried ginseng, 50g of pilose asiabell root, 50g of coastal glehnia root, 90g of Chinese magnoliavine fruit, 120g of medicinal indianmulberry root, 90g of Chinese angelica, 100g of spina date seed, 100g of danshen root, 100g of raw membranous milkvetch root, 120g of Chinese wolfberry root-bark, 90g of tangerine peel, 120g of south dodder seed, 150g of desertliving cistanche, 100g of barbary wolfberry fruit, 60g of Hangzhou white chrysanthemum, 100g of raspberry, 100g of common curculigo rhizome, 150g of epimedium herb, 60g of amur corktree bark, 120g of stir-fried largehead atractylodes rhizome, 100g of roasted malt, 100g of raw malt, 100g of rice sprout, 60g of chicken's gizzard-membrane, 30g of round cardamon fruit, 50g of villous amomum fruit, 150g of walnut meat, 100g of donkey-hide gelatin, 100g of glue, 100g of tortoise-hide glue and 100g of yellow tortoise gelatin.
The preparation process of the traditional Chinese medicine ointment formula is as follows:
(1) Mixing radix asparagi, radix Ophiopogonis, radix rehmanniae, achyranthis radix, rhizoma Dioscoreae, eucommiae cortex, corni fructus, poria, radix Codonopsis, radix Glehniae, fructus Schisandrae, radix Morindae officinalis, radix Angelicae sinensis, semen Ziziphi Spinosae, saviae Miltiorrhizae radix, radix astragali, cortex Lycii, pericarpium Citri Tangerinae, semen Cuscutae, cistanchis herba, fructus Lycii, flos Chrysanthemi, rubi fructus, rhizoma Curculiginis, herba Epimedii, cortex Phellodendri, parched Atractylodis rhizoma, parched fructus Hordei Germinatus, fructus oryzae, endothelium corneum Gigeriae Galli, colla Corii Asini, colla Plastri Testudinis, and oxhide gelatin, soaking in 15L water for 8 hr, and decocting with ten-function automatic decocting machine: the first decoction is carried out for 2 hours, the liquid medicine is filtered by a 120-mesh sieve, 10 liters of warm water is added for the second decoction, the decoction is carried out for 1 hour, the liquid medicine is filtered by the 120-mesh sieve, and about 15 liters of the liquid medicine is merged;
(2) Concentrating the medicinal liquid in a sandwich pressure steam concentrating pan, continuously manually stirring and concentrating to obtain fluid extract, adding radix Ginseng decoction, adding colla Corii Asini, colla Plastri Testudinis, and oxhide gelatin, which are soaked in 5 years old yellow wine for 3 days, and stirring;
(3) Continuously stirring with slow fire, adding semen Juglandis granule and xylitol adjuvant, continuously stirring, adding concentrated solution of fructus Amomi and fructus Amomi rotundus when decocting, and rapidly mixing to obtain paste;
the preparation method of the fructus amomi and fructus amomi concentrated solution comprises the following steps: crushing the raw materials rapidly with a small-sized traditional Chinese medicine pulverizer to obtain coarse powder, placing the coarse powder in a stainless steel sealing tank, adding boiled water, sealing for 3 hr, filtering the medicinal liquid with multiple layers of gauze, and squeezing the residue to obtain a concentrated medicinal liquid with strong fragrance, so as to maximally store the volatile oil.
Example 2
A traditional Chinese medicine paste formula for nourishing liver and kidney, soothing nerves and aiding sleep, which is different from the formula in the embodiment 1, and the traditional Chinese medicine paste formula comprises the following medicines:
50g of radix asparagi, 50g of radix ophiopogonis, 100g of radix rehmanniae, 50g of radix achyranthis bidentatae, 150g of Chinese yam, 50g of eucommia ulmoides, 50g of cornus officinalis, 100g of poria with hostwood, 50g of sun-dried ginseng, 50g of codonopsis pilosula, 50g of radix glehniae, 50g of schisandra chinensis, 100g of morinda officinalis, 60g of angelica sinensis, 50g of spina date seeds, 50g of salvia miltiorrhiza, 50g of raw astragalus membranaceus, 60g of cortex lycii radicis, 60g of pericarpium citri reticulatae, 100g of semen cuscutae, 100g of cistanche, 50g of wolfberry fruits, 40g of chrysanthemum morifolium, 50g of raspberry, 50g of rhizoma curculiginis, 100g of herba epimedii, 40g of cortex phellodendri, 100g of fried bighead atractylodes rhizome, 50g of fried malt, 50g of raw malt, 50g of rice sprout, 40g of endothelium corneum gigeriae galli, 10g of amomum cardamomum fruit, 40g of walnut meat, 100g of donkey-hide gelatin, 100g of glue and 100g of yellow tortoise gelatin.
