CN1451377A - 榄香烯注射剂及其制备方法和用途 - Google Patents
榄香烯注射剂及其制备方法和用途 Download PDFInfo
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- CN1451377A CN1451377A CN02117219A CN02117219A CN1451377A CN 1451377 A CN1451377 A CN 1451377A CN 02117219 A CN02117219 A CN 02117219A CN 02117219 A CN02117219 A CN 02117219A CN 1451377 A CN1451377 A CN 1451377A
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- Prior art keywords
- injection
- elemene
- dosage form
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- liposome
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Images
Abstract
Description
注射剂 | 剂量(mg/kg) | 抑瘤率 | 剂量(mg/kg) | 抑瘤率 | 剂量(mg/kg) | 抑瘤率 |
1A | 20 | 30.2% | 40 | 39.3% | 80 | 45.2% |
1B | 20 | 30.0% | 40 | 39.1% | 80 | 45.0% |
2A | 20 | 30.1% | 40 | 37.5% | 80 | 44.0% |
2B | 20 | 30.0% | 40 | 38.5% | 80 | 43.6% |
3A | 20 | 29.6% | 40 | 39.6% | 80 | 44.5% |
3B | 20 | 29.8% | 40 | 38.6% | 80 | 44.4% |
4A-1 | 20 | 30.4% | 40 | 38.5% | 80 | 46.0% |
4A-2 | 20 | 31.6% | 40 | 37.9% | 80 | 46.2% |
4B-1 | 20 | 30.2% | 40 | 37.4% | 80 | 45.3% |
4B-2 | 20 | 29.4% | 40 | 38.6% | 80 | 44.9% |
5A | 20 | 29.3% | 40 | 38.7% | 80 | 44.3% |
5B | 20 | 29.5% | 40 | 38.6% | 80 | 44.5% |
6A | 20 | 29.8% | 40 | 37.8% | 80 | 43.2% |
6R | 20 | 29.4% | 40 | 37.9% | 80 | 43.5% |
7A | 20 | 29.2% | 40 | 37.4% | 80 | 44.0% |
7B | 20 | 29.6% | 40 | 37.2% | 80 | 43.2% |
8A | 20 | 29.4% | 40 | 37.4% | 80 | 44.0% |
8B | 20 | 29.2% | 40 | 37.2% | 80 | 43.2% |
注射剂 | 剂量(mg/kg) | 抑瘤率 | 剂量(mg/kg) | 抑瘤率 | 剂量(mg/kg) | 抑瘤率 |
1A | 20 | 28.9% | 40 | 39.3% | 80 | 45.2% |
1B | 20 | 29.1% | 40 | 39.1% | 80 | 45.0% |
2A | 20 | 29.3% | 40 | 37.5% | 80 | 44.0% |
2B | 20 | 28.4% | 40 | 38.5% | 80 | 43.6% |
3A | 20 | 29.1% | 40 | 39.6% | 80 | 44.5% |
3B | 20 | 29.0% | 40 | 38.6% | 80 | 44.4% |
4A-1 | 20 | 29.4% | 40 | 38.5% | 80 | 46.0% |
4A-2 | 20 | 29.5% | 40 | 37.9% | 80 | 46.2% |
4B-1 | 20 | 28.8% | 40 | 37.4% | 80 | 45.3% |
4B-2 | 20 | 28.3% | 40 | 38.6% | 80 | 44.9% |
注射剂 | 剂量(mg/kg) | 抑瘤率 | 剂量(mg/kg) | 抑瘤率 | 剂量(mg/kg) | 抑瘤率 |
1A | 20 | 47.6% | 40 | 59.5% | 80 | 68.2% |
1B | 20 | 46.8% | 40 | 59.2% | 80 | 68.5% |
2A | 20 | 47.2% | 40 | 57.6% | 80 | 64.0% |
2B | 20 | 48.2% | 40 | 56.3% | 80 | 63.6% |
3A | 20 | 49.5% | 40 | 59.6% | 80 | 67.5% |
3B | 20 | 48.4% | 40 | 58.3% | 80 | 66.4% |
4A-1 | 20 | 49.3% | 40 | 58.4% | 80 | 67.0% |
4A-2 | 20 | 49.4% | 40 | 57.7% | 80 | 67.2% |
4B-1 | 20 | 48.6% | 40 | 57.2% | 80 | 66.3% |
4B-2 | 20 | 49.3% | 40 | 5 8.4% | 80 | 67.9% |
5A | 20 | 49.8% | 40 | 58.7% | 80 | 68.3% |
5B | 20 | 47.8% | 40 | 58.3% | 80 | 65.5% |
6A | 20 | 47.6% | 40 | 56.8% | 80 | 63.2% |
6B | 20 | 46.9% | 40 | 56.9% | 80 | 63.5% |
