CN1480226A - 孔状体的抗生素覆层及其制备方法和应用 - Google Patents
孔状体的抗生素覆层及其制备方法和应用 Download PDFInfo
- Publication number
- CN1480226A CN1480226A CNA031486231A CN03148623A CN1480226A CN 1480226 A CN1480226 A CN 1480226A CN A031486231 A CNA031486231 A CN A031486231A CN 03148623 A CN03148623 A CN 03148623A CN 1480226 A CN1480226 A CN 1480226A
- Authority
- CN
- China
- Prior art keywords
- laruate
- myristate
- poroid
- lauryl sulfate
- vancomycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
Abstract
Description
抗生素的加入量[mg] | 月桂酸钠的加入量[mg] | |
实施例1 | 59.1 | 72.0 |
实施例2 | 58.6 | 18.3 |
实施例3 | 61.8 | 91.0 |
抗生素的释放 | ||||||
实施例1 | 实施例2 | 实施例3 | ||||
时间[天] | 稀释 | 抑菌圈的直径[mm] | 稀释 | 抑菌圈的直径[mm] | 稀释 | 抑菌圈的直径[mm] |
1 | 1∶250 | 20.05 | 1∶100 | 20.30 | 1∶100 | 21.00 |
2 | 1∶100 | 17.10 | 1∶20 | 18.65 | 1∶40 | 21.50 |
3 | 1∶40 | 19.43 | 1∶10 | 18.73 | 1∶10 | 22.00 |
6 | 1∶5 | 20.20 | 未稀释 | 15.13 | 1∶5 | 22.20 |
9 | 未稀释 | 22.50 | 未稀释 | 0.00 | 1∶3 | 19.95 |
12 | 未稀释 | 23.35 | 未稀释 | 0.00 | 未稀释 | 23.00 |
时间[天] | 1 | 2 | 3 | 6 | 9 | 12 |
庆大霉素的释放(作为庆大霉素碱)[mg] | 16.28 | 2.97 | 1.65 | 0.19 | 0.09 | 0.11 |
Claims (15)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10227935.7 | 2002-06-21 | ||
DE10227935A DE10227935B4 (de) | 2002-06-21 | 2002-06-21 | Verfahren zur Herstellung einer antibiotische Beschichtung von porösen Körpern sowie Verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1480226A true CN1480226A (zh) | 2004-03-10 |
CN1310682C CN1310682C (zh) | 2007-04-18 |
Family
ID=29716605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB031486231A Expired - Fee Related CN1310682C (zh) | 2002-06-21 | 2003-06-23 | 孔状体的抗生素覆层及其制备方法和应用 |
Country Status (12)
Country | Link |
---|---|
US (1) | US7030093B2 (zh) |
EP (1) | EP1374923B1 (zh) |
JP (1) | JP4838488B2 (zh) |
CN (1) | CN1310682C (zh) |
AT (1) | ATE337802T1 (zh) |
BR (2) | BRPI0302074B1 (zh) |
CA (1) | CA2431984C (zh) |
DE (3) | DE10262176B4 (zh) |
DK (1) | DK1374923T3 (zh) |
ES (1) | ES2268220T3 (zh) |
PT (1) | PT1374923E (zh) |
ZA (1) | ZA200304798B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100418978C (zh) * | 2006-11-01 | 2008-09-17 | 福州大学 | 一种采用膜分离技术制备西索米星的方法 |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10318991A1 (de) * | 2003-04-25 | 2004-11-18 | Heraeus Kulzer Gmbh & Co. Kg | Poröser Körper mit antibiotischer Beschichtung, Verfahren zur Herstellung sowie Verwendung |
DE102004021739B4 (de) * | 2004-04-30 | 2007-11-22 | Heraeus Kulzer Gmbh | Metallimplantat mit Oberflächenbeschichtung |
DE102004060666B3 (de) * | 2004-12-15 | 2006-03-30 | Heraeus Kulzer Gmbh | Antibiotikum/Antibiotika enthaltendes Knochenersatzmaterial mit retardierender Wirkstofffreisetzung |
CN101247789B (zh) | 2005-05-27 | 2012-06-27 | 罗耶化学医药公司 | 可生物再吸收聚合物基质及其制造和使用方法 |
DE102006007245A1 (de) * | 2006-02-15 | 2007-08-23 | Heraeus Kulzer Gmbh | Implantatmaterial |
US20070197548A1 (en) * | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V S | Fluoroquinolone compositions |
US20070196398A1 (en) * | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V S | Fluoroquinolone fatty acid salt compositions |
DE102006016598A1 (de) * | 2006-04-06 | 2007-11-15 | Heraeus Kulzer Gmbh | Beschichtete Vaskulärimplantate |
DE102006060934A1 (de) * | 2006-12-20 | 2008-06-26 | Wolter, Dietmar F., Prof. Dr. | Saugdrainage mit einem antibakteriell wirkenden Materialdepot |
JP5131632B2 (ja) * | 2007-05-10 | 2013-01-30 | 国立大学法人 新潟大学 | 薬物徐放材料及びその製造方法 |