Example 3
A traditional Chinese medicine ointment formula for nourishing liver and kidney, soothing nerves and aiding sleep, which is different from the embodiment 1 in that the following medicines are used:
150g of asparagus, 150g of dwarf lilyturf tuber, 200g of rehmannia root, 150g of twotooth achyranthes root, 250g of common yam rhizome, 150g of eucommia bark, 150g of cornus fruit, 200g of Indian bread with pine, 100g of sun-dried ginseng, 100g of pilose asiabell root, 100g of coastal glehnia root, 120g of Chinese magnoliavine fruit, 150g of medicinal indianmulberry root, 120g of Chinese angelica, 150g of spina date seed, 150g of red-rooted salvia root, 150g of raw astragalus root, 100g of Chinese wolfberry root-bark, 120g of tangerine peel, 100g of south dodder seed, 200g of desertliving cistanche, 150g of barbary wolfberry fruit, 80g of Hangzhou white chrysanthemum, 150g of raspberry, 150g of common curculigo rhizome, 200g of epimedium herb, 80g of amur corktree bark, 100g of stir-fried largehead atractylodes rhizome, 150g of roasted malt, 150g of raw malt, 150g of rice sprout, 80g of chicken's gizzard-skin, 50g of round cardamon fruit, 80g of walnut meat, 200g of donkey-hide gelatin, 150g of glue 150g and 150g of yellow tortoise gelatin.
Efficacy test of cream formulation-taking the cream formulation of example 1 as an example
1. Clinical data
1) The clinical cases are from the traditional Chinese hospital in Wenzhou city, 280 evaluation cases are included, the time is 2017-2021, and the diagnosis standard, the inclusion standard and the exclusion standard of the clinical cases are respectively as follows:
(1) Compliance with the diagnostic criteria of the case:
the diagnosis standard of western medicine for the case needs to meet the diagnosis standard of chronic fatigue syndrome in the disease prevention and control center (CDC) of 1994 or the insomnia diagnosis standard of Chinese Insomnia diagnosis and treatment guideline for adults (2017 edition). Chronic fatigue syndrome criteria, fatigue (weakness) time lasting at least 6 months, and being diagnosable meeting at least 4 of the following 8 items: (1) short-term memory decline or inattention; (2) sore throat; (3) swollen and tender neck or axillary lymph nodes; (4) muscular soreness; (5) joint pain without redness and swelling; (6) new onset headache; (7) it can not restore energy after sleeping; (8) physical discomfort continued for 24 hours after physical or mental fatigue. Insomnia diagnosis standard, there are 1 or more of the following sleep-related symptoms: (1) difficulty in falling asleep; (2) difficulty in sleep maintenance; (3) awakening earlier than the desired time of getting up; (4) do not want to go to bed at the right time. The following 1 or more daytime symptoms associated with insomnia are present: (1) fatigue or lack of energy; inattention or memory impairment; impairment of social, household, professional or academic functions; (2) the mood is easy to be irritated or excited; (3) excessive concern with sleep problems or dissatisfaction with sleep quality.
