CN104739922B - A kind of Chinese medicine opens larynx sword mouthwash and preparation method thereof - Google Patents
A kind of Chinese medicine opens larynx sword mouthwash and preparation method thereof Download PDFInfo
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- CN104739922B CN104739922B CN201510188179.2A CN201510188179A CN104739922B CN 104739922 B CN104739922 B CN 104739922B CN 201510188179 A CN201510188179 A CN 201510188179A CN 104739922 B CN104739922 B CN 104739922B
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Abstract
The present invention relates to a kind of Chinese medicines to open larynx sword mouthwash and preparation method thereof, belong to drug field, active constituent is Crisped Ardisia Ardisia gigantifolia, subprostrate sophora, cicada slough, menthol, and said medicine is prepared into mouthwash by the present invention, convenient to use and significant effect, can provide more selections for clinic.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to Chinese medicine opens larynx sword mouthwash and preparation method thereof.
Background technique
CN1686185A discloses a kind of Chinese medicine composition, is prepared into spray by Crisped Ardisia Ardisia gigantifolia, subprostrate sophora, cicada slough,
Chinese medicine thinks that its effect is clearing heat and detoxicating, swelling and pain relieving, is mainly used for acute and chronic pharyngitis, tonsillitis, abscess of throat and mouth
The diseases such as chamber inflammation, canker sore.
CN103040927A is optimized for previous process, and obtained process modification opens larynx sword spray.
Opening larynx sword spray at present has been marketed products, has the effect of clearing heat and detoxicating, swelling and pain relieving.Accumulate for lung stomach
Abscess of throat caused by heat, dry mouth with bitter taste, swelling and aching of gum and canker sore, above patient of recurrent aphthous ulcer etc..
There is presently no open larynx sword mouthwash formulations.
Summary of the invention
The present invention is based on clinical use needs, research is prepared for a kind of Chinese medicine and opens larynx sword mouthwash formulations, the Chinese materia medica preparation
Raw material has Crisped Ardisia Ardisia gigantifolia, subprostrate sophora, cicada slough, 4 taste medicine of menthol, and each Chinese medicine weight ratio is Crisped Ardisia Ardisia gigantifolia: subprostrate sophora: cicada slough: thin
Lotus brain=200-350:200-350:150-280:0.8-1.2, preferably each Chinese medicine weight ratio are Crisped Ardisia Ardisia gigantifolia: subprostrate sophora: cicada
It sloughs off: menthol=270-350:270-350:220-280:0.8-1.2.
Preparation method are as follows: Crisped Ardisia Ardisia gigantifolia, subprostrate sophora, three taste of cicada slough add water to cook secondary, 2 hours first times, second
Secondary 1 hour, collecting decoction, filtration was concentrated into the clear cream that relative density is 1.05~1.10 (50 DEG C), ethyl alcohol is added, makes alcohol-containing
Amount stands 24 hours up to 80%, filtration, decompression filtrate recycling ethanol
With above-mentioned medicinal extract and menthol collectively as the active constituent of mouthwash.
By many experiments and research, present invention determine that the concrete composition of mouthwash includes: Crisped Ardisia Ardisia gigantifolia: subprostrate sophora:
Cicada slough=200-350g:200-350g:150-280g, preferably Crisped Ardisia Ardisia gigantifolia 270-350g, subprostrate sophora 270-350g, cicada slough
220-280g extracts to obtain medicinal extract, menthol 0.8-1.2g, wetting agent 2-10g, film forming agent 4-10g, sweet tea according to preceding method
Taste agent is appropriate, appropriate acid, appropriate essence, and 95% ethyl alcohol 20-100ml adds water to be prepared into 5000ml altogether.
Wherein wetting agent is selected from glycerine, D-sorbite, and film forming agent is selected from PEG400, polyvinylpyrrolidone, Bo Luosha
Nurse, polyoxyethylene hardened castor oil, sweetener are selected from one of xylitol, Steviosin, honey element, and acid is selected from lemon
One of acid, tartaric acid, malic acid.The effect of film forming agent is to promote the uniform presence of whole system drug, while extending
The residence time of site of action is to guarantee drug effect.Essence can be selected from red bayberry essence, flavoring apple essence, strawberry essence etc..
Mouthwash the preparation method comprises the following steps: menthol, wetting agent, film forming agent, sweetener, acid, essence are taken, with 95%
After ethyl alcohol stirring and dissolving, above-mentioned medicinal extract is added, adds water to 5000ml, stirs evenly, filter, it is filling, sterilizing to get.
A small amount of preservative, such as cetylpyridinium chloride can be also added in above-mentioned mouthwash as needed.