EP2018864A1 (en) | 2007-07-23 | 2009-01-28 | Biomet Deutschland GmbH | Pharmaceutical composition, substrate comprising a pharmaceutical composition, and use of a pharmaceutical composition |
AU2008349523B2 (en) * | 2008-01-29 | 2013-10-24 | Zimmer, Inc. | Implant device for use in an implant system |
US20090246250A1 (en) * | 2008-03-27 | 2009-10-01 | Affinergy | Coating compositions having improved performance |
DE102010020940B4 (de) | 2010-05-19 | 2014-09-25 | Heraeus Medical Gmbh | Antibiotische Beschichtung |
DE102010055560B4 (de) | 2010-12-23 | 2017-02-23 | Heraeus Medical Gmbh | Beschichtungsvorrichtung |
DE102010055559B4 (de) | 2010-12-23 | 2015-10-29 | Heraeus Medical Gmbh | Beschichtungsverfahren und Beschichtungsvorrichtung |
DE102010055562B4 (de) | 2010-12-23 | 2015-07-09 | Heraeus Medical Gmbh | Beschichtungsvorrichtung und Beschichtungsverfahren |
DE102010055561B4 (de) | 2010-12-23 | 2015-12-31 | Heraeus Medical Gmbh | Beschichtungsverfahren und Beschichtungsvorrichtung |
DE102011117526B4 (de) | 2011-11-03 | 2015-07-30 | Heraeus Medical Gmbh | Beschichtungsverfahren und Beschichtungsvorrichtung für medizinische Implantate |
US9492374B2 (en) | 2015-03-25 | 2016-11-15 | Jose Rafael Salinas Andrade | Composition and method for treatment of ulcers |
BR112020000196A2 (pt) | 2017-07-07 | 2020-07-07 | Epicentrx, Inc. | composições para administração parenteral de agentes terapêuticos |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3091572A (en) * | 1962-07-16 | 1963-05-28 | Schering Corp | Gentamycin and method of production |
CA950831A (en) | 1972-04-25 | 1974-07-09 | Leonard D. Kurtz | Biocidal salts |
FR2272680B1 (zh) | 1974-05-29 | 1978-07-21 | Hosbon Sa Lab | |
DE2843963A1 (de) * | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
DE2807132C2 (de) | 1978-02-20 | 1983-11-03 | Battelle-Institut E.V., 6000 Frankfurt | Implantierbares Pharmaka-Depot |
DE3206725A1 (de) * | 1981-05-13 | 1982-12-02 | Merck Patent Gmbh, 6100 Darmstadt | Schwer loesliche salze von aminoglykosidantibiotika |
DE3248328A1 (de) * | 1982-12-28 | 1984-06-28 | Bayer Ag, 5090 Leverkusen | Schwerloesliche salze von aminoglykosiden sowie diese enthaltende formulierungen mit verzoegerter wirkstoff-freigabe |
DE3377064D1 (en) | 1982-12-28 | 1988-07-21 | Bayer Ag | Stable aminoglycoside-penicillin injection formulation |
DE3414924A1 (de) * | 1984-04-19 | 1985-10-31 | Klaus Dr.med. Dr.med.habil. 8000 München Draenert | Beschichtetes verankerungsteil fuer implantate |
US4749585A (en) * | 1986-04-11 | 1988-06-07 | University Of Medicine And Dentistry Of New Jersey | Antibiotic bonded prosthesis and process for producing same |
DE3613213A1 (de) * | 1986-04-18 | 1987-10-22 | Merck Patent Gmbh | Tricalciumphosphat fuer implantationsmaterialien |
DE4304716A1 (de) * | 1993-02-16 | 1994-08-18 | Melzer Wolfgang | Lokal applizierbares Arzneimittel mit verzögerter Freisetzung |
DE4314871A1 (de) * | 1993-05-05 | 1994-11-10 | Merck Patent Gmbh | Lösungsmittel für ein schwerlösliches Gentamicin-Salz |
JPH0767895A (ja) * | 1993-06-25 | 1995-03-14 | Sumitomo Electric Ind Ltd | 抗菌性人工血管及び抗菌性手術用縫合糸 |
DE4404018A1 (de) * | 1994-02-09 | 1995-08-10 | Merck Patent Gmbh | Protrahiert freisetzende Darreichungsformen enthaltend Clindamycin-Palmitat |
DE19726412A1 (de) * | 1997-06-21 | 1998-12-24 | Merck Patent Gmbh | Implantatmaterial mit einer Träger-Wirkstoff-Kombination |
EP0985413A1 (de) * | 1998-08-06 | 2000-03-15 | Jörg Michael Dr. Dr. Schierholz | Medizinprodukte mit retardierter pharmakologischer Aktivität und Verfahren zu ihrer Herstellung |
