CN1554324A - Chinese medicinal tooth-paste - Google Patents
Chinese medicinal tooth-paste Download PDFInfo
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- CN1554324A CN1554324A CNA031596517A CN03159651A CN1554324A CN 1554324 A CN1554324 A CN 1554324A CN A031596517 A CNA031596517 A CN A031596517A CN 03159651 A CN03159651 A CN 03159651A CN 1554324 A CN1554324 A CN 1554324A
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Abstract
The Chinese medicinal toothpaste contains Chinese herbal medicine in 0.01-1.5 wt%, and the Chinese herbal medicine contains at least 10% common jasminorange extractum. The common jasminorange extractum is prepared with common jasminorange as material and through crushing, ethanol diacolation, decompression concentration of the diacolated liquid to obtain paste while recovering ethanol, and regulating pH to 7-10 to regulate yield of 50-150%. The toothpaste has the health functions of eliminating swelling, detoxicating, relieving pain, removing blood stasis, eliminating wind evil, etc. so that it has obvious effects of preventing and treating toothache, gum bleeding, gingivitis, periodontal abscess and other oral and tooth diseases.
Description
Technical field
The present invention relates to toothpaste, especially a kind of Chinese medicinal toothpaste that contains the vegetable Chinese herbal medicine composite.
Background technology
Toothpaste is indispensable oral cavity cleaning hygienic article in people's daily life, and the basic function of toothpaste is cleaning teeth, and fresh breath reaches the purpose that keeps oral cavity cleaning.In recent years, because the consumer healthcare realizes continuous enhancing, toothpaste has been proposed more requirement, therefore, both at home and abroad toothpaste market to clean the teeth be merely purpose toothpaste seldom, and the toothpaste of various functional types becomes the market mainstream, again because Chinese medicine has the incomparable advantages of Western medicine such as natural, safe, more becomes the most important thing of current development so market is the functional type toothpaste of active component with Chinese medicine.For example: Unilever produces Chinese Chinese herbal toothpaste, Colgate-Palmolive Colgate-Palmolive Company in Guangzhou produces Colgate-Palmolive herbaceous toothpaste, the black younger sister's herbal mixture toothpaste of U.S. company's production in morning, P﹠G's production Crest All-in-One (containing Chinese herbal medicine) toothpaste etc., and other also have tianqi toothpaste, Radix Scutellariae toothpaste, Radix Berberidis toothpaste or the like.(patent publication No. is CN1386492A to Chinese patent application " new type natural care toothpaste ", the applying date is: 05 month 18 days calendar year 2001) and Chinese patent application " a kind of medicated toothpaste " (patent publication No. is CN1336169A, and the applying date is: on 07 29th, 2000) two kinds of functional type toothpaste that contain medicinal herb components are disclosed respectively.In these toothpaste majority is a Chinese medicine and western medicine in conjunction with working, and is main functional component with Western medicine, though and other toothpaste based on Chinese medicine ingredients, effect is undesirable.
Summary of the invention
The purpose of this invention is to provide a kind of have obvious antiinflammatory, hemostasis, antibacterial, analgesic activity, and to medicable Chinese medicinal toothpastes of disease such as the common toothache in oral cavity, gingivitis, periodontitis, gingival hemorrhages.
The technical scheme that the Chinese medicinal toothpaste that the present invention adopts constitutes is: include the Chinese herbal medicine composite in its mastic:
A, the weight ratio content of described Chinese herbal medicine composite in described lotion of toothpaste are 0.05-1.5%, include weight ratio in this Chinese herbal medicine composite at least and be 10% murraya paniculata concrete;
B, described murraya paniculata concrete are with the Folium Et Cacumen Murrayae medical material, are crushed to 0.1-10 millimeter-sized particles material; As solvent, is that per minute 1-100 milliliter percolation extract with percolation speed with the ethanol of 40-90%, and percolate is through decompression recycling ethanol, after being concentrated into the clear paste that relative density is 1.0-1.3, regulate acid-base value, making pH value is 7-10, and the control yield is the thing that makes of 50-150%.
Such scheme also can further be specialized, comprise in the described Chinese herbal medicine composite: having weight ratio in A, the described Chinese herbal medicine composite at least is that 30% part is the extractum that is made by Folium Et Cacumen Murrayae and two kinds of Chinese herbal medicine of Radix Zanthoxyli, and the proportioning of these two kinds of former medicines of Chinese herbal medicine is that the former medicine of Folium Et Cacumen Murrayae is that 10-70 weight portion, the former medicine of Radix Zanthoxyli are the 30-90 weight portion; The extractum that B, described Folium Et Cacumen Murrayae and two kinds of Chinese herbal medicine of Radix Zanthoxyli make is that former medicine of the Folium Et Cacumen Murrayae of proportional quantity and the former medicated powder of Radix Zanthoxyli are broken to 0.1-10 millimeter-sized particles material and mixing; As solvent, is that per minute 1-100 milliliter percolation extract with percolation speed with the ethanol of 40-90%, and percolate is through decompression recycling ethanol, after being concentrated into the clear paste that relative density is 1.0-1.3, regulate acid-base value, making pH value is 7-10, and the control yield is the thing that makes of 50-150%.
Also can include chlorophyll solution in the said herbal medicine composite, the weight portion less than 70% of this chlorophyll solution in described Chinese herbal medicine composite, described chlorophyll solution is meant the paste sodium copper chlorophllin that total copper amount is 0.2-0.3%.
Except that the Chinese herbal medicine composite, its mastic composition also can comprise wetting agent as sorbitol etc., as the thickening agent of sodium carboxymethyl cellulose etc., as the sweeting agent of saccharin sodium etc., as the essence of thin He essence etc., as the foaming agent of sodium lauryl sulphate etc., the conventional composition of existing ordinary toothpastes such as stabilizing agent received etc. as the abrasive of calcite in powder etc., as benzoic acid.
In the middle of the said herbal medicine composite:
Folium Et Cacumen Murrayae: have another name called MANSHANXIANG, Murraya paniculata (L.) Jack., tetramerous jasminorange leaf etc., be rutaceae.With its dry stem and leaf, contain multiple Coumarins, flavone compound, volatile oil, alkaloid etc., warm in nature; Acrid in the mouth, little hardship.Be used to cure rheumatic arthralgia, treating swelling and pain by traumatic injury, toothache etc.Has promoting flow of QI and blood, eliminating stasis to stop pain, effects such as removing toxic substances and promoting subsidence of swelling, local anesthesia, spasmolytic, antiinflammatory, anticoagulation.
Radix Zanthoxyli: have another name called climing green pepper, Radix Zanthoxyli, two-sided pin etc., be rutaceae.Use its dry root, contain multiple alkaloid, lignanoid, flavone compound, property is flat, acrid in the mouth is bitter.Be used to cure traumatic injury, rheumatic arthralgia, toothache etc.Have promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, effects such as collateral dredging dispels the wind, antibiotic, antiinflammatory, pain relieving, calmness, spasmolytic, anticancer, anti-hepatitis virus also have effect to cardiovascular system in addition.
Chlorophyll: taking from the green plants leaf, is a kind of natural copper sodium, can be used as the non-polluted edible pigment.Has hemostasis and anti-inflammation, prevent halitosis, promote effects such as wound healing.
The present invention program compares the good effect that is had with existing medicated toothpaste:
Not only having stronger subduing swelling and detoxicating, promoting the circulation of QI to relieve pain, eliminating stagnation removing blood stasis collateral dredging dispels the wind, effects such as diuretic parasite killing, and have characteristics of natural, environmental protection, safety, to toothache, gingival hemorrhage, gingivitis, periodontal abscess, oral cavity such as pericoronitis, oral ulcer, pharyngolaryngitis and tooth disease have significant prophylactic-therapeutic effect, and can use chronically safely.
Toothpaste of the present invention and our company are produced the contrast test that the Radix Zanthoxyli Chinese medicinal toothpaste is done:
1, be kunming mice at Guangxi Chinese medicine institute to subjects, regular grade; The Wistar rat, regular grade; Content of the test is therapeutical effect test, the influencing test, analgesic activity test (writhing method), the mice docking bleeding time influenced test etc. Oleum Tiglii induced mice ear swelling of toothpaste of the present invention being carried out extracorporeal bacteria inhibitor test, tentative gingivitis, do with function and cure mainly relevant pharmacodynamics test, its efficacy outcomes is as follows:
Toothpaste of the present invention has in various degree inhibitory action to common antibacterials of oral cavity infection such as staphylococcus aureus, staphylococcus epidermidis, Pseudomonas aeruginosa, Candida albicans; Tentative gingivitis had the obvious treatment effect; Can obviously suppress the mice ear due to the Oleum Tiglii; Mouse writhing number of times due to the obvious minimizing glacial acetic acid; And tangible anastalsis arranged.Result of the test shows simultaneously: the effect of toothpaste of the present invention obviously is better than our company and produces the Radix Zanthoxyli Chinese medicinal toothpaste.
The external bacteriostasis of table 1 toothpaste of the present invention
| Test strain | MIC(g/ml) |
| Staphylococcus aureus | ????0.17 |
| Staphylococcus epidermidis | ????0.34 |
| Pseudomonas aeruginosa | ????0.34 |
| Candida albicans | ????0.34 |
Table 2 toothpaste of the present invention is to the therapeutical effect of tentative gingivitis
| Group | Suppression ratio % |
| The Radix Zanthoxyli Chinese medicinal toothpaste | ????44.4 ** |
| Toothpaste high dose group of the present invention | ????59.2 ** |
| Toothpaste low dose group of the present invention | ????48.1 ** |
Table 3 toothpaste of the present invention is to the influence of Oleum Tiglii induced mice ear swelling
| Group | Suppression ratio % |
| The Radix Zanthoxyli Chinese medicinal toothpaste | ????28.7 ** |
| Toothpaste high dose group of the present invention | ????58.2 ** |
| Dosage group in the toothpaste of the present invention | ????46.1 ** |
| Toothpaste low dose group of the present invention | ????33.3 ** |
The analgesic activity of table 4 toothpaste of the present invention
| Group | Suppression ratio % |
| The Radix Zanthoxyli Chinese medicinal toothpaste | ????89.1 ** |
| Toothpaste high dose group of the present invention | ????94.7 ** |
| Dosage group in the toothpaste of the present invention | ????90.2 ** |
| Toothpaste low dose group of the present invention | ????89.1 ** |
Table 5 toothpaste of the present invention is to the mice influence in docking bleeding time
| Group | Suppression ratio % |
| The Radix Zanthoxyli Chinese medicinal toothpaste | ????300.0±89.4 * |
| Toothpaste high dose group of the present invention | ????243.0±51.9 * |
| Dosage group in the toothpaste of the present invention | ????261.0±80.1 * |
| Toothpaste low dose group of the present invention | ????285.0±81.5 * |
Illustrate: in above-listed each table, administration group and substrate matched group compare, and being with * number is the data of null hypothesis P＜0.05, and band * * is the data of null hypothesis P＜0.01.
2, be kunming mice at Guangxi Chinese medicine institute to subjects, the 18-22 gram; The Wistar rat, the toxicology test that the 220-250 gram is done, toothpaste of the present invention is carried out acute toxicity test, comprise that maximum dosage-feeding determination test, rat oral cavity and the gums of mouse stomach administration smear the maximum dosage-feeding determination test of administration, and the local excitation test etc.The result is as follows:
It is 50.8 gram/kilograms that toothpaste of the present invention is given the maximum dosage-feeding of gastric infusion secondary in the mice one day; To smear the maximum dosage-feeding of administration secondary be 4 gram/kilograms for oral cavity and gums in the rat one day, and tangible poisoning manifestations and death condition do not appear in animal after the administration, all no abnormal and difference before and after its general body state, the behavioral activity administration; Oral cavity, coating position and gums mucosa also occur red and swollen, irritant reaction such as fester; The continuous coating of rat oral cavity and gums 7 days once a day, does not all have bad stimulation, and histological examination also finds no the infringement of pass.Prove toothpaste safety of the present invention, nontoxic.
The specific embodiment
The Chinese medicinal toothpaste that the present invention is contained Folium Et Cacumen Murrayae is described in further detail below.
Embodiment 1: the component of lotion of toothpaste comprises:
Sorbitol 18.0%
Carboxycellulose sodium 1.2%
Saccharin sodium 0.3%
Herba Menthae Rotundifoliae essence 0.9%
Sodium lauryl sulphate 2.0%
Calcite in powder 50.0%
Folium Et Cacumen Murrayae and Radix Zanthoxyli extractum 0.2%
Chlorophyll (total copper amount is 0.2-0.3%) 0.5%
Sodium benzoate 0.15%
The pure water surplus.
Above-mentioned Folium Et Cacumen Murrayae and Radix Zanthoxyli extractum are the former medicine of Folium Et Cacumen Murrayae and the former medicine of Radix Zanthoxyli by respectively accounting for is that 50% weight portion is crushed to 2 millimeter-sized particles materials with the two, and mixes; Ethanol with 60% is as solvent, is that 10 milliliters of percolation of per minute extract with percolation speed, and percolate is through decompression recycling ethanol, be concentrated into relative density and be 1.1 clear paste after, regulate acid-base value, making pH value is 9.2, and the control yield is 70% the thing that makes.
Above-mentioned lotion of toothpaste can adopt the dry method system cream production technology of conventional medicine toothpaste to make: liquid material such as the pure water that input measures in temporary cylinder, sorbitol; Powders such as the calcite in powder that input measures in pre-dispersed still, saccharin sodium, carboxycellulose sodium, sodium lauryl sulphate, sodium benzoate carry out pre-dispersed, mixing; Open system cream still vacuum pump and suck above-mentioned liquid material; Open scraper then, advance above-mentioned powder, drive agitator and colloid mill, after 5 minutes, drop into Chinese herbal medicine composites such as murraya paniculata concrete, Radix Zanthoxyli extractum, chlorophyll, drop into essence after 20 minutes, close colloid mill, agitator, scraper after 10 minutes successively, vacuum breaker stops vacuum pump, makes after the sampling detection is qualified.
Embodiment 2: the component of lotion of toothpaste comprises:
Sorbitol 20.0%
Glycerol 10.0%
Guar gum 0.6%
Carboxymethyl cellulose acid sodium 0.7%
Saccharin sodium 0.2%
Fruit essence 1.0%
Sodium lauryl sulphate 2.5%
Calcium hydrogen phosphate 40.0%
Silicon dioxide 8.0%
Murraya paniculata concrete 0.2%
Chlorophyll (total copper amount is 0.2-0.3%) 0.4%
Pure as jade by pure 0.05%
Tetrasodium pyrophosphate 0.2%
The pure water surplus.
Above-mentioned murraya paniculata concrete is that the former medicated powder of Folium Et Cacumen Murrayae is broken to 5 millimeter-sized particles materials; Ethanol with 50% is as solvent, is that 5 milliliters of percolation of per minute extract with percolation speed, and percolate is through decompression recycling ethanol, be concentrated into relative density and be 1.2 clear paste after, regulate acid-base value, making pH value is 9.5, and the control yield is 100% the thing that makes.
In the present embodiment, in temporary cylinder, drop into the liquid material that measures; In pre-dispersed still, drop into the powder grain material that measures, carry out pre-dispersed, mixing; Open system cream still vacuum pump and suck above-mentioned liquid material; Open scraper then, advance above-mentioned powder, drive agitator and colloid mill, after 5 minutes, drop into Chinese herbal medicine composites such as murraya paniculata concrete, drop into essence after 20 minutes, close colloid mill, agitator, scraper after 10 minutes successively, vacuum breaker stops vacuum pump, makes after the sampling detection is qualified.
Embodiment 3: the component of lotion of toothpaste comprises:
Sorbitol 16%
Propylene glycol 5%
Carrageenan 0.5%
Carboxymethyl cellulose acid sodium 0.6%
Saccharin sodium 0.3%
Thin He essence 1.2%
Sodium lauryl sulphate 2.3%
Silica 1 5%
Murraya paniculata concrete 0.3%
Pure as jade by pure 0.11%
The pure water surplus.
Above-mentioned murraya paniculata concrete is that the former medicated powder of Folium Et Cacumen Murrayae is broken to 1.5 millimeter-sized particles materials; Ethanol with 70% is as solvent, is that 15 milliliters of percolation of per minute extract with percolation speed, and percolate is through decompression recycling ethanol, be concentrated into relative density and be 1.0 clear paste after, regulate acid-base value, making pH value is 8.8, and the control yield is 110% the thing that makes.
The production technology of present embodiment lotion of toothpaste is with reference to embodiment 2.
Claims (3)
1, a kind of Chinese medicinal toothpaste includes the Chinese herbal medicine composite in its mastic, it is characterized in that:
A, the weight ratio content of described Chinese herbal medicine composite in described lotion of toothpaste are 0.05-1.5%, include weight ratio in this Chinese herbal medicine composite at least and be 10% murraya paniculata concrete;
B, described murraya paniculata concrete are with the Folium Et Cacumen Murrayae medical material, are crushed to 0.1-10 millimeter-sized particles material; As solvent, is that per minute 1-100 milliliter percolation extract with percolation speed with the ethanol of 40-90%, and percolate is through decompression recycling ethanol, after being concentrated into the clear paste that relative density is 1.0-1.3, regulate acid-base value, making pH value is 7-10, and the control yield is the thing that makes of 50-150%.
2, Chinese medicinal toothpaste according to claim 1 is characterized in that: comprise in the described Chinese herbal medicine composite:
Having weight ratio in A, the described Chinese herbal medicine composite at least is that 30% part is the extractum that is made by Folium Et Cacumen Murrayae and two kinds of Chinese herbal medicine of Radix Zanthoxyli, and the proportioning of these two kinds of former medicines of Chinese herbal medicine is that the former medicine of Folium Et Cacumen Murrayae is that 10-70 weight portion, the former medicine of Radix Zanthoxyli are the 30-90 weight portion;
The extractum that B, described Folium Et Cacumen Murrayae and two kinds of Chinese herbal medicine of Radix Zanthoxyli make is that former medicine of the Folium Et Cacumen Murrayae of proportional quantity and the former medicated powder of Radix Zanthoxyli are broken to 0.1-10 millimeter-sized particles material and mixing; As solvent, is that per minute 1-100 milliliter percolation extract with percolation speed with the ethanol of 40-90%, and percolate is through decompression recycling ethanol, after being concentrated into the clear paste that relative density is 1.0-1.3, regulate acid-base value, making pH value is 7-10, and the control yield is the thing that makes of 50-150%.
3, Chinese medicinal toothpaste according to claim 2 is characterized in that:
Include chlorophyll solution in A, the described Chinese herbal medicine composite, the weight portion less than 70% of this chlorophyll solution in described Chinese herbal medicine composite;
B, described chlorophyll solution are meant the paste sodium copper chlorophllin that total copper amount is 0.2-0.3%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03159651 CN1234342C (en) | 2003-09-24 | 2003-09-24 | Chinese medicinal tooth-paste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03159651 CN1234342C (en) | 2003-09-24 | 2003-09-24 | Chinese medicinal tooth-paste |
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| Publication Number | Publication Date |
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| CN1554324A true CN1554324A (en) | 2004-12-15 |
| CN1234342C CN1234342C (en) | 2006-01-04 |
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|---|---|---|---|
| CN 03159651 Expired - Lifetime CN1234342C (en) | 2003-09-24 | 2003-09-24 | Chinese medicinal tooth-paste |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579305A (en) * | 2012-03-29 | 2012-07-18 | 安徽两面针·芳草日化有限公司 | Natural medicine toothpaste with saussurea involucrata as major material |
| CN102579312A (en) * | 2012-03-23 | 2012-07-18 | 常熟市虞山绿茶有限公司 | Toothpaste for preventing and treating gingivitis and preparation method for toothpaste |
| CN102772342A (en) * | 2012-08-22 | 2012-11-14 | 柳州两面针股份有限公司 | Traditional Chinese medicine toothpaste capable of diminishing inflammation and relieving pain |
| CN105031283A (en) * | 2015-08-31 | 2015-11-11 | 王学宽 | Medicine combination preventing and treating dry socket |
| CN105106060A (en) * | 2015-08-26 | 2015-12-02 | 施如涛 | Traditional Chinese medicine toothpaste containing arnebia root oil |
| CN105106061A (en) * | 2015-08-26 | 2015-12-02 | 施如涛 | Traditional Chinese medicine toothpaste containing calamine |
| CN105106058A (en) * | 2015-08-26 | 2015-12-02 | 施如涛 | Traditional Chinese medicine toothpaste capable of relieving dental pain |
| CN105748356A (en) * | 2016-03-13 | 2016-07-13 | 新疆中草堂医药科技有限公司 | Compound Herba Achilleae Alpinae bitter toothpaste |
| CN106265395A (en) * | 2016-03-18 | 2017-01-04 | 新疆中草堂医药科技有限公司 | A kind of compound recipe snow chrysanthemum health-care toothpaste |
| CN110859790A (en) * | 2019-12-30 | 2020-03-06 | 柳州两面针股份有限公司 | Application of traditional Chinese medicine composition in preparation of oral care product |
| CN116983348A (en) * | 2023-08-31 | 2023-11-03 | 浙江工业大学 | Traditional Chinese medicine composition for inhibiting bone cancer pain and preparation and application thereof |
-
2003
- 2003-09-24 CN CN 03159651 patent/CN1234342C/en not_active Expired - Lifetime
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579312A (en) * | 2012-03-23 | 2012-07-18 | 常熟市虞山绿茶有限公司 | Toothpaste for preventing and treating gingivitis and preparation method for toothpaste |
| CN102579305A (en) * | 2012-03-29 | 2012-07-18 | 安徽两面针·芳草日化有限公司 | Natural medicine toothpaste with saussurea involucrata as major material |
| CN102579305B (en) * | 2012-03-29 | 2013-10-09 | 安徽两面针·芳草日化有限公司 | Natural medicine toothpaste with saussurea involucrata as major material |
| CN102772342A (en) * | 2012-08-22 | 2012-11-14 | 柳州两面针股份有限公司 | Traditional Chinese medicine toothpaste capable of diminishing inflammation and relieving pain |
| CN105106061A (en) * | 2015-08-26 | 2015-12-02 | 施如涛 | Traditional Chinese medicine toothpaste containing calamine |
| CN105106060A (en) * | 2015-08-26 | 2015-12-02 | 施如涛 | Traditional Chinese medicine toothpaste containing arnebia root oil |
| CN105106058A (en) * | 2015-08-26 | 2015-12-02 | 施如涛 | Traditional Chinese medicine toothpaste capable of relieving dental pain |
| CN105031283A (en) * | 2015-08-31 | 2015-11-11 | 王学宽 | Medicine combination preventing and treating dry socket |
| CN105748356A (en) * | 2016-03-13 | 2016-07-13 | 新疆中草堂医药科技有限公司 | Compound Herba Achilleae Alpinae bitter toothpaste |
| CN105748356B (en) * | 2016-03-13 | 2019-09-10 | 新疆中草堂医药科技有限公司 | A kind of compound Artemisia rupestris bitter taste toothpaste |
| CN106265395A (en) * | 2016-03-18 | 2017-01-04 | 新疆中草堂医药科技有限公司 | A kind of compound recipe snow chrysanthemum health-care toothpaste |
| CN110859790A (en) * | 2019-12-30 | 2020-03-06 | 柳州两面针股份有限公司 | Application of traditional Chinese medicine composition in preparation of oral care product |
| CN110859790B (en) * | 2019-12-30 | 2022-06-24 | 柳州两面针股份有限公司 | Application of traditional Chinese medicine composition in preparation of oral care product |
| CN116983348A (en) * | 2023-08-31 | 2023-11-03 | 浙江工业大学 | Traditional Chinese medicine composition for inhibiting bone cancer pain and preparation and application thereof |
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| Publication number | Publication date |
|---|---|
| CN1234342C (en) | 2006-01-04 |
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Granted publication date: 20060104 |