Water-wetter of gargling of the invention is preferably glycerine, and film forming agent is preferably PEG400 and polyvinylpyrrolidone
Combination.
Present invention determine that mouthwash preferably include following component: Crisped Ardisia Ardisia gigantifolia: subprostrate sophora: cicada slough=200-350g:
200-350g:150-280g, preferably Crisped Ardisia Ardisia gigantifolia 270-350g, subprostrate sophora 270-350g, cicada slough 220-280g, according to aforementioned
Method is extracted to obtain medicinal extract, menthol 0.8-1.2g, glycerine 2-10g, polyvinylpyrrolidone 2-5g, PEG4002-5g, wood
Sugar alcohol 1-2g, citric acid 2-4g, appropriate essence, 95% ethyl alcohol 20-100ml add water to be prepared into 5000ml altogether.
Mouthwash of the invention especially when using the combination of the polyvinylpyrrolidone and PEG400, can be improved
The drug effect of mouthwash, the mechanism of action may increase attachment and time of the drug in medication part for two kinds of component collaborations.
The override technical solution of mouthwash of the present invention be include following composition: Crisped Ardisia Ardisia gigantifolia 313g, subprostrate sophora 313g,
Cicada slough 250g extracts to obtain medicinal extract according to preceding method, menthol 1g, glycerine 5g, polyvinylpyrrolidone 3g,
PEG4003g, xylitol 1.5g, citric acid 3g, appropriate essence, 95% ethyl alcohol 50ml add water to be prepared into 5000ml altogether.
It is preferred that mouthwash the preparation method comprises the following steps: take menthol, glycerine, xylitol, citric acid, polyvinylpyrrolidone,
PEG400, essence are added above-mentioned medicinal extract, add water to 5000ml, stir evenly after 95% ethyl alcohol stirring and dissolving, filter, and fill
Dress, sterilizing to get.
The mouthwash formulations of the application are maintaining the same of good treatment canker sore effect compared with former spray
When, the effect of swelling and aching of gum is obviously improved, wherein the optimal technical scheme of the application, has used specific film forming agent
Combination, it is more significant for therapeutic effect.
Specific embodiment
The preparation of medicinal extract
Take Crisped Ardisia Ardisia gigantifolia 313g, subprostrate sophora 313g, cicada slough 250g.
The preparation method comprises the following steps: take Crisped Ardisia Ardisia gigantifolia 313g, subprostrate sophora 313g, cicada slough 250g, add water to cook secondary, 2 is small for the first time
When, second 1 hour, collecting decoction, filtration was concentrated into the clear cream that relative density is 1.05~1.10 (50 DEG C), second is added
Alcohol makes alcohol content up to 80%, stands 24 hours, filtration, decompression filtrate recycling ethanol and be condensed into relative density be 1.10~
The medicinal extract of 1.20 (80 DEG C) to get.
Embodiment 1
Drug prescription of the present invention:
Crisped Ardisia Ardisia gigantifolia 313g, subprostrate sophora 313g, cicada slough 250g, menthol 1g, glycerine 5g, xylitol 1.5g, citric acid
3g, polyvinylpyrrolidone 3g, PEG4003g, red bayberry essence is appropriate, 95% ethyl alcohol 50ml, and water is added to be prepared into 5000ml altogether.
The preparation method comprises the following steps: medicinal extract is prepared according to aforementioned medicinal extract preparation method, take menthol, glycerine, xylitol,
Citric acid, polyvinylpyrrolidone, PEG400, essence are added above-mentioned medicinal extract, add water to after 95% ethyl alcohol stirring and dissolving
5000ml is stirred evenly, filtration, it is filling, sterilizing to get.
Embodiment 2
Drug prescription of the present invention:
Eight pawl gold 313g, subprostrate sophora 313g, cicada slough 250g, menthol 1g, glycerine 5g, xylitol 1.5g, citric acid
3g, polyvinylpyrrolidone 6g, red bayberry essence is appropriate, 95% ethyl alcohol 50ml, and water is added to be prepared into 5000ml altogether.
The preparation method comprises the following steps: medicinal extract is prepared according to aforementioned medicinal extract preparation method, menthol, glycerine, xylitol, lemon are taken
Above-mentioned medicinal extract is added after 95% ethyl alcohol stirring and dissolving in lemon acid, polyvinylpyrrolidone, essence, adds water to 5000ml, stirring
Uniformly, filter, it is filling, sterilizing to get.
Embodiment 3
Drug prescription of the present invention:
Crisped Ardisia Ardisia gigantifolia 313g, subprostrate sophora 313g, cicada slough 250g, menthol 1g, glycerine 5g, xylitol 1.5g, citric acid
3g, PEG4006g, red bayberry essence is appropriate, 95% ethyl alcohol 50ml, and water is added to be prepared into 5000ml altogether.
The preparation method comprises the following steps: medicinal extract is prepared according to aforementioned medicinal extract preparation method, menthol, glycerine, xylitol, lemon are taken
Lemon acid, PEG400, essence are added above-mentioned medicinal extract, add water to 5000ml, stir evenly after 95% ethyl alcohol stirring and dissolving, filter
Cross, it is filling, sterilizing to get.
Embodiment 4
Drug prescription of the present invention:
Crisped Ardisia Ardisia gigantifolia 313g, subprostrate sophora 313g, cicada slough 250g, menthol 1g, glycerine 5g, xylitol 1.5g, citric acid
3g, poloxamer 6g, red bayberry essence is appropriate, 95% ethyl alcohol 50ml, and water is added to be prepared into 5000ml altogether.
The preparation method comprises the following steps: medicinal extract is prepared according to aforementioned medicinal extract preparation method, menthol, glycerine, xylitol, lemon are taken
Lemon acid, poloxamer, essence are added above-mentioned medicinal extract, add water to 5000ml, stir evenly after 95% ethyl alcohol stirring and dissolving,
Filtration, it is filling, sterilizing to get.
Embodiment 5
Drug prescription of the present invention:
Crisped Ardisia Ardisia gigantifolia 313g, subprostrate sophora 313g, cicada slough 250g, menthol 1g, glycerine 5g, xylitol 1.5g, citric acid
3g, polyoxyethylene hardened castor oil 6g, red bayberry essence is appropriate, 95% ethyl alcohol 50ml, and water is added to be prepared into 5000ml altogether.
The preparation method comprises the following steps: medicinal extract is prepared according to aforementioned medicinal extract preparation method, menthol, glycerine, xylitol, lemon are taken
Lemon acid, polyoxyethylene hardened castor oil, essence are added above-mentioned medicinal extract, add water to 5000ml after 95% ethyl alcohol stirring and dissolving,
Stir evenly, filter, it is filling, sterilizing to get.
Clinical or pharmacological effect example:
1, for the effect of swelling and aching of gum
Swelling and aching of gum patient totally 60 people, is randomly divided into 6 groups, every group of 10 people.Above-mentioned mouthwash embodiment 1-5 is taken to obtain respectively
To mouthwash, list out larynx sword spray and carry out treatment processing, wherein mouthwash and spray be all daily using 5 times,
For spray Direct spraying in swelling and aching of gum position (spray amount about 2ml), mouthwash carries out processing of gargling with 10ml mouthwash, gargles
Drug dosage after saliva is converted with spray is identical, treats 3 days, as a result as follows:
The standard of recovery from illness is that swelling and aching of gum symptom disappears, and effective standard is that swollen and pain symptom is all substantially reduced, is in vain
It is not improved compared with before treatment.
The experimental results showed that drug is more significant relative to spray effect after being prepared into mouthwash, 3 angel of mouthwash
It is 100% with the sum of rear cure rate and effective percentage, wherein cure rate at least 30%, up to 100%；And spray
The use of cure rate after 3 days is only 10%, and have it is 20% invalid.Its reason may cannot be goed deep into for spray in spraying use
Gum position, and mouthwash can more come into full contact with gum, to guarantee drug effect, sufficiently show selection and be prepared into mouthwash
Advantage after preparation.Wherein after using preferred film forming agent (the mouthwash embodiment 1) of the application, mouthwash effect is then more
Significantly, compared with single film forming agent, which create synergistic effects, significantly improve effect of drugs, produce unexpected effect
Fruit.
2, for the effect of canker sore
Canker sore patient totally 60 people (conventional ulcer), is randomly divided into 6 groups, every group of 10 people.Take above-mentioned mouthwash real respectively
Mouthwash that a 1-5 obtains is applied, larynx sword spray has been listed out and carries out treatment processing, wherein mouthwash and spray are all every
It is used 5 times, spray each spray amount about 2ml, and mouthwash carries out processing of gargling with 10ml mouthwash, mouthwash and is sprayed
Drug dosage after agent conversion is identical, treats 7 days.As a result as follows:
Criterion of therapeutical effect: recovery from illness: canker sore wound healing, pain disappear, do not influence to feed；Effective: oral ulcer surface subtracts
Small, ulcer number is reduced, and pain is clearly better, can influent stream food；Invalid: ulcer is not reduced, and pain symptom is not improved, shadow
Ring feed.
Test result shows effect and spray basic phase of the application medicine preparation at mouthwash for canker sore
When can effectively treat conventional canker sore, test group single cases do not have obvious effect, but obvious effective rate is held at
90% or more level.And then relative efficacy is more significant for the preferred embodiment of the present invention, cure rate significantly improves, and reaches
90%, higher than the level of other groups at most 60%.
To sum up, the mouthwash formulations of the application are while maintaining the effect of good treatment canker sore, for gum
The effect of swelling and pain is obviously improved, and is played a significant role for clinical application, and particularly preferably embodiment produces unexpected
Effect.
Claims (3)
1. a kind of Chinese medicine mouth wash preparation, which has Crisped Ardisia Ardisia gigantifolia, subprostrate sophora, cicada slough, 4 taste medicine of menthol, respectively
Chinese medicine weight ratio is Crisped Ardisia Ardisia gigantifolia: subprostrate sophora: cicada slough: menthol=200-350g:200-350g:150-280g:0.8-1.2g；
The Crisped Ardisia Ardisia gigantifolia, subprostrate sophora, cicada slough are extracted to obtain after medicinal extract as active constituent, medicinal extract the preparation method comprises the following steps: eight pawls
Jin Long, subprostrate sophora, three taste of cicada slough add water to cook secondary, 2 hours first times, second 1 hour, and collecting decoction filters, concentration
To the clear cream that 50 DEG C of relative densities are 1.05~1.10, ethyl alcohol is added, makes alcohol content up to 80%, stands 24 hours, filtration, filtrate
Ethyl alcohol is recovered under reduced pressure and is condensed into the medicinal extract that 80 DEG C of relative densities are 1.10~1.20；
Extract to obtain medicinal extract according to preceding method, menthol 0.8-1.2g, glycerine 2-10g, polyvinylpyrrolidone 2-5g,
PEG400 2-5g, xylitol 1-2g, citric acid 2-4g, appropriate essence, 95% ethyl alcohol 20-100ml add water to be prepared into altogether
5000ml。
2. Chinese medicine mouth wash preparation according to claim 1, each Chinese medicine material weight ratio is Crisped Ardisia Ardisia gigantifolia: subprostrate sophora:
Cicada slough: menthol=270-350g:270-350g:220-280g:0.8-1.2g.
3. Chinese medicine mouth wash preparation according to claim 1 or 2 takes Crisped Ardisia Ardisia gigantifolia 313g, subprostrate sophora 313g, cicada slough
250g extracts to obtain medicinal extract, menthol 1g, glycerine 5g, polyvinylpyrrolidone 3g, PEG400 3g, wood according to preceding method
Sugar alcohol 1.5g, citric acid 3g, appropriate essence, 95% ethyl alcohol 50ml add water to be prepared into 5000ml altogether.
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| CN201510188179.2A CN104739922B (en) | 2015-04-21 | 2015-04-21 | A kind of Chinese medicine opens larynx sword mouthwash and preparation method thereof |
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| CN104739922B true CN104739922B (en) | 2019-03-26 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105148115A (en) * | 2015-09-28 | 2015-12-16 | 王栩 | Oral administration medicine and mouthwash medicine for treating radioactive stomatitis |
| CN115813858A (en) * | 2022-12-16 | 2023-03-21 | 无锡济煜山禾药业股份有限公司 | Children spray for relieving acute pharyngitis and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686185A (en) * | 2005-03-22 | 2005-10-26 | 贵州三力制药有限责任公司 | Traditional Chinese medicina preparation for treating oral cavity, throat disease and its preparation method |
| CN1686482A (en) * | 2005-05-20 | 2005-10-26 | 北京正大绿洲医药科技有限公司 | Kaihoujian drip pill for treating throat disease and its preparation method |
| CN103040927A (en) * | 2011-10-13 | 2013-04-17 | 贵州三力制药有限责任公司 | Open-throat sword spray used for treating throat diseases and preparation method thereof |
-
2015
- 2015-04-21 CN CN201510188179.2A patent/CN104739922B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686185A (en) * | 2005-03-22 | 2005-10-26 | 贵州三力制药有限责任公司 | Traditional Chinese medicina preparation for treating oral cavity, throat disease and its preparation method |
| CN1686482A (en) * | 2005-05-20 | 2005-10-26 | 北京正大绿洲医药科技有限公司 | Kaihoujian drip pill for treating throat disease and its preparation method |
| CN103040927A (en) * | 2011-10-13 | 2013-04-17 | 贵州三力制药有限责任公司 | Open-throat sword spray used for treating throat diseases and preparation method thereof |
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