The traditional Chinese medicine syndrome refers to the diagnosis standard of liver and kidney deficiency syndrome in traditional Chinese medicine diagnostics and traditional Chinese medicine clinical diagnosis and treatment standard syndrome part, namely (1) the main symptoms: lassitude, asthenia, insomnia, amnesia, marasmus, short breath and low voice; (2) the following symptoms: lusterless complexion, palpitation, dizziness, tinnitus, spontaneous perspiration, night sweat, soreness of the waist and knees, lying-loving, hypokinesia, vomiting, clear saliva, flushed cheeks, red lips, dry mouth, dysphoria, anorexia, abdominal distention, loose stool, sexual function decline, spermatorrhea, and diarrhea; (3) tongue manifestation: pale, swollen and tender tongue with white and moist coating or red tongue with thin and small coating; (4) pulse conditions: deep and thready, or thready and rapid, or wiry and thready; wherein at least 1 item of each of the main symptoms, the secondary symptoms and the tongue pulse is satisfied.
(2) Case inclusion criteria:
(1) the southeast coastal area is mainly a resident living in Wenzhou city for a long time and is a middle-aged and old patient meeting the diagnosis standard; (2) age 40-85 years; (3) the patient can clearly self-state the illness and sign an informed consent;
(3) Case exclusion criteria:
(1) there are serious fundamental diseases such as heart, brain, liver, kidney and hematopoietic diseases; (2) patients suffering from mental or cognitive disorders; (3) those with a history of alcohol and drug abuse; (4) allergic to the components of the ointment formula; (5) women in lactation, pregnancy, and pregnancy preparation; (6) other clinical trial participants were participating or participated within 3 months.
2) The ointment formula administration method comprises the following steps:
(1) The taking method comprises the following steps: directly orally administered, or orally administered with warm boiled water;
(2) The dosage is as follows: 2 times per day, 1 spoon per time, half an hour to one hour before sleeping at night and taking on empty stomach in the early morning;
(3) Note that: use with cautions for patients with profuse phlegm-dampness; if the patients suffer from common cold, food injury, diarrhea, excessive internal heat, etc., the patients should pause taking or consult doctors; the spoon is required to be anhydrous and oilless when used;
(4) It is recommended that the soft extract is taken from a small dose, and one bottle of soft extract (180 mL/bottle) is taken in 7 days.
3) The clinical evaluation method comprises the following steps:
the traditional Chinese medicine syndrome score is quantitatively graded into 0, 2, 4 and 6 according to the main symptoms of absence, light, medium and heavy symptoms in turn, and the secondary symptoms of absence, light, medium and heavy symptoms in turn are quantitatively graded into 0, 1, 2 and 3 according to the standard of the clinical research guiding principle of new traditional Chinese medicines: (1) clinical cure: clinical symptoms and physical signs disappear or basically disappear, and the syndrome score is reduced by more than or equal to 90 percent; (2) improvement: the clinical symptoms and physical signs are obviously improved, and the syndrome integral is reduced by more than or equal to 70 percent but less than 90 percent; (3) effective: the clinical symptoms and physical signs are improved, and the syndrome integral is reduced by more than or equal to 30 percent but less than 70 percent; and (4) invalidation: clinical symptoms and physical signs are not obviously improved or even aggravated, and the syndrome score is reduced by less than 30%.
4) According to statistics, 280 people eating the paste formula eat for 2 months, wherein the fatigue is improved by 85 percent, the insomnia is improved by 80 percent, the waist soreness is improved by 82 percent, and the abdominal distension and constipation are improved by 60 percent.
Further specific case descriptions are provided below:
case 1: certain of plum, age 56, gender, residence: grape Jingyuan of south Vietnam street of Wenzhou city deer town;
symptoms are: the main symptoms are: insomnia, weakness; the secondary symptoms are as follows: tinnitus, soreness of the waist, abdominal distension and constipation, and lusterless complexion; the tongue is pale red, the coating is thin and white, and the pulse is wiry and thin;
prescription: the cream formulation of example 1;
the effect is as follows: after the ointment formula is taken for one month according to the medicine taking method, the self-complaint of abdominal distension, constipation, hypodynamia and soreness of waist are obviously improved; the bystander appeals that the complexion is ruddy and obvious, but insomnia still needs to eat 0.4mg of alprazolam and 5mg of thinking to sleep reluctantly, and chronic tinnitus still exists for many years;
the sleep is also obviously improved after the patient continues to take the cream formula for 2 months according to the advice of the doctor, the patient does not dare to stop taking the soporific medicine for sleeping all the year round, and the patient still takes 0.4mg of alprazolam before sleeping, but the sleeping time and the sleeping quality are improved compared with the prior art. In addition, tinnitus is only prone to develop after exertion. Meanwhile, the symptoms of mental appearance, weakness, waist soreness, abdominal distension, constipation and the like are obviously improved, and the working energy and the working efficiency can not be in the same day.
