CN1509292A - 使用c-myc反义寡聚物治疗癌症的结合的方法 - Google Patents
使用c-myc反义寡聚物治疗癌症的结合的方法 Download PDFInfo
- Publication number
- CN1509292A CN1509292A CNA028100719A CN02810071A CN1509292A CN 1509292 A CN1509292 A CN 1509292A CN A028100719 A CNA028100719 A CN A028100719A CN 02810071 A CN02810071 A CN 02810071A CN 1509292 A CN1509292 A CN 1509292A
- Authority
- CN
- China
- Prior art keywords
- myc
- antisense
- oligomer
- seq
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/314—Phosphoramidates
- C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29172701P | 2001-05-17 | 2001-05-17 | |
| US60/291,727 | 2001-05-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1509292A true CN1509292A (zh) | 2004-06-30 |
Family
ID=23121574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA028100719A Pending CN1509292A (zh) | 2001-05-17 | 2002-05-17 | 使用c-myc反义寡聚物治疗癌症的结合的方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030087861A1 (enExample) |
| EP (1) | EP1399462A4 (enExample) |
| JP (1) | JP2004537517A (enExample) |
| KR (1) | KR20040004629A (enExample) |
| CN (1) | CN1509292A (enExample) |
| CA (1) | CA2447052A1 (enExample) |
| NZ (1) | NZ530101A (enExample) |
| WO (1) | WO2002092617A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101624596B (zh) * | 2009-08-12 | 2011-01-26 | 广州金琪基因技术研究发展中心 | 一种靶向c-myc癌基因的外指引序列 |
| CN108338986A (zh) * | 2017-01-23 | 2018-07-31 | 深圳开悦生命科技有限公司 | 一种用于治疗癌症的小分子rna及其应用 |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7640582B2 (en) | 2003-04-16 | 2009-12-29 | Silicon Graphics International | Clustered filesystem for mix of trusted and untrusted nodes |
| EP2351844B1 (en) * | 2003-04-29 | 2014-06-11 | Sarepta Therapeutics, Inc. | Compositions for enhancing transport and antisense efficacy of nucleic acid analog into cells |
| US20050288246A1 (en) * | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
| US8815599B2 (en) | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| WO2006058038A2 (en) * | 2004-11-22 | 2006-06-01 | The Research Foundation Of State University Of New York At Buffalo | In vitro and in vivo silencing of human c-myc oncogene expression by poly-dnp-rna |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| JP5122474B2 (ja) | 2005-12-01 | 2013-01-16 | プロネイ・セラピューティクス・インコーポレイテッド | 両性リポソーム製剤 |
| JP5623016B2 (ja) * | 2005-12-01 | 2014-11-12 | プロネイ・セラピューティクス・インコーポレイテッドPronaitherapeutics, Inc. | 癌治療法およびそれに用いる医薬組成物 |
| WO2007065017A2 (en) * | 2005-12-01 | 2007-06-07 | Pronai Therapeutics, Inc. | Oligonucleotide cationic liposomal delivery system |
| US20070270371A1 (en) * | 2006-03-31 | 2007-11-22 | Brown Bob D | Dosing and scheduling of oligomers |
| ES2645410T3 (es) * | 2006-05-10 | 2017-12-05 | Sarepta Therapeutics, Inc. | Análogos de oligonucleótidos que tienen enlaces intersubunitarios catiónicos |
| JP5864100B2 (ja) * | 2007-06-29 | 2016-02-17 | サレプタ セラピューティクス インコーポレイテッド | 組織特異的ペプチドコンジュゲートおよび方法 |
| US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| US20110269665A1 (en) | 2009-06-26 | 2011-11-03 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| EP2576574A2 (en) | 2010-05-28 | 2013-04-10 | Sarepta Therapeutics, Inc. | Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups |
| WO2012031243A2 (en) | 2010-09-03 | 2012-03-08 | Avi Biopharma, Inc. | dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS |
| US9161948B2 (en) | 2011-05-05 | 2015-10-20 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| CN108864192A (zh) | 2011-11-18 | 2018-11-23 | 萨勒普塔医疗公司 | 功能改性的寡核苷酸及其亚单元 |
| ITMI20120275A1 (it) * | 2012-02-24 | 2013-08-25 | Biogenera Societa A Responsabilita Limitata | Oligonucleotidi per la modulazione dell'espressione genica e loro usi |
| KR102192591B1 (ko) * | 2013-09-09 | 2020-12-18 | 삼성전자주식회사 | c-Met 저해제 및 c-Myc 저해제를 포함하는 병용 투여용 약학 조성물 |
| WO2016048054A2 (ko) * | 2014-09-24 | 2016-03-31 | 삼성전자 주식회사 | 데이터 통신 보안을 위한 방법, 장치 및 시스템 |
| US11020417B2 (en) | 2015-06-04 | 2021-06-01 | Sarepta Therapeutics, Inc | Methods and compounds for treatment of lymphocyte-related diseases and conditions |
| MD3554553T2 (ro) | 2016-12-19 | 2022-10-31 | Sarepta Therapeutics Inc | Conjugați de oligomeri de omitere a exonului, pentru distrofie musculară |
| EP3790890A4 (en) | 2018-05-09 | 2022-03-02 | Ohio State Innovation Foundation | CYCLIC PEPTIDES OF CELL PENETRATION WITH ONE OR MORE HYDROPHOBIC RESIDUES |