7A | 20 | 48.2% | 40 | 56.4% | 80 | 66.0% |
7B | 20 | 46.8% | 40 | 56.2% | 80 | 63.2% |
注射剂 | 剂量(mg/kg) | 抑瘤率 | 剂量(mg/kg) | 抑瘤率 | 剂量(mg/kg) | 抑瘤率 |
1A | 20 | 23.1% | 40 | 29.8% | 80 | 35.4% |
1B | 20 | 23.0% | 40 | 29.6% | 80 | 35.2% |
2A | 20 | 22.8% | 40 | 27.8% | 80 | 34.0% |
2B | 20 | 22.8% | 40 | 28.5% | 80 | 33.3% |
3A | 20 | 22.9% | 40 | 29.8% | 80 | 34.2% |
3B | 20 | 23.0% | 40 | 28.7% | 80 | 34.8% |
4A-1 | 20 | 24.2% | 40 | 28.1% | 80 | 36.2% |
4A-2 | 20 | 24.4% | 40 | 27.9% | 80 | 36.2% |
4B-1 | 20 | 23.6% | 40 | 27.8% | 80 | 35.2% |
4B-2 | 20 | 23.2% | 40 | 28.7% | 80 | 34.4% |
5A | 20 | 23.4% | 40 | 28.7% | 80 | 34.8% |
5B | 20 | 24.1% | 40 | 28.6% | 80 | 34.5% |
6A | 20 | 22.4% | 40 | 27.9% | 80 | 33.2% |
6B | 20 | 22.6% | 40 | 27.8% | 80 | 33.4% |
7A | 20 | 22.4% | 40 | 27.5% | 80 | 34.1% |
7B | 20 | 22.2% | 40 | 27.3% | 80 | 33.6% |
Claims (19)
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CN2008101264162A CN101306182B (zh) | 2002-04-17 | 2002-04-17 | 榄香烯静脉乳剂及其制备方法 |
CNB021172196A CN100423714C (zh) | 2002-04-17 | 2002-04-17 | 榄香烯注射剂及其制备方法和用途 |
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CN1650846B (zh) * | 2004-12-07 | 2011-11-16 | 沈阳药科大学 | 榄香烯脂质体及其制备方法 |
WO2011140872A1 (zh) | 2010-05-10 | 2011-11-17 | Xie Tian | 抗肿瘤植物药榄香烯缓释片 |
CN101756900B (zh) * | 2010-02-25 | 2012-05-30 | 谢恬 | 一种榄香烯微乳 |
CN108186616A (zh) * | 2018-01-24 | 2018-06-22 | 天津中医药大学 | β-榄香烯在制备用于预防和/或治疗与IL-1相关的炎症性疾病的药物中的用途 |
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JP2023504821A (ja) * | 2019-12-03 | 2023-02-07 | 四川弘合生物科技有限公司 | エレメンを含む医薬組成物、その調製方法、及びその使用 |
CN117467626A (zh) * | 2023-10-31 | 2024-01-30 | 武汉软件工程职业学院(武汉开放大学) | 一种β-橄榄烯合成酶、基因及其应用 |
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CN1060038C (zh) * | 1993-02-15 | 2001-01-03 | 大连市医药科学研究所 | 榄香烯乳注射液及其制备方法 |
CN1084187C (zh) * | 1997-04-14 | 2002-05-08 | 中国远大国际集团有限公司 | 以β-榄香烯为有效成分的抗癌药物的制备方法及其组成 |
CN1221607A (zh) * | 1998-11-20 | 1999-07-07 | 大连市医药科学研究所 | 脂溶性药物脂质体生产工艺及榄香烯脂质体注射液 |
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2002
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1650846B (zh) * | 2004-12-07 | 2011-11-16 | 沈阳药科大学 | 榄香烯脂质体及其制备方法 |
CN101756900B (zh) * | 2010-02-25 | 2012-05-30 | 谢恬 | 一种榄香烯微乳 |
WO2011140872A1 (zh) | 2010-05-10 | 2011-11-17 | Xie Tian | 抗肿瘤植物药榄香烯缓释片 |
CN108186616A (zh) * | 2018-01-24 | 2018-06-22 | 天津中医药大学 | β-榄香烯在制备用于预防和/或治疗与IL-1相关的炎症性疾病的药物中的用途 |
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CN101306182A (zh) | 2008-11-19 |
CN100423714C (zh) | 2008-10-08 |
CN101306181B (zh) | 2011-06-29 |
CN101306181A (zh) | 2008-11-19 |
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