Case 2: zheng a certain, age 72 years, sex male, place of residence: zhenghui village in Wanquan Zhengyang county, pingyang, wenzhou city;
symptoms are as follows: the main symptoms are: insomnia (difficulty in falling asleep again after waking up after about 8 nights, repeated waking throughout the night, poor sleep quality), asthenia, amnesia, marked decline in memory and sometimes emotional anxiety; the secondary symptoms are as follows: dark and gloomy complexion, soreness and pain of the waist, lumbago, dizziness, abdominal distension and diarrhea; pale-red, swollen, tender and thin coating, ecchymosis under the tongue, deep and thready pulse;
prescription: the cream formulation of example 1;
the effects are as follows: when the ointment formula is taken for 2 months according to the medicine taking method, the insomnia is obviously improved compared with the prior art, the patient can fall asleep at 8 o 'clock later until the patient becomes awake at 3 o' clock in the morning of the next day, and the sleep quality is improved; the fatigue is improved, and the daily activities do not feel tired; soreness of waist and lumbago improved but still evident in afternoon to night; the hypomnesia still exists, but the family members complain of the stable emotion, clear and clear head and relieve dizziness during the administration period; the complexion becomes dark and bright and ruddy gradually; abdominal distension is only evident when overeating occurs and diarrhea remains. After the ointment formula is continuously taken for 2 months following the medical advice, the sleep is stable, the emotion is bright, the fatigue and the waist soreness are relieved, the abdominal distension does not exist after normal eating, the stool quality is soft, and the curative effect is satisfactory.

Claims (10)

1. The traditional Chinese medicine ointment formula for nourishing liver and kidney, soothing nerves and aiding sleep is characterized by comprising the following components: radix asparagi, radix Ophiopogonis, radix rehmanniae, achyranthis radix, rhizoma Dioscoreae, eucommiae cortex, corni fructus, poria, radix Ginseng, radix Codonopsis, radix Glehniae, fructus Schisandrae, radix Morindae officinalis, radix Angelicae sinensis, semen Ziziphi Spinosae, saviae Miltiorrhizae radix, radix astragali, cortex Lycii, pericarpium Citri Tangerinae, semen Cuscutae, cistanchis herba, fructus Lycii, flos Chrysanthemi, rubi fructus, rhizoma Curculiginis, herba Epimedii, cortex Phellodendri, parched Atractylodis rhizoma, parched fructus Hordei Germinatus, fructus oryzae, endothelium corneum Gigeriae Galli, fructus Amomi rotundus, fructus Amomi, semen Juglandis, colla Corii Asini, colla Plastri Testudinis, and gelatinum oxhide.
2. The traditional Chinese medicine ointment formula of claim 1, which is characterized by comprising the following components in parts by weight:
50-150 parts of radix asparagi, 50-150 parts of radix ophiopogonis, 100-200 parts of radix rehmanniae, 50-150 parts of radix achyranthis bidentatae, 150-250 parts of Chinese yam, 50-150 parts of eucommia ulmoides, 50-150 parts of cornus officinalis, 100-200 parts of poria with hostwood, 50-100 parts of sun-dried ginseng, 50-100 parts of codonopsis pilosula, 50-100 parts of radix glehniae, 50-120 parts of schisandra chinensis, 100-150 parts of morinda officinalis, 60-120 parts of angelica sinensis, 50-150 parts of spina date seed, 50-150 parts of salvia miltiorrhiza, 50-150 parts of raw astragalus membranaceus, 60-120 parts of cortex lycii radicis, 60-120 parts of pericarpium citri reticulatae, 100-150 parts of semen cuscutae, and 100-200 parts of cistanche, 50-150 parts of wolfberry fruit, 40-80 parts of Hangzhou white chrysanthemum, 50-150 parts of raspberry, 50-150 parts of curculigo orchioides, 100-200 parts of epimedium, 40-80 parts of golden cypress, 100-150 parts of fried bighead atractylodes rhizome, 50-150 parts of fried malt, 50-150 parts of raw malt, 50-150 parts of rice sprout, 40-80 parts of chicken's gizzard-membrane, 10-50 parts of amomum cardamomum, 40-80 parts of fructus amomi, 100-200 parts of walnut meat, 100-200 parts of donkey-hide gelatin, 100-200 parts of tortoise-shell glue and 100-200 parts of yellow gelatin.
3. The traditional Chinese medicine ointment formula of claim 1, which is characterized by comprising the following components in parts by weight:
100 parts of asparagus cochinchinensis, 100 parts of radix ophiopogonis, 150 parts of radix rehmanniae, 100 parts of radix achyranthis bidentatae, 200 parts of Chinese yam, 100 parts of eucommia ulmoides, 100 parts of cornus officinalis, 150 parts of poria with hostwood, 50 parts of sun-dried ginseng, 50 parts of codonopsis pilosula, 50 parts of radix glehniae, 90 parts of schisandra chinensis, 120 parts of morinda officinalis, 90 parts of angelica sinensis, 100 parts of spina date seeds, 100 parts of salvia miltiorrhiza, 100 parts of raw astragalus membranaceus, 120 parts of cortex lycii radicis, 90 parts of pericarpium citri reticulatae, 120 parts of semen cuscutae, 150 parts of cistanche, 100 parts of wolfberry fruits, 60 parts of Hangzhou white chrysanthemum, 100 parts of raspberry, 100 parts of curculigo orchioides, 150 parts of epimedium chinensis, 60 parts of golden cypress, 120 parts of fried bighead atractylodes rhizome, 100 parts of fried malt, 100 parts of raw malt, 100 parts of rice sprout, 60 parts of endothelium corneum gigeriae galli, 30 parts of amomum cardamomum, 50 parts of walnut meat, 100 parts of donkey-hide gelatin, 100 parts of tortoise-shell glue and 100 parts of yellow gelatin.
4. The traditional Chinese medicine ointment formula of any one of claims 1 to 3, which is characterized by further comprising one or more of yellow wine, honey and a sweetener.
5. The herbal paste formulation of claim 4, wherein the sweetener is xylitol.
6. The method for preparing the traditional Chinese medicine ointment formula according to any one of claims 1 to 5, which comprises the following steps:
(1) Soaking the above materials in water, decocting, separating medicinal liquid, concentrating, and collecting paste;
(2) Adding sun-dried ginseng decoction when concentrating to obtain fluid extract, adding colla Corii Asini, colla Plastri Testudinis and oxhide gelatin, and stirring;
(3) Decocting with slow fire to obtain paste, adding semen Juglandis, decocting to obtain suspension, adding the concentrated solution of fructus Amomi and fructus Amomi rotundus, and mixing.
7. The production method according to claim 6, wherein in step (1): the dosage ratio of the medicines to the water is 1.
8. The preparation method according to claim 6 or 7, wherein the decoction is first decocted for 1.5-2.5 h, the liquid medicine is separated, warm water with the mass of 60-70% of the first water is added into the dregs of a decoction and decocted for 1-1.5 h, the liquid medicine is separated, and the two liquid medicines are combined.
9. The preparation method according to claim 6, wherein the gelatin powder of the donkey-hide gelatin, the tortoise-shell gelatin and the oxhide gelatin in the step (2) is used after being soaked in yellow wine for 2 to 3 days.
10. The method of claim 6, wherein the concentrate of fructus Amomi and fructus Amomi rotundus in step (3) is prepared by: crushing the raw materials, putting the crushed raw materials into a sealed container, adding water, boiling for 2-3 h, and then separating liquid medicine to obtain concentrated solution;
and/or adding a sweetening agent or honey when decocting the pearl in the step (3).
CN202211245753.XA 2022-10-12 2022-10-12 Traditional Chinese medicine paste prescription suitable for middle-aged and elderly people to nourish liver and kidney, calm nerves and help sleep and preparation method thereof Withdrawn CN115554373A (en)

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