DE19855421C2 (de) * | 1998-11-02 | 2001-09-20 | Alcove Surfaces Gmbh | Implantat |
DE10114245A1 (de) * | 2001-03-22 | 2002-10-02 | Heraeus Kulzer Gmbh & Co Kg | Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung |
DE10114364A1 (de) * | 2001-03-22 | 2002-10-02 | Heraeus Kulzer Gmbh & Co Kg | Verfahren zur Herstellung von antibiotischen Kompositen |
IS6390A (is) * | 2001-08-31 | 2003-03-03 | Heraeus Kulzer Gmbh & Co. Kg | Reynsla af sýklalyfjahúðun skrokka sem í eru örholrými, þannig húðuðum skrokkum og einnig af notkunþeirra |
-
2002
- 2002-06-21 DE DE10262176A patent/DE10262176B4/de not_active Expired - Fee Related
- 2002-06-21 DE DE10227935A patent/DE10227935B4/de not_active Expired - Fee Related
-
2003
- 2003-05-28 DE DE50304820T patent/DE50304820D1/de not_active Expired - Lifetime
- 2003-05-28 DK DK03011967T patent/DK1374923T3/da active
- 2003-05-28 ES ES03011967T patent/ES2268220T3/es not_active Expired - Lifetime
- 2003-05-28 AT AT03011967T patent/ATE337802T1/de active
- 2003-05-28 EP EP03011967A patent/EP1374923B1/de not_active Expired - Fee Related
- 2003-05-28 PT PT03011967T patent/PT1374923E/pt unknown
- 2003-06-12 CA CA002431984A patent/CA2431984C/en not_active Expired - Fee Related
- 2003-06-17 BR BRPI0302074-6A patent/BRPI0302074B1/pt unknown
- 2003-06-17 BR BR0302074-6A patent/BR0302074A/pt not_active IP Right Cessation
- 2003-06-20 ZA ZA200304798A patent/ZA200304798B/xx unknown
- 2003-06-20 US US10/600,548 patent/US7030093B2/en not_active Expired - Lifetime
- 2003-06-20 JP JP2003177000A patent/JP4838488B2/ja not_active Expired - Fee Related
- 2003-06-23 CN CNB031486231A patent/CN1310682C/zh not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100418978C (zh) * | 2006-11-01 | 2008-09-17 | 福州大学 | 一种采用膜分离技术制备西索米星的方法 |
Also Published As
Publication number | Publication date |
---|---|
DE10227935B4 (de) | 2007-10-04 |
EP1374923A2 (de) | 2004-01-02 |
DK1374923T3 (da) | 2006-12-27 |
BR0302074A (pt) | 2004-04-27 |
PT1374923E (pt) | 2006-11-30 |
EP1374923A3 (de) | 2004-02-11 |
CA2431984A1 (en) | 2003-12-21 |
CA2431984C (en) | 2009-09-08 |
DE10227935A1 (de) | 2004-01-15 |
ES2268220T3 (es) | 2007-03-16 |
US7030093B2 (en) | 2006-04-18 |
ZA200304798B (en) | 2004-04-29 |
AU2003204863A1 (en) | 2004-01-15 |
EP1374923B1 (de) | 2006-08-30 |
ATE337802T1 (de) | 2006-09-15 |
CN1310682C (zh) | 2007-04-18 |
JP2004067679A (ja) | 2004-03-04 |
BRPI0302074B1 (pt) | 2018-02-14 |
JP4838488B2 (ja) | 2011-12-14 |
DE50304820D1 (de) | 2006-10-12 |
DE10262176B4 (de) | 2007-10-04 |
US20040048786A1 (en) | 2004-03-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: HERAEUS MEDICAL CO., LTD. Free format text: FORMER OWNER: HERAEUS KULZER GMBH Effective date: 20140326 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: HERAEUS KULZER GMBH Free format text: FORMER NAME: HERAEUS KULZER GMBH + CO. KG |
|
CP01 | Change in the name or title of a patent holder |
Address after: Hanau, Germany Patentee after: HERAEUS KULZER GmbH Address before: Hanau, Germany Patentee before: HERAEUS KULZER GmbH & Co.KG |
|
TR01 | Transfer of patent right |
Effective date of registration: 20140326 Address after: Germany's Maxwell Patentee after: Heraeus Medical GmbH Address before: Hanau, Germany Patentee before: Heraeus Kulzer GmbH |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070418 Termination date: 20200623 |
|
CF01 | Termination of patent right due to non-payment of annual fee |