| CA3107890A1 (en) * | 2018-08-21 | 2020-02-27 | Deep Genomics Incorporated | Therapeutic splice-switching oligonucleotides |
| US20220088031A1 (en) * | 2019-02-01 | 2022-03-24 | Health Research, Inc. | Methods and compositions for treating resistant and recurrent forms of cancer |
| AU2021270720A1 (en) | 2020-05-11 | 2022-12-08 | Stoke Therapeutics, Inc. | OPA1 antisense oligomers for treatment of conditions and diseases |
| US12378267B2 (en) | 2021-06-17 | 2025-08-05 | Entrada Therapeutics, Inc. | Synthesis of FMOC-protected morpholino monomers and oligomers |
| WO2023205451A1 (en) | 2022-04-22 | 2023-10-26 | Entrada Therapeutics, Inc. | Cyclic peptides for delivering therapeutics |
| KR20250155076A (ko) * | 2023-02-14 | 2025-10-29 | 스톡 테라퓨틱스, 인크. | 안티센스 올리고머 제형 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515781A (en) * | 1983-02-23 | 1985-05-07 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | 2',5'-Riboadenylate-morpholinoadenylate nucleotides |
| US6544755B1 (en) * | 1992-08-26 | 2003-04-08 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for treatment of diseases by expression of the c-Myc gene |
| CA2153158A1 (en) * | 1993-01-07 | 1994-07-21 | Andrew Zalewski | Antisense inhibition of c-myc to modulate the proliferation of smooth muscle cells |
| EP0932698A1 (en) * | 1996-03-26 | 1999-08-04 | Lynx Therapeutics, Inc. | Oligonucleotide treatments and compositions for human melanoma |
| JP2003533986A (ja) * | 2000-05-04 | 2003-11-18 | エイブイアイ バイオファーマ, インコーポレイテッド | スプライス領域アンチセンス組成物および方法 |
-
2002
- 2002-05-17 CA CA002447052A patent/CA2447052A1/en not_active Abandoned
- 2002-05-17 KR KR10-2003-7014985A patent/KR20040004629A/ko not_active Ceased
- 2002-05-17 WO PCT/US2002/015842 patent/WO2002092617A1/en not_active Ceased
- 2002-05-17 EP EP02769769A patent/EP1399462A4/en not_active Withdrawn
- 2002-05-17 JP JP2002589500A patent/JP2004537517A/ja active Pending
- 2002-05-17 CN CNA028100719A patent/CN1509292A/zh active Pending
- 2002-05-17 US US10/151,008 patent/US20030087861A1/en not_active Abandoned
- 2002-05-17 NZ NZ530101A patent/NZ530101A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101624596B (zh) * | 2009-08-12 | 2011-01-26 | 广州金琪基因技术研究发展中心 | 一种靶向c-myc癌基因的外指引序列 |
| CN108338986A (zh) * | 2017-01-23 | 2018-07-31 | 深圳开悦生命科技有限公司 | 一种用于治疗癌症的小分子rna及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1399462A4 (en) | 2008-03-05 |
| WO2002092617A1 (en) | 2002-11-21 |
| KR20040004629A (ko) | 2004-01-13 |
| US20030087861A1 (en) | 2003-05-08 |
| NZ530101A (en) | 2007-01-26 |
| CA2447052A1 (en) | 2002-11-21 |
| EP1399462A1 (en) | 2004-03-24 |
| JP2004537517A (ja) | 2004-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1509292A (zh) | 使用c-myc反义寡聚物治疗癌症的结合的方法 | |
| CN1189562C (zh) | 针对核糖核苷酸还原酶r1和r2组分的抗肿瘤反义序列 | |
| CN1918292A (zh) | 用于调节bcl-2的寡聚化合物 | |
| EP2263679B1 (en) | RNAi targeting cancer-related proteins | |
| US20100216867A1 (en) | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers | |
| CN1119830A (zh) | 反义抑制C-myc以调节平滑肌细胞的增殖 | |
| EP1876893A2 (en) | Cancer treatment by combined inhibition of proteasome and telomerase activities | |
| CN111440798A (zh) | 用于调节sod-1表达的组合物 | |
| KR20150014493A (ko) | 고 형질도입 효율 raav 벡터, 조성물 및 사용 방법 | |
| JP4424857B2 (ja) | リボヌクレオチドレダクターゼのr1及びr2成分に対する抗腫瘍アンチセンス配列 | |
| CN101849007A (zh) | 用于调节her3的rna拮抗剂化合物 | |
| CN1240439C (zh) | 肿瘤基因开关药物 | |
| JP2022031642A (ja) | アンチセンスオリゴヌクレオチド | |
| CN1298445A (zh) | 神经纤维网素反义寡核苷酸序列及其用于调控细胞生长的方法 | |
| WO1998054203A1 (en) | Inhibition of stress activated protein kinase (sapk) pathway and sensitization of cells to cancer therapies | |
| KR101579638B1 (ko) | 티미딜산 합성효소에 대한 RNAi 분자 및 그의 용도 | |
| JP2017506232A (ja) | 腫瘍を治療するための阻害性オリゴヌクレオチド | |
| WO2013066485A2 (en) | Compositions and methods for treatment of metastatic cancer | |
| KR102680316B1 (ko) | 안티센스 올리고뉴클레오타이드 | |
| JP2023013932A (ja) | SARS-CoV-2 RNA配列に基づく新規siRNA及びその利用 | |
| KR20190009961A (ko) | Bcl2 유전자 및 bi-1 유전자의 발현을 동시에 억제하는 핵산 | |
| KR101464360B1 (ko) | 리보자임과 shRNA를 함유하는 아데노바이러스 및 이를 포함하는 암 치료용 조성물 | |
| CN1387567A (zh) | 肽与核酸类似物诸如pna、lna、或吗啉代之间的缀合物 | |
| WO2024186688A2 (en) | Compositions and methods for delivery of low dose effector agents | |
| AU2012345707A1 (en) | Treatment of B cell lymphomas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |